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Conserved domains on  [gi|61676186|ref|NP_006488|]
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hypermethylated in cancer 1 protein isoform 1 [Homo sapiens]

Protein Classification

hypermethylated in cancer 1 protein( domain architecture ID 13604407)

hypermethylated in cancer 1 protein (Hic-1) is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'

Gene Symbol:  HIC1
Gene Ontology:  GO:0008270|GO:0003677|GO:0005515
PubMed:  17120193|22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ super family cl38908
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 7-136 2.20e-73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


The actual alignment was detected with superfamily member cd18333:

Pssm-ID: 453885 [Multi-domain]  Cd Length: 121  Bit Score: 233.26  E-value: 2.20e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   7 APGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18333   1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  87 LadgaeaaaaAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKY 136
Cdd:cd18333  81 L---------SEGDPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRNGKY 121
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 5.08e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.08e-06
                          10        20
                  ....*....|....*....|....*.
gi 61676186   558 RLTEHMRIHSGEKPYECQVCGGKFAQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 3.74e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 3.74e-05
                          10        20
                  ....*....|....*....|...
gi 61676186   516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
482-594 6.45e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 6.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186 482 GELLRPYRCAS--CDKSYKDPATLRQHEKTHWLTRPYPC--TICGKKFTQRGTM-----TRHMRSHLGLKPFACD--ACG 550
Cdd:COG5048 316 GESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNeppqsLQQYKDLKNDKKSETLsnSCI 395

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186 551 MRFTRQYRLTEHmRIHSGEKPYECQVCGGKFAQQR---NLISHMKMH 594
Cdd:COG5048 396 RNFKRDSNLSLH-IITHLSFRPYNCKNPPCSKSFNrhyNLIPHKKIH 441
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 204-306 6.64e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   204 PGPAAALCASERRCSPlcGLDLSKKSPPGS-----AAPERPLAERElpPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKL 278
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAP--GGDVRRRPPSRSpaakpAAPARPPVRRL--ARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                          90       100
                  ....*....|....*....|....*...
gi 61676186   279 EEAAPPSDPfrggSGSPGPEPPGRPDGP 306
Cdd:PHA03247 2919 PQPQPPPPP----QPQPPPPPPPRPQPP 2942
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-136 2.20e-73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 233.26  E-value: 2.20e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   7 APGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18333   1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  87 LadgaeaaaaAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKY 136
Cdd:cd18333  81 L---------SEGDPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRNGKY 121
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 18-133 1.52e-27

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 106.96  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186    18 LNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYTGRLadgaea 93
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDVSPEDFEALLEFMYTGKL------ 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 61676186    94 aaaaavapGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:pfam00651  75 --------ISEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 29-133 3.01e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186     29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNL------LNLDHdmVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPG 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdkseIYLDD--VSPEDFRALLNFLYTGKL-------------DL 65

                           90       100       110
                   ....*....|....*....|....*....|.
gi 61676186    103 AEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKL 96
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 5.08e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.08e-06
                          10        20
                  ....*....|....*....|....*.
gi 61676186   558 RLTEHMRIHSGEKPYECQVCGGKFAQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 3.74e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 3.74e-05
                          10        20
                  ....*....|....*....|...
gi 61676186   516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA03098 PHA03098
kelch-like protein; Provisional
 18-133 6.62e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.30  E-value: 6.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   18 LNNQRtkgfLCD--VIIVVQNALFRAHKNVLAASSAYLKSLV-----VHDNLLNLDHDMvspavFRLVLDFIYTGRLadg 90
Cdd:PHA03098   4 FELQK----FCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFknnfkENEINLNIDYDS-----FNEVIKYIYTGKI--- 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 61676186   91 aeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:PHA03098  72 ----------NITSNNVKDILSIANYLIIDFLINLCINYIIKI 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
542-590 7.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.70e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 61676186 542 KPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISH 590
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
482-594 6.45e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 6.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186 482 GELLRPYRCAS--CDKSYKDPATLRQHEKTHWLTRPYPC--TICGKKFTQRGTM-----TRHMRSHLGLKPFACD--ACG 550
Cdd:COG5048 316 GESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNeppqsLQQYKDLKNDKKSETLsnSCI 395

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186 551 MRFTRQYRLTEHmRIHSGEKPYECQVCGGKFAQQR---NLISHMKMH 594
Cdd:COG5048 396 RNFKRDSNLSLH-IITHLSFRPYNCKNPPCSKSFNrhyNLIPHKKIH 441
ZnF_C2H2 smart00355
zinc finger;
516-538 7.68e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 37.06  E-value: 7.68e-04
                           10        20
                   ....*....|....*....|...
gi 61676186    516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 486-535 2.43e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.43e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61676186 486 RPYrCASCDKSYKDPATLRQHEK-THwltrpYPCTICGKKFTQRGTMTRHM 535
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHC 45
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-306 6.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   204 PGPAAALCASERRCSPlcGLDLSKKSPPGS-----AAPERPLAERElpPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKL 278
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAP--GGDVRRRPPSRSpaakpAAPARPPVRRL--ARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                          90       100
                  ....*....|....*....|....*...
gi 61676186   279 EEAAPPSDPfrggSGSPGPEPPGRPDGP 306
Cdd:PHA03247 2919 PQPQPPPPP----QPQPPPPPPPRPQPP 2942
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 488-510 7.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|...
gi 61676186   488 YRCASCDKSYKDPATLRQHEKTH 510
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-136 2.20e-73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 233.26  E-value: 2.20e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   7 APGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18333   1 VPSHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGR 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  87 LadgaeaaaaAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKY 136
Cdd:cd18333  81 L---------SEGDPGSEQNLGAVLAAASYLQIPDLVALCKKKLKRNGKY 121
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-135 9.25e-62

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 201.99  E-value: 9.25e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18216   1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLDQDMVSPTVFQQILDFIYTGKL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  88 adgaeaaaaaAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGK 135
Cdd:cd18216  81 ----------LDSLFEEPNLSEVLAAANYLQLPDLAALCRSKLKRGGK 118
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-135 2.67e-56

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 187.48  E-value: 2.67e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18334   2 PNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMVNPTVFRQILDFIYTGKL 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  88 adgaeaaaaAAVAPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGK 135
Cdd:cd18334  82 ---------LTSDQPGEQNFNALLTAASYLQLHDLAALCRKKLKRNGK 120
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 18-133 1.52e-27

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 106.96  E-value: 1.52e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186    18 LNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYTGRLadgaea 93
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDVSPEDFEALLEFMYTGKL------ 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 61676186    94 aaaaavapGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:pfam00651  75 --------ISEENVDDLLAAADKLQIPSLVDKCEEFLIKS 106
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-127 2.24e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 100.98  E-value: 2.24e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV--HDNLLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18217   1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKdtEDNIVFLDQSQVSADGFQKLLEFIYTGNL 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61676186  88 adgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCK 127
Cdd:cd18217  81 -------------NLDSWNVAEIHQAASYLGMEEVVAKCK 107
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 4.51e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 100.67  E-value: 4.51e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYL----KSLVVHDNLLNLDHDMVSPAVFRLVLD 80
Cdd:cd18194   1 MEFPEHSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFhlfyRDRLDKRDLVRLNSDIVTAPAFGLLLD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 61676186  81 FIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18194  81 FMYEGRL-------------ALRDLPVEDVLAAASYLHMYDIVKVCKGRLQ 118
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-132 7.41e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 100.88  E-value: 7.41e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYL----KSLVVHDNLLNLDHDMVSPAVFRLVLD 80
Cdd:cd18324   1 MEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFhlfyKDQLDKRDIVHLNSDIVTAPAFALLLE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 61676186  81 FIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18324  81 FMYEGKL-------------QFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE 119
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 9.57e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 99.90  E-value: 9.57e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYL----KSLVVHDNLLNLDHDMVSPAVFRLVLD 80
Cdd:cd18323   1 MEFPDHSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFhmfyKEQLDKRDLVCINNEIVTAPAFSLLLE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 61676186  81 FIYTGRLADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18323  81 FMYEGRLSFNDTPVED-------------VLAAASYLHMNDIVKVCKKRLQ 118
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 3.65e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 98.18  E-value: 3.65e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKsLVVHDNL-----LNLDHDMVSPAVFRLVL 79
Cdd:cd18325   1 MEFPDHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLdkrdiVHLNSDIVTAPAFSLLL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 61676186  80 DFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18325  80 EFMYEGKL-------------EFSSLPVEDVLAAASYLHMYDIVKVCKGKLK 118
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-127 1.29e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 93.26  E-value: 1.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDH-----DMVSPAVFRLVLDFIYT 84
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPstasfDVFSSDAFSIILDFVYS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCK 127
Cdd:cd18199  81 GKL-------------SLTSQNVIEVMSAASYLQMTDVINVCK 110
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-131 1.43e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 87.81  E-value: 1.43e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH----DNLLNLDH-DMVSPAVFRLVLDFI 82
Cdd:cd18230   2 TSHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQvqktSDQATVTHlDIVTAQGFKAIIDFM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 61676186  83 YTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18230  82 YSAHL-------------ALTSKNVIEVMSAASYLQMTDIVQACHNFIK 117
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-127 2.25e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 87.19  E-value: 2.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD-----NLLNLDHDMVSPAVFRLVLDFIYT 84
Cdd:cd18329   4 HQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNaketgQPTVATFDVFSPDTFTIILDFVYS 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCK 127
Cdd:cd18329  84 GKL-------------SLTSQNVIEVMSAASYLQMTDVISVCK 113
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-127 3.16e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 86.52  E-value: 3.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  13 QLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDH-----DMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18330   4 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHstaslDIVTSEAFSIILDFLYSGKL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61676186  88 adgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCK 127
Cdd:cd18330  84 -------------DLCSENVIEVMSAASYLQMTDVVNFCK 110
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 6.30e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 86.02  E-value: 6.30e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKsLVVHD------NLLNLDHDMVSPAVFRLV 78
Cdd:cd18956   1 MEFPEHGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH-LFYRDrpaggrDTVRLNGDIVTAPAFGRL 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61676186  79 LDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18956  80 LDFMYEGRL-------------DLRSLPVEDVLAAASYLHMYDIVKVCKGRLR 119
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-130 1.71e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 84.49  E-value: 1.71e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYT 84
Cdd:cd18225   1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18225  81 GKL-------------PPGKHNFTKIISVADSLQMFDVAVSCKNLL 113
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-131 1.78e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 84.62  E-value: 1.78e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  13 QLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDH------DMVSPAVFRLVLDFIYTGR 86
Cdd:cd18201   7 QLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQttvthlDVVAVQGFSVILDFMYSGN 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61676186  87 LADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18201  87 LVLTSQNAIE-------------VMSVASYLQMTEVVQSCRNFIK 118
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-117 1.51e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 80.68  E-value: 1.51e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD------NLLNLDHdmVSPAVFRLVLDFIYTGRLadgaeaaaaaava 100
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkesssSEIELDD--VSPEAFEALLDYIYTGEL------------- 65

                        90
                ....*....|....*..
gi 61676186 101 PGAEPSLGAVLAAASYL 117
Cdd:cd18186  66 ELSEENVEELLAAADKL 82
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 29-133 3.01e-18

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 80.43  E-value: 3.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186     29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNL------LNLDHdmVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPG 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesdkseIYLDD--VSPEDFRALLNFLYTGKL-------------DL 65

                           90       100       110
                   ....*....|....*....|....*....|.
gi 61676186    103 AEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:smart00225  66 PEENVEELLELADYLQIPGLVELCEEFLLKL 96
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-87 4.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 80.64  E-value: 4.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV-HDNL---LNLDHDMVSPAVFRLVLDFIY 83
Cdd:cd18192   2 PSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFInHQHTtaqLNLSNMKISAECFDLILQFMY 81


                ....
gi 61676186  84 TGRL 87
Cdd:cd18192  82 LGKI 85
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 7.80e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 79.91  E-value: 7.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLN----LDHDMVSPAVFRLVLDFIY 83
Cdd:cd18198   6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDqqnvYEIDFVSPEALTALLEFAY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18198  86 TATL-------------TVSTANVGDILSAARLLEIPCVSHVC 115
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 9.65e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 79.54  E-value: 9.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDH----DMVSPAVFRLVLDFIY 83
Cdd:cd18328   6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYvyeiDFVTPEALSAILEFAY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18328  86 TSTL-------------TITTSNVKHILNAAQMLEIQCIINVC 115
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 1.26e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 79.21  E-value: 1.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYL--KSLVVHDNLLNLDhDMVSPAVFRLVLDFI 82
Cdd:cd18227   3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRRIVLP-DVMNPRVFENILLSC 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 61676186  83 YTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18227  82 YTGRL-------------VLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 7.20e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 77.28  E-value: 7.20e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL------VVHDNLLNLdhDMVSPAVFRLVLDF 81
Cdd:cd18326   6 PDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLftsgavVDQQNVYEI--DFVSAEALTALLDF 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61676186  82 IYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18326  84 AYTATL-------------TVSTSNVGDILSAARLLEIPAVSHVC 115
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 8.07e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 76.75  E-value: 8.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSP----AVFRLVLDFIYTG 85
Cdd:cd18223   1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPdlkaEVFAEILNFIYSS 80


                ..
gi 61676186  86 RL 87
Cdd:cd18223  81 KV 82
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 1.18e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 76.12  E-value: 1.18e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV-HDNLLNLdhDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18206   3 PQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVdQKDVVHL--DISNAAGLGQVLEFMYTAK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61676186  87 LadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18206  81 L-------------SLSPENVDDVLAVATFLQMQDIVTAC 107
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 4.47e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 74.89  E-value: 4.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD-----NLLNLDHDmVSPAVFRLVLDFIYT 84
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQlkcnlSVINLDPE-INPEGFNILLDFMYT 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18331  86 SRL-------------NLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 6.02e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 74.75  E-value: 6.02e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDFIY 83
Cdd:cd18256   3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmsesSKDVVQIHG--VEPDIFHILLDFIY 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18256  81 TGVV-------------EVTVSNVQELLVAADMLQLTEVVEICCEFLKGQ 117
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 1.08e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 74.13  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV-------------HDNLLNLDHdmVSPAVFR 76
Cdd:cd18228   2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVgqasprlvlvspaGKCVLDLHH--VTVTGFA 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 61676186  77 LVLDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18228  80 PLLEYAYTSTL-------------SINTENIIDVLAAASYMQMFNVANTCSEFMK 121
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 1.10e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 73.37  E-value: 1.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKS-----LVVHDNLLNLDHDmVSPAVFRLVLDFIYT 84
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSiftdqLKNNVSVINLDPE-IEPEGFRILLDFMYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 61676186  85 GRLADGAEAAAaaavapgaepslgAVLAAASYLQIPDLVALCKK 128
Cdd:cd18215  81 SRLNLREGNIM-------------AVMATAMYLQMEHVVDTCRK 111
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 2.20e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 72.48  E-value: 2.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLad 89
Cdd:cd18232   1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGEL-- 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 61676186  90 gaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKK 128
Cdd:cd18232  79 -----------ALTRENRDRVLLAAKELRVPEAVELCQR 106
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-123 2.36e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 72.91  E-value: 2.36e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLV-----VHDNLLNLDhDMVSpAVFRLVLDFIYT 84
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFadegeVGQSIYMLE-GMVA-ETFGALLEFIYT 83

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLV 123
Cdd:cd18212  84 GCL-------------QVGEKSLEQILATAQFLKVNDLV 109
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 5.25e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 71.99  E-value: 5.25e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-HDMVSPAVFRLVLDFIY 83
Cdd:cd18290   5 MEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVElPAAVQPQSFQQILSFCY 84


                ....
gi 61676186  84 TGRL 87
Cdd:cd18290  85 TGRL 88
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-131 1.06e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 71.23  E-value: 1.06e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMV-SPAVFRLVLDFIY 83
Cdd:cd18222   3 LEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIkNPTVFEQLLSFCY 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18222  83 TGRI-------------CLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 1.09e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 70.69  E-value: 1.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH-----DNLLNLDHDMVSPavFRLVLDFIYT 84
Cdd:cd18233   1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNsssqkNDVFHLDIKNVGG--IGQILDFMYT 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18233  79 SHL-------------DLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 1.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 71.08  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH-------------------DNLLNLDHdmV 70
Cdd:cd18195   1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSplplgaaavaaapgatqspERVLELPG--V 78

                        90
                ....*....|....*..
gi 61676186  71 SPAVFRLVLDFIYTGRL 87
Cdd:cd18195  79 KAGVFSDVLNFIYSSRV 95
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 1.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 70.67  E-value: 1.10e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNllNLDH-----DMVSPAVFRLVLDFIYT 84
Cdd:cd18209   1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKE--NESQsvfqlDFCEPDAFENVLNYIYS 78


                ...
gi 61676186  85 GRL 87
Cdd:cd18209  79 SSL 81
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 1.50e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 70.61  E-value: 1.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD-NLLNLDHDMVSPAVFRLVLDFIYTGRLa 88
Cdd:cd18260   1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDpSLQRVELNDISPLGLATVITYAYTGKL- 79

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 61676186  89 dgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18260  80 ------------TLSLYTIGSTISAASYLQIHALVKMC 105
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 3.64e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 69.35  E-value: 3.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL----VVHDNLLNLDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMftggMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18255  81 EL-------------TLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSA 115
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 4.36e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 69.21  E-value: 4.36e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18306   1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDsdgeSILTVKLDGLDPDAVEVLVNYAYTS 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18306  81 RL-------------EVPADLVKSVYSAAKKLKMDRVKKACGDFLLEK 115
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-123 6.78e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 68.90  E-value: 6.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-HDMVSPAVFRLVLDFIY 83
Cdd:cd18289   7 IEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFElPATVPPACFQQILSFCY 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61676186  84 TGRLADGAEAAAaaavapgaepslgAVLAAASYLQIPDLV 123
Cdd:cd18289  87 TGKLTMAASEQL-------------VVMYTAGFLQIQHIV 113
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-130 6.82e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 68.92  E-value: 6.82e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHDMVSPAVFRLVLDF 81
Cdd:cd18196   2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTvaegdqTMNMIQLDSEVVTAEAFAALIDM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 61676186  82 IYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18196  82 MYTSTL-------------MLGESNVMDVLLAASHLHLNSVVKACKHYL 117
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 7.18e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 68.34  E-value: 7.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLkslvvHDNLLNLDHD------MVSPAVFRLVLDFIY 83
Cdd:cd18200   1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYF-----HDKLLLNDTNclvlpsVIEAAAFENLLQLIY 75

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18200  76 SGRL-------------TLCMDALPSHLLVASGLQMWQVVDRCSELLK 110
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-131 8.99e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 68.51  E-value: 8.99e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   6 EAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMV-SPAVFRLVLDFIYT 84
Cdd:cd18220   4 DVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIkNPNVFEQLLSFCYT 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18220  84 GRM-------------SLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 9.23e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 67.93  E-value: 9.23e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLV-VHDNLLNLdhDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18219   4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFsVAGQVVEL--NFIRADIFAEILNYIYSSKI 80
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-126 2.41e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 66.59  E-value: 2.41e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  14 LLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD------NLLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18245   1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppkddgSTYKIELEGISVEVMEEILDYIYTGQI 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 61676186  88 adgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18245  81 -------------KLSEDNIQDIVQAADLLLMTDLKDLC 106
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-132 2.78e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 67.51  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL-----------VVHDNLlnldhdmVSPAVFRLV 78
Cdd:cd18264  11 HGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALfkdytqeskarVIHLPV-------VSAAGLQRV 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 61676186  79 LDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18264  84 LDFIYTSWL-------------SLSLDTLEDTLEAASYLQVTEAIGLCSQYLIN 124
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 4.36e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 66.39  E-value: 4.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH---DNLLNLDHDMVSPAVFRLVLDF 81
Cdd:cd18224   4 LHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLStelDVARTYVVDFITPANFEKVLSF 83


                ....*.
gi 61676186  82 IYTGRL 87
Cdd:cd18224  84 IYTSEL 89
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 5.81e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 66.02  E-value: 5.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV-------------HDNLLNLdhDMVSPAV 74
Cdd:cd18327   6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTgggggsgdlgaggGQDVCEL--DFVGPEA 83

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 61676186  75 FRLVLDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18327  84 LGALLEFAYTATL-------------TISSSNMREVLRAARLLEIPCVADAC 122
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-87 6.45e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 65.86  E-value: 6.45e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   6 EAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH--DNLLNLD-HDMVSPAVFRLVLDFI 82
Cdd:cd18277   6 ESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGqaDAELNITlPEEVTVKGFEPLIQFA 85


                ....*
gi 61676186  83 YTGRL 87
Cdd:cd18277  86 YTAKL 90
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-87 7.51e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 65.25  E-value: 7.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-HDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18210   2 PEITSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVLLKNMSSISlPGVMDPGAFESVLASAYTGK 81


                .
gi 61676186  87 L 87
Cdd:cd18210  82 L 82
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-86 7.70e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 66.07  E-value: 7.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   9 GHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDN--LLNLDHDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18213   3 SHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSseCIKIQPTDIQPDIFSYLLHIMYTGK 82
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-128 2.09e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 64.11  E-value: 2.09e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLV-----VHDNLLNLDHDmVSPAVFRLVLDFIYT 84
Cdd:cd18332   2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFsgrvgEGVSVLTLPSG-LEARGFQLLLDFMYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKK 128
Cdd:cd18332  81 SRL-------------PLTPRTVPAVLAAATYLQMEHVVETCRR 111
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 2.21e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 64.60  E-value: 2.21e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL----VVHDNLLNLDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18261  11 HKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMfslcMVESEADEVNLHGVTSLGLKQALDFAYTG 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18261  91 QI-------------LLEPGVIQDVLAAGSHLQLLELLSLCSHYL 122
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 4.08e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 63.66  E-value: 4.08e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDM----VSPAVFRLVLDFIYTG 85
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVelkdAEPDIIELLVEFAYTA 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18237  84 RI-------------SVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQ 118
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 5.41e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 63.09  E-value: 5.41e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDN--LLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18193   4 HGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTseCVRLKPTDIQPDIFSYLLHLMYTGKM 83
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-87 1.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 62.27  E-value: 1.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   6 EAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAY-LKSLV---VHDNLLNLDHDmVSPAVFRLVLDF 81
Cdd:cd18278  10 ESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYfLQALVgqtENDLVVSLPEE-VTARGFGPLLQF 88


                ....*.
gi 61676186  82 IYTGRL 87
Cdd:cd18278  89 AYTAKL 94
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 29-126 2.36e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 60.44  E-value: 2.36e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLV----VHDNLLNLDHDMVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPGAE 104
Cdd:cd18314   8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmIESNLKEVTLEDVEPEIFETVLKYMYTGQV-------------TLSE 74

                        90       100
                ....*....|....*....|..
gi 61676186 105 PSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18314  75 ENVLDLLMLASKYQVPDLEKLC 96
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-132 2.75e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 61.52  E-value: 2.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   4 TMEAPGHSRQLLLQLNNQRTKG-FLCDVIIVVQNALFRAHKNVLAASSAYLKSlVVHDNL------LNLDHDMVSPAVFR 76
Cdd:cd18207   3 TYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFES-VFSAQEgdggtpRELEMHTISSKVFG 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 61676186  77 LVLDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18207  82 DILDFAYTSRI-------------VVRLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-126 3.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.20  E-value: 3.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  28 CDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNL-------LNLDHDMVSPAVFRLVLDFIYTGRLadgaeaaaaaava 100
Cdd:cd18307   2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMkatdelsITIDCDYLSPETVEQLLDYFYTGKI------------- 68

                        90       100
                ....*....|....*....|....*.
gi 61676186 101 PGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18307  69 VISEKNVEDLLKGAKYFNIPRLKDHC 94
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-134 4.39e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 60.26  E-value: 4.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  11 SRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLkslvvHDNLLnLDHD------MVSPAVFRLVLDFIYT 84
Cdd:cd18229   2 SKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFF-----HDKLL-LGHSeievppVVPAQTVRQLVEFMYS 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  85 GRLADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALCKKRLKRHG 134
Cdd:cd18229  76 GSLVVAQSEALQ-------------ILTAASILQIKTVIDECTQIISQSR 112
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-85 9.90e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 59.76  E-value: 9.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   9 GHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYT 84
Cdd:cd18242   3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEmsekGKSEVELQGLTASTMEILLDFVYT 82


                .
gi 61676186  85 G 85
Cdd:cd18242  83 E 83
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 1.12e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 59.48  E-value: 1.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVhDNLLNLDHDMVS-----PAVFRLVLDFIYT 84
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFT-GNLSEKENSEVEfqcidETALQAIVEYAYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18257  80 GTV-------------FISQATVESLLPAANLLQIKLVLKEC 108
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 1.62e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 58.78  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  17 QLNNQRT-KGFLCDVIIVV--QNALFRAHKNVLAASSAYLKSLVVHDNLL---NLDHDMVSPAVFRLVLDFIYTGRLadg 90
Cdd:cd18231   3 RLNEQRLfQPDLCDVDIVLvrQRSTFPAHKGVLAAYSQFFHSLFTQNKQLqrvELSLEALTSQGLQQILNFIYTSKL--- 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  91 aeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18231  80 ----------LVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 2.15e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 58.51  E-value: 2.15e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH---DNLLNLDHDMVSPAVFRLVLDFIYTGR 86
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKlevDSSSVIEIDFLRSDIFEEVLNYMYTAK 80


                .
gi 61676186  87 L 87
Cdd:cd18204  81 I 81
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-125 4.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 57.50  E-value: 4.86e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTK-GFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV---HDNLLNLDHdmVSPAVFRLVLDFIYTG 85
Cdd:cd18226   4 YNKNLLKYLNDDRQKqSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSknpNTDAVTLDH--VSYSVFQHLLEFLYTS 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVAL 125
Cdd:cd18226  82 EF-------------FVYENEIPLVLEAAKFLDIIDAVKL 108
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-87 6.16e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 57.17  E-value: 6.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   9 GHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNlDHDMV------SPAVFRLVLDFI 82
Cdd:cd18202   1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVS-SHEAVvdlsgfCKSSFLPLLEFA 79


                ....*
gi 61676186  83 YTGRL 87
Cdd:cd18202  80 YTSEL 84
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-87 6.26e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 57.26  E-value: 6.26e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61676186  24 KGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLV----VHDNLLNLDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18295  16 QGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFetkwKDKREINLKHPLVNPDAFRALLQYLYTGRL 83
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-87 1.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 57.14  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   5 MEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNA--------LFRAHKNVLAASSAYLKSLVV------HDNLLNLdHDmV 70
Cdd:cd18273   4 LEDAAHARALLAQLKSFYDARLLTDVTIEVNGPgsgpgsgrLFPCNRNVLAAASPYFKSMFTgglyesKQETVTI-HD-V 81

                        90
                ....*....|....*..
gi 61676186  71 SPAVFRLVLDFIYTGRL 87
Cdd:cd18273  82 DSESMALIIDYCYTGRV 98
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-133 1.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 56.53  E-value: 1.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  13 QLLLQLnnqRTKGFLCDVIIVVQNALFRAHKNVLAASSAY-------------LKSLVVHDnllnLDHDMVSpavfrLVL 79
Cdd:cd18238   4 KVLHQF---YENGELCDVTLKVGEKSIHCHRLVLACVSPYframftsemaeskQDSITIKD----IDEEAVE-----LLV 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 61676186  80 DFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18238  72 DFAYTGKL-------------TLTVDNVQSLLYAASLLQVEEVAKACCEFMKDH 112
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-87 2.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 55.75  E-value: 2.58e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  12 RQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD-------NLLNLDHDMVSPAVFRLVLDFIYT 84
Cdd:cd18258   2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSsrdsgggEKLELTMSNINADVLELLLEFVYT 81


                ...
gi 61676186  85 GRL 87
Cdd:cd18258  82 GSL 84
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-85 3.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 55.03  E-value: 3.62e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61676186  18 LNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVvhDNLLN------LDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18240   8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALF--TNGWNetekkvYKIPGVSPEMMELIIEYAYTR 79
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-133 3.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 55.18  E-value: 3.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  11 SRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD---------NLLNLDHDMVSPavfrlVLDF 81
Cdd:cd18268   7 SSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNfressqakvDLKGIDSDVLDQ-----IVDY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 61676186  82 IYTGRLadgaeaaaaaavapgaEPSLGAVLA---AASYLQIPDLVALCKKRLKRH 133
Cdd:cd18268  82 VYTGEI----------------LITRDNVLPlmeAASMLQYPKLFEACSLYLQDQ 120
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-87 5.00e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 55.02  E-value: 5.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH------DNLLNLdHDMVSPAVFRLVLDF 81
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNglreslDSTVNF-HDSLHPEVLELLLDF 81


                ....*.
gi 61676186  82 IYTGRL 87
Cdd:cd18254  82 AYSSRI 87
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 6.41e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 53.88  E-value: 6.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKsLVVHDNLLNLDHDMVSPAVFRLVLDFIYTGRLad 89
Cdd:cd18205   1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFE-ILFHRNSQHYTLDFLSPKTFQQILEYAYTATL-- 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 61676186  90 gaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18205  78 -----------QAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-127 1.05e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 53.37  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  29 DVIIVVQNAL-FRAHKNVLAASSAYLKSLVVHDNLLNLDHDmVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPGAEPSL 107
Cdd:cd18299  14 DVVFILQGGVrIFAHRIVLAAASSVFADLFLMMTVVTLDSD-ITPEAFRRVLEFLYTGVL-------------DENEDDL 79

                        90       100
                ....*....|....*....|
gi 61676186 108 GAVLAAASYLQIPDLVALCK 127
Cdd:cd18299  80 KELKDAAELLELFDLVMMCT 99
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 1.34e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 53.53  E-value: 1.34e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  11 SRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKslvvhDNLLNLDHDMVSPAVFRL-----VLDFIYTG 85
Cdd:cd18208   9 SNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQ-----DKLLLGYSDIEIPSVVSVqsvqkLIDFMYSG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  86 RLADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALCKK 128
Cdd:cd18208  84 VLRVSQSEALQ-------------ILTAASILQIKTVIDECTR 113
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 4-87 1.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 53.32  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   4 TMEAPGHSRQLLLQLNNQRTKGFLCDVIIVVQN----ALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDMVS-----PAV 74
Cdd:cd18211   2 LLESKSAPSNLLNEMHKLRLLGHLCDVTVQVEHqgskEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMlneiyTAD 81

                        90
                ....*....|...
gi 61676186  75 FRLVLDFIYTGRL 87
Cdd:cd18211  82 FASFLEFVYTAKV 94
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-126 2.85e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 52.77  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   9 GHSRQLLLQLNNQRTKGFLCDVIIVV----QNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLV 78
Cdd:cd18248   3 DHTKEAFQIMNELRLSQQLCDVTLKVkyqdPKEEFMAHKVVLASSSPYFKAMFTsglrecGMEVVPIEG--VHPCVMSRL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61676186  79 LDFIYTGRLadgaeaaaaaavapgaepSLGA-----VLAAASYLQIPDLVALC 126
Cdd:cd18248  81 IEFAYTASI------------------SVGEkcvlhVLPGAVMYQMDSVVKAC 115
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-131 3.08e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 52.25  E-value: 3.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNL-DHDMVSPAVFRLVLDFIYTGRLa 88
Cdd:cd18218   1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWcLGEGISPSTFKQLLDFVYGESV- 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  89 dgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18218  80 ------------EVQPGELRPLLEAARALEVESLEEACWRALG 110
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-133 3.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 52.46  E-value: 3.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL-------------VVHDnllnldhdmVSPAV 74
Cdd:cd18250   2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMfagelresradrvVLHG---------VSAEI 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61676186  75 FRLVLDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18250  73 LGLLLDFSYTGRV-------------TVTQDNVEALLRAADLFQFPSVKEACCAYLQQR 118
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 27-85 5.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 50.63  E-value: 5.40e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLVvhDNLLNLDHDMVS-PAV----FRLVLDFIYTG 85
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL--KETPPDEHPVIIlPDVpyseLKALLDFIYTG 62
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-126 5.67e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 51.71  E-value: 5.67e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  13 QLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV-------HDNLLNLdHDMVSPAVFRLVlDFIYTG 85
Cdd:cd18293   1 TAFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSsepppagQKVVLEL-QGLKAHTLLKLV-DFLYTS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 61676186  86 RLADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALC 126
Cdd:cd18293  79 ELEVSSEEAQD-------------VLAAARRLQISELESLC 106
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 5.71e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 51.65  E-value: 5.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIY 83
Cdd:cd18339   2 PAHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDmsesKAKKIEIKDVDGQTLSKLIDYIY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18339  82 TAEI-------------EVTEENVQVLLPAASLLQLMDVRQNC 111
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-130 5.93e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 51.73  E-value: 5.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNA--LFRAHKNVLAASSAYLKSLVV----HDNLLNLDHDMVSPAVFRLVLDFIY 83
Cdd:cd18239   6 HSSVVLQGFDQLRGEGLLCDVTLVPGDGdeTFPVHRAMMASASDYFKAMFTggmkEQELMCIKLHGVSKIGLKNIIDFIY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18239  86 TAKL-------------SLNMDNLQDTLEAASFLQILPVLDFCKVLL 119
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-132 6.94e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 51.51  E-value: 6.94e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  17 QLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-----HDMVSPAVFRLVlDFIYTGRLadga 91
Cdd:cd18247   9 VMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQdeitmQGIEPSALEALI-NFAYSGRI---- 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 61676186  92 eaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18247  84 ---------AIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-87 6.97e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 52.30  E-value: 6.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLV------VHDNLLNLdHDMVSPAVFRLVLDF 81
Cdd:cd18267  21 SSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFsgglkeSQDSEVNF-HDSIHPEVLELLLDY 99


                ....*.
gi 61676186  82 IYTGRL 87
Cdd:cd18267 100 AYSSRV 105
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-132 7.39e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 51.82  E-value: 7.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDFIY 83
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmreaHQKEVELVG--ASYIGLKAVIDFLY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18266  86 SSEL-------------PLDGGNIDYVLETAHLLQIWKVVDFCCEYLEN 121
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-132 7.69e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 51.42  E-value: 7.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVvhdnLLNLDHD-----MVSPAVFRLVLDFI 82
Cdd:cd18203   6 PGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQF----LLNPSSElqvslMHSSRVVADLLLSC 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  83 YTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18203  82 YTGAL-------------EFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-87 1.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 50.98  E-value: 1.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-----HDmVSPAVFRLVLDFI 82
Cdd:cd18259  13 PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISarveiKD-VDPAVMESLIDFA 91


                ....*
gi 61676186  83 YTGRL 87
Cdd:cd18259  92 YTGKL 96
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-137 2.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 50.16  E-value: 2.61e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDF 81
Cdd:cd18265   4 PCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGghlkesRQAVVEIQK--VSAAAMEVLLDY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 61676186  82 IYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYC 137
Cdd:cd18265  82 MYGGGL-------------RIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPC 124
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 2.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 49.61  E-value: 2.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL---VVHDNLLNLDHdmVSPAVFRLVLDFIYTGR 86
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFfqdFTQEPLVEIEG--VSNMAFRHLIEFTYTAK 78


                .
gi 61676186  87 L 87
Cdd:cd18221  79 L 79
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-87 3.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 49.00  E-value: 3.16e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLVVH--DNLLNLD-HDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGqtDGDLVITlPEEVTVKGFEPLLQFAYTAKL 64
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 4.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 49.65  E-value: 4.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNldHDMVSPAVfRLVLDFIYTGRL 87
Cdd:cd18243  13 PSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSINNLVL--QGCSSIGL-RLVLEYLYTANV 89

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 61676186  88 adgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18243  90 -------------TLSLDTVEEVLSVSKILHIPQVTKLC 115
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-133 5.36e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 49.03  E-value: 5.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLdHDMVSPAVfRLVLDFIY 83
Cdd:cd18276   4 HSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTcglmecSQREVVL-HDITAESV-SIILNYMY 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18276  82 SSDL-------------HLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDH 118
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 8.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 48.58  E-value: 8.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDF 81
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTgdlsesRANRVTLQD--VDGKALLLLIDY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61676186  82 IYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18235  80 VYTAEI-------------QVTEENVQVLLPAANLLQLTDVRDAC 111
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-138 1.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 47.91  E-value: 1.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNL----LNLDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHResreMLVEINGILAEAMDCFLQYVYTG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRHGKYCH 138
Cdd:cd18253  81 KV-------------KITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCN 120
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-128 1.28e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 48.06  E-value: 1.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNA-LFRAHKNVLAASSAYLKSLVVHDNLLNLDHDM----VSPAVFRLVLDFI 82
Cdd:cd18274   3 PLHACSILQQLKAMYDEGQLTDIVVEVDHGkTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVrivgVEAESMHLVLDYA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 61676186  83 YTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKK 128
Cdd:cd18274  83 YTSRV-------------TLTEANVQALFTAASIFQIPSLQDQCAQ 115
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-87 1.52e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 47.62  E-value: 1.52e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSL-------------VVHDnllnldhdmVSPAVFRLVLDFIYTGRL 87
Cdd:cd18287  24 DVTFVVEEKRFPAHRVILAARSEYFRALlyggmresqqseiELKD---------TNAEAFKALLKYIYTGRL 86
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-85 3.20e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 46.13  E-value: 3.20e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHDN----------LLNLDHdmVSPAVFRLVLDFIYTG 85
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLltsedavgcdVVHIEK--VPPEIFEQLLQFIYTD 84
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 4.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 46.35  E-value: 4.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVhDNLLNLDHDM-----VSPAVFRLVLDFIYT 84
Cdd:cd18251   6 HSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFA-GGLREMQQTEvlihgVSYNAMCKILDFIYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18251  85 SEL-------------ELSLDNVQETLTAACQLQIPEVIGFC 113
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 5.08e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 5.08e-06
                          10        20
                  ....*....|....*....|....*.
gi 61676186   558 RLTEHMRIHSGEKPYECQVCGGKFAQ 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 8-126 6.72e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 45.83  E-value: 6.72e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   8 PGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSL----VVHDNLLNLDHDMVSPAVFRLVLDFIY 83
Cdd:cd18338   2 PRHMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMftgeMSESRAKRVRIKEVDGWTLKMLIDYVY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 61676186  84 TGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18338  82 TAEI-------------QVTEENVQVLLPAAGLLQLQDVKKTC 111
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-130 1.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 45.40  E-value: 1.06e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  28 CDVIIVVQNALFRAHKNVLAASSAYLKS-------------LVVHDnllnldhdmVSPAVFRLVLDFIYTGRLADGAEAA 94
Cdd:cd18280  15 ADVTFNVDGEKFRAHKLVLAARSPVFRSmlfgpmreenegeIVIED---------VEPPVFKALLHFIYKDELPDDVEPA 85

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 61676186  95 AAAAVAPGAEPSLgAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18280  86 GSDSSSLDTTMAQ-HLLAAADRYALERLRLLCESRL 120
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 15-139 1.23e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 44.94  E-value: 1.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  15 LLQLNNQrtkGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVvhdnllnLDHDM-----------VSPAVFRLVLDFIY 83
Cdd:cd18286   8 LLQLFLN---GEDSDITIKVDGKTFKAHRCILCARSSYFAAML-------SGSWAesnsseitltgVSHAAVSFVLLFIY 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61676186  84 TGRLadgaeaaaaaavAPGAEPSLGAVLAAASYLQIPDL--VALCKkrLKRhgKYCHL 139
Cdd:cd18286  78 GGVL------------DLPDDVNLGELLSLADMYGLDGLkdVVAYT--LRR--DYCHF 119
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 1.83e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 44.48  E-value: 1.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  14 LLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLK-------SLVVHDNLLNldhdmvSPAVFRLVLDFIYTGR 86
Cdd:cd18197  12 VLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRdqfllnqSKQVRITILQ------SAEVGRKLLLSCYTGA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 61676186  87 LadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18197  86 L-------------EVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 2.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 44.27  E-value: 2.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLDHDM----VSPAVFRLVLDFIYTG 85
Cdd:cd18336   2 HAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIkmegVDPDALKALVHYAYTG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18336  82 VL-------------ELKEDTIESLLAAACLLQLSQVIDVC 109
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 2.67e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 44.61  E-value: 2.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  14 LLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV---------HDNLLNLDhdmvsPAVFRLVLDFIYT 84
Cdd:cd18270  13 LLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMsglseskqtHVHLRNVD-----AATLQIIITYAYT 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 61676186  85 GRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18270  88 GNL-------------AINDSTVEQLYETACFLQVEDVLQRCREYL 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-120 3.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 43.63  E-value: 3.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHDnllNLDHDMVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPGAEPSLG 108
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRD---ILKVKGLSYATLRLLVDYVYSGRM-------------AVSKDNVV 69

                        90
                ....*....|..
gi 61676186 109 AVLAAASYLQIP 120
Cdd:cd18275  70 EVVAGARFLQMP 81
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-126 3.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 44.18  E-value: 3.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  24 KGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDnLLNLDHDMV-----SPAVFRLVLDFIYTGRLadgaeaaaaaa 98
Cdd:cd18244  27 EGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTAD-MRERDQDKIhlkglTATGFSHVLQFMYYGTI----------- 94

                        90       100
                ....*....|....*....|....*...
gi 61676186  99 vaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18244  95 --ELSMLTVHEILQAAMYVQLTEVVKFC 120
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-85 3.74e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 43.82  E-value: 3.74e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLvVHDNL------------LNLdHDmVSPAVFRLVLDFIYTG 85
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKAL-LRDHFaeseenngsipvVTL-HD-VSPEVFAIVLYYIYTD 84
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 516-538 3.74e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.75  E-value: 3.74e-05
                          10        20
                  ....*....|....*....|...
gi 61676186   516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-132 4.74e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 43.59  E-value: 4.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD---------NLLNLDHDMVspavfRLVLD 80
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGElaesrqtevTIRDIDERAM-----ELLID 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 61676186  81 FIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18249  81 FAYTSQI-------------TVEEGNVQTLLPAACLLQLAEIQEVCCEFLKR 119
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-132 5.11e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 42.74  E-value: 5.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYTGRLadgaeaaaaaavaPG 102
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDvreaTEEEIKLKDVDPDALWTLVQYCYTGRL-------------EL 67

                        90       100       110
                ....*....|....*....|....*....|
gi 61676186 103 AEPSLGAVLAAASYLQIPDLVALCKKRLKR 132
Cdd:cd18234  68 KEDNVESLLATACLLQLSEVVEACCGFLMK 97
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-130 5.50e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 43.30  E-value: 5.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  14 LLLQ--LNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDnlLNLDHDM------VSPAVFRLVLDFIYTG 85
Cdd:cd18236   9 LVLQngLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCND--LKEKYEEkiiikgVDAETMQILLDYTYTS 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRL 130
Cdd:cd18236  87 KV-------------LITKQNVQRVLEAASLFQFLRMVDACASFL 118
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 30-87 6.14e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 41.88  E-value: 6.14e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61676186  30 VIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDFIYTGRL 87
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRggfresGQAEINLRD--ISPEDFRALLEFLYGGKR 62
PHA03098 PHA03098
kelch-like protein; Provisional
 18-133 6.62e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.30  E-value: 6.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   18 LNNQRtkgfLCD--VIIVVQNALFRAHKNVLAASSAYLKSLV-----VHDNLLNLDHDMvspavFRLVLDFIYTGRLadg 90
Cdd:PHA03098   4 FELQK----FCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFknnfkENEINLNIDYDS-----FNEVIKYIYTGKI--- 71

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 61676186   91 aeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:PHA03098  72 ----------NITSNNVKDILSIANYLIIDFLINLCINYIIKI 104
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
542-590 7.70e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 7.70e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 61676186 542 KPFACDACGMRFTRQYRLTEHMRIHSGEKPYECQVCGGKFAQQRNLISH 590
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELS 80
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-85 7.94e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 43.34  E-value: 7.94e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61676186  25 GFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLdHDmVSPAVFRLVLDFIYTG 85
Cdd:cd18272  30 GLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTsnlkeaRNRVIEL-KD-VSESVFQLLVDYIYHG 94
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-133 8.03e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 42.65  E-value: 8.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLvVHDNLLNLDHDMV-----SPAVFRLVLDFIYTGrladgaeaaaAAAVAP 101
Cdd:cd18297  12 MSDVTFLVEGRPFYAHKIVLVTASDRFKSM-LSSGSTEAQTPVIeipdiRYDIFQLMMQYLYTG----------GVESLD 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 61676186 102 GAEPSLGAVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18297  81 VAQDDALELLRAASFFQLDGLKRHCEILLSQQ 112
PHA02713 PHA02713
hypothetical protein; Provisional
 10-131 8.41e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.77  E-value: 8.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   10 HSRQLLLQLNNQRTKGFLCDVIIVVQNAL-FRAHKNVLAASSAYLKSL-----VVHDNLLNLDHDMVSPAVFRLVLDFIY 83
Cdd:PHA02713   8 HNRRVVSNISNLLDDDILCDVIITIGDGEeIKAHKTILAAGSKYFRTLfttpmIIRDLVTRVNLQMFDKDAVKNIVQYLY 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 61676186   84 TGRLadgaeaaaaaavapgAEPSLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:PHA02713  88 NRHI---------------SSMNVIDVLKCADYLLIDDLVTDCESYIK 120
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-130 8.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 42.90  E-value: 8.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   3 DTMEAPGHSRQLLLQ--LNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFR 76
Cdd:cd18340   1 DQVEELRLYQQTLLQdgLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDleesKKREIVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 61676186  77 LVLDFIYTGRLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC----KKRL 130
Cdd:cd18340  81 KILHYIYTSEI-------------EITEQNVQDIFAAANMFQIPSIFTVCvsflQKRL 125
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 1.31e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 41.85  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  11 SRQLLLQLNNQRtkgfLCDVIIVV-QNA-LFRAHKNVLAASSAYLKS--------------LVVHDnllnldhdmVSPAV 74
Cdd:cd18294   2 AADMKSLINNPE----FSDVKFLVgPERqEIFAHKCILAARCEVFRAmfltgpqkestqspLVLSD---------IEPEV 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 61676186  75 FRLVLDFIYTGRLADGAEAAAAaavapgaepslgaVLAAASYLQIPDLVALCKK 128
Cdd:cd18294  69 FRAVLEFIYTNCVTLSNHTVIE-------------VLAAAVEYGLDELRKLCER 109
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-86 1.46e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 42.13  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   7 APGHSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLvVHDNLLNLDHDMV-----SPAVFRLVLDF 81
Cdd:cd18271   4 AECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAM-FEVNMKERDDGSVtisnlSPKAVKAFLDY 82


                ....*
gi 61676186  82 IYTGR 86
Cdd:cd18271  83 AYTGK 87
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-86 2.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 41.76  E-value: 2.04e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHD---------NLLNLDHDmvspaVFRLVLDFIYTGR 86
Cdd:cd18345  20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEmeerkqnrvEITDVDHE-----VMREMLRFIYTGK 81
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-133 2.27e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 41.48  E-value: 2.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-----HDMvSPAVFRLVLDFIYTGRLADGAEAAAAAAvapga 103
Cdd:cd18344  25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKnpieiHDL-DPQVFKEMMGFIYTGKAPHLHSHSMACD----- 98

                        90       100       110
                ....*....|....*....|....*....|
gi 61676186 104 epslgaVLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18344  99 ------VLAAADKYGLEGLKVLCEDALCRN 122
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-86 2.85e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 40.98  E-value: 2.85e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHD---------NLLNLDHDmvspaVFRLVLDFIYTGR 86
Cdd:cd18279  20 DCCLCVGGQEFQAHKAILAARSPVFSAMFEHEmeeskknrvEINDVDPE-----VFKEMMRFIYTGK 81
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-87 5.08e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 40.35  E-value: 5.08e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 61676186  27 LCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLN-------LDHDMVSPAVFRLVLDFIYTGRL 87
Cdd:cd18292  17 LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSEskqseieLVEDPECAAVFEKFLRYLYTGQI 84
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-87 5.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 40.78  E-value: 5.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHDNLLNLD-----HDmVSPAVFRLVLDFIYT 84
Cdd:cd18246  22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQthvtlHD-IDPQALEQLVQYAYT 100


                ...
gi 61676186  85 GRL 87
Cdd:cd18246 101 AEI 103
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
482-594 6.45e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 6.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186 482 GELLRPYRCAS--CDKSYKDPATLRQHEKTHWLTRPYPC--TICGKKFTQRGTM-----TRHMRSHLGLKPFACD--ACG 550
Cdd:COG5048 316 GESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNeppqsLQQYKDLKNDKKSETLsnSCI 395

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 61676186 551 MRFTRQYRLTEHmRIHSGEKPYECQVCGGKFAQQR---NLISHMKMH 594
Cdd:COG5048 396 RNFKRDSNLSLH-IITHLSFRPYNCKNPPCSKSFNrhyNLIPHKKIH 441
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-57 7.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 40.23  E-value: 7.35e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 61676186   6 EAPGHSRQLLLQLNNQRTKGFLCDVIIVVQNAL---FRAHKNVLAASSAYLKSLV 57
Cdd:cd18241   2 ECSSHCSELSWRQNEQRKQGLFCDITLAFGGAGgreFRAHRSVLAAATEYFTPLL 56
ZnF_C2H2 smart00355
zinc finger;
516-538 7.68e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 37.06  E-value: 7.68e-04
                           10        20
                   ....*....|....*....|...
gi 61676186    516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-126 8.45e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.53  E-value: 8.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  23 TKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLDHdmVSPAVFRLVLDFIYTGRLadgaeaaaa 96
Cdd:cd18300   5 NKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGgnfresSAKEVELPG--VSKETFLALLEYLYTDQA--------- 73

                        90       100       110
                ....*....|....*....|....*....|
gi 61676186  97 aaVAPGAEPSLGaVLAAASYLQIPDLVALC 126
Cdd:cd18300  74 --PILEDGDCVG-LIVLANRLCLPRLVALC 100
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-86 8.97e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 39.60  E-value: 8.97e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSLVVHD------NLLNLDHdmVSPAVFRLVLDFIYTGR 86
Cdd:cd18343  23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEmeeskkNRVEIND--VDPEVFKEMMRFIYTGK 84
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 1.23e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 39.64  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  10 HSRQLLLQLNNQRTKGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVVHD----NLLNLDHDMVSPAVFRLVLDFIYTG 85
Cdd:cd18335   2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDvceaKQEEIKMEGIDPNALWDLVQFAYTG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 61676186  86 RLadgaeaaaaaavaPGAEPSLGAVLAAASYLQIPDLVALC 126
Cdd:cd18335  82 CL-------------ELKEDTIENLLAAACLLQLSQVVEVC 109
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 572-594 2.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|...
gi 61676186   572 YECQVCGGKFAQQRNLISHMKMH 594
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 486-535 2.43e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.54  E-value: 2.43e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 61676186 486 RPYrCASCDKSYKDPATLRQHEK-THwltrpYPCTICGKKFTQRGTMTRHM 535
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVHC 45
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-132 2.49e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 38.25  E-value: 2.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  24 KGFLCDVIIVVQNALFRAHKNVLAASSAYLKSLVV------HDNLLNLdhDMVSPAVFRLVLDFIYTGRLadgaeaaaaa 97
Cdd:cd18263  10 KGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTsgmkesTQSVVQL--PTIPAKDLRLLISFAYSGIL---------- 77

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 61676186  98 avapgaEPSLGAVLAAAS---YLQIPDLVALCKKRLKR 132
Cdd:cd18263  78 ------HLSWENLFEATCtalQLQISGALALCLDFLQR 109
PHA03247 PHA03247
large tegument protein UL36; Provisional
 204-306 6.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 6.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186   204 PGPAAALCASERRCSPlcGLDLSKKSPPGS-----AAPERPLAERElpPRPDSPPSAGPAAYKEPPLALPSLPPLPFQKL 278
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAP--GGDVRRRPPSRSpaakpAAPARPPVRRL--ARPAVSRSTESFALPPDQPERPPQPQAPPPPQ 2918

                          90       100
                  ....*....|....*....|....*...
gi 61676186   279 EEAAPPSDPfrggSGSPGPEPPGRPDGP 306
Cdd:PHA03247 2919 PQPQPPPPP----QPQPPPPPPPRPQPP 2942
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 488-510 7.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|...
gi 61676186   488 YRCASCDKSYKDPATLRQHEKTH 510
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-131 7.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 36.92  E-value: 7.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  29 DVIIVVQNALFRAHKNVLAASSAYLKSlvvhDNLLN---LDHDMVSPAVFRLVLDFIYTGRLADGAEAAAaaavapgaep 105
Cdd:cd18303  20 DITIKLADKSIPAHKFVLAARSEKWSN----ENLAStneLDLSDISYEVVLALLRWLYTDELDLTLDDEF---------- 85

                        90       100
                ....*....|....*....|....*.
gi 61676186 106 sLGAVLAAASYLQIPDLVALCKKRLK 131
Cdd:cd18303  86 -LLELMKAAKRFQLTDLVERCERALM 110
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 516-538 8.06e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 34.54  E-value: 8.06e-03
                          10        20
                  ....*....|....*....|...
gi 61676186   516 YPCTICGKKFTQRGTMTRHMRSH 538
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 26-133 8.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 37.29  E-value: 8.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61676186  26 FLCDV-IIVVQNALFRAHKNVLAASSAYLKSLVVHD------NLLNLDHDMVSPA------VFRLVLDFIYTGRLADGAE 92
Cdd:cd18310  17 FYSDAeIIVEGGRPVPVHRCILAARSPFFRDIFASAkaeganTKPKLELRELIPGgivgydAFMLVLSYLYSGRLRLVPK 96

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 61676186  93 AAAAAAVAPGAEPSLGA-------VLAAASYLQIPDLVALCKKRLKRH 133
Cdd:cd18310  97 EGSACVDSDCWHVACRPavdfaleVLYAASVFQIPELVSLFQRRLLDF 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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