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Conserved domains on  [gi|19913369|ref|NP_006444|]
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transducin beta-like protein 3 [Homo sapiens]

Protein Classification

WD40 and Utp13 domain-containing protein( domain architecture ID 10646028)

protein containing domains WD40, and Utp13

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 7.77e-68

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.18  E-value: 7.77e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  73 DLSPDNEVLVTASRALLLAQWAWQEGSVtRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGAL-LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 153 VVHLVAFHPDPTRLLlfSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 233 VPVfesveaavllPEEPVSQLGVkSP-GLYFLTAGDQGTLRVWEAASGQCVYTqaqppgpgqelthctlahtagvvltat 311
Cdd:COG2319 158 LTG----------HSGAVTSVAF-SPdGKLLASGSDDGTVRLWDLATGKLLRT--------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 312 adhnlllyearslrlqkqfagyseevldvrflgpedshvvvasnspclkvfelqtsacqiLHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 200 ------------------------------------------------------------LTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 392 ASCAKDQSVRIWRMNkAGQvmCVAQGSGHTHSVGTVCCSRlKESFLVTGSQDCTVKLWPLpkallskntapDNGPILlqa 471
Cdd:COG2319 220 ASGSADGTVRLWDLA-TGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL-----------ATGELL--- 281

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 472 qTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ 551
Cdd:COG2319 282 -RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 19913369 552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 2.35e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


:

Pssm-ID: 462540  Cd Length: 139  Bit Score: 173.08  E-value: 2.35e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATMLRLRRDQKEALLRFCVTWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19913369   728 CHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 5.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19913369    594 NNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 7.77e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.18  E-value: 7.77e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  73 DLSPDNEVLVTASRALLLAQWAWQEGSVtRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGAL-LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 153 VVHLVAFHPDPTRLLlfSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 233 VPVfesveaavllPEEPVSQLGVkSP-GLYFLTAGDQGTLRVWEAASGQCVYTqaqppgpgqelthctlahtagvvltat 311
Cdd:COG2319 158 LTG----------HSGAVTSVAF-SPdGKLLASGSDDGTVRLWDLATGKLLRT--------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 312 adhnlllyearslrlqkqfagyseevldvrflgpedshvvvasnspclkvfelqtsacqiLHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 200 ------------------------------------------------------------LTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 392 ASCAKDQSVRIWRMNkAGQvmCVAQGSGHTHSVGTVCCSRlKESFLVTGSQDCTVKLWPLpkallskntapDNGPILlqa 471
Cdd:COG2319 220 ASGSADGTVRLWDLA-TGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL-----------ATGELL--- 281

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 472 qTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ 551
Cdd:COG2319 282 -RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 19913369 552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-633 9.63e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.49  E-value: 9.63e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 328 KQFAGYSEEVLDVRFLgPEDSHVVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 407 KAGQVMCVAqgsGHTHSVGTVCCSRlKESFLVTGSQDCTVKLWPLPKAllskntapdngpillQAQTTQRCHDKDINSVA 486
Cdd:cd00200  82 TGECVRTLT---GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG---------------KCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASV 566
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19913369 567 LKVAFvSRGTQLLSSGS-DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Cdd:cd00200 223 NSVAF-SPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 2.35e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 173.08  E-value: 2.35e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATMLRLRRDQKEALLRFCVTWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19913369   728 CHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 376-592 2.47e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 67.42  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  376 TDIVLALDVFRKGWLFASCAKDQSVRIWRMN---KAGQVM--CVAQGSGHThSVGTVCCSRLKESFLVTGSQDCTVKLWP 450
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiiKDGRDIhyPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  451 LPKAllskntapdngpillQAQTTQRCHDKDINSVAIAPND-KLLATGSQDRTAKLWALPQCQLLGVFSGhRRGLWCVQF 529
Cdd:PLN00181 562 VARS---------------QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQF 625

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19913369  530 -SPMDQVLATASADGTIKLWALQDFSC-LKTFEGHDASVLKVAFVSRGTqLLSSGSDGLVKLWTI 592
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 512-548 1.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.53e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19913369    512 QLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
512-548 4.35e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.35e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19913369   512 QLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 5.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19913369    594 NNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
595-632 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19913369   595 NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-594 7.77e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.18  E-value: 7.77e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  73 DLSPDNEVLVTASRALLLAQWAWQEGSVtRLWKAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPG 152
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGAL-LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 153 VVHLVAFHPDPTRLLlfSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRT 232
Cdd:COG2319  80 AVLSVAFSPDGRLLA--SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 233 VPVfesveaavllPEEPVSQLGVkSP-GLYFLTAGDQGTLRVWEAASGQCVYTqaqppgpgqelthctlahtagvvltat 311
Cdd:COG2319 158 LTG----------HSGAVTSVAF-SPdGKLLASGSDDGTVRLWDLATGKLLRT--------------------------- 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 312 adhnlllyearslrlqkqfagyseevldvrflgpedshvvvasnspclkvfelqtsacqiLHGHTDIVLALDVFRKGWLF 391
Cdd:COG2319 200 ------------------------------------------------------------LTGHTGAVRSVAFSPDGKLL 219

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 392 ASCAKDQSVRIWRMNkAGQvmCVAQGSGHTHSVGTVCCSRlKESFLVTGSQDCTVKLWPLpkallskntapDNGPILlqa 471
Cdd:COG2319 220 ASGSADGTVRLWDLA-TGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDL-----------ATGELL--- 281

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 472 qTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ 551
Cdd:COG2319 282 -RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                       490       500       510       520
                ....*....|....*....|....*....|....*....|...
gi 19913369 552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKN 594
Cdd:COG2319 361 TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-633 9.63e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.49  E-value: 9.63e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 328 KQFAGYSEEVLDVRFLgPEDSHVVVASNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMN 406
Cdd:cd00200   3 RTLKGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 407 KAGQVMCVAqgsGHTHSVGTVCCSRlKESFLVTGSQDCTVKLWPLPKAllskntapdngpillQAQTTQRCHDKDINSVA 486
Cdd:cd00200  82 TGECVRTLT---GHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETG---------------KCLTTLRGHTDWVNSVA 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 487 IAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASV 566
Cdd:cd00200 143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19913369 567 LKVAFvSRGTQLLSSGS-DGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Cdd:cd00200 223 NSVAF-SPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-449 3.60e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.95  E-value: 3.60e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 144 THHFRGSPGVVHLVAFHPDPTrlLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGK--LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 224 LQSCQATRTVPVFESveaavllpeePVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPgqeLTHCTLAHT 303
Cdd:cd00200  80 LETGECVRTLTGHTS----------YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW---VNSVAFSPD 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 304 AGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLgPEDSHVVVASNSPCLKVFELQTSAC-QILHGHTDIVLAL 382
Cdd:cd00200 147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFS-PDGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENGVNSV 225

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19913369 383 DVFRKGWLFASCAKDQSVRIWRMNKAGqvmCVAQGSGHTHSVGTVCCSRLKeSFLVTGSQDCTVKLW 449
Cdd:cd00200 226 AFSPDGYLLASGSEDGTIRVWDLRTGE---CVQTLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIW 288
Utp13 pfam08625
Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex ...
 654-786 2.35e-50

Utp13 specific WD40 associated domain; Utp13 is a component of the five protein Pwp2 complex that forms part of a stable particle subunit independent of the U3 small nucleolar ribonucleoprotein that is essential for the initial assembly steps of the 90S pre-ribosome. Pwp2 is capable of interacting directly with the 35 S pre-rRNA 5' end.


Pssm-ID: 462540  Cd Length: 139  Bit Score: 173.08  E-value: 2.35e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369   654 QQELDNLLHEKRYLRALGLAISLDRPHTVLTVIQAIRRDPEACEK------LEATMLRLRRDQKEALLRFCVTWNTNSRH 727
Cdd:pfam08625   1 EQELQNLLRNKDYREAILLALTLNHPHRLLKLFKALLTSADDEGSitglkeLDEVIKTLSDEQLEKLLKYIRDWNTNAKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 19913369   728 CHEAQAVLGVLLRREAPEELLAYEGVRAALEALLPYTERHFQRLSRTLQAAAFLDFLWH 786
Cdd:pfam08625  81 SHVAQRVLNALLKSYPPEELLELPGLKEILEALIPYTERHFSRLDRLVQESYLLDYTLQ 139
WD40 COG2319
WD40 repeat [General function prediction only];
372-632 2.78e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 170.48  E-value: 2.78e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 372 LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRmnkAGQVMCVAQGSGHTHSVGTVCCSRLKEsFLVTGSQDCTVKLWPL 451
Cdd:COG2319  32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLD---AAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 452 PKAllskntapdngpillQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSP 531
Cdd:COG2319 108 ATG---------------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 532 MDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGL 611
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                       250       260
                ....*....|....*....|.
gi 19913369 612 HCSRLDDHALTGASDSRVILW 632
Cdd:COG2319 253 AFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 513-632 2.47e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.37  E-value: 2.47e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 513 LLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTI 592
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19913369 593 KNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
454-632 3.28e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 3.28e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 454 ALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMD 533
Cdd:COG2319  11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 534 QVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHC 613
Cdd:COG2319  91 RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                       170
                ....*....|....*....
gi 19913369 614 SRLDDHALTGASDSRVILW 632
Cdd:COG2319 171 SPDGKLLASGSDDGTVRLW 189
WD40 COG2319
WD40 repeat [General function prediction only];
486-632 9.40e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 9.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369 486 AIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDAS 565
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19913369 566 VLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 376-592 2.47e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 67.42  E-value: 2.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  376 TDIVLALDVFRKGWLFASCAKDQSVRIWRMN---KAGQVM--CVAQGSGHThSVGTVCCSRLKESFLVTGSQDCTVKLWP 450
Cdd:PLN00181 483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECEsiiKDGRDIhyPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWD 561

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  451 LPKAllskntapdngpillQAQTTQRCHDKDINSVAIAPND-KLLATGSQDRTAKLWALPQCQLLGVFSGhRRGLWCVQF 529
Cdd:PLN00181 562 VARS---------------QLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQF 625

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19913369  530 -SPMDQVLATASADGTIKLWALQDFSC-LKTFEGHDASVLKVAFVSRGTqLLSSGSDGLVKLWTI 592
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 512-548 1.53e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.53e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19913369    512 QLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
512-548 4.35e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.35e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19913369   512 QLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLW 548
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-223 1.34e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19913369    184 DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
185-223 1.63e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 1.63e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19913369   185 RSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 552-590 2.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 2.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19913369    552 DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 111-238 3.53e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 3.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  111 PVATMAFDP-TSTLLATGGCDGAVRVWDIVRHYGTH-------HFRGSPGVVHLVAFHPDPTRLLLfSSATDAAIRVWSL 182
Cdd:PTZ00421  77 PIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQnisdpivHLQGHTKKVGIVSFHPSAMNVLA-SAGADMVVNVWDV 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19913369  183 QDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFES 238
Cdd:PTZ00421 156 ERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
WD40 pfam00400
WD domain, G-beta repeat;
553-590 2.17e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 2.17e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19913369   553 FSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-137 3.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.27e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 19913369    108 HTAPVATMAFDPTSTLLATGGCDGAVRVWD 137
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
472-506 4.19e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19913369   472 QTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 474-506 4.65e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 4.65e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 19913369    474 TQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
108-137 6.78e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.78e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 19913369   108 HTAPVATMAFDPTSTLLATGGCDGAVRVWD 137
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 369-403 5.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 19913369    369 CQILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 462-632 9.39e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 9.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  462 PDNGPILLQaqttqrcHDKDINSVAIAP-NDKLLATGSQDRTAKLWALPQCQLLGVFS-------GHRRGLWCVQFSP-M 532
Cdd:PTZ00421  65 ASNPPILLG-------QEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPsA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  533 DQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDK----- 607
Cdd:PTZ00421 138 MNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrc 217

                        170       180
                 ....*....|....*....|....*...
gi 19913369  608 VWglhCSRLDDHALTGASDS---RVILW 632
Cdd:PTZ00421 218 LW---AKRKDLIITLGCSKSqqrQIMLW 242
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 118-224 1.24e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  118 DPTstLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVhLVAFHPDPTRLLLFSSAtDAAIRVWSLQD-RSCLAVLTAHYS 196
Cdd:PLN00181 587 DPT--LLASGSDDGSVKLWSINQGVSIGTIKTKANIC-CVQFPSESGRSLAFGSA-DHKVYYYDLRNpKLPLCTMIGHSK 662

                         90       100
                 ....*....|....*....|....*...
gi 19913369  197 AVTSLAFsADGHTMLSSGRDKICIIWDL 224
Cdd:PLN00181 663 TVSYVRF-VDSSTLVSSSTDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 534-632 1.52e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19913369  534 QVLATASADGTIKLwalqdFSCLKTF-EGHDASVLKVAFVSRG------------TQLLSSGSDGLVKLWTIKNNECVRT 600
Cdd:PLN00181 496 EFFATAGVNKKIKI-----FECESIIkDGRDIHYPVVELASRSklsgicwnsyikSQVASSNFEGVVQVWDVARSQLVTE 570

                         90       100       110
                 ....*....|....*....|....*....|...
gi 19913369  601 LDAHEDKVWGLHCSRLDDHAL-TGASDSRVILW 632
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLW 603
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 594-633 5.35e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 5.35e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19913369    594 NNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWK 633
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
413-449 5.99e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 5.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19913369   413 CVAQGSGHTHSVGTVCCSRlKESFLVTGSQDCTVKLW 449
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 413-449 6.58e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.58e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 19913369    413 CVAQGSGHTHSVGTVCCSRlKESFLVTGSQDCTVKLW 449
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
595-632 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19913369   595 NECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILW 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
370-403 6.30e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 6.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 19913369   370 QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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