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Conserved domains on  [gi|5729852|ref|NP_006569|]
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guanine nucleotide-binding protein subunit beta-5 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-353 1.11e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.03  E-value: 1.11e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 130
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  131 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 209
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  210 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 287
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5729852  288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-353 1.11e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.03  E-value: 1.11e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 130
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  131 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 209
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  210 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 287
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5729852  288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
54-352 3.76e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 3.76e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  134 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 213
Cdd:COG2319 191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 293
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 5729852  294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 214-352 3.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 3.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 290
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5729852   291 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 352
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-91 1.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 5729852      53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
315-352 9.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 9.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 5729852    315 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-353 1.11e-84

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 258.03  E-value: 1.11e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFT-----TNKEHAVTMpcTWVMACAYAPSgcaIACGGLDNKCS 130
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETgellrTLKGHTGPV--RDVAASADGTY---LASGSSDKTIR 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  131 VYPLTFDKnenmaaKKKSVAMHTNYLSACSFTNsDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetg 209
Cdd:cd00200  77 LWDLETGE------CVRTLTGHTSYVSSVAFSP-DGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  210 NTFVSGGC-DKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIY-SKESIIFgas 287
Cdd:cd00200 147 GTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrGHENGVN--- 223

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5729852  288 SVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA 353
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
54-352 3.76e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 3.76e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  134 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 213
Cdd:COG2319 191 LATGK------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD--GRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIifGASSVDFSL 293
Cdd:COG2319 263 SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSP 340

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 5729852  294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319 341 DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
56-352 5.54e-59

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 195.52  E-value: 5.54e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYplt 135
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  136 fdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFV 213
Cdd:COG2319 148 -----DLATGKllRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD--GKLLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSL 293
Cdd:COG2319 221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS--GGVNSVAFSP 298

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 5729852  294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319 299 DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
56-352 1.60e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.66  E-value: 1.60e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   56 RRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 135
Cdd:COG2319  29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  136 fdknenMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNTFVSG 215
Cdd:COG2319 109 ------TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD--GKLLASG 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  216 GCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSG 295
Cdd:COG2319 181 SDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHS--GSVRSVAFSPDG 258

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 5729852  296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
54-312 7.72e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 7.72e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYp 133
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW- 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  134 ltfdkneNMAAKK--KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSetGNT 211
Cdd:COG2319 232 -------DLATGKllRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD--GKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  212 FVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDF 291
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT--GAVTSVAF 380

                       250       260
                ....*....|....*....|.
gi 5729852  292 SLSGRLLFAGYNDYTINVWDV 312
Cdd:COG2319 381 SPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
54-269 1.86e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 1.86e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  134 LTFDKnenmaaKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFV 213
Cdd:COG2319 275 LATGE------LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP--DGKTLA 346

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 5729852  214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 269
Cdd:COG2319 347 SGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-352 1.34e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 1.34e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  187 LLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLY 266
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  267 DLRADREVAIYS--KESIifgaSSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGS 344
Cdd:cd00200  79 DLETGECVRTLTghTSYV----SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154


                ....*...
gi 5729852  345 WDHTLRVW 352
Cdd:cd00200 155 QDGTIKLW 162
WD40 COG2319
WD40 repeat [General function prediction only];
54-228 1.03e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.03e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   54 KTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYP 133
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  134 LtfdkneNMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNTFV 213
Cdd:COG2319 317 L------ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT--SVAFSPDGRTLA 388

                       170
                ....*....|....*
gi 5729852  214 SGGCDKKAMVWDMRS 228
Cdd:COG2319 389 SGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
167-352 1.18e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 1.18e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  167 QILTASGDGTCALWDVESGQLLQSFHGHGADVLclDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVR 246
Cdd:COG2319   8 ALAAASADLALALLAAALGALLLLLLGLAAAVA--SLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  247 YYPSGDAFASGSDDATCRLYDLRADREVAIYSKESiiFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHEN 326
Cdd:COG2319  86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                       170       180
                ....*....|....*....|....*.
gi 5729852  327 RVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319 164 AVTSVAFSPDGKLLASGSDDGTVRLW 189
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-225 1.10e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 1.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDsfttnkehavtmpctwvmacayapsgcaiacggLDNKCSVY 132
Cdd:cd00200 167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---------------------------------LSTGKCLG 213

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  133 PLTFdknenmaakkksvamHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTF 212
Cdd:cd00200 214 TLRG---------------HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP--DGKRL 276

                       170
                ....*....|...
gi 5729852  213 VSGGCDKKAMVWD 225
Cdd:cd00200 277 ASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 214-352 3.21e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 3.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   214 SGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYyPSGDA--FASGSDDATCRLYDLRADREVA-IYSKESIifgaSSVD 290
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY-SSADPtlLASGSDDGSVKLWSINQGVSIGtIKTKANI----CCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 5729852   291 F-SLSGRLLFAGYNDYTINVWDvLKGSRVSI--LFGHENRVSTLRVSpDGTAFCSGSWDHTLRVW 352
Cdd:PLN00181 625 FpSESGRSLAFGSADHKVYYYD-LRNPKLPLctMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-91 1.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.11e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 5729852      53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 314-352 4.96e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 4.96e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 5729852     314 KGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
315-352 9.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 9.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 5729852    315 GSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
53-91 1.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5729852     53 MKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD 91
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.69e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 5729852     228 SGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 165-275 1.96e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   165 DMQILTASGDGTCALWDVESGQLLQS-------FHGHGADVLCLDLAPSeTGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
Cdd:PTZ00421  88 PQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPS-AMNVLASAGADMVVNVWDVERGKAVEVIKC 166

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 5729852   238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVA 275
Cdd:PTZ00421 167 HSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVS 204
WD40 pfam00400
WD domain, G-beta repeat;
229-267 4.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 4.67e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 5729852    229 GQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYD 267
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
250-352 5.05e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 5.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852  250 SGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 329
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100
                ....*....|....*....|...
gi 5729852  330 TLRVSPDGTAFCSGSWDHTLRVW 352
Cdd:COG2319  83 SVAFSPDGRLLASASADGTVRLW 105
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-312 5.26e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 5.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   108 VMACAYAPSGCAIACGGLDNKCSVYPLT--FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESG 185
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECEsiIKDGRDIHYPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   186 QLLQSFHGHGADVLCLDLAPSETgNTFVSGGCDKKAMVWDMRSGQCVQAFEThESDINSVRyYPS--GDAFASGSDDATC 263
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSSADP-TLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQ-FPSesGRSLAFGSADHKV 642

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 5729852   264 RLYDLRADR----EVAIYSKEsiifgASSVDFSLSGRLLfAGYNDYTINVWDV 312
Cdd:PLN00181 643 YYYDLRNPKlplcTMIGHSKT-----VSYVRFVDSSTLV-SSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 184-225 2.47e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 5729852     184 SGQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 225
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 292-351 6.24e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 6.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   292 SLSGRLLFAGYnDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRV 351
Cdd:PTZ00421 136 SAMNVLASAGA-DMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
185-225 1.00e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 5729852    185 GQLLQSFHGHGADVLCLDLAPSetGNTFVSGGCDKKAMVWD 225
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD--GKLLASGSDDGTVKVWD 39
WD40_like pfam17005
WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat ...
 240-320 3.35e-03

WD40-like domain; This is a family of proteins which have weak homology to the WD40 repeat family. Members are largely from microsporidia and related species.


Pssm-ID: 407205 [Multi-domain]  Cd Length: 301  Bit Score: 38.88  E-value: 3.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852    240 SDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYS--KESIIFgassVDFsLSGRLLFAGYNDYTINVWDVLKGSR 317
Cdd:pfam17005   1 TEIYSIDISKKGSYILYGGKDDTCTVYDFENLDLVSIVEgfSDSVIF----CKF-LDDDLILVVTLDGTIMESLLKNDQE 75


                  ...
gi 5729852    318 VSI 320
Cdd:pfam17005  76 IEN 78
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 152-181 3.95e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 3.95e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 5729852     152 HTNYLSACSFTNSDMQILTASGDGTCALWD 181
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 152-240 9.89e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 37.57  E-value: 9.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5729852   152 HTNYLSACSFTNSDMQILTASG-DGTCALWDVESGQLLQSFHGHGADVLCLDLapSETGNTFVSGGCDKKAMVWDMRSGQ 230
Cdd:PTZ00421 124 HTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEW--NLDGSLLCTTSKDKKLNIIDPRDGT 201

                         90
                 ....*....|
gi 5729852   231 CVQAFETHES 240
Cdd:PTZ00421 202 IVSSVEAHAS 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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