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Conserved domains on  [gi|5453593|ref|NP_006357|]
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adenylyl cyclase-associated protein 2 isoform 1 [Homo sapiens]

Protein Classification

adenylyl cyclase-associated protein( domain architecture ID 12014817)

adenylyl cyclase-associated family protein similar to Saccharomyces cerevisiae adenylyl cyclase-associated protein (CAP) which is a modular actin monomer binding protein that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
323-475 5.11e-90

Adenylate cyclase associated (CAP) C terminal;


:

Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 270.90  E-value: 5.11e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593    323 PVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQI 402
Cdd:pfam08603   3 PKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSFQV 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5453593    403 QVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQ--DGDYREFPIPEQFKTAWDGSKLITEPAEI 475
Cdd:pfam08603  83 QVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgeDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
7-64 2.95e-13

Adenylate cyclase associated (CAP) N terminal;


:

Pssm-ID: 460113  Cd Length: 72  Bit Score: 64.69  E-value: 2.95e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593      7 LVERLERAVSRLESL-----------SAESHRPPGNCGEVNGVIAGVA-PSVEAFDKLMDSMVAEFLKNS 64
Cdd:pfam01213   3 LVKRLEAATSRLEDIaisasgssassSASSSGGGAPSAAAPAPAASPApPSVEAFDELISGPVAPFVELS 72
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
323-475 5.11e-90

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 270.90  E-value: 5.11e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593    323 PVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQI 402
Cdd:pfam08603   3 PKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSFQV 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5453593    403 QVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQ--DGDYREFPIPEQFKTAWDGSKLITEPAEI 475
Cdd:pfam08603  83 QVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgeDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
7-64 2.95e-13

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 64.69  E-value: 2.95e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593      7 LVERLERAVSRLESL-----------SAESHRPPGNCGEVNGVIAGVA-PSVEAFDKLMDSMVAEFLKNS 64
Cdd:pfam01213   3 LVKRLEAATSRLEDIaisasgssassSASSSGGGAPSAAAPAPAASPApPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
359-396 7.69e-10

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 54.06  E-value: 7.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 5453593     359 CEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVIN 396
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Name Accession Description Interval E-value
CAP_C pfam08603
Adenylate cyclase associated (CAP) C terminal;
323-475 5.11e-90

Adenylate cyclase associated (CAP) C terminal;


Pssm-ID: 462532 [Multi-domain]  Cd Length: 157  Bit Score: 270.90  E-value: 5.11e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593    323 PVLELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVINSQDIQI 402
Cdd:pfam08603   3 PKKELEGNKWIVENQENNKPIVIEDTEMNQSVYIFNCKNSTIQIKGKVNAISLDNCKKTSVVVDSLVSSVEVINCQSFQV 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5453593    403 QVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQ--DGDYREFPIPEQFKTAWDGSKLITEPAEI 475
Cdd:pfam08603  83 QVLGKVPTISIDKTDGGQIYLSKESLDTEIVTSKSSEMNVNVPGgeDGDYVEFPIPEQFKTTIKDGKLVTEVVEH 157
CAP_N pfam01213
Adenylate cyclase associated (CAP) N terminal;
7-64 2.95e-13

Adenylate cyclase associated (CAP) N terminal;


Pssm-ID: 460113  Cd Length: 72  Bit Score: 64.69  E-value: 2.95e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5453593      7 LVERLERAVSRLESL-----------SAESHRPPGNCGEVNGVIAGVA-PSVEAFDKLMDSMVAEFLKNS 64
Cdd:pfam01213   3 LVKRLEAATSRLEDIaisasgssassSASSSGGGAPSAAAPAPAASPApPSVEAFDELISGPVAPFVELS 72
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
359-396 7.69e-10

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 54.06  E-value: 7.69e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 5453593     359 CEKSTIQIKGKVNSIIIDNCKKLGLVFDNVVGIVEVIN 396
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
CARP smart00673
Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;
397-434 5.60e-09

Domain in CAPs (cyclase-associated proteins) and X-linked retinitis pigmentosa 2 gene product;


Pssm-ID: 197827  Cd Length: 38  Bit Score: 51.36  E-value: 5.60e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 5453593     397 SQDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVS 434
Cdd:smart00673   1 CESCTIQVSGKVNTISIDKCKKCSIYLGPVSGSPEIVN 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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