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Conserved domains on  [gi|20143971|ref|NP_006059|]
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toll-like receptor 6 precursor [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 17988233)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971    641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20143971    719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886  14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886  94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886 165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 20143971 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886 241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886 194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20143971 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 20143971    529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971    641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20143971    719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.35e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.66  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   642 FHAFISYSEHDS-AWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20143971   721 HNLFhEGSNNLILILLEPIPQ------NSIPNKYHKLKALMTQRTYLQWP------------KEKSKRGLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIA 155
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886  14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886  94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886 165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 20143971 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886 241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886 194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20143971 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 20143971    529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
76-133 3.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20143971    76 SELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 1.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  353 STFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMtkDMPSLEILDVSWNSLeSGRHKENCTWVESIVV 432
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSL-SGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  433 LNLSSNMLTDSVFRCLP--PRIKVLDLHSNKIK-SVPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSV 507
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSL 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143971  508 SHPSADFFQSCQKMRSIKAGDNPFqcTCEL-REFVK----NIDQVSSEVLEGWPDSYKCDYPE 565
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-208 2.54e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   43 LIHVPKDLPLKTKVLDMSQNYIAELQvsdMSFLSELTVLRLSHNRIQLLDLSVfkfNQDLEYLDLSHNQLQKISCHPIVS 122
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELP---ERLPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  123 FRHLDLSFNDFKALP-----------------ICKEFGNLSQLNFLGLSAMKLQKL-DLLP--IAHLHLSYILLdlrnYY 182
Cdd:PRK15370 306 ITHLNVQSNSLTALPetlppglktleagenalTSLPASLPPELQVLDVSKNQITVLpETLPptITTLDVSRNAL----TN 381

                        170       180
                 ....*....|....*....|....*.
gi 20143971  183 IKENETESLQILNAKTLHLVFHPTSL 208
Cdd:PRK15370 382 LPENLPAALQIMQASRNNLVRLPESL 407
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 558-582 8.44e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 37.42  E-value: 8.44e-04
                          10        20
                  ....*....|....*....|....*
gi 20143971   558 SYKCDYPESYRGSPLKDFHMSELSC 582
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 1.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.37e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20143971  78 LTVLRLSHNRIQllDLSVFKFNQDLEYLDLSHNQLQKIS--CHPIVSFRHL---DLSFNdfkalPICK 140
Cdd:cd21340 122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLrelDLTGN-----PVCK 182
LRR_8 pfam13855
Leucine rich repeat;
450-505 2.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   450 PRIKVLDLHSNKIKSVPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-780 2.54e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 139.38  E-value: 2.54e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971    641 QFHAFISYSEHDsaWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20143971    719 AHHNLFHEGSNNLILILLEPIPQNsIPNKYHKLKALMtQRTYLQWPKEKSKRglFWANIRAA 780
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYA 136
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-778 2.35e-21

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 91.66  E-value: 2.35e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   642 FHAFISYSEHDS-AWVKSELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20143971   721 HNLFhEGSNNLILILLEPIPQ------NSIPNKYHKLKALMTQRTYLQWP------------KEKSKRGLFWANIR 778
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIA 155
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-738 3.45e-18

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 80.82  E-value: 3.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   645 FISYSEHDSAWVKsELVPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 724
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 20143971   725 HEGSNNLILILLEP 738
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
249-531 4.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.97  E-value: 4.41e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 249 STLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVF 328
Cdd:COG4886  14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 329 SEMNIMMLTISDTPFIHMLcphapSTFKFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEIL 408
Cdd:COG4886  94 DLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDLPEP---LGNLTNLKSL 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 409 DVSWNSLES-GRHKENCTwveSIVVLNLSSNMLTD--SVFRCLPpRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSL 485
Cdd:COG4886 165 DLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 20143971 486 TDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 531
Cdd:COG4886 241 TDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-546 1.66e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.66e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 356 KFLNFTQNVFTDsIFEKCSTLVKLETLILQKNGLKDLFKVglmTKDMPSLEILDVSWNSLESGRHK-ENCTwveSIVVLN 434
Cdd:COG4886 139 KELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELDLSNNQITDLPEPlGNLT---NLEELD 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 435 LSSNMLTD---SVFRClpPRIKVLDLHSNKIKSVPkQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPS 511
Cdd:COG4886 212 LSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288

                       170       180       190
                ....*....|....*....|....*....|....*
gi 20143971 512 ADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQ 546
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-327 3.09e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.03  E-value: 3.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  55 KVLDMSQNYIAELqVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISCH--PIVSFRHLDLSFND 132
Cdd:COG4886 116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQ 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 133 FKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYILLD---------------LRNYYIKENE----TESLQ 192
Cdd:COG4886 194 ITDLP--EPLGNLTNLEELDLSGNQLTDLP-EPLANLtNLETLDLSnnqltdlpelgnltnLEELDLSNNQltdlPPLAN 270

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQF 272
Cdd:COG4886 271 LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALL 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20143971 273 LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTV 327
Cdd:COG4886 351 TLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-283 5.06e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  55 KVLDMSQNYIAELQVSdMSFLSELTVLRLSHNRIQLLDLSVFKFNQdLEYLDLSHNQLQKISC-HPIVSFRHLDLSFNDF 133
Cdd:COG4886 185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDLPElGNLTNLEELDLSNNQL 262

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971 134 KALPICKEFGNLSQLNFLG--LSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAI 211
Cdd:COG4886 263 TDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20143971 212 QVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNI 283
Cdd:COG4886 343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 1.63e-09

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 53.97  E-value: 1.63e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 20143971    529 NPFQCTCELREFVKNIDQvssEVLEGWPDSYKCDYPESYRGsPLKDFHMSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
76-133 3.04e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 3.04e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20143971    76 SELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDF 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 1.50e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 58.32  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  353 STFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMtkDMPSLEILDVSWNSLeSGRHKENCTWVESIVV 432
Cdd:PLN00113 236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSL-SGEIPELVIQLQNLEI 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  433 LNLSSNMLTDSVFRCLP--PRIKVLDLHSNKIK-SVPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSV 507
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSL 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20143971  508 SHPSADFFQSCQKMRSIKAGDNPFqcTCEL-REFVK----NIDQVSSEVLEGWPDSYKCDYPE 565
Cdd:PLN00113 393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-529 2.31e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  353 STFKFLNFTQNVFTDSIfeKCSTLVKLETLILQKNGLKdlfkvGLMTKDM---PSLEILDVSWNSLeSGRHKENCTWVES 429
Cdd:PLN00113 118 SSLRYLNLSNNNFTGSI--PRGSIPNLETLDLSNNMLS-----GEIPNDIgsfSSLKVLDLGGNVL-VGKIPNSLTNLTS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  430 IVVLNLSSNMLTDSVFRCLpPRIKVLDL----HSNKIKSVPKQVVKLEALQELNVAFNSLTDL--PGCGSFSSLSVLIID 503
Cdd:PLN00113 190 LEFLTLASNQLVGQIPREL-GQMKSLKWiylgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPipSSLGNLKNLQYLFLY 268

                        170       180
                 ....*....|....*....|....*.
gi 20143971  504 HNSVSHPSADFFQSCQKMRSIKAGDN 529
Cdd:PLN00113 269 QNKLSGPIPPSIFSLQKLISLDLSDN 294
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
352-489 6.32e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 46.61  E-value: 6.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  352 PSTFKFLNFTQNVFTDsIFEKCSTlvKLETLILQKNglkdlfKVGLMTKDMPS-LEILDVSWNSLES-GRHKENctwveS 429
Cdd:PRK15370 240 PDTIQEMELSINRITE-LPERLPS--ALQSLDLFHN------KISCLPENLPEeLRYLSVYDNSIRTlPAHLPS-----G 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  430 IVVLNLSSNMLT----------------DSVFRCLP----PRIKVLDLHSNKIKSVPKQVVKleALQELNVAFNSLTDLP 489
Cdd:PRK15370 306 ITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLP 383
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-180 1.18e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  47 PKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRiQLLDLSvfkfnqDLEYLDLSHNQLQKI--SCHPIVSFR 124
Cdd:COG4886  67 LLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-ELSNLT------NLESLDLSGNQLTDLpeELANLTNLK 139

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 20143971 125 HLDLSFNDFKALPicKEFGNLSQLNFLGLSAMKLQKLDlLPIAHL-HLSYilLDLRN 180
Cdd:COG4886 140 ELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP-EELGNLtNLKE--LDLSN 191
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
378-545 1.42e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.46  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  378 KLETLILQKNGLKDLFKvglmtKDMPSLEILDVSWNSLESGRHkencTWVESIVVLNLSSNMLTDSVFRcLPPRIKVLDL 457
Cdd:PRK15370 200 QITTLILDNNELKSLPE-----NLQGNIKTLYANSNQLTSIPA----TLPDTIQEMELSINRITELPER-LPSALQSLDL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  458 HSNKIKSVPKQVVklEALQELNVAFNSLTDLPGCGSfSSLSVLIIDHNSVSHPSADFFQScqkMRSIKAGDNPFQCTCE- 536
Cdd:PRK15370 270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLP-SGITHLNVQSNSLTALPETLPPG---LKTLEAGENALTSLPAs 343


                 ....*....
gi 20143971  537 LREFVKNID 545
Cdd:PRK15370 344 LPPELQVLD 352
LRR_8 pfam13855
Leucine rich repeat;
55-112 1.81e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.81e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 20143971    55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQL 112
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
43-208 2.54e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   43 LIHVPKDLPLKTKVLDMSQNYIAELQvsdMSFLSELTVLRLSHNRIQLLDLSVfkfNQDLEYLDLSHNQLQKISCHPIVS 122
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELP---ERLPSALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHLPSG 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  123 FRHLDLSFNDFKALP-----------------ICKEFGNLSQLNFLGLSAMKLQKL-DLLP--IAHLHLSYILLdlrnYY 182
Cdd:PRK15370 306 ITHLNVQSNSLTALPetlppglktleagenalTSLPASLPPELQVLDVSKNQITVLpETLPptITTLDVSRNAL----TN 381

                        170       180
                 ....*....|....*....|....*.
gi 20143971  183 IKENETESLQILNAKTLHLVFHPTSL 208
Cdd:PRK15370 382 LPENLPAALQIMQASRNNLVRLPESL 407
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 558-582 8.44e-04

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 37.42  E-value: 8.44e-04
                          10        20
                  ....*....|....*....|....*
gi 20143971   558 SYKCDYPESYRGSPLKDFHMSELSC 582
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 78-140 1.37e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.37e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20143971  78 LTVLRLSHNRIQllDLSVFKFNQDLEYLDLSHNQLQKIS--CHPIVSFRHL---DLSFNdfkalPICK 140
Cdd:cd21340 122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLrelDLTGN-----PVCK 182
LRR_8 pfam13855
Leucine rich repeat;
450-505 2.08e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.08e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   450 PRIKVLDLHSNKIKSVPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 505
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 358-450 5.98e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 5.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971  358 LNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLmtKDMPSLEILDVSWNSLeSGRHKENCTWVESIVVLNLSS 437
Cdd:PLN00113 504 LKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASF--SEMPVLSQLDLSQNQL-SGEIPKNLGNVESLVQVNISH 580

                         90
                 ....*....|...
gi 20143971  438 NMLTDSvfrcLPP 450
Cdd:PLN00113 581 NHLHGS----LPS 589
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-148 9.30e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.45  E-value: 9.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20143971   53 KTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQ-----KISCHPIVSfrHLD 127
Cdd:PLN00113 476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqipaSFSEMPVLS--QLD 553

                         90       100
                 ....*....|....*....|.
gi 20143971  128 LSFNDFKAlPICKEFGNLSQL 148
Cdd:PLN00113 554 LSQNQLSG-EIPKNLGNVESL 573
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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