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Conserved domains on  [gi|225543525|ref|NP_006437|]
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solute carrier organic anion transporter family member 1B1 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
27-561 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17457:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 455  Bit Score: 785.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17457    1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYsketninssenststlstclinqilslnraspeivgkGCLKESGSYMWIYVFMGNMLRGIGET 186
Cdd:cd17457   81 GSVLTALPHFFMGYYKY-------------------------------------GCLKESGSYMWVYVLMGNMLRGIGET 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17457  124 PIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSG 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtGFFQSFKSILTNPLYVMFVLLTL 346
Cdd:cd17457  204 LFSIISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTL 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17457  241 LQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYF 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17457  321 FIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSC 400
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 507 LEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17457  401 LEVTGSQNRNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
 
Name Accession Description Interval E-value
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
27-561 0e+00

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 785.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17457    1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYsketninssenststlstclinqilslnraspeivgkGCLKESGSYMWIYVFMGNMLRGIGET 186
Cdd:cd17457   81 GSVLTALPHFFMGYYKY-------------------------------------GCLKESGSYMWVYVLMGNMLRGIGET 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17457  124 PIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSG 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtGFFQSFKSILTNPLYVMFVLLTL 346
Cdd:cd17457  204 LFSIISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTL 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17457  241 LQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYF 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17457  321 FIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSC 400
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 507 LEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17457  401 LEVTGSQNRNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
29-621 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 626.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525   29 MFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGG 108
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  109 VLTALPHFfmgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsymwIYVFMGNMLRGIGETPI 188
Cdd:pfam03137  81 LLFALPHF-------------------------------------------------------LSFFLGQLLLGIGGTPI 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  189 VPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVdlsTIRITPTDSRWVGAWWLNFLVSGLF 268
Cdd:pfam03137 106 YTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV---SITLTPKDPRWVGAWWLGFLIAGLL 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  269 SIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITknvtGFFQSFKSILTNPLYVMFVLLTLLQ 348
Cdd:pfam03137 183 LLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLK----DFPKALKRLLKNPVYMLLTLASVFE 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  349 VSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFI 428
Cdd:pfam03137 259 FLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFL 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  429 LCENKSVAGLTMTYDGNNPVTshrDVPLSYCNSDCNCDESQWEPVCGNNG-ITYISPCLAGCKSSSGNKKPIVFYNCSCL 507
Cdd:pfam03137 339 GCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCS 415
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  508 EVTGLQNRNYSAHLGECPRDdaCTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILA 587
Cdd:pfam03137 416 CGSQDSGGNGSATPGKCPSD--CSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPG 493
                         570       580       590
                  ....*....|....*....|....*....|....
gi 225543525  588 PIYFGALIDTTCIKWsTNNCGTRGSCRTYNSTSF 621
Cdd:pfam03137 494 PILFGALIDSTCLLW-GKTCGGRGNCWLYDNDKL 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-649 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 549.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525    1 MDQNQHLNKTAEAQPSENKKTR--YCNG--LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIG 76
Cdd:TIGR00805   1 MGETEKDIATHESSAGLKPRPRclQSLFskIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525   77 NLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSkETNINSSENSTSTLSTCLINQILSLNrasPE 156
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYS-TTVSSTGNLSSANSFLCMENLTQTLR---PT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  157 IVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVD 236
Cdd:TIGR00805 157 QDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  237 IGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTpnKPQKERKASLSLHvlETNDEKDQTANLTNQGK 316
Cdd:TIGR00805 237 TGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKT--LPKEGKRVNVDVH--EAEKLEKSRGEDRKKNS 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  317 NITKNvtgFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYI 396
Cdd:TIGR00805 313 GITKD---FPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFI 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  397 IKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTM-TYDGNNPVTSHRDvplsyCNSDCNCDESQWEPVCG 475
Cdd:TIGR00805 390 MKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNNpSNDQPLYVENRTD-----CNRQCSCDSSIWDPVCG 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  476 NNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGlqnrNYSAHLGECPRDdaCTRKFYFFVaiqVLNLFFSALGGTSH 555
Cdd:TIGR00805 465 DNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPG----NSSAKKGLCDPP--CATSLQYFL---ILFIPLSFIYFITA 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  556 V---MLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSML 632
Cdd:TIGR00805 536 VpgyMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIAL 615
                         650
                  ....*....|....*..
gi 225543525  633 RVSSLVLYIILIYAMKK 649
Cdd:TIGR00805 616 RGSSLLPLFFILILARK 632
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
31-427 1.87e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.40  E-value: 1.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  31 LAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVL 110
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 111 TALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFMgnMLRGIGETPIVP 190
Cdd:COG2814   92 CAL----------------------------------------------------APSLWLLLAAR--FLQGLGAGALFP 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiritptdsrwvgAWWLNFLVSGLFSI 270
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLAL 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 271 ISSIP-FFFLPQTPNKPQKERKASLslhvletndekdqtanltnqgknitknvtgffqsfKSILTNPLYVMFVLLTLLQV 349
Cdd:COG2814  176 LALLLlLRLLPESRPAARARLRGSL-----------------------------------RELLRRPRLLLLLLLAFLLG 220
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543525 350 SSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIpIFASGMFLGGYIIKKFKLNTVGIAkfscFTAVMSLSFYLLYFF 427
Cdd:COG2814  221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGRRRLLLI----GLLLLALGLLLLALA 293
 
Name Accession Description Interval E-value
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
27-561 0e+00

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 785.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17457    1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYsketninssenststlstclinqilslnraspeivgkGCLKESGSYMWIYVFMGNMLRGIGET 186
Cdd:cd17457   81 GSVLTALPHFFMGYYKY-------------------------------------GCLKESGSYMWVYVLMGNMLRGIGET 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17457  124 PIVPLGISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSG 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtGFFQSFKSILTNPLYVMFVLLTL 346
Cdd:cd17457  204 LFSIISAIPFFFLP-------------------------------------------GFFQSLKSILTNRLYVMFVCLTL 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17457  241 LQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYF 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17457  321 FIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIVFHNCSC 400
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 507 LEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17457  401 LEVTGSQNRNYSAHLGECPRDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
27-561 0e+00

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 715.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17400    1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYSketninssenststlstclinqilslnraspeivgkgclkesgsYMWIYVFMGNMLRGIGET 186
Cdd:cd17400   81 GCFLKALPHFFMNQYEYS--------------------------------------------LMWIYVFVGNILRGIGET 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17400  117 PILPLGISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICG 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgffqsfksiltnPLYVMFVLLTL 346
Cdd:cd17400  197 GVSVLTAIPFFFLP-------------------------------------------------------PIYMLFILVSV 221
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17400  222 IQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSF 301
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17400  302 LMTCENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYNCSC 381
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 507 LEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17400  382 IQTSGNSSANLSLCDGGCPRDPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
29-621 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 626.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525   29 MFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGG 108
Cdd:pfam03137   1 FFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  109 VLTALPHFfmgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsymwIYVFMGNMLRGIGETPI 188
Cdd:pfam03137  81 LLFALPHF-------------------------------------------------------LSFFLGQLLLGIGGTPI 105
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  189 VPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVdlsTIRITPTDSRWVGAWWLNFLVSGLF 268
Cdd:pfam03137 106 YTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKV---SITLTPKDPRWVGAWWLGFLIAGLL 182
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  269 SIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTANLTNQGKNITknvtGFFQSFKSILTNPLYVMFVLLTLLQ 348
Cdd:pfam03137 183 LLLTAIPFFFFPKSLPGAAKRRAKKKKEPHSQDIADLKKTKSLKKLGPSLK----DFPKALKRLLKNPVYMLLTLASVFE 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  349 VSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFI 428
Cdd:pfam03137 259 FLLIAGYATFLPKYIETQFGLSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFFL 338
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  429 LCENKSVAGLTMTYDGNNPVTshrDVPLSYCNSDCNCDESQWEPVCGNNG-ITYISPCLAGCKSSSGNKKPIVFYNCSCL 507
Cdd:pfam03137 339 GCPNSPVAGITVPYGGTQQLS---GNLTSSCNSDCSCSTSAYSPVCGSDGgYTSPCPCGAGCSSSSGAGKSTYICNCCCS 415
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  508 EVTGLQNRNYSAHLGECPRDdaCTRKFYFFVAIQVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILA 587
Cdd:pfam03137 416 CGSQDSGGNGSATPGKCPSD--CSNKLPPFLALLFLASFFSSLSRTPGTLVILRCVPPEDKSFALGLQFLILRLLGFIPG 493
                         570       580       590
                  ....*....|....*....|....*....|....
gi 225543525  588 PIYFGALIDTTCIKWsTNNCGTRGSCRTYNSTSF 621
Cdd:pfam03137 494 PILFGALIDSTCLLW-GKTCGGRGNCWLYDNDKL 526
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
27-561 0e+00

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 611.39  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17459    1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYskETNINSSENSTSTLSTCLI--NQILSLNRASPEIVGKGCLKESGSYMWIYVFMGNMLRGIG 184
Cdd:cd17459   81 GTFLIALPHFFMGRYKY--ETAIQSSSNSTVSISPCSLepSPQLHSIESSDSKTGTGCEKEPGSSMWIYVFLGNLLRGIG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 185 ETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLV 264
Cdd:cd17459  159 ETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 265 SGLFSIISSIPFFFLPQTPNKpqkerkaslslhvletndekdqtanltnqgknitknvtGFFQSFKSILTNPLYVMFVLL 344
Cdd:cd17459  239 AGVITLLSAVPFWFLPKSLPK--------------------------------------DFLPSLKNLLGNPVYFLYLCT 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 345 TLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLL 424
Cdd:cd17459  281 SILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGYLLLLS 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 425 YFFILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNC 504
Cdd:cd17459  361 FFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGKNTVFHNC 440
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 225543525 505 SCLEVTGLQNRNYSAHLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17459  441 SCIGIPSSASGSSSAILGQCPKGNACARMFLYFLAISVISSFTLSLGGTPGYILLIR 497
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
27-561 0e+00

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 552.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17458    2 LKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYskETNINSSENSTSTLSTCLINQILSLNrasPEIVGKGCLKESGSYMWIYVFMGNMLRGIGET 186
Cdd:cd17458   82 GCFLASLPHFLMGRYEY--ESTVSTTSNSSSRVPLCLANQSLSHN---VTQLPSECEKESMSLMWIFVLVGNLLRGIGET 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17458  157 PVMPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICA 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPQTPNKPQKERKASLSLHVLETNDEKDQTaNLTNQGKNITKNvtgFFQSFKSILTNPLYVMFVLLTL 346
Cdd:cd17458  237 GVNFLAGLPFWFLPKSLPKEGEENETEPSKTLTVELEENKGQ-ETKQEMYEIAKD---FLPFLKSLFRNPIYMLFIIVTV 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17458  313 LQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAF 392
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17458  393 WMGCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGKNMVFQNCSC 472
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 507 LEVTGLQNRNYSAhLGECPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17458  473 VAASGFPSQNSSA-VGQCDKGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIR 526
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
1-649 0e+00

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 549.33  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525    1 MDQNQHLNKTAEAQPSENKKTR--YCNG--LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIG 76
Cdd:TIGR00805   1 MGETEKDIATHESSAGLKPRPRclQSLFskIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525   77 NLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFMGYYRYSkETNINSSENSTSTLSTCLINQILSLNrasPE 156
Cdd:TIGR00805  81 NLLLIIFVSYFGTKLHRPIVIGAGCAIMGLGSLLSSLPHFLMGRYSYS-TTVSSTGNLSSANSFLCMENLTQTLR---PT 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  157 IVGKGCLKESGSYMWIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVD 236
Cdd:TIGR00805 157 QDPSECQKQHKSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVD 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  237 IGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQTpnKPQKERKASLSLHvlETNDEKDQTANLTNQGK 316
Cdd:TIGR00805 237 TGSVNTEDLIITPTDPRWIGAWWIGFLVCGFVALLTSIPLFFFPKT--LPKEGKRVNVDVH--EAEKLEKSRGEDRKKNS 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  317 NITKNvtgFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYI 396
Cdd:TIGR00805 313 GITKD---FPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFI 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  397 IKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTM-TYDGNNPVTSHRDvplsyCNSDCNCDESQWEPVCG 475
Cdd:TIGR00805 390 MKKFKLNVKKAAYFAICLSTLEYLLYSPKFLITCESAPVAGVNNpSNDQPLYVENRTD-----CNRQCSCDSSIWDPVCG 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  476 NNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTGlqnrNYSAHLGECPRDdaCTRKFYFFVaiqVLNLFFSALGGTSH 555
Cdd:TIGR00805 465 DNGLAYLSPCHAGCRMSVGTGSNMVFTNCSCIQTPG----NSSAKKGLCDPP--CATSLQYFL---ILFIPLSFIYFITA 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  556 V---MLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTNNCGTRGSCRTYNSTSFSRVYLGLSSML 632
Cdd:TIGR00805 536 VpgyMVLLRCVKSEERSLGLGLQWFCIRVFGTIPAPILFGALIDVTCLHWQTLKCGASGACRMYDNDNLRVIYLGLTIAL 615
                         650
                  ....*....|....*..
gi 225543525  633 RVSSLVLYIILIYAMKK 649
Cdd:TIGR00805 616 RGSSLLPLFFILILARK 632
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
27-560 1.24e-122

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 371.19  E-value: 1.24e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17336    1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFmgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsymwiyvFMGNMLRGIGET 186
Cdd:cd17336   81 GCFLLALPHFL---------------------------------------------------------FVGQFLLGIGSS 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLStirITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17336  104 PLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWLGFLILG 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgffqsfksiltnPLYVMFVLLTL 346
Cdd:cd17336  181 ILLLIVSIPLFFFP-------------------------------------------------------PIFILLLLAIV 205
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYF 426
Cdd:cd17336  206 FESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLF 285
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 427 FILCENKSVAGLTMTYDGNNpvtshrDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd17336  286 FLGCDNPPIAGVTTPYGSSS------SPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSSDAGNGTKTYSNCSC 359
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....
gi 225543525 507 LEVTGLQNRNYSAHlgeCPRDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIV 560
Cdd:cd17336  360 INSGTATSSGCPPD---CSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITL 410
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
27-525 8.50e-105

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 327.53  E-value: 8.50e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17461    2 IKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYSketninssenststlstclinqilslnraspeivgkgclkesgsyMWIYVFMGNMLRGIGET 186
Cdd:cd17461   82 GAFLLTLPHFLSEPYQYS---------------------------------------------MWVLMVVAQLLAGIGTV 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17461  117 PIQPFGISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISS 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPQtpnKPQKERKASLSLHVL-ETNDEKDQTANLTNqgknitknvtgFFQSFKSI----LTNPLYVMF 341
Cdd:cd17461  197 GLLVLTSLPYFFFPR---EMLVGKKPSPEGDMLrKKEDEKKEEGSLLD-----------FIKRFPKMfvklLLNPLFMLL 262
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 342 VlLTLLQVSSYIGAF-TYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFScfTAVMSLS 420
Cdd:cd17461  263 V-LAQCTFSSVIAGLsTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFS--VVILSIS 339
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 421 FYLL--YFFILCENKSVAGltmtydGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKP 498
Cdd:cd17461  340 IMLCvpLFFMGCSTQDVAG------VYPKTSNSSDGPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMDSST 413
                        490       500       510
                 ....*....|....*....|....*....|
gi 225543525 499 ---IVFYNCSCLEVTGLQNrnySAHLGECP 525
Cdd:cd17461  414 yrqQIYSNCSCIPDLSGEK---PAKTGSCP 440
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
28-557 3.62e-103

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 321.12  E-value: 3.62e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  28 KMFLAALSLSFIakTLGAIIM---KSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIM 104
Cdd:cd17403    2 KGFLFFLCIFAF--LQGMVVNgfvNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 105 GIGGVLTALPHFFmgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsymwiyVFM-GNMLRGI 183
Cdd:cd17403   80 GIGSLVFALPHFT--------------------------------------------------------VFIlAQLLHGA 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 184 GETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDlSTIRITPTDSRWVGAWWLNFL 263
Cdd:cd17403  104 GATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQVD-SELGLTPDDPRWVGAWWLGFL 182
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 264 VSGLFSIISSIPFFFLPQTpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgffqsfksiltnplyvmFVL 343
Cdd:cd17403  183 ISGALALIIAFPLLGFPPT----------------------------------------------------------FMF 204
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 344 LTLLQVS-SYIGAFTYVF--KYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLS 420
Cdd:cd17403  205 LNLAGASeGMLLAGFATFlpKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFL 284
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 421 FYLLyFFILCENKSVAGLTMTYdGNNPVTSHRDVpLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIV 500
Cdd:cd17403  285 FSFI-LLIYCPNAPFAGVTVPY-GNSPLEGTSNL-TSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDDGQKV 361
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 225543525 501 FYNCSCLEVTGLqNRNYSAHLGECPRDDACTRKFYFFVAIQVLnLFFSALGGTSHVM 557
Cdd:cd17403  362 YSNCSCIQSNSS-KTSTAATGKACPCETCCQKLYLFLAVFFLL-IVFTFMSSTPALS 416
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
27-561 1.89e-100

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 316.33  E-value: 1.89e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17460    1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYsketninssenststlstclinqilslnraspeivgkgclkesgsymwIYVFMGNMLRGIGET 186
Cdd:cd17460   81 AGFLMALPHFISEPYEY------------------------------------------------GILFLGQLLLGIGGV 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17460  113 PIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAA 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLpqtpnkPQKERKASLSLHVLETNDEKDQTANL---TNQGKNITknVTGFFQSFKSI----LTNPLYV 339
Cdd:cd17460  193 TLVALSAVPYFFF------PREMPKEVVELQPREKKLAKTMLKKLkslSDILQNLS--LLQFIKKFPRIllrtLRNPIYL 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 340 MFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSL 419
Cdd:cd17460  265 LVVLAQVNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCL 344
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 420 SFYLLYFFILCENKSVAGLTMTYDgnnpvTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSS---GNK 496
Cdd:cd17460  345 FFALPLLFIGCSTQKIAGITHRTS-----SSPGLELSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSVNvqaLDN 419
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 225543525 497 KPIVFYNCSCLEVTGLQNrnySAHLGECprDDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17460  420 SVVNYTDCSCVSEGGPVG---AASPGTC--GSGCSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
27-561 2.49e-94

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 299.15  E-value: 2.49e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAK-TLGAIIMkSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMG 105
Cdd:cd17402    1 IKIFLVSECALMLAQgTVGAYLV-SVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 106 IGGVLTALPHFFMGYYryskETNInssenststlstclinqilslnraspeivgkgclkesgsyMWIYVFMGNMLRGIGE 185
Cdd:cd17402   80 LGALLSALPEFLTHQY----KTNM----------------------------------------MYLLLIGAQVLLGIGA 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 186 TPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVS 265
Cdd:cd17402  116 TPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLC 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 266 GLFSIISSIPFFFLPQtpnkpqkerkaslSLHVLEtndekdqtanltnqgknITKNVTgffqsfKSILTNPLYVMFVLLT 345
Cdd:cd17402  196 GALLFFSALLMFGFPQ-------------SLQQLR-----------------VIPKVT------KHLLSNPVFTCIVLAA 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 346 LLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLY 425
Cdd:cd17402  240 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 426 FFILCENKSVAGLTMTYdGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSgnkkpivFYNCS 505
Cdd:cd17402  320 LFLGCDTGPVAGVTVPY-GNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTN-------LSGCA 391
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 225543525 506 CLevTGLQNRNYSAHLGECPRdDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17402  392 CL--SSVPAENATVVPGKCPS-PGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
28-567 1.88e-91

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 291.18  E-value: 1.88e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  28 KMFLAALS-LSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17404    1 KAFLVCMClLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsymwiyvfMGNMLRGIGET 186
Cdd:cd17404   81 GSFLFSLPHFFI---------------------------------------------------------LAQILIGMGGT 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVdlsTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17404  104 PIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLST---PPDISPGDPRWIGAWWGGFLLCG 180
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPQtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgffqsfksiltnPLYvMFVLLTL 346
Cdd:cd17404  181 IALLLVAFPFFTFPK------------------------------------------------------MTF-LVVSLGY 205
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 347 LQVSSYIGAF-TYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLY 425
Cdd:cd17404  206 CMELAIVSGFiTFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTL 285
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 426 FFILCENKSVAGLTMTY-DGNNPVTSHRDVPLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFY-N 503
Cdd:cd17404  286 FFLGCESIKLAGITIPYtTGPSLSSTHGRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRNYtN 365
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543525 504 CSClevtgLQNRNYSAH----LGECPRDDACTRKFYFFVAIQVLnLFFsalggtshVMLIVKIVQPEL 567
Cdd:cd17404  366 CAC-----LQSRSSISPptvgQGSQLQAGPCSRTCNTLIPFLIL-LFI--------VTLITACAQMPA 419
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
27-561 2.24e-87

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 280.96  E-value: 2.24e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  27 LKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGI 106
Cdd:cd17401    1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 107 GGVLTALPHFFMGYYRYSketninssenststlstclinqilslnraspeivgkgclkesgsymwiYVFMGNMLRGIGET 186
Cdd:cd17401   81 GAFLLTLPHFISEPYQYG------------------------------------------------IMVVAQLLLGIGGV 112
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 187 PIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSG 266
Cdd:cd17401  113 PIQPFGISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAA 192
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 267 LFSIISSIPFFFLPQtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgFFQSFKSI----LTNPLYVMFV 342
Cdd:cd17401  193 ALLVLTSFPYFFFPR-------------------------------------------FIKRFPCIflrtLRNPIFLLVV 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 343 LLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY 422
Cdd:cd17401  230 LAQVTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFC 309
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 423 LLYFFILCENKSVAGLtmtydgNNPVTSHRDVPLSY-CNSDCNCDESQWEPVCGNNGITYISPCLAGCK----SSSGNKK 497
Cdd:cd17401  310 VPLFFIGCSTPTIAGV------YPPSSSSSIHPQSPaCRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSninmSTSATSK 383
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 225543525 498 PIVFYNCSCleVTGlqnRNYSAHLGECPrdDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17401  384 QVIYTNCSC--VTG---GSASAKTGSCP--SPCSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
52-550 3.30e-73

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 243.20  E-value: 3.30e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  52 IIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFfmgyyrysketnins 131
Cdd:cd17462   27 ITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFALPHF--------------- 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 132 senststlstclinqilslnraspeivgkgclkesgsymwiYVFM-GNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLG 210
Cdd:cd17462   92 -----------------------------------------TVFMlGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIG 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 211 ILNAIAMIGPIIGFTLGSLFSKMYVDIGyvdlSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPffflpqtpnkpqker 290
Cdd:cd17462  131 IFYTAAIVGPAAGYLLGGFFLNIYTEIG----RQTELTPENPLWVGAWWIGFLGAGAAALLIALP--------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 291 kaslslhvletndekdqtanltnqgknitknVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQP 370
Cdd:cd17462  192 -------------------------------ILGYPRQLPGLLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLS 240
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 371 SSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLsFYLLYFFILCENKSVAGLTMTYDGNNPVTS 450
Cdd:cd17462  241 ASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSL-LAIFIFSLHCPNVPMAGVTASYRGSVLPEG 319
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 451 HRDVPLSyCNSDCNCDESQWEPVCGNNGITYISPCLAGCKS--SSGNKKPIVFYNCSCLEVTGLQNrnySAHLGECPRDD 528
Cdd:cd17462  320 SLNLTAL-CNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEaySDIRNGQKVYQDCSCVAGNLSVG---FGEASAGKCTS 395
                        490       500
                 ....*....|....*....|....
gi 225543525 529 ACTRK--FYFFVAIQVLNLFFSAL 550
Cdd:cd17462  396 NCNHMplLLAFVFLVILFTFLCSI 419
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
51-540 1.11e-72

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 241.57  E-value: 1.11e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  51 SIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFFmgyyrysketnin 130
Cdd:cd17463   26 SISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGSLVFSLPHFF------------- 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 131 ssenststlstclinqilslnraspeivgkgclkesgsymwiyVF-MGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYL 209
Cdd:cd17463   93 -------------------------------------------VFiLGQLLLGVGGTPLYTLGTAYIDDSVPTHKSSLYI 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 210 GILNAIAMIGPIIGFTLGSLFSKMYVDIGYVdlSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFfflpqtpnkpqke 289
Cdd:cd17463  130 GIGYGMSVLGPAIGYLLGGQLLNIYIDVNKG--QSVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPF------------- 194
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 290 rkaslslhvletndekdqtanltnqgknitknvTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQ 369
Cdd:cd17463  195 ---------------------------------SCFPKHLPGLLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQ 241
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 370 PSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNpVT 449
Cdd:cd17463  242 TSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCGNDPFAGVSETYNGTG-KI 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 450 SHRDVPlsyCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLEVTglqNRNYSAHLGECPRDDA 529
Cdd:cd17463  321 GNLTAP---CNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDKKKVYYNCSCIGNF---TEEFSANTTKCEEGKK 394
                        490       500
                 ....*....|....*....|
gi 225543525 530 CTRK---------FYFFVAI 540
Cdd:cd17463  395 CETTcknlpiflcFFFFVVI 414
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
51-561 4.80e-37

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 143.83  E-value: 4.80e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  51 SIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTALPHFfmgyyrysketnin 130
Cdd:cd17405   25 SIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGLGSMLFAFPFF-------------- 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 131 ssenststlstclinqilslnraspeivgkgclkesgsymwIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLG 210
Cdd:cd17405   91 -----------------------------------------TFHIAGQCIQGIAGMPIYILGITFIFDNIPTSSAGIYLG 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 211 ILNAIAMIGPIIGFTLGSLFSKMYVDIgyvdlSTIRITPTDS--RWVGAWWLNFLVSGLFSIISSIPFFFLPQtpnkpqk 288
Cdd:cd17405  130 IAHSAYLIGYLLGYVGGLPNFQPPPNE-----KSVEIEVNKVyqLWQSGWWKTFLIAAAIAWCTSFPLVCFPT------- 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 289 erkaslslhvletndekdqtanltnqgknitknvtgffqSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYG 368
Cdd:cd17405  198 ---------------------------------------SLPGLLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFL 238
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 369 QPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYLLYFFILCENKSVAGLTMTYDGNNPV 448
Cdd:cd17405  239 LTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFFVECQTVTFAGINEDYDGYGQL 318
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 449 TSHRdvplSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC----LEVTGLQNRNYSAHLGEC 524
Cdd:cd17405  319 GNLT----APCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTEKTYYNCSCikegLAAADDEGDFIDAIAGKC 394
                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 225543525 525 prdDACTRKFYFFVAIQVLNLFFSALGGTSHVMLIVK 561
Cdd:cd17405  395 ---DSKCYKLPLFFAFYFSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
455-508 2.17e-26

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 102.00  E-value: 2.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 225543525 455 PLSYCNSDCNCDESQWEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSCLE 508
Cdd:cd01330    1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNSTGSGGSKIYTNCSCVG 54
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
460-506 1.19e-16

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 74.07  E-value: 1.19e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 225543525  460 NSDCNCDESQWEPVCGNNGITYISPC---LAGCKSSSGNKKPIVFYNCSC 506
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKEEKVKYDGSC 50
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
34-430 4.13e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 80.55  E-value: 4.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  34 LSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVLTAL 113
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 114 PHffmgyyrysketninssenststlstclinqilslnraspeivgkgclkesgsyMWIYVFMGNMLRGIGETPIVPLGL 193
Cdd:cd06174   81 AP------------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVL 106
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 194 SYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSkmyvdigyvdlstiritptdSRWVGAWWLNFLVSGLFSIISS 273
Cdd:cd06174  107 ALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA--------------------SSLGFGWRAVFLIAAALALLAA 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 274 IPFFFLPQTPNKPQKERKASLSLHVletndekdqtanltnqgknitknvtgFFQSFKSILTNPLYVMFVLLTLLQVSSYI 353
Cdd:cd06174  167 ILLLLVVPDPPESARAKNEEASSKS--------------------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYY 220
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 354 GAFTYVFKYVEQQYGQPSSKANILLGVITIPIFAsGMFLGGYIIKKF----KLNTVGIAKFSCFTAVMSLSFYLLYFFIL 429
Cdd:cd06174  221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGAL-GSLLLGLLSDRLigrkPLLLIGLLLMALGLALLLLAPSLLLLLLL 299

                 .
gi 225543525 430 C 430
Cdd:cd06174  300 L 300
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
31-427 1.87e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 75.40  E-value: 1.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  31 LAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVL 110
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 111 TALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFMgnMLRGIGETPIVP 190
Cdd:COG2814   92 CAL----------------------------------------------------APSLWLLLAAR--FLQGLGAGALFP 117
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiritptdsrwvgAWWLNFLVSGLFSI 270
Cdd:COG2814  118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF----------------------GWRWVFLVNAVLAL 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 271 ISSIP-FFFLPQTPNKPQKERKASLslhvletndekdqtanltnqgknitknvtgffqsfKSILTNPLYVMFVLLTLLQV 349
Cdd:COG2814  176 LALLLlLRLLPESRPAARARLRGSL-----------------------------------RELLRRPRLLLLLLLAFLLG 220
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 225543525 350 SSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIpIFASGMFLGGYIIKKFKLNTVGIAkfscFTAVMSLSFYLLYFF 427
Cdd:COG2814  221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL-GGVLGALLAGRLADRFGRRRLLLI----GLLLLALGLLLLALA 293
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
465-506 2.77e-11

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 58.44  E-value: 2.77e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 225543525 465 CDESQwEPVCGNNGITYISPCLAGCKSSSGNKKPIVFYNCSC 506
Cdd:cd00104    1 CPKEY-DPVCGSDGKTYSNECHLGCAACRSGRSITVAHNGPC 41
MFS_1 pfam07690
Major Facilitator Superfamily;
29-438 1.37e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 63.21  E-value: 1.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525   29 MFLAALSLSFIAKTLGAIImkssIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGG 108
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPAL----PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  109 VLTALPHffmgyyrysketninssenststlstclinqilslnraspeivgkgclkesGSYMWIYVFMgnmLRGIGETPI 188
Cdd:pfam07690  77 LLLLFAS---------------------------------------------------SLWLLLVLRV---LQGLGAGAL 102
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  189 VPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiritptDSRWVgawwlnFLVSGLF 268
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAA------FLILAIL 160
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  269 SIISSIPFFFLPQTPNKPQKERKASLslhvletndekdqtanltnqgknitknVTGFFQSFKSILTNPLYVMFVLLtLLQ 348
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEA---------------------------RLSLIVAWKALLRDPVLWLLLAL-LLF 212
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  349 VSSYIGAFTYVFKYVEqQYGQPSSKANILLGVITIpIFASGMFLGGYIIKKFKLNTVGIakFSCFTAVMSLSFYLLYFFI 428
Cdd:pfam07690 213 GFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGL-LGAIGRLLLGRLSDRLGRRRRLL--LALLLLILAALGLLLLSLT 288
                         410
                  ....*....|
gi 225543525  429 LCENKSVAGL 438
Cdd:pfam07690 289 LSSLWLLLAL 298
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
179-430 2.83e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.43  E-value: 2.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 179 MLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdiGYvdlstiritptdsRWVgaw 258
Cdd:cd17325   92 FLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL---GY-------------RAP--- 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 259 wlnFLVSGLFSIISSIPFFFLPQTPNKPQKERKASLSLhvletndekdqtanltnqgknitknvtgFFQSFKSILTNPLY 338
Cdd:cd17325  153 ---FLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR----------------------------LRSGLRLLLRDRRL 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 339 VMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYI--IKKFKLNTVGIAKFSCFTAV 416
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSdrIGRKPLILIGLLLSAVALLL 281
                        250
                 ....*....|....*.
gi 225543525 417 MSL--SFYLLYFFILC 430
Cdd:cd17325  282 LPLatSFWLLLLLLAL 297
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
29-436 3.09e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 53.39  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  29 MFLAALsLSFIAKTLGAIIMKSsiihIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGG 108
Cdd:cd17328    4 LFLINL-LNYMDRFTIAGVLPD----IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAAT 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 109 VLTAL-PHFFMgyyrysketninssenststlstclinqiLSLNRaspeivgkgclkesgsymwiyvfmgnMLRGIGETP 187
Cdd:cd17328   79 LLSSFaPNFWQ-----------------------------LLLFR--------------------------ALVGIGEAS 103
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 188 IVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKmyvdigyvdlstiritptdsrWVGAWWLNFLVSGL 267
Cdd:cd17328  104 YSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ---------------------ATGGWRWAFRVTGV 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 268 FSIISSIPFFFLPQTPNKPQKERKASLSLHvletndekdqtanltnqgknitknVTGFFQSFKSILTNPLYVMFVLLTLL 347
Cdd:cd17328  163 LGVLLAILLLLFVREPPRGAAEGGVMAKST------------------------ATSFLADLKALAKNPSFILSTLGFTA 218
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 348 qVSSYIGAFTY----VFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSC-FTAVMSLSFY 422
Cdd:cd17328  219 -VSFVTGALAFwaptFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCaVGLLAAAPFL 297
                        410
                 ....*....|....
gi 225543525 423 LLYFFILCENKSVA 436
Cdd:cd17328  298 FLALVLALSNLLLA 311
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
31-430 6.65e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.16  E-value: 6.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  31 LAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVL 110
Cdd:COG0738   10 LIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 111 TALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFMgnMLRGIGETPIVP 190
Cdd:COG0738   90 FAL----------------------------------------------------APSYPLLLLAL--FLLGLGLGLLDV 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 191 LGLSYIDDFAKEGHSSLyLGILNAIAMIGPIIGFTLGSLFSKMYVDIgyvdlstiritptdsrwvgAWWLNFLVSGLFSI 270
Cdd:COG0738  116 AANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGLSL-------------------SWHLPYLILAVLLL 175
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 271 ISSIPFFFLPqtpnkpqkerkaslsLHVLETNDEKDqtanltnqgknitknvTGFFQSFKSILTNPLYVMFVLLTLLQVS 350
Cdd:COG0738  176 LLALLFLRSK---------------LPEIEEEEEEA----------------AGSAASLKSLLKNPRLLLGGLAIFLYVG 224
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 351 SYIGAFTYVFKYVEQQYGQPSSKANILLGVITIpIFASGMFLGGYIIKKFKLNTV-----GIAKFSCFTAVMSLSFYL-L 424
Cdd:COG0738  225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWG-GMTIGRFLGGFLLKRFGPVRLlrlsaLLAAVGLLLALLAPGPWLaL 303

                 ....*.
gi 225543525 425 YFFILC 430
Cdd:COG0738  304 IGLALV 309
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
323-427 5.67e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.52  E-value: 5.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 323 TGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFAsGMFLGGYIIKKF-K 401
Cdd:COG2211  215 VSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL-GAPLWPRLAKRFgK 293
                         90       100
                 ....*....|....*....|....*.
gi 225543525 402 LNTVGIAkfscfTAVMSLSFYLLYFF 427
Cdd:COG2211  294 KKAFIIG-----LLLAALGLLLLFFL 314
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
171-427 5.70e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 46.00  E-value: 5.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 171 WIYVFMGNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiritpt 250
Cdd:cd17324   87 FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL---------------- 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 251 dsrwvgAWWLNFLVSGLFSIISSIPF-FFLPQTPNKPQKERkaslslhvletndekdqtanltnqgknitknvtGFFQSF 329
Cdd:cd17324  151 ------GWRAAFLAIAVLALLAALLLwRLLPSLPPKKPGSL---------------------------------GLLSSL 191
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 330 KSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFAsGMFLGGYIIKKFKLNTVGIAk 409
Cdd:cd17324  192 LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVV-GSPLAGRLADRGGRRALLIA- 269
                        250
                 ....*....|....*...
gi 225543525 410 fscfTAVMSLSFYLLYFF 427
Cdd:cd17324  270 ----LLLLAAALLLLTLL 283
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
30-430 2.71e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.71  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  30 FLAALSLSFIAkTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGV 109
Cdd:cd17474    1 LYAVFFATLLA-VLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 110 LTALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFmgNMLRGIGETPIV 189
Cdd:cd17474   80 LCGL----------------------------------------------------SDSFALLLAG--RALQGIGAAGLG 105
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 190 PLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLfskmyvdIGYVDlstiritptdsrwvgaWWLNFLVSGLFS 269
Cdd:cd17474  106 PLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-------LAAIS----------------WRYPFFLLAALI 162
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 270 IISSIPFFFLPQTPNKPQKERKASLSLHvletndekdqtanltnqgknitknvtgffqsFKSILTNPLYVMFVLLTLLQV 349
Cdd:cd17474  163 PVAFLAILFLLPEPKEKAKSSSATKLRD-------------------------------LKKALRGRGLLTFLVSAFLYF 211
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 350 SSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFYL--LYFF 427
Cdd:cd17474  212 FLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVpsLALL 291

                 ...
gi 225543525 428 ILC 430
Cdd:cd17474  292 LIA 294
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
166-438 7.54e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.20  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 166 SGSYMWIYVFmgNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYVDigyvdlsti 245
Cdd:cd17316   86 LPTPILLLVL--RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSG--------- 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 246 ritptdsrwVGAWWLNFLVSGLFSIISsipfFFLpqtpnkpqkeRKASLslhvletndekdqtanltnqgknitknvtgf 325
Cdd:cd17316  155 ---------DWGWRILFLIGALPALLA----LLL----------RRRTL------------------------------- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 326 fqsfksiltnplyvMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIpIFASGMFLGGYIIKKFklntv 405
Cdd:cd17316  181 --------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL-GALVGALIAGLLSDRI----- 240
                        250       260       270
                 ....*....|....*....|....*....|...
gi 225543525 406 GIAKFSCFTAVMSLSFYLLYFFILCENKSVAGL 438
Cdd:cd17316  241 GRKKTLVIGLILSGILALPLFYLLSGSPTLLLL 273
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
29-427 7.85e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 7.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  29 MFLAALSLSFIAKTLGAIImkssiIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGG 108
Cdd:COG2271   15 LFLAYFLNYLDRSNLSVAA-----PPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 109 VLTALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFMgnMLRGIGETPI 188
Cdd:COG2271   90 LLFGF----------------------------------------------------ATSFWQLLLLR--FLLGLGEAGF 115
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 189 VPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdiGYvdlstiritptdsRWVgawwlnFLVSGLF 268
Cdd:COG2271  116 FPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GW-------------RAA------FLILGLP 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 269 SIISSIPFFflpqtpnkpqkerkaslslhvletndekdqtanltnqgknitknvtgffqsfksiltnplyVMFVLLTLLQ 348
Cdd:COG2271  174 GLLLALLRF-------------------------------------------------------------WLLALAYFLV 192
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 225543525 349 VSSYIGAFTYVFKYVEQQYGQPSSKANILLGVITIPIFAsGMFLGGYIIKKFKLNTVGIakFSCFTAVMSLSFYLLYFF 427
Cdd:COG2271  193 YFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIV-GSLLGGWLSDRLGRRRKLV--LAIGLLLAALALLLLALL 268
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
22-121 8.01e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 8.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  22 RYCNGLKMFLAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGC 101
Cdd:cd06173  202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
                         90       100
                 ....*....|....*....|
gi 225543525 102 FIMGIGGVLTALPHFFMGYY 121
Cdd:cd06173  282 LLLGLALLVLGLSPSLWLLL 301
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
168-427 8.68e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 8.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 168 SYMWIYVFMgnMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiri 247
Cdd:COG2223   92 SYWLLLLLG--LLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------------- 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 248 tptdsrwvgAWWLNFLVSGLFSIISSIPF-FFLPQTPNKPQKERKASLSlhvletndekdqtanltnqgknitknvtgff 326
Cdd:COG2223  157 ---------GWRNAFLILGILLLVVAVLAwLFLRDPPAGAAAAAKASLR------------------------------- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 327 qSFKSILTNPLYVMFVLLTLLQVSSYIGAFTYVFKYVEQQYGQPSSKANILLGVitIPIFAS-GMFLGGYIIKKFKLNTV 405
Cdd:COG2223  197 -DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAAL--FALLGAlGRPLGGWLSDRIGGRRV 273
                        250       260
                 ....*....|....*....|..
gi 225543525 406 GIAkfscFTAVMSLSFYLLYFF 427
Cdd:COG2223  274 LLI----VFALMALGLLLLALA 291
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
31-282 9.26e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 41.72  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525  31 LAALSLSFIAKTLGAIIMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGGVL 110
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 111 TALphffmgyyrysketninssenststlstclinqilslnraspeivgkgclkeSGSYMWIYVFmgNMLRGIGETPIVP 190
Cdd:COG0477   96 CGL----------------------------------------------------APSPELLIAA--RALQGIGAGGLMP 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543525 191 LGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLFSKMYvdigyvdlstiritptdsrwvgAWWLNFLVSGLFSI 270
Cdd:COG0477  122 GALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL----------------------GWRWIFLINAPLGL 179
                        250
                 ....*....|..
gi 225543525 271 ISSIPFFFLPQT 282
Cdd:COG0477  180 LALVLRLRLPES 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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