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Conserved domains on  [gi|5174447|ref|NP_006089|]
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small ribosomal subunit protein RACK1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-311 4.16e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 283.07  E-value: 4.16e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5174447  245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200 231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-311 4.16e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 283.07  E-value: 4.16e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5174447  245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200 231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 3.09e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 244.05  E-value: 3.09e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    6 TLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNSSnpI 164
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG--HTGAVRSVAFSPDGK--L 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSP 298

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5174447  244 NRYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Cdd:COG2319 299 DGKLLASGSDdGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-222 2.92e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.17  E-value: 2.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHsewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5174447   158 PNSSNPIIVSCGWDKLVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 1.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 5174447      94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.84e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.84e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5174447     95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-311 4.16e-95

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 283.07  E-value: 4.16e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    7 LRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDGT 86
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNssNPII 165
Cdd:cd00200  75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRG--HTDWVNSVAFSPD--GTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  166 VSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN 244
Cdd:cd00200 151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5174447  245 RYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQ 311
Cdd:cd00200 231 GYLLASGSEdGTIRVWDLRTGECVQTL---------SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 3.09e-78

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 244.05  E-value: 3.09e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    6 TLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNSSnpI 164
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTG--HTGAVRSVAFSPDGK--L 218

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSP 298

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5174447  244 NRYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Cdd:COG2319 299 DGKLLASGSDdGTVRLWDLATGKLLRTL---------TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 COG2319
WD40 repeat [General function prediction only];
6-313 3.38e-77

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 241.35  E-value: 3.38e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    6 TLRGTLKGHNGWVTQIATTPqfpD--MILSASRDKTIIMWKLTRdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSW 83
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSP---DgkTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSD 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNSSn 162
Cdd:COG2319 183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTG--HSGSVRSVAFSPDGR- 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  163 pIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCF 241
Cdd:COG2319 260 -LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAF 338

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5174447  242 SPNRYWLCAATGP-SIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313
Cdd:COG2319 339 SPDGKTLASGSDDgTVRLWDLATGELLRTL---------TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
6-317 1.82e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.61  E-value: 1.82e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    6 TLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTrdetnyGIPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319  27 ALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA------GALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVqdESHSEWVSCVRFSPNSSnpI 164
Cdd:COG2319 101 TVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAtGKLLRTL--TGHSGAVTSVAFSPDGK--L 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  165 IVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSP 243
Cdd:COG2319 177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSP 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5174447  244 NRYWLCAATG-PSIKIWDLEGKIIVDELkqevistssKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Cdd:COG2319 257 DGRLLASGSAdGTVRLWDLATGELLRTL---------TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322
WD40 COG2319
WD40 repeat [General function prediction only];
43-317 2.93e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 179.34  E-value: 2.93e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   43 WKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVS 122
Cdd:COG2319  16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  123 GSRDKTIKLWNTLGVcKYTVQDESHSEWVSCVRFSPNSSnpIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSP 202
Cdd:COG2319  96 ASADGTVRLWDLATG-LLLRTLTGHTGAVRSVAFSPDGK--TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447  203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPN-RYWLCAATGPSIKIWDLEGKIIVDELkqevistssK 280
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDgKLLASGSADGTVRLWDLATGKLLRTL---------T 243

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 5174447  281 AEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Cdd:COG2319 244 GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280
WD40 COG2319
WD40 repeat [General function prediction only];
6-181 7.57e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 7.57e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    6 TLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWKLTRDEtnygiPQRALRGHSHFVSDVVISSDGQFALSGSWDG 85
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGE-----LLRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   86 TLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-GVCKYTVQDesHSEWVSCVRFSPNSSnpI 164
Cdd:COG2319 311 TVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTG--HTGAVTSVAFSPDGR--T 386

                       170
                ....*....|....*..
gi 5174447  165 IVSCGWDKLVKVWNLAN 181
Cdd:COG2319 387 LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-133 3.26e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 3.26e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    2 TEQMTLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMWkltrdETNYGIPQRALRGHSHFVSDVVISSDGQFALSG 81
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLW-----DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 5174447   82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:cd00200 238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-222 2.92e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 58.17  E-value: 2.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    80 SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN-TLGVCKYTVQDESHsewVSCVRFs 157
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSiNQGVSIGTIKTKAN---ICCVQF- 625

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5174447   158 PNSSNPIIVSCGWDKLVKVWNLANCKLK-TNHIGHTGYLNTVTVSpDGSLCASGGKDGQAMLWDLN 222
Cdd:PLN00181 626 PSESGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLS 690
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 1.54e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.00  E-value: 1.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 5174447      94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.84e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.84e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5174447     95 GTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 31-261 4.78e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 4.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    31 ILSASRDKTIIMWKLTRDETnygipQRALRGHSHFVSDVVISS-DGQFALSGSWDGTLRLWDLTTGTTtrrfVGHTK--- 106
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQL-----VTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVS----IGTIKtka 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   107 DVLSVAFSSDN-RQIVSGSRDKTIKLWN----TLGVCKYTvqdeSHSEWVSCVRFSPNSSnpiIVSCGWDKLVKVWNLAN 181
Cdd:PLN00181 619 NICCVQFPSESgRSLAFGSADHKVYYYDlrnpKLPLCTMI----GHSKTVSYVRFVDSST---LVSSSTDNTLKLWDLSM 691

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   182 CKLKTNH------IGHTGYLNTVTVSPDGSLCASGGKDGQAMLW--------------DLNEGKHLYTLDGGDIINALCF 241
Cdd:PLN00181 692 SISGINEtplhsfMGHTNVKNFVGLSVSDGYIATGSETNEVFVYhkafpmpvlsykfkTIDPVSGLEVDDASQFISSVCW 771

                        250       260
                 ....*....|....*....|.
gi 5174447   242 SPNRYWLCAA-TGPSIKIWDL 261
Cdd:PLN00181 772 RGQSSTLVAAnSTGNIKILEM 792
WD40 pfam00400
WD domain, G-beta repeat;
53-91 6.25e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 6.25e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5174447     53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-314 1.14e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   108 VLSVAFSSDNRQIVSGSRDKTIKLWNtlgvCKYTVQD--ESHSEWVSCVRFSPNSS-------NPIIVSCGWDKLVKVWN 178
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFE----CESIIKDgrDIHYPVVELASRSKLSGicwnsyiKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   179 LANCKLKTNHIGHTGYLNTVTVSP-DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSpnrywlcAATGPSIK 257
Cdd:PLN00181 562 VARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFP-------SESGRSLA 634

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 5174447   258 IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTI 314
Cdd:PLN00181 635 FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-91 5.09e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.09e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 5174447      53 GIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWD 91
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 102-213 2.67e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 2.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447   102 VGHTKDVLSVAFSS-DNRQIVSGSRDKTIKLWN------TLGVCKYTVQDESHSEWVSCVRFSPnSSNPIIVSCGWDKLV 174
Cdd:PTZ00421  72 LGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeeglTQNISDPIVHLQGHTKKVGIVSFHP-SAMNVLASAGADMVV 150

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 5174447   175 KVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKD 213
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKD 189
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 145-178 2.72e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.72e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 5174447     145 ESHSEWVSCVRFSPNSSnpIIVSCGWDKLVKVWN 178
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK--YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 190-220 5.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 5.36e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 5174447     190 GHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
145-178 6.56e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 6.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 5174447    145 ESHSEWVSCVRFSPNSSnpIIVSCGWDKLVKVWN 178
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGK--LLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
183-220 1.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 5174447    183 KLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWD 220
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 11-133 3.57e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 3.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLtrdetNYGIPQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLW 90
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI-----NQGVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYY 645

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 5174447    91 DLTTGTTTR-RFVGHTKDVLSVAFsSDNRQIVSGSRDKTIKLWN 133
Cdd:PLN00181 646 DLRNPKLPLcTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWD 688
PTZ00421 PTZ00421
coronin; Provisional
 11-131 3.75e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 3.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRD--ETNYGIPQRALRGHSHFVSDVVI--SSDGQFALSGSwDGT 86
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEglTQNISDPIVHLQGHTKKVGIVSFhpSAMNVLASAGA-DMV 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 5174447    87 LRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKL 131
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-44 1.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 5174447       4 QMTLRGTLKGHNGWVTQIATTPQFpDMILSASRDKTIIMWK 44
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 2.90e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.90e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5174447      5 MTLRGTLKGHNGWVTQIATTPQfPDMILSASRDKTIIMW 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVW 38
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 81-230 3.16e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 3.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447     81 GSWDGTLRLWDLTTGTTTRRfVGHTKDVLS-VAFSSDNRQIVSGSRDKTIKLWNTLGVC---KYTVQDESHSEWVSCVRf 156
Cdd:pfam20426 100 GNWENSFQVISLNDGRMVQS-IRQHKDVVScVAVTSDGSILATGSYDTTVMVWEVLRGRsseKRSRNTQTEFPRKDHVI- 177

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5174447    157 spnSSNPIIVSCGWDKLVkvwnlaNCklktnhightgylntVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTL 230
Cdd:pfam20426 178 ---AETPFHILCGHDDII------TC---------------LYVSVELDIVISGSKDGTCIFHTLREGRYVRSI 227
PTZ00420 PTZ00420
coronin; Provisional
 11-92 3.48e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 3.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447    11 LKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYG---IPQRALRGHSHFVSDVVISSDGQFAL-SGSWDGT 86
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikDPQCILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149


                 ....*.
gi 5174447    87 LRLWDL 92
Cdd:PTZ00420 150 VNIWDI 155
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 59-128 4.17e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.51  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5174447     59 LRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFV-----------------------GHTKDVLSVAFSS 115
Cdd:pfam20426 120 IRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKRSrntqtefprkdhviaetpfhilcGHDDIITCLYVSV 199

                          90
                  ....*....|...
gi 5174447    116 DNRQIVSGSRDKT 128
Cdd:pfam20426 200 ELDIVISGSKDGT 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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