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Conserved domains on  [gi|5454084|ref|NP_006406|]
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serine palmitoyltransferase 1 isoform a [Homo sapiens]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 11-472 2.04e-172

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02822:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 481  Bit Score: 493.10  E-value: 2.04e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    11 VEMVQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPLVPPVPK---- 75
Cdd:PLN02822  13 LERVTMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrp 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    76 DHPALNYniVSGPpshKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKF 155
Cdd:PLN02822  92 EPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   156 MKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDqknpRKA 235
Cdd:PLN02822 167 LGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRK 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   236 RVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIG 315
Cdd:PLN02822 243 KKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   316 GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFH 395
Cdd:PLN02822 323 GFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVF 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   396 LQLEESTGSREQDVRLLQEIVDQCMNRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVL 472
Cdd:PLN02822 403 LHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 11-472 2.04e-172

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 493.10  E-value: 2.04e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    11 VEMVQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPLVPPVPK---- 75
Cdd:PLN02822  13 LERVTMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrp 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    76 DHPALNYniVSGPpshKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKF 155
Cdd:PLN02822  92 EPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   156 MKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDqknpRKA 235
Cdd:PLN02822 167 LGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRK 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   236 RVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIG 315
Cdd:PLN02822 243 KKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   316 GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFH 395
Cdd:PLN02822 323 GFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVF 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   396 LQLEESTGSREQDVRLLQEIVDQCMNRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVL 472
Cdd:PLN02822 403 LHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 2.18e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.21  E-value: 2.18e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   84 IVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:COG0156  23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156 103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  242 IVVEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGInIDDIDLISANMENALASIGGFCCG 320
Cdd:COG0156 171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAG 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKvVGESLSPAFHLQLEe 400
Cdd:COG0156 249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVG- 325

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5454084  401 stgsreqDVRLLQEIVDQCMNRSIALTQARYlekeekclppPS-------IRVVVTVEQTEEELERAASTIKEVAQA 470
Cdd:COG0156 326 -------DAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 3.41e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.47  E-value: 3.41e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   98 KECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454   1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  178 YSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVVEGLYMNTGTICPL 257
Cdd:cd06454  81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454 152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  338 SASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKVVGESLSPAFHLQLEEStgsreqdvRLLQEIVD 417
Cdd:cd06454 231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDP--------AKAVAFSD 301

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 5454084  418 QCMNRSIALTQARY---LEKEEKclpppsIRVVVTVEQTEEELERAASTIKEV 467
Cdd:cd06454 302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 1.47e-23

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 101.23  E-value: 1.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084     98 KECINFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLAKFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    242 IVVEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRgVTEHYGINiDDIDLISAN-MENALASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDA-VATRALLA-EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKVVGeSLSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    395 HLQLeestGSREQDVRLLQEIVDQCmnrSIALTQARYLEKeekclpPPSIRVVVTVeQTEEELERAASTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
 
Name Accession Description Interval E-value
PLN02822 PLN02822
serine palmitoyltransferase
 11-472 2.04e-172

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 493.10  E-value: 2.04e-172
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    11 VEMVQALYEAPAY-----------HLILEGILILWIIRLLFSKTYKLQERSdLTVKEKEELIEEWQPEPLVPPVPK---- 75
Cdd:PLN02822  13 LERVTMLLEAPLAravvfgvhiggHLVVEGLLIVVIVFLLSQKSYKPPKRP-LTEKEIDELCDEWTPEPLIPPITEemrp 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    76 DHPALNYniVSGPpshKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKF 155
Cdd:PLN02822  92 EPPVLES--AAGP---HTIINGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   156 MKTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDqknpRKA 235
Cdd:PLN02822 167 LGTPDSILYSYGLSTIFSVIPAFCKKGDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLEKLTAEN----KRK 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   236 RVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIG 315
Cdd:PLN02822 243 KKLRRYIVVEAIYQNSGQIAPLDEIVRLKEKYRFRVLLDESNSFGVLGKSGRGLSEHFGVPIEKIDIITAAMGHALATEG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   316 GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISGLKVVGESLSPAFH 395
Cdd:PLN02822 323 GFCTGSARVVDHQRLSSSGYVFSASLPPYLASAAITAIDVLEDNPSVLAKLKENIALLHKGLSDIPGLSIGSNTLSPIVF 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   396 LQLEESTGSREQDVRLLQEIVDQCMNRS---IALTQARYLekeEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVL 472
Cdd:PLN02822 403 LHLEKSTGSAKEDLSLLEHIADRMLKEDsvlVVVSKRSTL---DKCRLPVGIRLFVSAGHTESDILKASESLKRVAASVL 479
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 101-472 3.98e-112

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 336.49  E-value: 3.98e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   101 INFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPAYSK 180
Cdd:PLN03227   1 LNFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   181 RGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPEL 260
Cdd:PLN03227  81 RGDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQVRAQDVALKRKPTDQRRFLVVEGLYKNTGTLAPLKEL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   261 VKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGIN-IDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCFSA 339
Cdd:PLN03227 161 VALKEEFHYRLILDESFSFGTLGKSGRGSLEHAGLKpMVHAEIVTFSLENAFGSVGGMTVGSEEVVDHQRLSGSGYCFSA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   340 SLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIS---------GLKVVGESLSPAFHLQLEESTGSREQD-V 409
Cdd:PLN03227 241 SAPPFLAKADATATAGELAGPQLLNRLHDSIANLYSTLTNSShpyalklrnRLVITSDPISPIIYLRLSDQEATRRTDeT 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5454084   410 RLLQEIVDQCMNRSIALTQAR-YLEKEEKCLPPPSIRVVVTVEQTEEELERAASTIKEVAQAVL 472
Cdd:PLN03227 321 LILDQIAHHSLSEGVAVVSTGgHVKKFLQLVPPPCLRVVANASHTREDIDKLLTVLGEAVEAIL 384
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 84-470 2.18e-80

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 254.21  E-value: 2.18e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   84 IVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:COG0156  23 VLESPQGPRVTIDGREVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSGGSRLVSGTTPLHEELEEELAEFLGKEAALL 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  164 YSYGFATIASAIPAYSKRGDIVFVDRA--ACfaIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqknPRKARvtRRF 241
Cdd:COG0156 103 FSSGYAANLGVISALAGRGDLIFSDELnhAS--IIDGARLSGAKVVRFRHNDMDDLERLLKK--------ARAAR--RKL 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  242 IVVEGLY-MnTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGInIDDIDLISANMENALASIGGFCCG 320
Cdd:COG0156 171 IVTDGVFsM-DGDIAPLPEIVELAEKYGALLYVDDAHGTGVLGETGRGLVEHFGL-EDRVDIIMGTLSKALGSSGGFVAG 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  321 RSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKvVGESLSPAFHLQLEe 400
Cdd:COG0156 249 SKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPELRERLWENIAYFREGLKEL-GFD-LGPSESPIVPVIVG- 325

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5454084  401 stgsreqDVRLLQEIVDQCMNRSIALTQARYlekeekclppPS-------IRVVVTVEQTEEELERAASTIKEVAQA 470
Cdd:COG0156 326 -------DAERALALADALLERGIYVSAIRP----------PTvpkgtarLRITLSAAHTEEDIDRLLEALAEVGKE 385
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 98-467 3.41e-78

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 247.47  E-value: 3.41e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   98 KECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:cd06454   1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  178 YSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEqeiedqkNPRKARvtRRFIVVEGLYMNTGTICPL 257
Cdd:cd06454  81 LAGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLRE-------ARRPYG--KKLIVTEGVYSMDGDIAPL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  258 PELVKLKYKYKARIFLEESLSFGVLGEHGRGVtEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYCF 337
Cdd:cd06454 152 PELVDLAKKYGAILFVDEAHSVGVYGPHGRGV-EEFGGLTDDVDIIMGTLGKAFGAVGGYIAGSKELIDYLRSYARGFIF 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084  338 SASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKVVGESLSPAFHLQLEEStgsreqdvRLLQEIVD 417
Cdd:cd06454 231 STSLPPAVAAAALAALEVLQGGPERRERLQENVRYLRRGLKEL-GFPVGGSPSHIIPPLIGDDP--------AKAVAFSD 301

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 5454084  418 QCMNRSIALTQARY---LEKEEKclpppsIRVVVTVEQTEEELERAASTIKEV 467
Cdd:cd06454 302 ALLERGIYVQAIRYptvPRGTAR------LRISLSAAHTKEDIDRLLEALKEV 348
PLN02483 PLN02483
serine palmitoyltransferase
 96-471 4.35e-55

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 191.13  E-value: 4.35e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    96 NGKECINFASFNFLGLLD-----NPRVkaaaLASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFAT 170
Cdd:PLN02483  98 KTRRCLNLGSYNYLGFAAadeycTPRV----IESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYAT 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   171 IASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQknPRKARVTRRFIV-VEGLYM 249
Cdd:PLN02483 174 NSTIIPALIGKGGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLREQIAEGQ--PRTHRPWKKIIViVEGIYS 251

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   250 NTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQR 329
Cdd:PLN02483 252 MEGELCKLPEIVAVCKKYKAYVYLDEAHSIGAVGKTGRGVCELLGVDPADVDIMMGTFTKSFGSCGGYIAGSKELIQYLK 331

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   330 LSGQGYCFSASL-PPLLAAAAIEALNIMEE---NPGifavlKEKCGQIHK-------ALQGIsGLKVVGESLSPAFHLQL 398
Cdd:PLN02483 332 RTCPAHLYATSMsPPAVQQVISAIKVILGEdgtNRG-----AQKLAQIREnsnffrsELQKM-GFEVLGDNDSPVMPIML 405

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5454084   399 EESTG----SREqdvrllqeivdqCMNRSIALTQARYlekeeKCLPP--PSIRVVVTVEQTEEELERAASTIKEVAQAV 471
Cdd:PLN02483 406 YNPAKipafSRE------------CLKQNVAVVVVGF-----PATPLllARARICISASHSREDLIKALEVISEVGDLV 467
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 84-343 6.75e-49

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 172.30  E-value: 6.75e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    84 IVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:PRK06939  28 ITSPQGADITVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMASVRFICGTQDLHKELEEKLAKFLGTEDAIL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   164 YSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQeiedqknpRKARVTRRFIV 243
Cdd:PRK06939 108 YSSCFDANGGLFETLLGKEDAIISDALNHASIIDGVRLCKAKRYRYANNDMADLEAQLKEA--------KEAGARHKLIA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   244 VEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGInIDDIDLISANMENALA-SIGGFCCGRS 322
Cdd:PRK06939 180 TDGVFSMDGDIAPLPEICDLADKYDALVMVDDSHAVGFVGENGRGTVEHFGV-MDRVDIITGTLGKALGgASGGYTAGRK 258

                        250       260
                 ....*....|....*....|.
gi 5454084   323 FVIDHQRLSGQGYCFSASLPP 343
Cdd:PRK06939 259 EVIDWLRQRSRPYLFSNSLAP 279
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 84-468 1.43e-48

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 171.11  E-value: 1.43e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    84 IVSGPPSHKTVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAII 163
Cdd:PRK05958  25 PREGGAGRWLVVDGRRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRLVTGNSPAHEALEEELAEWFGAERALL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   164 YSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqeiedqknpRKARVTRRFIV 243
Cdd:PRK05958 105 FSSGYAANLAVLTALAGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVDALEALL-----------AKWRAGRALIV 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   244 VEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGInIDDIDLIS-ANMENALASIGGFCCGRS 322
Cdd:PRK05958 174 TESVFSMDGDLAPLAELVALARRHGAWLLVDEAHGTGVLGPQGRGLAAEAGL-AGEPDVILvGTLGKALGSSGAAVLGSE 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   323 FVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGISglKVVGESLSPAFHLQLeest 402
Cdd:PRK05958 253 TLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPERRERLAALIARLRAGLRALG--FQLMDSQSAIQPLIV---- 326

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 5454084   403 GSREQDVRLLQeivdQCMNRSIALTqarylekeekCLPPPS-------IRVVVTVEQTEEELERAASTIKEVA 468
Cdd:PRK05958 327 GDNERALALAA----ALQEQGFWVG----------AIRPPTvpagtsrLRITLTAAHTEADIDRLLEALAEAL 385
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 98-343 5.79e-31

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 123.81  E-value: 5.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    98 KECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PRK13392  46 RRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAGAGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALST 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   178 YSKR--GDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEIEDQKnprkarvtrrFIVVEGLYMNTGTIC 255
Cdd:PRK13392 126 LGKLlpGCVILSDALNHASMIEGIRRSGAEKQVFRHNDLADLEEQLASVDPDRPK----------LIAFESVYSMDGDIA 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   256 PLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGInIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGY 335
Cdd:PRK13392 196 PIEAICDLADRYNALTYVDEVHAVGLYGARGGGIAERDGL-MDRIDMIQGTLAKAFGCLGGYIAASADLIDFVRSFAPGF 274


                 ....*...
gi 5454084   336 CFSASLPP 343
Cdd:PRK13392 275 IFTTALPP 282
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
98-464 1.47e-23

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 101.23  E-value: 1.47e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084     98 KECINFASFNFLGLLdnprVKAAALASLKkygVGTCGPRGFYGTFDVHLDLEDRLAKFM--------KTEEAIIYSYGFA 169
Cdd:pfam00155   1 TDKINLGSNEYLGDT----LPAVAKAEKD---ALAGGTRNLYGPTDGHPELREALAKFLgrspvlklDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    170 TIASAIPAYSK-RGDIVFVDRAACFAIQKGLQASRSDIKLFK-------HNDMADLERLLKEQeiedqknprkarvtRRF 241
Cdd:pfam00155  74 ANIEALIFLLAnPGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK--------------PKV 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    242 IVVEGLYMNTGTICPLPELVKL---KYKYKARIFLEESLSFGVLGEHGRgVTEHYGINiDDIDLISAN-MENALASIG-- 315
Cdd:pfam00155 140 VLHTSPHNPTGTVATLEELEKLldlAKEHNILLLVDEAYAGFVFGSPDA-VATRALLA-EGPNLLVVGsFSKAFGLAGwr 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    316 -GFCCGRSFVIDHQRLSGQGYCFSASLPPLLAAAAIEALNIMEENPGIFAVLKEKCGQIHKALQGIsGLKVVGeSLSPAF 394
Cdd:pfam00155 218 vGYILGNAAVISQLRKLARPFYSSTHLQAAAAAALSDPLLVASELEEMRQRIKERRDYLRDGLQAA-GLSVLP-SQAGFF 295

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    395 HLQLeestGSREQDVRLLQEIVDQCmnrSIALTQARYLEKeekclpPPSIRVVVTVeQTEEELERAASTI 464
Cdd:pfam00155 296 LLTG----LDPETAKELAQVLLEEV---GVYVTPGSSPGV------PGWLRITVAG-GTEEELEELLEAI 351
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
92-343 2.48e-19

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 89.68  E-value: 2.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    92 KTVVNGK----ECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYG 167
Cdd:PRK07179  44 KHLVLGKtpgpDAIILQSNDYLNLSGHPDIIKAQIAALQEEGDSLVMSAVFLHDDSPKPQFEKKLAAFTGFESCLLCQSG 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   168 FATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLkeqeiedqknprkarvtRRF----IV 243
Cdd:PRK07179 124 WAANVGLLQTIADPNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQI-----------------ERHgpgiIV 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   244 VEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINiDDIDLISANMENALASIGGFCCGRSF 323
Cdd:PRK07179 187 VDSVYSTTGTIAPLADIVDIAEEFGCVLVVDESHSLGTHGPQGAGLVAELGLT-SRVHFITASLAKAFAGRAGIITCPRE 265

                        250       260
                 ....*....|....*....|
gi 5454084   324 VIDHQRLSGQGYCFSASLPP 343
Cdd:PRK07179 266 LAEYVPFVSYPAIFSSTLLP 285
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 101-294 9.74e-18

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 84.45  E-value: 9.74e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   101 INFASFNFLGLLDNPRVKAAALASLKKY-------GVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIAS 173
Cdd:PRK05937   7 IDFVTNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   174 AIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMADLERLLKEQeiedqknpRKARVTRRFIVVEGLYMNTGT 253
Cdd:PRK05937  87 LCAHLSSVTDYVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLESC--------RQRSFGRIFIFVCSVYSFKGT 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 5454084   254 ICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYG 294
Cdd:PRK05937 159 LAPLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGFCHSLG 199
PRK07505 PRK07505
hypothetical protein; Provisional
 83-317 1.14e-17

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 84.65  E-value: 1.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    83 NIVSGPPSHK--TVVNGKECINFASFNFLGLLDNPRVKAAALASLKKYGV-GTCGPRGFYgTFDVHLDLEDRLAKFMKTE 159
Cdd:PRK07505  29 GLTVGEREGIliTLADGHTFVNFVSCSYLGLDTHPAIIEGAVDALKRTGSlHLSSSRTRV-RSQILKDLEEALSELFGAS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   160 EAIIYSYGFAT------IASAIPAYSKRGDIVFvDRAA--CFAIQKGLQASRSDIKLFKHNDMADLERLLKEQEiedqkn 231
Cdd:PRK07505 108 VLTFTSCSAAHlgilplLASGHLTGGVPPHMVF-DKNAhaSLNILKGICADETEVETIDHNDLDALEDICKTNK------ 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   232 prkarvtRRFIVVEGLYmNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRG-VTEHYGINIDDIDLISANMENA 310
Cdd:PRK07505 181 -------TVAYVADGVY-SMGGIAPVKELLRLQEKYGLFLYIDDAHGLSIYGKNGEGyVRSELDYRLNERTIIAASLGKA 252


                 ....*..
gi 5454084   311 LASIGGF 317
Cdd:PRK07505 253 FGASGGV 259
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 98-342 1.06e-16

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 82.42  E-value: 1.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084    98 KECINFASFNFLGLLDNPRVKAAALASLKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFMKTEEAIIYSYGFATIASAIPA 177
Cdd:PLN02955 102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   178 YSKRGDIVFVD-------RAACF-------AIQKGLQ-ASR---SDIKLFKHNDMADLERLLKEQEIEdqknprkarvtR 239
Cdd:PLN02955 182 IGSVASLLAASgkplkneKVAIFsdalnhaSIIDGVRlAERqgnVEVFVYRHCDMYHLNSLLSSCKMK-----------R 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5454084   240 RFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEESLSFGVLGEHGRGVTEHYGINiDDIDLISANMENALASIGGF-- 317
Cdd:PLN02955 251 KVVVTDSLFSMDGDFAPMEELSQLRKKYGFLLVIDDAHGTFVCGENGGGVAEEFNCE-ADVDLCVGTLSKAAGCHGGFia 329

                        250       260
                 ....*....|....*....|....*
gi 5454084   318 CCGRSFVIDHQRlsGQGYCFSASLP 342
Cdd:PLN02955 330 CSKKWKQLIQSR--GRSFIFSTAIP 352
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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