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Conserved domains on  [gi|19923362|ref|NP_006279|]
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thy-1 membrane glycoprotein isoform 1 preproprotein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 22-123 2.52e-22

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


:

Pssm-ID: 409540  Cd Length: 76  Bit Score: 84.47  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362  22 VTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFgtvgvpehtyrsrtnftskynmkvlyLSAFTSKDEGT 101
Cdd:cd20948   1 SPSDTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQELF--------------------------LPAITENNEGT 54

                        90       100
                ....*....|....*....|..
gi 19923362 102 YTCALHHSGHSPPISSQNVTVL 123
Cdd:cd20948  55 YTCSAHNSLTGKNISLVLSVTV 76
 
Name Accession Description Interval E-value
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 22-123 2.52e-22

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 84.47  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362  22 VTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFgtvgvpehtyrsrtnftskynmkvlyLSAFTSKDEGT 101
Cdd:cd20948   1 SPSDTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQELF--------------------------LPAITENNEGT 54

                        90       100
                ....*....|....*....|..
gi 19923362 102 YTCALHHSGHSPPISSQNVTVL 123
Cdd:cd20948  55 YTCSAHNSLTGKNISLVLSVTV 76
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 21-117 8.64e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.49  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362    21 KVTSLTACLVDQSLRLDCRHeNTSSSPIQYEFSLTRETKKHVLFGTvgvpeHTYRSRTNFTskynmkvLYLSAFTSKDEG 100
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSA-STGSPGPDVTWSKEGGTLIESLKVK-----HDNGRTTQSS-------LLISNVTKEDAG 67

                          90
                  ....*....|....*..
gi 19923362   101 TYTCALHHSGHSPPISS 117
Cdd:pfam00047  68 TYTCVVNNPGGSATLST 84
IGv smart00406
Immunoglobulin V-Type;
33-105 7.00e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.59  E-value: 7.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362     33 SLRLDCRHENTSSSpiQYEFSLTRETKKHVL-------FGTVGVPEHTYRSRTNFTSKY--NMKVLYLSAFTSKDEGTYT 103
Cdd:smart00406   1 SVTLSCKFSGSTFS--SYYVSWVRQPPGKGLewlgyigSNGSSYYQESYKGRFTISKDTskNDVSLTISNLRVEDTGTYY 78


                   ..
gi 19923362    104 CA 105
Cdd:smart00406  79 CA 80
 
Name Accession Description Interval E-value
IgC2_CEACAM5-like cd20948
Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell ...
 22-123 2.52e-22

Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains; The members here are composed of the fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), also known as CD66e (Cluster of Differentiation 66e), is a cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Diseases associated with CEACAM5 include lung cancer and rectum cancer. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C2-set of IgSF domains, having A, B, and E strands in one beta-sheet and A', G, F, C' in the other. Unlike other Ig domain sets, the C2-set lacks the D strand.


Pssm-ID: 409540  Cd Length: 76  Bit Score: 84.47  E-value: 2.52e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362  22 VTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKKHVLFgtvgvpehtyrsrtnftskynmkvlyLSAFTSKDEGT 101
Cdd:cd20948   1 SPSDTYYLSGENLNLSCHAASNPPAQYSWTINGTFQTSSQELF--------------------------LPAITENNEGT 54

                        90       100
                ....*....|....*....|..
gi 19923362 102 YTCALHHSGHSPPISSQNVTVL 123
Cdd:cd20948  55 YTCSAHNSLTGKNISLVLSVTV 76
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 21-117 8.64e-07

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 44.49  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362    21 KVTSLTACLVDQSLRLDCRHeNTSSSPIQYEFSLTRETKKHVLFGTvgvpeHTYRSRTNFTskynmkvLYLSAFTSKDEG 100
Cdd:pfam00047   1 SAPPTVTVLEGDSATLTCSA-STGSPGPDVTWSKEGGTLIESLKVK-----HDNGRTTQSS-------LLISNVTKEDAG 67

                          90
                  ....*....|....*..
gi 19923362   101 TYTCALHHSGHSPPISS 117
Cdd:pfam00047  68 TYTCVVNNPGGSATLST 84
IGv smart00406
Immunoglobulin V-Type;
33-105 7.00e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.59  E-value: 7.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362     33 SLRLDCRHENTSSSpiQYEFSLTRETKKHVL-------FGTVGVPEHTYRSRTNFTSKY--NMKVLYLSAFTSKDEGTYT 103
Cdd:smart00406   1 SVTLSCKFSGSTFS--SYYVSWVRQPPGKGLewlgyigSNGSSYYQESYKGRFTISKDTskNDVSLTISNLRVEDTGTYY 78


                   ..
gi 19923362    104 CA 105
Cdd:smart00406  79 CA 80
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 32-122 1.73e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923362     32 QSLRLDCRhentSSSPIQYEFSLTRETKKHVLfgtvgvpehtYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGH 111
Cdd:smart00410  10 ESVTLSCE----ASGSPPPEVTWYKQGGKLLA----------ESGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSG 75

                           90
                   ....*....|.
gi 19923362    112 SpPISSQNVTV 122
Cdd:smart00410  76 S-ASSGTTLTV 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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