|
Name |
Accession |
Description |
Interval |
E-value |
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
618-840 |
3.17e-172 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 528.08 E-value: 3.17e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 777
Cdd:cd18003 81 YYGSAKERKLKRQGWMKPNSFHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 778 LQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd18003 161 LQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMSEGSQEENEELVRRLHKVLRPFLLRR 223
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
618-840 |
1.48e-95 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 308.66 E-value: 1.48e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQGWTKPN------AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNlytrdaPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCRNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd18002 161 LLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKTGLNEHQLKRLHMILKPFMLRR 229
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
621-907 |
2.33e-95 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 310.77 E-value: 2.33e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 621 YQHIGLDWLVTMYEK-KLNGILADEMGLGKTIQTISLLAHLACEKGNWG-PHLIIVPTSVMLNWEMELKRWC--PSFKIL 696
Cdd:pfam00176 1 YQIEGVNWMLSLENNlGRGGILADEMGLGKTLQTISLLLYLKHVDKNWGgPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 697 TYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGT 776
Cdd:pfam00176 81 VLHGNKRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRWILTGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 777 PLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMPKKYEHV 856
Cdd:pfam00176 161 PLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIE------RGGGKKGVSRLHKLLKPFLLRRTKKDVEKSLPPKVEYI 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 857 IRCRLSKRQRCLYDDFMAQTTTKETLAT----GHFMSVINILMQLRKVCNHPNLF 907
Cdd:pfam00176 235 LFCRLSKLQRKLYQTFLLKKDLNAIKTGeggrEIKASLLNILMRLRKICNHPGLI 289
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
616-842 |
1.20e-92 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 300.01 E-value: 1.20e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 695
Cdd:cd17997 2 GTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 775
Cdd:cd17997 82 VVLIGDKEERADIIRDVLLPGKFDVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRLLLTG 161
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146219843 776 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltgmiEGSQEYNEGLVKRLHKVLRPFLLRRVK 842
Cdd:cd17997 162 TPLQNNLHELWALLNFLLPDVFTSSEDFDEWFNV------NNCDDDNQEVVQRLHKVLRPFLLRRIK 222
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
611-918 |
2.37e-92 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 326.37 E-value: 2.37e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 611 PLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWC 690
Cdd:PLN03142 163 PSCIKGKMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 691 PSFKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRR 770
Cdd:PLN03142 243 PVLRAVKFHGNPEERAHQREELLVAGKFDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 771 LLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltgmieGSQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQMP 850
Cdd:PLN03142 323 LLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQI-------SGENDQQEVVQQLHKVLRPFLLRRLKSDVEKGLP 395
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146219843 851 KKYEHVIRCRLSKRQRCLYDDFMaQTTTKETLATGHFMSVINILMQLRKVCNHPNLF---DPRPvtsPFIT 918
Cdd:PLN03142 396 PKKETILKVGMSQMQKQYYKALL-QKDLDVVNAGGERKRLLNIAMQLRKCCNHPYLFqgaEPGP---PYTT 462
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
609-909 |
1.43e-91 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 314.47 E-value: 1.43e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 609 PIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKR 688
Cdd:COG0553 233 SLPAGLKATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELK-ERGLARPVLIVAPTSLVGNWQRELAK 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 689 WCPSFKILTYYGAqKERKLKRQGWtkpNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQ 768
Cdd:COG0553 312 FAPGLRVLVLDGT-RERAKGANPF---EDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRAKAVRALKAR 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 769 RRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLtgmiegsQEYNEGLVKRLHKVLRPFLLRRVKVDVEKQ 848
Cdd:COG0553 388 HRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPI-------EKGDEEALERLRRLLRPFLLRRTKEDVLKD 460
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 849 MPKKYEHVIRCRLSKRQRCLYDDFMAQTTTKETLATG--HFMSVINILMQLRKVCNHPNLFDP 909
Cdd:COG0553 461 LPEKTEETLYVELTPEQRALYEAVLEYLRRELEGAEGirRRGLILAALTRLRQICSHPALLLE 523
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
616-842 |
5.68e-87 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 284.26 E-value: 5.68e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 695
Cdd:cd17996 2 GTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 LTYYGAQKERKlKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLN-FNSQRRLLLT 774
Cdd:cd17996 82 IVYKGTPDVRK-KLQSQIRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHARYRLLLT 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 775 GTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGM-----IEGSQEYNEGLVKRLHKVLRPFLLRRVK 842
Cdd:cd17996 161 GTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPFANTgeqvkIELNEEETLLIIRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
618-797 |
8.87e-85 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 275.98 E-value: 8.87e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKlKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 777
Cdd:cd17919 81 YHGSQRERA-QIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLLLTGTP 159
|
170 180
....*....|....*....|
gi 146219843 778 LQNSLMELWSLMHFLMPHVF 797
Cdd:cd17919 160 LQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
616-842 |
9.75e-85 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 278.12 E-value: 9.75e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 695
Cdd:cd18009 2 GVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLR-ERGVWGPFLVIAPLSTLPNWVNEFARFTPSVPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 LTYYGAQKERK-LKRQGWTKPNA---FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd18009 81 LLYHGTKEERErLRKKIMKREGTlqdFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNSDNRL 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWF-----SNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRRVK 842
Cdd:cd18009 161 LLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFdfsslSDNAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
614-842 |
1.74e-77 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 256.34 E-value: 1.74e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 614 LRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSF 693
Cdd:cd18012 1 LKATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRK-EEGRKGPSLVVAPTSLIYNWEEEAAKFAPEL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 694 KILTYYGAQKERKLKRQgwtkPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLL 773
Cdd:cd18012 80 KVLVIHGTKRKREKLRA----LEDYDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKALKADHRLAL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 774 TGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQeyNEGLVKRLHKVLRPFLLRRVK 842
Cdd:cd18012 156 TGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKP----IEKDG--DEEALEELKKLISPFILRRLK 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
616-852 |
2.83e-73 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 245.73 E-value: 2.83e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 695
Cdd:cd18064 14 GKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 775
Cdd:cd18064 94 VCLIGDKDQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146219843 776 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnplTGMIEGSQEynegLVKRLHKVLRPFLLRRVKVDVEKQMPKK 852
Cdd:cd18064 174 TPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD---TNNCLGDQK----LVERLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
618-797 |
2.12e-69 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 231.89 E-value: 2.12e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLK-EIGIPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQG-WTKPNAFHVCITSYKLVL---QDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLL 773
Cdd:cd17998 80 YYGSQEERKHLRYDiLKGLEDFDVIVTTYNLATsnpDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLLL 159
|
170 180
....*....|....*....|....
gi 146219843 774 TGTPLQNSLMELWSLMHFLMPHVF 797
Cdd:cd17998 160 TGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
617-840 |
3.06e-69 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 233.02 E-value: 3.06e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 617 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 696
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 697 TYYGAQKERKLKRQ-----GWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd17993 81 VYLGDIKSRDTIREyefyfSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNRL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKewfsnpltgmiEGSQEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd17993 161 LITGTPLQNSLKELWALLHFLMPGKFDIWEEFE-----------EEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
616-842 |
2.45e-68 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 231.06 E-value: 2.45e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKI 695
Cdd:cd18065 14 GTLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEFKRWVPSLRA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 LTYYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTG 775
Cdd:cd18065 94 VCLIGDKDARAAFIRDVMMPGEWDVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTG 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146219843 776 TPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnplTGMIEGSQEynegLVKRLHKVLRPFLLRRVK 842
Cdd:cd18065 174 TPLQNNLHELWALLNFLLPDVFNSADDFDSWFD---TKNCLGDQK----LVERLHAVLKPFLLRRIK 233
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
618-840 |
4.30e-66 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 224.05 E-value: 4.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPsFKILT 697
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD-MNVVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQ-------GWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 766
Cdd:cd17995 80 YHGSGESRQIIQQyemyfkdAQGRKKKgvykFDVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLT 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 767 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSnpltGMIEGSQeyneglVKRLHKVLRPFLLRR 840
Cdd:cd17995 160 LEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG----DLKTAEQ------VEKLQALLKPYMLRR 223
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
2032-2167 |
1.14e-63 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 213.49 E-value: 1.14e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2032 FPDLRLIQYDcGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRI 2111
Cdd:cd18793 1 LPPKIEEVVS-GKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDI 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 146219843 2112 FCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLI 2167
Cdd:cd18793 80 RVFLLSTKAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
603-842 |
1.61e-61 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 212.21 E-value: 1.61e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 603 TTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNW 682
Cdd:cd18062 9 TEKVEKQSSLLVNGVLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 683 EMELKRWCPSFKILTYYGAQKERK----LKRQGwtkpnAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 758
Cdd:cd18062 89 VYEFDKWAPSVVKVSYKGSPAARRafvpQLRSG-----KFNVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 759 WQSL-LNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNP--LTG-MIEGSQEYNEGLVKRLHKVLR 834
Cdd:cd18062 164 TQVLnTHYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeKVDLNEEETILIIRRLHKVLR 243
|
....*...
gi 146219843 835 PFLLRRVK 842
Cdd:cd18062 244 PFLLRRLK 251
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
618-840 |
6.99e-61 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 208.83 E-value: 6.99e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 777
Cdd:cd18006 81 YMGDKEKRLDLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLLLTGTP 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 778 LQNSLMELWSLMHFLMPHVFQshREFKEWFSNPLTGMIEGSqeyneGLVKRLHKVLRPFLLRR 840
Cdd:cd18006 161 IQNSLQELYALLSFIEPNVFP--KDKLDDFIKAYSETDDES-----ETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
599-842 |
9.19e-61 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 209.92 E-value: 9.19e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 599 YTLA---TTQVKTPIPLLLRGQLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVP 675
Cdd:cd18063 2 YTVAhaiTERVEKQSSLLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 676 TSVMLNWEMELKRWCPSFKILTYYGAQKERK-LKRQgwTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNF 754
Cdd:cd18063 82 LSTLSNWTYEFDKWAPSVVKISYKGTPAMRRsLVPQ--LRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNH 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 755 KSQRWQSL-LNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNP--LTG-MIEGSQEYNEGLVKRLH 830
Cdd:cd18063 160 HCKLTQVLnTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPfaMTGeRVDLNEEETILIIRRLH 239
|
250
....*....|..
gi 146219843 831 KVLRPFLLRRVK 842
Cdd:cd18063 240 KVLRPFLLRRLK 251
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
617-840 |
7.48e-59 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 204.08 E-value: 7.48e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 617 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 696
Cdd:cd18054 20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQREFEIWAPEINVV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 697 TYYGAQKERKLKRQ-GWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd18054 100 VYIGDLMSRNTIREyEWIHSQTkrlkFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNpltGMIEGSQEyneglvkrLHKVLRPFLLRR 840
Cdd:cd18054 180 LITGTPLQNSLKELWSLLHFIMPEKFEFWEDFEEDHGK---GRENGYQS--------LHKVLEPFLLRR 237
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
618-840 |
4.45e-55 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 192.95 E-value: 4.45e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWG-----PHLIIVPTSVMLNWEMELKRWCPS 692
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFnsenlPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 693 F--KILTYYGAQKERKLKRQGWTKPNafhVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRR 770
Cdd:cd17999 81 AflKPLAYVGPPQERRRLREQGEKHN---VIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKAVKQLKANHR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 771 LLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIE---GSQEYNEGL--VKRLHKVLRPFLLRR 840
Cdd:cd17999 158 LILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDskaSAKEQEAGAlaLEALHKQVLPFLLRR 232
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
2021-2192 |
4.27e-52 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 197.76 E-value: 4.27e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2021 LHRIVCNMRTQF-PDLRLIQYDCGKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQ 2099
Cdd:COG0553 510 RLRQICSHPALLlEEGAELSGRSAKLEALLELLEELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERD 589
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2100 ALMERFNADKRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKK 2179
Cdd:COG0553 590 ELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILEL 669
|
170
....*....|...
gi 146219843 2180 ANQKRMLGDMAIE 2192
Cdd:COG0553 670 LEEKRALAESVLG 682
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
618-840 |
1.10e-51 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 182.96 E-value: 1.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMF-DSGLIKSVLVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQGWTKpNAFHVCITSYKLVL---QDHQAFRRKN--WRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLL 772
Cdd:cd18001 80 FHGTSKKERERNLERIQ-RGGGVLLTTYGMVLsntEQLSADDHDEfkWDYVILDEGHKIKNSKTKSAKSLREIPAKNRII 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 773 LTGTPLQNSLMELWSLMHFLMPH-VFQSHREFKEWFSNPLTGMIE-----GSQEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd18001 159 LTGTPIQNNLKELWALFDFACNGsLLGTRKTFKMEFENPITRGRDkdatqGEKALGSEVAENLRQIIKPYFLRR 232
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
617-840 |
7.20e-51 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 181.02 E-value: 7.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 617 QLREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKIL 696
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWAPQMNAV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 697 TYYGAQKERKLKR-QGWTKPNA----FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd18053 100 VYLGDINSRNMIRtHEWMHPQTkrlkFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEwfsnpltgmiEGSQEYNEGLVKrLHKVLRPFLLRR 840
Cdd:cd18053 180 LITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEE----------EHGKGREYGYAS-LHKELEPFLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
618-840 |
3.57e-50 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 177.25 E-value: 3.57e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAqkerklkrqgwtkpnafHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTP 777
Cdd:cd17994 81 YVGD-----------------HVLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLLLTGTP 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 778 LQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd17994 144 LQNNLEELFHLLNFLTPERFNNLQGFLEEFADI----------SKEDQIKKLHDLLGPHMLRR 196
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
618-840 |
5.53e-50 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 178.64 E-value: 5.53e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVtmyekKLNGILADEMGLGKTIQTISL-LAHLACEKGNWGPH----------------LIIVPTSVML 680
Cdd:cd18008 1 LLPYQKQGLAWML-----PRGGILADEMGLGKTIQALALiLATRPQDPKIPEELeenssdpkklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 681 NWEMELKR--WCPSFKILTYYGAQKERKLKrqgwtKPNAFHVCITSYKLVLQDHQAFRRKN----------------WRY 742
Cdd:cd18008 76 QWKDEIEKhtKPGSLKVYVYHGSKRIKSIE-----ELSDYDIVITTYGTLASEFPKNKKGGgrdskekeasplhrirWYR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 743 LILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLtgmiegsQEYN 822
Cdd:cd18008 151 VILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF-------SKND 223
|
250
....*....|....*...
gi 146219843 823 EGLVKRLHKVLRPFLLRR 840
Cdd:cd18008 224 RKALERLQALLKPILLRR 241
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
2043-2212 |
1.50e-49 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 194.25 E-value: 1.50e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2043 GKLQTLAVLLRQLKAEGHRVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNAD-KRIFCFILSTRSG 2121
Cdd:PLN03142 471 GKMVLLDKLLPKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPgSEKFVFLLSTRAG 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2122 GVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLISERTVEENILKKANQKRMLGDMAIEGGNFTtayf 2201
Cdd:PLN03142 551 GLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLALDALVIQQGRLA---- 626
|
170
....*....|...
gi 146219843 2202 KQQTIR--ELFDM 2212
Cdd:PLN03142 627 EQKTVNkdELLQM 639
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
618-794 |
9.72e-46 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 164.42 E-value: 9.72e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YY----GAQKERKLKRQGWTKP------NAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNS 767
Cdd:cd18000 81 LHssgsGTGSEEKLGSIERKSQlirkvvGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACKQLRT 160
|
170 180
....*....|....*....|....*..
gi 146219843 768 QRRLLLTGTPLQNSLMELWSLMHFLMP 794
Cdd:cd18000 161 PHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
618-840 |
1.89e-45 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 165.63 E-value: 1.89e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGN--------------------WGPHLIIVPTS 677
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVLGKTGTrrdrennrprfkkkppassaKKPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 678 VMLNWEMELKRWcPSFKILTYYGAQKERKLkrQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQ 757
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDEL--EGRLKAGRLEVVVTTYDTLRRCIDSLNSINWSAVIADEAHRIKNPKSK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 758 RWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQEYN---------EGLVKR 828
Cdd:cd18005 158 LTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEP----IKRGQRHTatarelrlgRKRKQE 233
|
250
....*....|..
gi 146219843 829 LHKVLRPFLLRR 840
Cdd:cd18005 234 LAVKLSKFFLRR 245
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
618-840 |
2.63e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 164.44 E-value: 2.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACeKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 697
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFL-MGIRGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKL---------KRQGWTKPN--AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 766
Cdd:cd18058 79 YHGSQISRQMiqqyemyyrDEQGNPLSGifKFQVVITTFEMILADCPELKKINWSCVIIDEAHRLKNRNCKLLEGLKLMA 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 767 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 840
Cdd:cd18058 159 LEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDLKT----------EEQVKKLQSILKPMMLRR 222
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
618-840 |
1.86e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 162.49 E-value: 1.86e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKER----------------------KLKRQGWTKpnaFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFK 755
Cdd:cd18055 81 YTGDKDSRaiirenefsfddnavkggkkafKMKREAQVK---FHVLLTSYELVTIDQAALGSIRWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 756 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRP 835
Cdd:cd18055 158 SKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGP 227
|
....*
gi 146219843 836 FLLRR 840
Cdd:cd18055 228 HMLRR 232
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
618-840 |
4.00e-44 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 160.99 E-value: 4.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 697
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVY-NVGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQ---------GWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 766
Cdd:cd18060 79 YHGSLASRQMIQQyemyckdsrGRLIPGAykFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 767 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 840
Cdd:cd18060 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
618-840 |
2.79e-42 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 155.99 E-value: 2.79e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKER----------------------KLKRQGWTKpnaFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFK 755
Cdd:cd18057 81 YTGDKESRsvirenefsfednairsgkkvfRMKKEAQIK---FHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 756 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmiegsqeYNEGLVKRLHKVLRP 835
Cdd:cd18057 158 SKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI----------SKEDQIKKLHDLLGP 227
|
....*
gi 146219843 836 FLLRR 840
Cdd:cd18057 228 HMLRR 232
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
618-840 |
1.06e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 154.03 E-value: 1.06e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACeKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 697
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYL-KGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKR---------QGWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 766
Cdd:cd18059 79 YHGSQASRRTIQlyemyfkdpQGRVIKGSykFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMD 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 767 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 840
Cdd:cd18059 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
618-840 |
2.05e-41 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 153.68 E-value: 2.05e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLACEKGNWGPHLIIVPTSVMLNWEMELKRWCPSFKILT 697
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKLKRQ-----------GWTKPN--------AFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 758
Cdd:cd18056 81 YVGDKDSRAIIREnefsfednairGGKKASrmkkeasvKFHVLLTSYELITIDMAILGSIDWACLIVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 759 WQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLtgmiegsqeyNEGLVKRLHKVLRPFLL 838
Cdd:cd18056 161 FRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADIA----------KEDQIKKLHDMLGPHML 230
|
..
gi 146219843 839 RR 840
Cdd:cd18056 231 RR 232
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
618-840 |
1.14e-39 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 148.97 E-value: 1.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWlvtMYE-----KKLNG---ILADEMGLGKTIQTISLLAHLACEKGNWGPH----LIIVPTSVMLNWEME 685
Cdd:cd18004 1 LRPHQREGVQF---LYDcltgrRGYGGggaILADEMGLGKTLQAIALVWTLLKQGPYGKPTakkaLIVCPSSLVGNWKAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 686 LKRWCPS--FKILTYYGAQKERKLKRQGWTKPNAFHVCITSYKLvlqdhqaFRRKNWRY--------LILDEAQNIKNFK 755
Cdd:cd18004 78 FDKWLGLrrIKVVTADGNAKDVKASLDFFSSASTYPVLIISYET-------LRRHAEKLskkisidlLICDEGHRLKNSE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 756 SQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT-----GMIEGSQEYNEGLVKRLH 830
Cdd:cd18004 151 SKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILrsrdpDASEEDKELGAERSQELS 230
|
250
....*....|
gi 146219843 831 KVLRPFLLRR 840
Cdd:cd18004 231 ELTSRFILRR 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
618-834 |
1.22e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 145.90 E-value: 1.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLD--W--LVTMYEKKLNG---ILADEMGLGKTIQTISLL-AHLACEKGNWGPhLIIVPTSVMLNWEMELKRW 689
Cdd:cd18007 1 LKPHQVEGVRflWsnLVGTDVGSDEGggcILAHTMGLGKTLQVITFLhTYLAAAPRRSRP-LVLCPASTLYNWEDEFKKW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 690 CPS----FKILTYYGAQKERKLK----RQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRY-----------LILDEAQN 750
Cdd:cd18007 80 LPPdlrpLLVLVSLSASKRADARlrkiNKWHKEGGVLLIGYELFRNLASNATTDPRLKQEFiaalldpgpdlLVLDEGHR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 751 IKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGSQEYNEGLVKRLH 830
Cdd:cd18007 160 LKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKP----IEAGQCVDSTEEDVRL 235
|
....
gi 146219843 831 KVLR 834
Cdd:cd18007 236 MLKR 239
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
618-840 |
1.93e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 144.76 E-value: 1.93e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNGILADEMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLNWEMELKRWCpSFKILT 697
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEIL-LTGIRGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 698 YYGAQKERKL---------KRQGWTKPNA--FHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNFN 766
Cdd:cd18061 79 YHGSLISRQMiqqyemyfrDSQGRIIRGAyrFQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLKLMN 158
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 767 SQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqeynEGLVKRLHKVLRPFLLRR 840
Cdd:cd18061 159 LEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDLKT----------EEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
640-840 |
6.59e-34 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 131.17 E-value: 6.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 640 ILADEMGLGKTIQTISLLAHLaceKGNWgPHLIIVPTSVMLNWEMELKRWCPSFKILTYYGAQKERKLKRQGWTKpnafh 719
Cdd:cd18010 20 LIADEMGLGKTVQAIAIAAYY---REEW-PLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKSKDGLRDGDAK----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 720 VCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLLNF--NSQRRLLLTGTPLQNSLMELWSLMHFLMPHVF 797
Cdd:cd18010 91 VVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIELFTQLDALDPKLF 170
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 146219843 798 QSHREFKEWFSNPLTGMIEGSQEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd18010 171 GRFHDFGRRYCAAKQGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
2043-2156 |
5.17e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 116.16 E-value: 5.17e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2043 GKLQTLAVLLRqlKAEGHRVLIFTQMTRMLDvLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRIFcfILSTRSGG 2122
Cdd:pfam00271 1 EKLEALLELLK--KERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDV--LVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 146219843 2123 VGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIG 2156
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
634-840 |
2.85e-28 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 116.03 E-value: 2.85e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 634 EKKLNGILADEMGLGKTIQTISLLAHlacekgnwGPHLIIVPTSVMLNWEMELKRWCPS--FKILTYYGAQKERKLKRQG 711
Cdd:cd18071 46 ELVRGGILADDMGLGKTLTTISLILA--------NFTLIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGERNRDPKLLS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 712 wtkpnAFHVCITSYKLVLQDHQA-----FRRKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELW 786
Cdd:cd18071 118 -----KYDIVLTTYNTLASDFGAkgdspLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 146219843 787 SLMHFLMPHVFQSHREFKEWFSNPLTgmiegsqEYNEGLVKRLHKVLRPFLLRR 840
Cdd:cd18071 193 SLLSFLHLKPFSNPEYWRRLIQRPLT-------MGDPTGLKRLQVLMKQITLRR 239
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
610-790 |
5.65e-28 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 113.74 E-value: 5.65e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 610 IPLLLRGQLREYQHIGLDWlvtMYEKKLNGILADEMGLGKTIQ-TISLLAHLAceKGNWGPHLIIVPT-SVMLNWEMELK 687
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEA---LLSGLRDVILAAPTGSGKTLAaLLPALEALK--RGKGGRVLVLVPTrELAEQWAEELK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 688 RWCPSF--KILTYYGAQKERKLKRQgWTKpNAFHVCITSYKLVLQD--HQAFRRKNWRYLILDEAQNIKN--FKSQrWQS 761
Cdd:smart00487 76 KLGPSLglKVVGLYGGDSKREQLRK-LES-GKTDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDggFGDQ-LEK 152
|
170 180 190
....*....|....*....|....*....|.
gi 146219843 762 LLNF--NSQRRLLLTGTPLQNSLMELWSLMH 790
Cdd:smart00487 153 LLKLlpKNVQLLLLSATPPEEIENLLELFLN 183
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
618-840 |
2.42e-27 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 113.34 E-value: 2.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTMYEKKLNG-ILADEMGLGKTIQTISLLahLACEKG-------------NWGPH-----------LI 672
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALI--LAQKNTqnrkeeekekaltEWESKkdstlvpsagtLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 673 IVPTSVMLNWEMELKRWCPS--FKILTYYGAQKERK---LKRqgwtkpnaFHVCITSYKLVLQDHQAFR---------RK 738
Cdd:cd18072 79 VCPASLVHQWKNEVESRVASnkLRVCLYHGPNRERIgevLRD--------YDIVITTYSLVAKEIPTYKeesrssplfRI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 739 NWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPltgmIEGS 818
Cdd:cd18072 151 AWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQVDNK----SRKG 226
|
250 260
....*....|....*....|..
gi 146219843 819 QEyneglvkRLHKVLRPFLLRR 840
Cdd:cd18072 227 GE-------RLNILTKSLLLRR 241
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
618-840 |
1.15e-26 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 111.41 E-value: 1.15e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWL---VT-MYEKKLNG-ILADEMGLGKTIQTISLLAHLACEKGNWGPHL----IIVPTSVMLNWEMELKR 688
Cdd:cd18067 1 LRPHQREGVKFLyrcVTgRRIRGSHGcIMADEMGLGKTLQCITLMWTLLRQSPQCKPEIdkaiVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 689 WC-PSFKILTYYGAQKERKL-KRQGW--------TKPnafhVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQR 758
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKEIDrKLVQWasqqgrrvSTP----VLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 759 WQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPL-----TGMIEGSQEYNEGLVKRLHKVL 833
Cdd:cd18067 157 YQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPIlkgrdADASEKERQLGEEKLQELISIV 236
|
....*..
gi 146219843 834 RPFLLRR 840
Cdd:cd18067 237 NRCIIRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
618-840 |
1.48e-26 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 110.71 E-value: 1.48e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLvtmYE----KKLNG----ILADEMGLGKTIQTISLLAHLACEkGNWGPH------LIIVPTSVMLNWE 683
Cdd:cd18066 1 LRPHQREGIEFL---YEcvmgMRVNErfgaILADEMGLGKTLQCISLIWTLLRQ-GPYGGKpvikraLIVTPGSLVKNWK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 684 MELKRWCPSFKILTYYGAQKErklKRQGWTKPNAFHVCITSYKLVLQDHQAFRRKNWRYLILDEAQNIKNFKSQRWQSLL 763
Cdd:cd18066 77 KEFQKWLGSERIKVFTVDQDH---KVEEFIASPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 764 NFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLTGMIEGS-----QEYNEGLVKRLHKVLRPFLL 838
Cdd:cd18066 154 SLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTatpeeKKLGEARAAELTRLTGLFIL 233
|
..
gi 146219843 839 RR 840
Cdd:cd18066 234 RR 235
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
640-811 |
2.74e-24 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 104.13 E-value: 2.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 640 ILADEMGLGKTIQTIS----LLAHLACEKGnwgphLIIVPTSVMLNWEMELKRWCPS-----------FKILTYYGAQKE 704
Cdd:cd18069 32 ILAHSMGLGKTLQVISfldvLLRHTGAKTV-----LAIVPVNTLQNWLSEFNKWLPPpealpnvrprpFKVFILNDEHKT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 705 RKLKRQ---GWTKPNAfhvcitsykLVLQDHQAFR-RKNWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQN 780
Cdd:cd18069 107 TAARAKvieDWVKDGG---------VLLMGYEMFRlRPGPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQN 177
|
170 180 190
....*....|....*....|....*....|.
gi 146219843 781 SLMELWSLMHFLMPHVFQSHREFKEWFSNPL 811
Cdd:cd18069 178 NLIEYWCMVDFVRPDFLGTRQEFSNMFERPI 208
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
639-828 |
4.06e-24 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 104.20 E-value: 4.06e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 639 GILADEMGLGKTIQTISLLaH--LACEK-GNWGPHLIIVPTSVMLNWEMELKRWCPSFKI--------LTYYGAQKERKL 707
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFL-HtvLLCEKlENFSRVLVVCPLNTVLNWLNEFEKWQEGLKDeekievneLATYKRPQERSY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 708 KRQGWTKPNAfhVCITSYKL---VLQDHQAFRRKNWR-------------YLILDEAQNIKNFKSQRWQSLLNFNSQRRL 771
Cdd:cd18068 110 KLQRWQEEGG--VMIIGYDMyriLAQERNVKSREKLKeifnkalvdpgpdFVVCDEGHILKNEASAVSKAMNSIRTKRRI 187
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 772 LLTGTPLQNSLMELWSLMHFLMPHVFQSHREFKEWFSNPLT-GMIEGSQEYNEGLVKR 828
Cdd:cd18068 188 VLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQnGQCADSTLVDVRVMKK 245
|
|
| HSA |
pfam07529 |
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. ... |
127-193 |
2.30e-23 |
|
HSA domain; This domain is predicted to bind DNA and is often found associated with helicases. This region does not form a compact domain in the known structures.
Pssm-ID: 462194 [Multi-domain] Cd Length: 67 Bit Score: 95.72 E-value: 2.30e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 127 VPEPPR-PKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEERaRREEQAKLRR 193
Cdd:pfam07529 1 RDEPERrEKTHHDYLLEEILWHSKDFKQERRWKRARAKKLARAVAQYHKNIEKEEQK-RIEREEKQRL 67
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
2073-2156 |
2.40e-23 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 96.13 E-value: 2.40e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2073 DVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKRifCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRC 2152
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 146219843 2153 HRIG 2156
Cdd:smart00490 79 GRAG 82
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
640-797 |
1.22e-21 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 95.82 E-value: 1.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 640 ILADEMGLGKTIQTIsLLAHLACEKGNWGPHLIIVPTSVMLNWEMEL--KRWCPsFKILTYYGAQKERKLKRQGWTkpnA 717
Cdd:cd18011 21 LLADEVGLGKTIEAG-LIIKELLLRGDAKRVLILCPASLVEQWQDELqdKFGLP-FLILDRETAAQLRRLIGNPFE---E 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 718 FHVCITSYKLVLQD---HQAFRRKNWRYLILDEAQNIKN----FKSQRWQ--SLLNFNSQRRLLLTGTPLQNSLMELWSL 788
Cdd:cd18011 96 FPIVIVSLDLLKRSeerRGLLLSEEWDLVVVDEAHKLRNsgggKETKRYKlgRLLAKRARHVLLLTATPHNGKEEDFRAL 175
|
....*....
gi 146219843 789 MHFLMPHVF 797
Cdd:cd18011 176 LSLLDPGRF 184
|
|
| HSA |
smart00573 |
domain in helicases and associated with SANT domains; |
125-196 |
1.30e-21 |
|
domain in helicases and associated with SANT domains;
Pssm-ID: 214727 [Multi-domain] Cd Length: 73 Bit Score: 90.92 E-value: 1.30e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 125 PKVPEPPRPKGHWDYLCEEMQWLSADFAQERRWKRGVARKVVRMVIRHHEEQRQKEER-ARREEQAKLRRIAS 196
Cdd:smart00573 1 QKLEEERRRKQHWDHLLEEMIWHAKDFKEEHKWKIAAAKKMAKAVMDYHQNKEKEEERrEEKNEKRRLRKLAA 73
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1366-1834 |
2.25e-20 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 100.40 E-value: 2.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1366 PTPtlvrPLLKLVHSPSPEVSASAPGAAPL----TISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPI 1441
Cdd:PHA03247 2551 PPP----PLPPAAPPAAPDRSVPPPRPAPRpsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1442 SVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATapSLSSSQTP 1521
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLT--SLADPPPP 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1522 GHPLLLAPTSShVPGLNSTVAPACSPVLVPASALASPFPSAPN----PAPAQASLLAPASSASQALATPLAPMAAPQTAI 1597
Cdd:PHA03247 2705 PPTPEPAPHAL-VSATPLPPGPAAARQASPALPAAPAPPAVPAgpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL 2783
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1598 LAPSPAPPLAPLPVLAPSPGAAPVlassqtPVPVMAPSSTPGTSLASASPVPAPTPvlapsstqtmlPAPVPSPLPSPAS 1677
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADP------PAAVLAPAAALPPAASPAGPLPPPTS-----------AQPTAPPPPPGPP 2846
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1678 TQTLALAPALAPtlGGSSPSQtlslgtGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAP--GPPLGPTQTLSLAPAPPLA 1755
Cdd:PHA03247 2847 PPSLPLGGSVAP--GGDVRRR------PPSRSPAAKPAAPARPPVRRLARPAVSRSTESfaLPPDQPERPPQPQAPPPPQ 2918
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 1756 PASPVGPAPAHTLTLAPASSSASLLAPasvqTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLP 1834
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPLAP----TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST 2993
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1339-1866 |
9.71e-19 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 95.01 E-value: 9.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1339 PAVLNPRPTLTPGRLPTPTLGTARAPMpTPTLVRPLLKLVHS----PSPEVSASAPGAAPltissplhvPSSLPGPASSP 1414
Cdd:PHA03247 2506 PDAPPAPSRLAPAILPDEPVGEPVHPR-MLTWIRGLEELASDdagdPPPPLPPAAPPAAP---------DRSVPPPRPAP 2575
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1415 MPIP------NSSPLASPVSSTVSVPL--SSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPA 1486
Cdd:PHA03247 2576 RPSEpavtsrARRPDAPPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD 2655
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1487 ApgppslAPSGASPSASALTLGLATAPSlsssqtpghplllAPTSSHVPglnstvaPACSPVLVPASALASPFPSAPNPA 1566
Cdd:PHA03247 2656 P------APGRVSRPRRARRLGRAAQAS-------------SPPQRPRR-------RAARPTVGSLTSLADPPPPPPTPE 2709
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1567 PaqasllaPASSASQALATPLAPMAAPQTAilapspapPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASAS 1646
Cdd:PHA03247 2710 P-------APHALVSATPLPPGPAAARQAS--------PALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAA 2774
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1647 PVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLslgtgnPQGPFPTQTLSLTPASSLVP 1726
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL------PPPTSAQPTAPPPPPGPPPP 2848
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1727 TPAQTLSLAPGPPL---GPTQTLSLAPAPPLAPASPVGPAPAHT----------LTLAPASSSASLLAPASVQTLTLSPA 1793
Cdd:PHA03247 2849 SLPLGGSVAPGGDVrrrPPSRSPAAKPAAPARPPVRRLARPAVSrstesfalppDQPERPPQPQAPPPPQPQPQPPPPPQ 2928
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 146219843 1794 PVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTM-VSRLPVSKDEPDTLTLRSGPPSPPSTATS 1866
Cdd:PHA03247 2929 PQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVaVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
618-792 |
9.39e-17 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 82.01 E-value: 9.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVtmyEKKLNGILADeMGLGKTIQTISLLAHLAcEKGNWGPHLIIVPTSVMLN-WEMELKRWcPSFKIL 696
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQ-LDDFTRRVLVIAPLRVARStWPDEVEKW-NHLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 697 TYYGA-QKERKLKRQGWTKPNAFHVCITSYK-LVLQDHQAFrrkNWRYLILDEAQNIKNFKSQRWQSL--LNFNSQRRLL 772
Cdd:cd18013 75 TVSVAvGTERQRSKAANTPADLYVINRENLKwLVNKSGDPW---PFDMVVIDELSSFKSPRSKRFKALrkVRPVIKRLIG 151
|
170 180
....*....|....*....|
gi 146219843 773 LTGTPLQNSLMELWSLMHFL 792
Cdd:cd18013 152 LTGTPSPNGLMDLWAQIALL 171
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
618-805 |
1.37e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 79.31 E-value: 1.37e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLDWLVTmyekkLNGILADEMGLGKTIQTISLLAH------------LACEKGNWGPH-------------LI 672
Cdd:cd18070 1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVEVLALILLhprpdndldaadDDSDEMVCCPDclvaetpvsskatLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 673 IVPTSVMLNWEMELKRWCP-SFKILTYYGAQKERKLKrqgwtKPNAFHVC-----ITSYKlVLQD-------------HQ 733
Cdd:cd18070 76 VCPSAILAQWLDEINRHVPsSLKVLTYQGVKKDGALA-----SPAPEILAeydivVTTYD-VLRTelhyaeanrsnrrRR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 734 AFRRK----------NWRYLILDEAQNIKNFKSQRWQSLLNFNSQRRLLLTGTPLQNSLMELWSLMHFLMPHVFQSHREF 803
Cdd:cd18070 150 RQKRYeappsplvlvEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFLGVEPFCDSDWW 229
|
..
gi 146219843 804 KE 805
Cdd:cd18070 230 AR 231
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1227-1738 |
1.24e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.06 E-value: 1.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1227 AVGQPRPLQRNVVHLVSAggQHHLISQPAHVALIQAVAPTPGPTPVSVLPSSTPsttPAPTGLSLPLAANQVPPTMVNNT 1306
Cdd:PHA03247 2567 SVPPPRPAPRPSEPAVTS--RARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP---PDTHAPDPPPPSPSPAANEPDPH 2641
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1307 GVVKIVVRQAPRDgltpvpplapaprppSSGLPAVLNPRPTLTPGRLPTPTLGTAR-APMPTPTLVRPLLKLVHSPSPEv 1385
Cdd:PHA03247 2642 PPPTVPPPERPRD---------------DPAPGRVSRPRRARRLGRAAQASSPPQRpRRRAARPTVGSLTSLADPPPPP- 2705
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1386 saSAPGAAPLTISSPLHVPSSlPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPltv 1465
Cdd:PHA03247 2706 --PTPEPAPHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP--- 2779
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1466 sasGPALltsvTPPLAPVVPAAPGPPSLAPSGASPSASALtlglATAPSLSSSQTPGHPLllAPTSSHVPGLNSTVAPAC 1545
Cdd:PHA03247 2780 ---PRRL----TRPAVASLSESRESLPSPWDPADPPAAVL----APAAALPPAASPAGPL--PPPTSAQPTAPPPPPGPP 2846
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1546 SPVLVPASALASPFPSAPNPAPAQASllapassasqalATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASS 1625
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRPPSRSPA------------AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAP 2914
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1626 QTPVPVMAPSSTPGTSLASASPvPAPTPVLAPSSTqtmlPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTG 1705
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPTTD----PAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP 2989
|
490 500 510
....*....|....*....|....*....|...
gi 146219843 1706 NPQGPFPTQtLSLTPASSLVPTPAQTLSLAPGP 1738
Cdd:PHA03247 2990 ASSTPPLTG-HSLSRVSSWASSLALHEETDPPP 3021
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1401-1798 |
9.83e-13 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 74.42 E-value: 9.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1401 LHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPL 1480
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1481 APVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSS--HVPGLNSTVAPACSPvlvPASALASP 1558
Cdd:pfam03154 254 QPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPFPLTPQSSqsQVPPGPSPAAPGQSQ---QRIHTPPS 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1559 FPSAPNPAPAQASLLAPASSASQAL----ATPLAPMAAPQTailapspapplapLPVLAPSPGAAPVLASSQTPVPvmaP 1634
Cdd:pfam03154 331 QSQLQSQQPPREQPLPPAPLSMPHIkpppTTPIPQLPNPQS-------------HKHPPHLSGPSPFQMNSNLPPP---P 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1635 SSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPvpsPLPSPASTQTLALAPAlaptlgGSSPSQTLSLGTGNPQGPFPTQ 1714
Cdd:pfam03154 395 ALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPP---PAQPPVLTQSQSLPPP------AASHPPTSGLHQVPSQSPFPQH 465
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1715 tlsltpasSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPA-----SSSASLLAPASVQTLT 1789
Cdd:pfam03154 466 --------PFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPvqikeEALDEAEEPESPPPPP 537
|
....*....
gi 146219843 1790 LSPAPVPTL 1798
Cdd:pfam03154 538 RSPSPEPTV 546
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1498-1832 |
1.53e-11 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 69.99 E-value: 1.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1498 ASPSASALTLGlATAPSLSSSQTpghplllapTSSHVPGLNSTVAPACSPVL---VPASALASPFPSAPNPApAQASLLA 1574
Cdd:pfam17823 65 AAPAPVTLTKG-TSAAHLNSTEV---------TAEHTPHGTDLSEPATREGAadgAASRALAAAASSSPSSA-AQSLPAA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1575 PASSASQALATPLAPM------AAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPV 1648
Cdd:pfam17823 134 IAALPSEAFSAPRAAAcranasAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGIS 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1649 PAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTqtlSLTPASSlvpTP 1728
Cdd:pfam17823 214 TAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHAR---RLSPAKH---MP 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1729 AQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPA---HTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQT 1805
Cdd:pfam17823 288 SDTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTpspSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLH 367
|
330 340
....*....|....*....|....*...
gi 146219843 1806 LALAP-ASTQSPASQASSLVVSASGAAP 1832
Cdd:pfam17823 368 TSMIPeVEATSPTTQPSPLLPTQGAAGP 395
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
616-777 |
4.47e-11 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 68.51 E-value: 4.47e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 616 GQLREYQHIGLD-WLVTMYEKKLNGILADEMGLGKTIqtisLLAHLACEKGNWGPHLIIVPTSVMLN-WEMELKRWCPSF 693
Cdd:COG1061 79 FELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV----LALALAAELLRGKRVLVLVPRRELLEqWAEELRRFLGDP 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 694 KIltyygaqkerklkrQGWTKPNAFHVCITSY-KLVLQDHQAFRRKNWRYLILDEAQNIKnfkSQRWQSLLN-FNSQRRL 771
Cdd:COG1061 155 LA--------------GGGKKDSDAPITVATYqSLARRAHLDELGDRFGLVIIDEAHHAG---APSYRRILEaFPAAYRL 217
|
....*.
gi 146219843 772 LLTGTP 777
Cdd:COG1061 218 GLTATP 223
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1492-1739 |
4.17e-10 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 65.67 E-value: 4.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1492 SLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQAS 1571
Cdd:PRK12323 344 ALAPDEYAGFTMTLLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1572 llAPASSASQALAtplapmAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSStpgtslASASPVPAP 1651
Cdd:PRK12323 424 --ARRSPAPEALA------AARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAP------ARAAPAAAP 489
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1652 TPVLAPSSTQTMLPAPVPSPLPSPAstqtlALAPALAPTLGGSSPsqtlslGTGNPQGPFPTQTLSLTPASSLVPTPAQT 1731
Cdd:PRK12323 490 APADDDPPPWEELPPEFASPAPAQP-----DAAPAGWVAESIPDP------ATADPDDAFETLAPAPAAAPAPRAAAATE 558
|
....*...
gi 146219843 1732 LSLAPGPP 1739
Cdd:PRK12323 559 PVVAPRPP 566
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1424-1743 |
6.99e-10 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 64.60 E-value: 6.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1424 ASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTpPLAPVVPAAPGPPSLAPSGASPSAS 1503
Cdd:pfam17823 107 ADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRA-AIAAASAPHAASPAPRTAASSTTAA 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1504 ALTLGLATAPSLSSSQTPGhplLLAPTSSHVPGLNSTVAPACSPVLVpasalaspfpSAPNPAPAQASLLAPASSASQAL 1583
Cdd:pfam17823 186 SSTTAASSAPTTAASSAPA---TLTPARGISTAATATGHPAAGTALA----------AVGNSSPAAGTVTAAVGTVTPAA 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1584 ATPLApmAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASA-SPVPAPTPVLAPSSTQT 1662
Cdd:pfam17823 253 LATLA--AAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTdQPVHNTAGEPTPSPSNT 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1663 MLPAPVPSPLPSPAST-------QTLALAPALAPTLGGS-SPSQTLSLGTGNPQGPFPTQTLSlTPASSLVPTPAQTLSL 1734
Cdd:pfam17823 331 TLEPNTPKSVASTNLAvvtttkaQAKEPSASPVPVLHTSmIPEVEATSPTTQPSPLLPTQGAA-GPGILLAPEQVATEAT 409
|
....*....
gi 146219843 1735 APGPPLGPT 1743
Cdd:pfam17823 410 AGTASAGPT 418
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1335-1744 |
6.05e-09 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 62.11 E-value: 6.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1335 SSGLPAVLNPRPTLTPGRLPTPTLGTARAPM-PTPTLVRPLLklvhSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASS 1413
Cdd:PHA03307 74 GPGTEAPANESRSTPTWSLSTLAPASPAREGsPTPPGPSSPD----PPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1414 PMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSL 1493
Cdd:PHA03307 150 ASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAA 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1494 APSGASPSASAltlglatapSLSSSQTPGHPLLLAPTSSHVPGlnstVAPACSPVLVPASALASPFPSAPNPAPAQASLL 1573
Cdd:PHA03307 230 DDAGASSSDSS---------SSESSGCGWGPENECPLPRPAPI----TLPTRIWEASGWNGPSSRPGPASSSSSPRERSP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1574 APASSASQALATPLAPMAAPqtailapspapplaplpvLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTP 1653
Cdd:PHA03307 297 SPSPSSPGSGPAPSSPRASS------------------SSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1654 VLAPSSTQTmlPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQtlslgtgnpQGPFPTqTLSLTPASSLVPTPAQTLS 1733
Cdd:PHA03307 359 PADPSSPRK--RPRPSRAPSSPAASAGRPTRRRARAAVAGRARRR---------DATGRF-PAGRPRPSPLDAGAASGAF 426
|
410
....*....|.
gi 146219843 1734 LAPGPPLGPTQ 1744
Cdd:PHA03307 427 YARYPLLTPSG 437
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1515-2020 |
6.89e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.26 E-value: 6.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1515 LSSSQTPGHPLL---------LAPTSSHVPGLNSTVAPACSPVlvPASALASPFPSAPNPAPAQASLLA-------PASS 1578
Cdd:PHA03247 2469 LLGELFPGAPVYrrpaearfpFAAGAAPDPGGGGPPDPDAPPA--PSRLAPAILPDEPVGEPVHPRMLTwirgleeLASD 2546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1579 ASQALATPLAPMAAPQTA-----ILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVpvmAPSSTPGTSLASASPVPAPT- 1652
Cdd:PHA03247 2547 DAGDPPPPLPPAAPPAAPdrsvpPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPV---DDRGDPRGPAPPSPLPPDTHa 2623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1653 ---PVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTlSLGTGNPQGPFPTQTL-SLTPASSLVPTP 1728
Cdd:PHA03247 2624 pdpPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA-AQASSPPQRPRRRAARpTVGSLTSLADPP 2702
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1729 AQTLSLAPGPPLGPTQTLSLAPAPPLApaspvGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLAL 1808
Cdd:PHA03247 2703 PPPPTPEPAPHALVSATPLPPGPAAAR-----QASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1809 APASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPfylds 1888
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL----- 2852
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1889 leekrkrqrserlerifqlseaHGALAPvyGTEVLDFCTLPQPVASPIGPRSPgpshptfwtyteaahravlfPQQRLDQ 1968
Cdd:PHA03247 2853 ----------------------GGSVAP--GGDVRRRPPSRSPAAKPAAPARP--------------------PVRRLAR 2888
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1969 LSEIIERFIFVMPPVE-APPPSLHACHPPPWLAPRQAAFQEQLASELWPRARP 2020
Cdd:PHA03247 2889 PAVSRSTESFALPPDQpERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP 2941
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1243-1677 |
1.43e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 60.94 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1243 SAGGQHHLISQPAhvALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANqvPPTmvnntgvvkivvRQAPRDGLT 1322
Cdd:pfam03154 160 SSAQQQILQTQPP--VLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGS--PAT------------SQPPNQTQS 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1323 PVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHS----PSPEVSASAPGAAPLTIS 1398
Cdd:pfam03154 224 TAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSlqtgPSHMQHPVPPQPFPLTPQ 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1399 S-----PLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSlPISVPTTLPAPASAPLTIPISA----PLTVSASG 1469
Cdd:pfam03154 304 SsqsqvPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA-PLSMPHIKPPPTTPIPQLPNPQshkhPPHLSGPS 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1470 PALLTSVTPPLAPVVPAAPGPPSLAPSGASPsasaltlglatapslsssqtpghPLLLAPTSSHVPGlnstvAPACSPVL 1549
Cdd:pfam03154 383 PFQMNSNLPPPPALKPLSSLSTHHPPSAHPP-----------------------PLQLMPQSQQLPP-----PPAQPPVL 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1550 -----VPASALASPFPSAPNPAPAQASLlaPASSASQALATPLAPMAAPQTAILAPSPAPPLaplpvlapsPGAAPVlaS 1624
Cdd:pfam03154 435 tqsqsLPPPAASHPPTSGLHQVPSQSPF--PQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP---------PSSASV--S 501
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1625 SQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPAS 1677
Cdd:pfam03154 502 SSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTPSHAS 554
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1031-1592 |
2.42e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.34 E-value: 2.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1031 ELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTP 1110
Cdd:PHA03247 2542 ELASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDT 2621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1111 PAPvrlspaPPPGSSSLLKPLTVPPGYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQL 1190
Cdd:PHA03247 2622 HAP------DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL 2695
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1191 ASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQP-RPLQRNVVHLVSAGGQhhlisqPAHVALIQAVAPTPGP 1269
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGG------PARPARPPTTAGPPAP 2769
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1270 TPVSVLPSSTPSTTPAPTGLSLPLAANQVPptmvnntgvvkivvrqAPRDGLTPVPP-LAPAPRPPSSGLPAVLNPRPT- 1347
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSESRESLP----------------SPWDPADPPAAvLAPAAALPPAASPAGPLPPPTs 2833
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1348 -------LTPGRLPTPTL--------------GTARAPMPTPTLVRpllklvHSPSPEVSASAPGAAPLTISSPLHVPSS 1406
Cdd:PHA03247 2834 aqptappPPPGPPPPSLPlggsvapggdvrrrPPSRSPAAKPAAPA------RPPVRRLARPAVSRSTESFALPPDQPER 2907
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1407 LPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPA-----LLTSVTPPLA 1481
Cdd:PHA03247 2908 PPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVavprfRVPQPAPSRE 2987
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1482 PVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPlllaptSSHVPGLNSTVAPACSPVLVPASAL------ 1555
Cdd:PHA03247 2988 APASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQTLWP------PDDTEDSDADSLFDSDSERSDLEALdplppe 3061
|
570 580 590
....*....|....*....|....*....|....*...
gi 146219843 1556 -ASPFPSAPNPAPAQASllAPASSASQALATPLAPMAA 1592
Cdd:PHA03247 3062 pHDPFAHEPDPATPEAG--ARESPSSQFGPPPLSANAA 3097
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1384-1867 |
2.54e-07 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 56.85 E-value: 2.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1384 EVSASAPGAAPLTI----------SSPLHVPSSLPGPASSPMPIPNSSPLASPvSSTVSVPLSSSlpisVPTTLPAPASa 1453
Cdd:pfam05109 390 DITVSGLGTAPKTLiitrtatnatTTTHKVIFSKAPESTTTSPTLNTTGFAAP-NTTTGLPSSTH----VPTNLTAPAS- 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1454 plTIPISAPLTVSASGPALLTSVTPPLApvvpaapgpPSLAPSGASPSASALTLglaTAPslSSSQTPGHPLLLAPTssh 1533
Cdd:pfam05109 464 --TGPTVSTADVTSPTPAGTTSGASPVT---------PSPSPRDNGTESKAPDM---TSP--TSAVTTPTPNATSPT--- 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1534 vPGLNSTVAPACSPVL---VPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPqtailapspapplaplp 1610
Cdd:pfam05109 525 -PAVTTPTPNATSPTLgktSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTP----------------- 586
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1611 vlapSPGAAPVLASSQTPVPVMAPSSTPGTslaSASPVPAPTPVLAPSSTQTMlPAPVPSPLPSPASTQTLALAPALAPT 1690
Cdd:pfam05109 587 ----TPNATSPTVGETSPQANTTNHTLGGT---SSTPVVTSPPKNATSAVTTG-QHNITSSSTSSMSLRPSSISETLSPS 658
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1691 LGGSSPSQTLSLGTGNPQG--------PFPTQTLSLTpASSLVPTPAQTlSLAPGPPLGPTQTLslapapplapaspvgP 1762
Cdd:pfam05109 659 TSDNSTSHMPLLTSAHPTGgenitqvtPASTSTHHVS-TSSPAPRPGTT-SQASGPGNSSTSTK---------------P 721
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1763 APAHTLTLAPASSSASLLAPASVQTltlsPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVT---MVS 1839
Cdd:pfam05109 722 GEVNVTKGTPPKNATSPQAPSGQKT----AVPTVTSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTrynATT 797
|
490 500 510
....*....|....*....|....*....|....*...
gi 146219843 1840 RLPVSKD----------EPDTLTLRSGPPSPPSTATSF 1867
Cdd:pfam05109 798 YLPPSTSsklrprwtftSPPVTTAQATVPVPPTSQPRF 835
|
|
| DISARM_DrmD_b |
NF038318 |
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component ... |
2091-2161 |
3.90e-07 |
|
DISARM system SNF2-like helicase DrmD, short form; DrmD, a SNF2-like helicase, is a component of class 1 DISARM (Defence Island System Associated with Restriction Modification), which contains a DNA adenine N6 methyltransferase. This HMM describes a distinct form that is somewhat shorter than the majority of DrmD proteins.
Pssm-ID: 468472 [Multi-domain] Cd Length: 868 Bit Score: 56.23 E-value: 3.90e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146219843 2091 GSTRVEQRQALMERFNADKRIfcfILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQTRDV 2161
Cdd:NF038318 469 YGRSVEYKHAIVDYFKNNAKI---LIVTDAGSEGLNLQFCNTVINYDLPWNPQKIEQRIGRCHRYGQKNDV 536
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1643-1843 |
5.60e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 55.65 E-value: 5.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1643 ASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPAS 1722
Cdd:PRK12323 377 AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAA 456
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1723 SLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLS---------PA 1793
Cdd:PRK12323 457 APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESipdpatadpDD 536
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 146219843 1794 PVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPV----TMVSRLPV 1843
Cdd:PRK12323 537 AFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDgdwpALAARLPV 590
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1547-1867 |
6.03e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.54 E-value: 6.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1547 PVLVPASALASPfPSAPNPAPAQASLLAPASSAsqalaTPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPV-LASS 1625
Cdd:pfam03154 172 PVLQAQSGAASP-PSPPPPGTTQAATAGPTPSA-----PSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQrLPSP 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1626 QTPVPVMAPSSTPgtslASASPVPAPTPVLapSSTQTMLPAPV---PSPLPSPASTQTLALAPALAPTLGGSSPSqtlsl 1702
Cdd:pfam03154 246 HPPLQPMTQPPPP----SQVSPQPLPQPSL--HGQMPPMPHSLqtgPSHMQHPVPPQPFPLTPQSSQSQVPPGPS----- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1703 gtgnPQGPFPTQTLSLTPASSLVPTPAQ---TLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASL 1779
Cdd:pfam03154 315 ----PAAPGQSQQRIHTPPSQSQLQSQQpprEQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNL 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1780 LAPASVQTLTlspaPVPTLGPAAAQT--LALAPASTQSPASQASSLVVSASGAAPlpvtmvsrlPVSKDEPDTLTLRSGP 1857
Cdd:pfam03154 391 PPPPALKPLS----SLSTHHPPSAHPppLQLMPQSQQLPPPPAQPPVLTQSQSLP---------PPAASHPPTSGLHQVP 457
|
330
....*....|
gi 146219843 1858 PSPPSTATSF 1867
Cdd:pfam03154 458 SQSPFPQHPF 467
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1550-1865 |
7.26e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 55.38 E-value: 7.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1550 VPASALASPFPSAPNPAPAQASLLAPASSASQALATplAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPV 1629
Cdd:PRK07764 398 APSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAP--APAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPE 475
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1630 PVMAPSSTPGTSLASASPVPAPTPVLAPSSTQT-------------------------MLPAPVPSPL---------PSP 1675
Cdd:PRK07764 476 PTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDaatlrerwpeilaavpkrsrktwaiLLPEATVLGVrgdtlvlgfSTG 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1676 ASTQTLA-------LAPALAPTLG---------GSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPP 1739
Cdd:PRK07764 556 GLARRFAspgnaevLVTALAEELGgdwqveavvGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAA 635
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1740 LGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPA-------- 1811
Cdd:PRK07764 636 PAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAAtppagqad 715
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1812 ----STQSPASQASSLVVSASGAAPLP-----VTMVSRLPVSKDEPDTLTLRSGPPSPPSTAT 1865
Cdd:PRK07764 716 dpaaQPPQAAQGASAPSPAADDPVPLPpepddPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1510-1864 |
7.45e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 55.38 E-value: 7.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1510 ATAPSL------------SSSQTPG--HPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASllAP 1575
Cdd:PRK07764 348 ATSPRLllellcarmllpSASDDERglLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAP--AP 425
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1576 ASSASQAlatpLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVL 1655
Cdd:PRK07764 426 AAAPQPA----PAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1656 APSSTQT-------------------------MLPAPVPSPL---------PSPASTQTLA-------LAPALAPTLG-- 1692
Cdd:PRK07764 502 APAGADDaatlrerwpeilaavpkrsrktwaiLLPEATVLGVrgdtlvlgfSTGGLARRFAspgnaevLVTALAEELGgd 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1693 -------GSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPA 1765
Cdd:PRK07764 582 wqveavvGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPD 661
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1766 HTLTLAPASSSASLLAPASVQTLTLSPAPVPTLG-----PAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSR 1840
Cdd:PRK07764 662 ASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGaapaqPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPL 741
|
410 420
....*....|....*....|....
gi 146219843 1841 LPVSKDEPDTLTLRSGPPSPPSTA 1864
Cdd:PRK07764 742 PPEPDDPPDPAGAPAQPPPPPAPA 765
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1261-1658 |
8.67e-07 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 55.18 E-value: 8.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1261 QAVAPTPGPTPVSVLPSSTPSTTP------APTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPP 1334
Cdd:PHA03307 22 PRPPATPGDAADDLLSGSQGQLVSdsaelaAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1335 SSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLV----HSPSPEVSASAPGAAPLTISSPLHVPSSLPGP 1410
Cdd:PHA03307 102 REGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGpppaASPPAAGASPAAVASDAASSRQAALPLSSPEE 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1411 ASSPMPipnsSPLASPVSSTVSVPLSS-----SLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVP 1485
Cdd:PHA03307 182 TARAPS----SPPAEPPPSTPPAAASPrpprrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1486 AAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPlLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNP 1565
Cdd:PHA03307 258 PRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSP-SPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESS 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1566 APAQASLLA-PASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQT------PVPVMAPSSTP 1638
Cdd:PHA03307 337 RGAAVSPGPsPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARrrdatgRFPAGRPRPSP 416
|
410 420
....*....|....*....|
gi 146219843 1639 GTSLASASPVPAPTPVLAPS 1658
Cdd:PHA03307 417 LDAGAASGAFYARYPLLTPS 436
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1539-1769 |
1.23e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 53.99 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1539 STVAPACSPVLVPASALASPFPSAPNPAPAQAslLAPASSASQALATPLAPMAAPQTAilapspapPLAPLPVLAPSPGA 1618
Cdd:COG3469 2 SSVSTAASPTAGGASATAVTLLGAAATAASVT--LTAATATTVVSTTGSVVVAASGSA--------GSGTGTTAASSTAA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1619 APVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLAlAPALAPTLGGSSPSQ 1698
Cdd:COG3469 72 TSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTT-SGASATSSAGSTTTT 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146219843 1699 TLSLGTGNPQGPfPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASpvGPAPAHTLT 1769
Cdd:COG3469 151 TTVSGTETATGG-TTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPT--PGLPKHVLV 218
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1336-1728 |
1.45e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 54.30 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1336 SGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLK--LVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASS 1413
Cdd:PHA03378 447 SQAPTVVLHRPPTQPLEGPTGPLSVQAPLEPWQPLPHPQVTpvILHQPPAQGVQAHGSMLDLLEKDDEDMEQRVMATLLP 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1414 PMPIPNSSPLASPVSSTVSVPLSSSLPISVPTT----LPAPASAPLTI-PISAPLT--VSASGPALLTSVTP-PLAPVVP 1485
Cdd:PHA03378 527 PSPPQPRAGRRAPCVYTEDLDIESDEPASTEPVhdqlLPAPGLGPLQIqPLTSPTTsqLASSAPSYAQTPWPvPHPSQTP 606
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1486 AAPGPPSLAPSGASPSASALTLglatapslssSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNP 1565
Cdd:PHA03378 607 EPPTTQSHIPETSAPRQWPMPL----------RPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQP 676
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1566 APAQASLLAPASSASQALATPLA---PMAAPQTA-ILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPV------------ 1629
Cdd:PHA03378 677 SPTGANTMLPIQWAPGTMQPPPRaptPMRPPAAPpGRAQRPAAATGRARPPAAAPGRARPPAAAPGRArppaaapgrarp 756
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1630 PVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPS--PASTQTLALAPALAPTLGGSSPSQTLSLGT--G 1705
Cdd:PHA03378 757 PAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQagPTSMQLMPRAAPGQQGPTKQILRQLLTGGVkrG 836
|
410 420
....*....|....*....|...
gi 146219843 1706 NPQGPFPTQTLSLTPAsslVPTP 1728
Cdd:PHA03378 837 RPSLKKPAALERQAAA---GPTP 856
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1310-1695 |
1.76e-06 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 54.15 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1310 KIVVRQAPRDGLTPVPPLAP--APRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPT-LVRPLLKLVHSPSPEVS 1386
Cdd:pfam05109 418 KVIFSKAPESTTTSPTLNTTgfAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDN 497
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1387 ASAPGAAPLT-----ISSPLHVPSSlPGPA-SSPMPIPNSSPLA--SPVSSTVSVPLSSSLPISVPTTLPAPASAPL--- 1455
Cdd:pfam05109 498 GTESKAPDMTsptsaVTTPTPNATS-PTPAvTTPTPNATSPTLGktSPTSAVTTPTPNATSPTPAVTTPTPNATIPTlgk 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1456 TIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASP---SASALTLGLATAPSLSSSQTPGHPLLLAPT-- 1530
Cdd:pfam05109 577 TSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPpknATSAVTTGQHNITSSSTSSMSLRPSSISETls 656
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1531 -------SSHVPGLNS---TVAPACSPVLVPASALASPFPSAPNPAP---AQASLLAPASSASQALATPLAPMAAPQTAI 1597
Cdd:pfam05109 657 pstsdnsTSHMPLLTSahpTGGENITQVTPASTSTHHVSTSSPAPRPgttSQASGPGNSSTSTKPGEVNVTKGTPPKNAT 736
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1598 LAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSST-PGTSLASASPVPA----PTPVLAPSSTQTMLPAPVPSPL 1672
Cdd:pfam05109 737 SPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTSTePTTDYGGDSTTPRtrynATTYLPPSTSSKLRPRWTFTSP 816
|
410 420
....*....|....*....|...
gi 146219843 1673 PSPASTQTLALAPALAPTLGGSS 1695
Cdd:pfam05109 817 PVTTAQATVPVPPTSQPRFSNLS 839
|
|
| COG4935 |
COG4935 |
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ... |
1252-1830 |
2.47e-06 |
|
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443962 [Multi-domain] Cd Length: 641 Bit Score: 53.29 E-value: 2.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1252 SQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAP 1331
Cdd:COG4935 2 AAGGAGSTTGLAAAVLAAAAGTGSAATAEGGAASTATSAAVAGASAAAAAATAVGAGASSLAASAAAAAAAASGAAAGAV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1332 RPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPtlvrpllkLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPA 1411
Cdd:COG4935 82 DAAPAAATVVGAALGVVAVAGAGLAATASGAAAGAVA--------AAANGNTGAGPGSGGTGGGSGGAGAAAAAAALSAA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1412 SSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPP 1491
Cdd:COG4935 154 GAAVGVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVAGGAAGGGGGGGGGGGLGGAAGGGGAGLAAAGGGG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1492 SLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQAS 1571
Cdd:COG4935 234 GGAAAAAAAGVGGLGAAATAAAADGGGGGGAGAAGAGGSAGAAAGGAGAGVVGAAAGGGDAALGGAVGAAGTGNAAAAAA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1572 LLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAP 1651
Cdd:COG4935 314 ASAGSGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGGAGTAAAAGGGAAAAAAGGAAAAGAAAGAAAGAAA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1652 TPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQT 1731
Cdd:COG4935 394 GAAAAGGVASAAGAVGAGTAAGASATAAVSTGAASGSSTTSSTGTTATATGLGGGADAGSTSTGTGSAAGAAGGTTTATS 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1732 LSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQtlalapa 1811
Cdd:COG4935 474 GLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGAAGTTNSTATFSNTTDVAIPDNGPAGVT------- 546
|
570
....*....|....*....
gi 146219843 1812 stqspasqaSSLVVSASGA 1830
Cdd:COG4935 547 ---------STITVSGGGA 556
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1468-1691 |
2.52e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 53.34 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1468 SGPAllTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPlllaptsshVPGLNSTVAPACSP 1547
Cdd:PRK12323 372 AGPA--TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARR---------SPAPEALAAARQAS 440
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1548 VLVPASALASPFPSAPNPAPAQASllAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQT 1627
Cdd:PRK12323 441 ARGPGGAPAPAPAPAAAPAAAARP--AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAP 518
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1628 PVPVMAPSSTPGTSLASAS-PVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALA-----PALAPTL 1691
Cdd:PRK12323 519 AGWVAESIPDPATADPDDAfETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMfdgdwPALAARL 588
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1448-1689 |
2.60e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 53.31 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1448 PAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVvpAAPGPPSLAPSGASPSASAltlgLATAPSLSSSQtpghplll 1527
Cdd:PRK07003 367 APGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAV--TGAAGAALAPKAAAAAAAT----RAEAPPAAPAP-------- 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1528 APTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLA 1607
Cdd:PRK07003 433 PATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARA 512
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1608 PLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTS-----------------------LASASPVPAPTPVLAPSSTQTML 1664
Cdd:PRK07003 513 PAAASREDAPAAAAPPAPEARPPTPAAAAPAARAggaaaaldvlrnagmrvssdrgaRAAAAAKPAAAPAAAPKPAAPRV 592
|
250 260
....*....|....*....|....*
gi 146219843 1665 PAPVPSPLPSPASTQTLALAPALAP 1689
Cdd:PRK07003 593 AVQVPTPRARAATGDAPPNGAARAE 617
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1494-1839 |
2.87e-06 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 53.04 E-value: 2.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1494 APSGASPS--ASALTLGLATAPSLSSSqtpghplllAPTSShVPGLNSTVAPAcspvlvpASALASPFPSAPNPAPAQAS 1571
Cdd:pfam17823 117 AAASSSPSsaAQSLPAAIAALPSEAFS---------APRAA-ACRANASAAPR-------AAIAAASAPHAASPAPRTAA 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1572 llAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVmapsstPGTSLASASPVPAP 1651
Cdd:pfam17823 180 --SSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPA------AGTVTAAVGTVTPA 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1652 TPVLAPSSTQTMLPAPVPSPLPSPASTQtlalapalaPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLT----PASSLVPT 1727
Cdd:pfam17823 252 ALATLAAAAGTVASAAGTINMGDPHARR---------LSPAKHMPSDTMARNPAAPMGAQAQGPIIQVstdqPVHNTAGE 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1728 PAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASvqtlTLSPAPVPTLGPAAAQTLA 1807
Cdd:pfam17823 323 PTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEATSP----TTQPSPLLPTQGAAGPGIL 398
|
330 340 350
....*....|....*....|....*....|....
gi 146219843 1808 LAP--ASTQSPASQASSLVVSASGAAPLPVTMVS 1839
Cdd:pfam17823 399 LAPeqVATEATAGTASAGPTPRSSGDPKTLAMAS 432
|
|
| TALPID3 |
pfam15324 |
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ... |
1645-1828 |
2.98e-06 |
|
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.
Pssm-ID: 434634 [Multi-domain] Cd Length: 1288 Bit Score: 53.35 E-value: 2.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1645 ASPVPAPTPVLAPSsTQTMLPAPVPSPLPSP-ASTQTLALAPALAPTLGGS---SPSQTLSLGTGNPQGPFPTQtlsltP 1720
Cdd:pfam15324 966 EPPVAASVPGDLPT-KETLLPTPVPTPQPTPpCSPPSPLKEPSPVKTPDSSpcvSEHDFFPVKEIPPEKGADTG-----P 1039
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1721 ASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLA-----PASSSASLLAPASVQTLT------ 1789
Cdd:pfam15324 1040 AVSLVITPTVTPIATPPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDLPleeenPNSEQEELHPRAVVMSVArdeepe 1119
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 146219843 1790 --LSPAPVPTLGPAAAQTL-ALAPASTQSPASQASSLVVSAS 1828
Cdd:pfam15324 1120 svVLPASPPEPKPLAPPPLgAAPPSPPQSPSSSSSTLESSSS 1161
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1618-1844 |
3.26e-06 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 52.59 E-value: 3.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1618 AAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPsPLPSPASTQTLALAPALAPTLGGSSPS 1697
Cdd:COG5651 160 AAVALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIG-GLNSGSGPIGLNSGPGNTGFAGTGAAA 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1698 QTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSA 1777
Cdd:COG5651 239 GAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGAGGAAGA 318
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 146219843 1778 SLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVS 1844
Cdd:COG5651 319 AGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAAA 385
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1379-1862 |
3.57e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 53.25 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1379 HSPSPEVSASAPGAAPLTISSPLHVPSSLPGPAsspmPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIP 1458
Cdd:PHA03307 20 FFPRPPATPGDAADDLLSGSQGQLVSDSAELAA----VTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1459 ISAPLTVSASGPALLTSVTPPlapvvpaapgppslAPSGASPSASALTLGLATAPSLSSSQTPGHPlllAPTSSHVPGLN 1538
Cdd:PHA03307 96 APASPAREGSPTPPGPSSPDP--------------PPPTPPPASPPPSPAPDLSEMLRPVGSPGPP---PAASPPAAGAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1539 STVAPACSPvlvPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGA 1618
Cdd:PHA03307 159 PAAVASDAA---SSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1619 APVLASSQtpvpvmapSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPAStqtlalaPALAPTLGGSSPSQ 1698
Cdd:PHA03307 236 SSDSSSSE--------SSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAS-------SSSSPRERSPSPSP 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1699 TLSLGTGNPQGPFPTQTLSLTPASSLvptpAQTLSLAPGPplgptqtlslapapplaPASPVGPAPAHTLTLAPASSSAS 1778
Cdd:PHA03307 301 SSPGSGPAPSSPRASSSSSSSRESSS----SSTSSSSESS-----------------RGAAVSPGPSPSRSPSPSRPPPP 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1779 LLAPASVQTLTLSPAPVPTLGPAAAQTLALApastqspASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSGPP 1858
Cdd:PHA03307 360 ADPSSPRKRPRPSRAPSSPAASAGRPTRRRA-------RAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPL 432
|
....
gi 146219843 1859 SPPS 1862
Cdd:PHA03307 433 LTPS 436
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1558-1681 |
4.60e-06 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 52.41 E-value: 4.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1558 PFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSST 1637
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAV 445
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 146219843 1638 PGTSlaSASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTL 1681
Cdd:PRK14951 446 ALAP--APPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
638-776 |
4.81e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 48.94 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 638 NGILADEMGLGKTIQTISLLAHLACEKGnwGPHLIIVPT-SVMLNWEMELKRW-CPSFKILTYYGAqkERKLKRQGWTKP 715
Cdd:cd00046 3 NVLITAPTGSGKTLAALLAALLLLLKKG--KKVLVLVPTkALALQTAERLRELfGPGIRVAVLVGG--SSAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 716 NAfHVCITSYKLV---LQDHQAFRRKNWRYLILDEAQNI-KNFKSQRWQSLLNFNSQ----RRLLLTGT 776
Cdd:cd00046 79 DA-DIIIATPDMLlnlLLREDRLFLKDLKLIIVDEAHALlIDSRGALILDLAVRKAGlknaQVILLSAT 146
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1385-1593 |
7.61e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 51.68 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1385 VSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLT 1464
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1465 VSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGaSPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPA 1544
Cdd:COG3469 81 TATAAAAAATSTSATLVATSTASGANTGTSTVT-TTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETA 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 146219843 1545 CSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAP 1593
Cdd:COG3469 160 TGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPP 208
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
1356-1811 |
7.63e-06 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 52.18 E-value: 7.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1356 PTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPL 1435
Cdd:COG3321 854 PGRGRRRVPLPTYPFQREDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALV 933
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1436 SSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSL 1515
Cdd:COG3321 934 ALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLA 1013
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1516 SSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQT 1595
Cdd:COG3321 1014 AAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAA 1093
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1596 AILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSP 1675
Cdd:COG3321 1094 ALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAAL 1173
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1676 ASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLA 1755
Cdd:COG3321 1174 LLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAA 1253
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 146219843 1756 PASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPA 1811
Cdd:COG3321 1254 ALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAA 1309
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1466-1707 |
9.02e-06 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 51.05 E-value: 9.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1466 SASGPAL-LTSVTPPLAPvvpaapgppSLAPSGASPSASALTLGLATAPSLSSSQTPGhpllLAPTSshVPGLNSTVAPA 1544
Cdd:COG5651 156 AASAAAVaLTPFTQPPPT---------ITNPGGLLGAQNAGSGNTSSNPGFANLGLTG----LNQVG--IGGLNSGSGPI 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1545 CSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLAS 1624
Cdd:COG5651 221 GLNSGPGNTGFAGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGA 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1625 SQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGT 1704
Cdd:COG5651 301 GAAAATGLGLGAGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASG 380
|
...
gi 146219843 1705 GNP 1707
Cdd:COG5651 381 GGA 383
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2241-2362 |
1.08e-05 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 50.67 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2241 LEQALCRAED-EEDIRAATQAKAEQVAELAEFNEndgfpagegeeagrpgaedeEMSRAEQEIAALVEQLTPIEryamKF 2319
Cdd:COG4372 33 LRKALFELDKlQEELEQLREELEQAREELEQLEE--------------------ELEQARSELEQLEEELEELN----EQ 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 146219843 2320 LEASLEEV--SREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG4372 89 LQAAQAELaqAQEELESLQEEAEELQEELEELQKERQDLEQQRKQ 133
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1568-1778 |
1.24e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 50.66 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1568 AQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGT------- 1640
Cdd:COG5651 159 AAAVALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFagtgaaa 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1641 ----SLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQ---GPFPT 1713
Cdd:COG5651 239 gaaaAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLgagGAAGA 318
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 1714 QTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSAS 1778
Cdd:COG5651 319 AGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGA 383
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1344-1745 |
1.63e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.75 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1344 PRPTLTPGRLPTPTLGTARAPMPTPTlvrpllklVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPL 1423
Cdd:PRK07764 406 PAAAPAPAAAAPAAAAAPAPAAAPQP--------APAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPT 477
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1424 ASPVSSTVSVPLSsslpisvPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTpplaPVVPAAPGPPSLAPSGASPSAS 1503
Cdd:PRK07764 478 AAPAPAPPAAPAP-------AAAPAAPAAPAAPAGADDAATLRERWPEILAAVP----KRSRKTWAILLPEATVLGVRGD 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1504 ALTLGLATAPSLSSSQTPGHPLLLAPTSSHVpgLNSTVAPACspVLVPASAlASPFPSAPNPAPAQASLLAPASSASQAL 1583
Cdd:PRK07764 547 TLVLGFSTGGLARRFASPGNAEVLVTALAEE--LGGDWQVEA--VVGPAPG-AAGGEGPPAPASSGPPEEAARPAAPAAP 621
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1584 ATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPvmAPSSTPGTSLASASPVPAPTPVLAPSSTQTM 1663
Cdd:PRK07764 622 AAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDG--WPAKAGGAAPAAPPPAPAPAAPAAPAGAAPA 699
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1664 LPAP----VPSPLPSPASTQTLALAPAlaptlGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSlVPTPAQTLSLAPGPP 1739
Cdd:PRK07764 700 QPAPapaaTPPAGQADDPAAQPPQAAQ-----GASAPSPAADDPVPLPPEPDDPPDPAGAPAQP-PPPPAPAPAAAPAAA 773
|
....*.
gi 146219843 1740 LGPTQT 1745
Cdd:PRK07764 774 PPPSPP 779
|
|
| PspA |
COG1842 |
Phage shock protein A [Transcription, Signal transduction mechanisms]; |
2240-2362 |
2.50e-05 |
|
Phage shock protein A [Transcription, Signal transduction mechanisms];
Pssm-ID: 441447 [Multi-domain] Cd Length: 217 Bit Score: 48.28 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2240 ILEQALcraED-EEDIRAATQAKAEQVAELAefnendgfpagegeeagrpgaedeemsRAEQEIAALVEQLTPIERYAMK 2318
Cdd:COG1842 27 MLDQAI---RDmEEDLVEARQALAQVIANQK---------------------------RLERQLEELEAEAEKWEEKARL 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 146219843 2319 FLEASLEEVSRE---ELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG1842 77 ALEKGREDLAREaleRKAELEAQAEALEAQLAQLEEQVEKLKEALRQ 123
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1345-1580 |
2.77e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 49.87 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1345 RPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPgPASSPMPIPNSSPLA 1424
Cdd:PRK12323 364 RPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRS-PAPEALAAARQASAR 442
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1425 SPVSstVSVPLSSSLPISVPTTLPAPASA---PLTIPISAPLTVSASGPALLTSVTPPLapvvpaapgpPSLAPSGASPS 1501
Cdd:PRK12323 443 GPGG--APAPAPAPAAAPAAAARPAAAGPrpvAAAAAAAPARAAPAAAPAPADDDPPPW----------EELPPEFASPA 510
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 1502 ASALTLGLATAPSLSSSQtpghplllaPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSAS 1580
Cdd:PRK12323 511 PAQPDAAPAGWVAESIPD---------PATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGD 580
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
1560-1698 |
3.11e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 49.86 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1560 PSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPG 1639
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 1640 TSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQ 1698
Cdd:PRK07994 441 SEPAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKA 499
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
618-777 |
3.14e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 46.53 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 618 LREYQHIGLD-WLVTMYEKKlnGILADEMGLGKTIQTISLLAHLACEKgnwgpHLIIVPTSVMLN-WEMELKRWCPSFKI 695
Cdd:cd17926 1 LRPYQEEALEaWLAHKNNRR--GILVLPTGSGKTLTALALIAYLKELR-----TLIVVPTDALLDqWKERFEDFLGDSSI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 696 ltyyGAQKERKLKrqgwTKPNAFHVCITSYKLVLQDHQAFRRKN-WRYLILDEAQNI--KNFKsqrwQSLLNFNSQRRLL 772
Cdd:cd17926 74 ----GLIGGGKKK----DFDDANVVVATYQSLSNLAEEEKDLFDqFGLLIVDEAHHLpaKTFS----EILKELNAKYRLG 141
|
....*
gi 146219843 773 LTGTP 777
Cdd:cd17926 142 LTATP 146
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1576-1807 |
3.94e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 49.12 E-value: 3.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1576 ASSASQALAtpLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPTPVL 1655
Cdd:COG5651 155 AAASAAAVA--LTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNTGFA 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1656 APSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLA 1735
Cdd:COG5651 233 GTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLGA 312
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146219843 1736 PGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLA 1807
Cdd:COG5651 313 GGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
2253-2344 |
4.07e-05 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 49.57 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2253 DIRAATQAKAEQVAELAEFNENDGFPAGEG-EEAGRPGAE--DEEMSRAEQEIAALVEQLTPIERyAMKFLEASLEEVSR 2329
Cdd:PRK04863 1024 SLKSSYDAKRQMLQELKQELQDLGVPADSGaEERARARRDelHARLSANRSRRNQLEKQLTFCEA-EMDNLTKKLRKLER 1102
|
90
....*....|....*
gi 146219843 2330 eELKQAEEQVEAARK 2344
Cdd:PRK04863 1103 -DYHEMREQVVNAKA 1116
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2170-2362 |
4.87e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 49.37 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2170 RTVEEniLKKANQKRMLGDMAIEGGNFTTAYFKQQTIRELFDMPLEEPSSSSVPSAPEEEEETVASKQTHILEQALCRAE 2249
Cdd:PTZ00121 1552 KKAEE--LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2250 DE-EDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAED----EEMSRAEQEIAALVEQLTPIERYAMKFLE--- 2321
Cdd:PTZ00121 1630 EEkKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDkkkaEEAKKAEEDEKKAAEALKKEAEEAKKAEElkk 1709
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 146219843 2322 ASLEEVSR-EELKQAEE----QVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:PTZ00121 1710 KEAEEKKKaEELKKAEEenkiKAEEAKKEAEEDKKKAEEAKKDEEE 1755
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1552-1785 |
8.83e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.97 E-value: 8.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1552 ASALASPfpsapnpapaqasllaPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPV 1631
Cdd:COG5651 159 AAAVALT----------------PFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1632 MAPSSTPGT------SLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTG 1705
Cdd:COG5651 223 NSGPGNTGFagtgaaAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGA 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1706 NPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASV 1785
Cdd:COG5651 303 AAATGLGLGAGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGG 382
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
1527-1739 |
8.95e-05 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 48.06 E-value: 8.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1527 LAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAilapspappl 1606
Cdd:PRK12727 55 LETARSDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQA---------- 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1607 aplpvlapsPGAAPVLASSqTPVPVMAPSSTPgtslASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPA 1686
Cdd:PRK12727 125 ---------PAAAPVRAAS-IPSPAAQALAHA----AAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAPVVAAPA 190
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1687 LAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPP 1739
Cdd:PRK12727 191 PVPAIAAALAAHAAYAQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAAP 243
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
1640-1869 |
9.62e-05 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 48.21 E-value: 9.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1640 TSLASASPVPAPTPVLAPSSTQTMLPAPVPSP-LPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSL 1718
Cdd:COG3469 1 SSSVSTAASPTAGGASATAVTLLGAAATAASVtLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1719 TPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTlTLAPASSSASLLAPASVQTLTLSPAPVPTL 1798
Cdd:COG3469 81 TATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSST-AGSTTTSGASATSSAGSTTTTTTVSGTETA 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146219843 1799 GPAAAQTLALAPASTQSPASQASSlvvSASGAAPLPVTmvsrlpvskdepdtltlrsgPPSPPSTATSFGG 1869
Cdd:COG3469 160 TGGTTTTSTTTTTTSASTTPSATT---TATATTASGAT--------------------TPSATTTATTTGP 207
|
|
| SOBP |
pfam15279 |
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ... |
1404-1673 |
1.08e-04 |
|
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.
Pssm-ID: 464609 [Multi-domain] Cd Length: 325 Bit Score: 47.12 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1404 PSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPV 1483
Cdd:pfam15279 85 PASTRSESVSPGPSSSASPSSSPTSSNSSKPLISVASSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLGRPPGSP 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1484 VPAAPGPPSLAPSGASPSASALTlglataPSLSSSQTPGHPLllaPTSSHVPGLNStvapacspvlvpasALASPFPSAP 1563
Cdd:pfam15279 165 PMSMTPRGLLGKPQQHPPPSPLP------AFMEPSSMPPPFL---RPPPSIPQPNS--------------PLSNPMLPGI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1564 NPAPAQASLLAPASSAsqALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPgtSLA 1643
Cdd:pfam15279 222 GPPPKPPRNLGPPSNP--MHRPPFSPHHPPPPPTPPGPPPGLPPPPPRGFTPPFGPPFPPVNMMPNPPEMNFGLP--SLA 297
|
250 260 270
....*....|....*....|....*....|...
gi 146219843 1644 SASPVPA---PTPVLAPsstqtmLPAPVPSPLP 1673
Cdd:pfam15279 298 PLVPPVTvlvPYPVIIP------LPVPIPIPIP 324
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
2040-2158 |
1.33e-04 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 44.42 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2040 YDCGKLQTLAVLLRQLKAEGH--RVLIFTQMTRMLDVLEQFLTYHGHLYLRLDGSTRVEQRQALMERFNADKrifCFIL- 2116
Cdd:cd18787 6 VVVEEEEKKLLLLLLLLEKLKpgKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGK---VRVLv 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 146219843 2117 ST----RsggvGVNLTGADTVVFYDsdwnptMDAQAQDRCHRIGQT 2158
Cdd:cd18787 83 ATdvaaR----GLDIPGVDHVINYD------LPRDAEDYVHRIGRT 118
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
1540-1866 |
1.57e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 47.86 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1540 TVAPACSPVLVPASALASPFPSAPNPaPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAA 1619
Cdd:PHA03307 69 TGPPPGPGTEAPANESRSTPTWSLST-LAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPP 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1620 PVLASSQTPVPVMAPSSTPGTSLASASPV---------PAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALA-- 1688
Cdd:PHA03307 148 PAASPPAAGASPAAVASDAASSRQAALPLsspeetaraPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGrs 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1689 ------PTLGGSSPSQTLSLGTG----NPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPAS 1758
Cdd:PHA03307 228 aaddagASSSDSSSSESSGCGWGpeneCPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGP 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1759 PVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMV 1838
Cdd:PHA03307 308 APSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR 387
|
330 340
....*....|....*....|....*...
gi 146219843 1839 SRlpVSKDEPDTLTLRSGPPSPPSTATS 1866
Cdd:PHA03307 388 RR--ARAAVAGRARRRDATGRFPAGRPR 413
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1544-1672 |
1.62e-04 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 47.40 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1544 ACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPlaPMAAPQTAilaPSPAPPLAPLPVLAPSPGAAPVLA 1623
Cdd:PRK14951 370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAAS--APAAPPAA---APPAPVAAPAAAAPAAAPAAAPAA 444
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 146219843 1624 SSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPL 1672
Cdd:PRK14951 445 VALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1419-1628 |
2.43e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.79 E-value: 2.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1419 NSSPlASPVSSTVSVPLSSSLPISVPTtlPAPASAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGA 1498
Cdd:PRK12323 371 GAGP-ATAAAAPVAQPAPAAAAPAAAA--PAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGA 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1499 SPSASAL--TLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPA 1576
Cdd:PRK12323 448 PAPAPAPaaAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIP 527
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 146219843 1577 SSASQALATPLAPMAAPQTAILAPSPAPPLAPLPvlapsPGAAPVLASSQTP 1628
Cdd:PRK12323 528 DPATADPDDAFETLAPAPAAAPAPRAAAATEPVV-----APRPPRASASGLP 574
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1381-1630 |
2.53e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.77 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1381 PSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSV-PLSSSLPISVPTTLPAPASAPLTIPI 1459
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEaPPAAPAPPATADRGDDAADGDAPVPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1460 SAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGhplllaptsshVPGLNS 1539
Cdd:PRK07003 452 KANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPA-----------AASRED 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1540 TVAPACSPVlvPASALASPFPSAP--NPAPAQASL---------------LAPASSASQALATPLAPM-AAPQTAILAPS 1601
Cdd:PRK07003 521 APAAAAPPA--PEARPPTPAAAAPaaRAGGAAAALdvlrnagmrvssdrgARAAAAAKPAAAPAAAPKpAAPRVAVQVPT 598
|
250 260
....*....|....*....|....*....
gi 146219843 1602 PAPPLAPLPVLAPSPGAAPVLASSQTPVP 1630
Cdd:PRK07003 599 PRARAATGDAPPNGAARAEQAAESRGAPP 627
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
1537-1693 |
2.68e-04 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 46.65 E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1537 LNSTVAPACSPVLVPA-SALASPFPSAPNPAPAQASLLAP--ASSASQALATPLAPMAAPQT-AILAPSPAPPLAPLPVL 1612
Cdd:PHA03269 15 INLIIANLNTNIPIPElHTSAATQKPDPAPAPHQAASRAPdpAVAPTSAASRKPDLAQAPTPaASEKFDPAPAPHQAASR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1613 APSPGAAPVLASSQTPVPVMAPSStpgtslasaSPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLG 1692
Cdd:PHA03269 95 APDPAVAPQLAAAPKPDAAEAFTS---------AAQAHEAPADAGTSAASKKPDPAAHTQHSPPPFAYTRSMEHIACTHG 165
|
.
gi 146219843 1693 G 1693
Cdd:PHA03269 166 G 166
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1616-1825 |
2.93e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.79 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1616 PGAAPVLASSQTPVPVMAPSSTPGTslASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQ----TLALAPALAPTL 1691
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAA--PAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARgpggAPAPAPAPAAAP 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1692 GGSSPSQTLSLGTgnPQGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLA 1771
Cdd:PRK12323 459 AAAARPAAAGPRP--VAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDD 536
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 146219843 1772 PASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVV 1825
Cdd:PRK12323 537 AFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPV 590
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
2228-2362 |
3.22e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.47 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2228 EEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFnendgfpagEGEEAgrpgAEDEEMSRAEQEIAALVE 2307
Cdd:COG1196 257 ELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARL---------EQDIA----RLEERRRELEERLEELEE 323
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 2308 QLTPIERyAMKFLEASLEEVsREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG1196 324 ELAELEE-ELEELEEELEEL-EEELEEAEEELEEAEAELAEAEEALLEAEAELAE 376
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2228-2362 |
3.38e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 46.30 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2228 EEEETVASKQTHiLEQALCRAEDEEDIRAATQAKAEQVAELAEFNENdgfpAGEGEEAGRPGAE-DEEMSRAEQEIAALV 2306
Cdd:COG4717 102 EELEELEAELEE-LREELEKLEKLLQLLPLYQELEALEAELAELPER----LEELEERLEELRElEEELEELEAELAELQ 176
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 2307 EQLtpiERYAMKFLEASLEEVSR--EELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG4717 177 EEL---EELLEQLSLATEEELQDlaEELEELQQRLAELEEELEEAQEELEELEEELEQ 231
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
1474-1689 |
3.43e-04 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 46.04 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1474 TSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQT--PGHPLLLAPTSSHVPGLNSTVAPACSPVLVP 1551
Cdd:COG5651 162 VALTPFTQPPPTITNPGGLLGAQNAGSGNTSSNPGFANLGLTGLNQVgiGGLNSGSGPIGLNSGPGNTGFAGTGAAAGAA 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1552 ASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGA-----APVLASSQ 1626
Cdd:COG5651 242 AAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLglgagGAAGAAGA 321
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1627 TPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAP 1689
Cdd:COG5651 322 TGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGGGAA 384
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
1622-1730 |
4.20e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 45.92 E-value: 4.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1622 LASSQTPVPVMAPSSTPG-TSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPsPASTQTLALAPALAPTLGGSSPSQTL 1700
Cdd:PRK14971 386 PAAAPQPSAAAAASPSPSqSSAAAQPSAPQSATQPAGTPPTVSVDPPAAVPVN-PPSTAPQAVRPAQFKEEKKIPVSKVS 464
|
90 100 110
....*....|....*....|....*....|
gi 146219843 1701 SLGTGNpQGPFPTQTLSLTPASSLVPTPAQ 1730
Cdd:PRK14971 465 SLGPST-LRPIQEKAEQATGNIKEAPTGTQ 493
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
2241-2359 |
4.55e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.91 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2241 LEQALCRAEDEEDIRAATQAKAEQVAELAEFNendgfpAGEGEEAGRPGAEDEEMSRAEQEIAALVEQLTPIERYAMKFL 2320
Cdd:COG4717 349 LQELLREAEELEEELQLEELEQEIAALLAEAG------VEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELL 422
|
90 100 110
....*....|....*....|....*....|....*....
gi 146219843 2321 EASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQE 2359
Cdd:COG4717 423 EALDEEELEEELEELEEELEELEEELEELREELAELEAE 461
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1615-1988 |
5.02e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.83 E-value: 5.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1615 SPGAAPV-LASSQTPVPVMAPSSTPGTSlASASPVPAPTPVLAPSSTQTMLP---APVPSPLP-SPASTQTLALAPALAP 1689
Cdd:PHA03378 566 APGLGPLqIQPLTSPTTSQLASSAPSYA-QTPWPVPHPSQTPEPPTTQSHIPetsAPRQWPMPlRPIPMRPLRMQPITFN 644
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1690 TLGGSSPSQ------TLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQTLslAPGPPLGPTQTLSLAPAPPLAPASPVGPA 1763
Cdd:PHA03378 645 VLVFPTPHQppqveiTPYKPTWTQIGHIPYQPSPTGANTMLPIQWAPGT--MQPPPRAPTPMRPPAAPPGRAQRPAAATG 722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1764 PAHTLTLAPASSSASLLAPasvqtltlSPAPVPTLGPAAAQTLALAPASTQSPAsqasslvvsASGAAPLPVTMVSRLPV 1843
Cdd:PHA03378 723 RARPPAAAPGRARPPAAAP--------GRARPPAAAPGRARPPAAAPGRARPPA---------AAPGAPTPQPPPQAPPA 785
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1844 SKDEPDTLTLRSGPPSPPSTATSFGGPRPRRQPPPPPRSPFYLDSLEEKRKRQRSERLERIFQLSEAHGALAPVYGT--E 1921
Cdd:PHA03378 786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTsdK 865
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 1922 VLDFCTLPQPVASPIG-PRSPGPSHPTfwtyteAAHRAVLFPQQRLDQlseiiERFIFVMPPVEAPPP 1988
Cdd:PHA03378 866 IVQAPVFYPPVLQPIQvMRQLGSVRAA------AASTVTQAPTEYTGE-----RRGVGPMHPTDIPPS 922
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1360-1834 |
5.15e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 45.83 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1360 TARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSS-PLASPVSSTVSVPLSSS 1438
Cdd:PHA03378 444 TPHSQAPTVVLHRPPTQPLEGPTGPLSVQAPLEPWQPLPHPQVTPVILHQPPAQGVQAHGSMlDLLEKDDEDMEQRVMAT 523
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1439 LPISVPTTLPAPASAPLTIpiSAPLTVSASGPALLTSVTPPLAPVVpaapgppSLAPSGASPSASALTLGLATApslsss 1518
Cdd:PHA03378 524 LLPPSPPQPRAGRRAPCVY--TEDLDIESDEPASTEPVHDQLLPAP-------GLGPLQIQPLTSPTTSQLASS------ 588
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1519 qTPGHplllAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPmaaPQTAIL 1598
Cdd:PHA03378 589 -APSY----AQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQP---PQVEIT 660
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1599 APSPAPPlaplpvlapSPGAAPVLASSQTPVPVMAPSSTPGTSLA-SASPVPAPTPVLAPSSTQ--TMLPAPVPSPLPSP 1675
Cdd:PHA03378 661 PYKPTWT---------QIGHIPYQPSPTGANTMLPIQWAPGTMQPpPRAPTPMRPPAAPPGRAQrpAAATGRARPPAAAP 731
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1676 ASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPAS--SLVPTPAQTLSLAPGPPLGPTQTLSLAPAPP 1753
Cdd:PHA03378 732 GRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPppQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMP 811
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1754 LAPASPVGPAPA---HTLTLAPASSSASLLAPASVQTL-TLSPAPVPTLGPAAAQTLA---LAPAST--QSPASQASSLV 1824
Cdd:PHA03378 812 RAAPGQQGPTKQilrQLLTGGVKRGRPSLKKPAALERQaAAGPTPSPGSGTSDKIVQApvfYPPVLQpiQVMRQLGSVRA 891
|
490
....*....|
gi 146219843 1825 VSASGAAPLP 1834
Cdd:PHA03378 892 AAASTVTQAP 901
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
1354-1740 |
5.20e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 45.82 E-value: 5.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1354 PTPTLGTARAPMPTPtlvRPLLKLVHSPSPE---VSASAPGAAPLTISSPLHVPSSL-PGPASS--PMPIPNSSP---LA 1424
Cdd:PHA03379 409 SEPTYGTPRPPVEKP---RPEVPQSLETATShgsAQVPEPPPVHDLEPGPLHDQHSMaPCPVAQlpPGPLQDLEPgdqLP 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1425 SPVSStvsvplssslPISVPTTLPAPA--------SAPLTIPISAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPS 1496
Cdd:PHA03379 486 GVVQD----------GRPACAPVPAPAgpivrpweASLSQVPGVAFAPVMPQPMPVEPVPVPTVALERPVCPAPPLIAMQ 555
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1497 GASPSASALTLGLATAPSlSSSQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAP----AQASL 1572
Cdd:PHA03379 556 GPGETSGIVRVRERWRPA-PWTPNPPRSPSQMSVRDRLARLRAEAQPYQASVEVQPPQLTQVSPQQPMEYPlepeQQMFP 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1573 LAPASSASQALATPLAPMAAPQTAILapspapplaplpvlapspgaapvlaSSQTPVPVMAPSSTPGTSLASASPVPAPT 1652
Cdd:PHA03379 635 GSPFSQVADVMRAGGVPAMQPQYFDL-------------------------PLQQPISQGAPLAPLRASMGPVPPVPATQ 689
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1653 PvlapsstqTMLPAPVPSPLPSPAST-QTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLtPASSLVPTPAQT 1731
Cdd:PHA03379 690 P--------QYFDIPLTEPINQGASAaHFLPQQPMEGPLVPERWMFQGATLSQSVRPGVAQSQYFDL-PLTQPINHGAPA 760
|
....*....
gi 146219843 1732 LSLAPGPPL 1740
Cdd:PHA03379 761 AHFLHQPPM 769
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1449-1802 |
6.57e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.61 E-value: 6.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1449 APASAPLTIPISAPLTVSASGPALLTSVTPPlapvvpAAPGPPSLAPSGASPSASALtlglATAPSLSSSQtpghplllA 1528
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAV------TGAAGAALAPKAAAAAAATR----AEAPPAAPAP--------P 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1529 PTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAP 1608
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1609 LPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTS-----------------------LASASPVPAPTPVLAPSSTQTMLP 1665
Cdd:PRK07003 514 AAASREDAPAAAAPPAPEARPPTPAAAAPAARAggaaaaldvlrnagmrvssdrgaRAAAAAKPAAAPAAAPKPAAPRVA 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1666 APVPSP----LPSPASTQTLALAPALAPTLGGSSPSQTLSlgtGNPQGPFPTQTLSLTPASSLVP---TPAQTLSLAPGP 1738
Cdd:PRK07003 594 VQVPTPraraATGDAPPNGAARAEQAAESRGAPPPWEDIP---PDDYVPLSADEGFGGPDDGFVPvfdSGPDDVRVAPKP 670
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146219843 1739 PLGPTQTLSLAPAPPLAPASPVG-----PAPAHTLTLAPAS---SSASLLAPASVQTLTLSpAPVPTLGPAA 1802
Cdd:PRK07003 671 ADAPAPPVDTRPLPPAIPLDAIGfdgewPALAARLPLKGVAyqlAFNSELTAADGGTLKLA-VPVPQYADAA 741
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
1518-1744 |
7.94e-04 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 45.43 E-value: 7.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1518 SQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASL--------LAPASSASQALATPLAP 1589
Cdd:PHA03379 468 AQLPPGPLQDLEPGDQLPGVVQDGRPACAPVPAPAGPIVRPWEASLSQVPGVAFApvmpqpmpVEPVPVPTVALERPVCP 547
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1590 mAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVmapSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVP 1669
Cdd:PHA03379 548 -APPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPSQMSV---RDRLARLRAEAQPYQASVEVQPPQLTQVSPQQPME 623
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 146219843 1670 SPLPSPASTQTLALAPALAPTLGGSspsqtlslgtGNPQGPFPTQTLSLT-PASSLVPTPAQTLSLAPGPPLGPTQ 1744
Cdd:PHA03379 624 YPLEPEQQMFPGSPFSQVADVMRAG----------GVPAMQPQYFDLPLQqPISQGAPLAPLRASMGPVPPVPATQ 689
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
1616-1724 |
8.38e-04 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 45.10 E-value: 8.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1616 PGAAPVLASSQTPVPVMAPsstpgTSLASASPVPAPtpvlAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSS 1695
Cdd:PHA03269 56 PAVAPTSAASRKPDLAQAP-----TPAASEKFDPAP----APHQAASRAPDPAVAPQLAAAPKPDAAEAFTSAAQAHEAP 126
|
90 100
....*....|....*....|....*....
gi 146219843 1696 PSQTLSLGTGNPQGPFPTQTlslTPASSL 1724
Cdd:PHA03269 127 ADAGTSAASKKPDPAAHTQH---SPPPFA 152
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
1565-1843 |
8.83e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.23 E-value: 8.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1565 PAPAQASLLAPASSASQALATPL-APMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPS-STPGTSL 1642
Cdd:PRK07003 360 PAVTGGGAPGGGVPARVAGAVPApGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPApPATADRG 439
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1643 ASASPVPAPTPVLAPSstqtmlPAPVPSPLPSPASTQTLALAPALAPTlggsspsqtlslgtgnPQGPFPTQTLSLTPAS 1722
Cdd:PRK07003 440 DDAADGDAPVPAKANA------RASADSRCDERDAQPPADSGSASAPA----------------SDAPPDAAFEPAPRAA 497
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1723 SLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSA-SLLAPASVQTLT-LSPAPVPTLGP 1800
Cdd:PRK07003 498 APSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAlDVLRNAGMRVSSdRGARAAAAAKP 577
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 146219843 1801 AAAQTLALAPA------STQSPASQASSLVVSASGAAPLPVTMVSRLPV 1843
Cdd:PRK07003 578 AAAPAAAPKPAaprvavQVPTPRARAATGDAPPNGAARAEQAAESRGAP 626
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
2228-2362 |
9.73e-04 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 45.06 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2228 EEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAEL---------------AEFNENDGFPAGEGEEAGRpgaED 2292
Cdd:TIGR02169 343 REIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrdelkdyrekleklkREINELKRELDRLQEELQR---LS 419
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2293 EEMSRAEQEIAALVEQLTPieryamkfLEASLEEVsREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:TIGR02169 420 EELADLNAAIAGIEAKINE--------LEEEKEDK-ALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDR 480
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2228-2356 |
1.12e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 44.91 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2228 EEEETVASKQTHI--LEQALCRAEDE-EDIRAATQAKAEQVAELAEFNEndgfpagEGEEA-GRPGAEDEEMSRAEQEIA 2303
Cdd:COG4913 658 WDEIDVASAEREIaeLEAELERLDASsDDLAALEEQLEELEAELEELEE-------ELDELkGEIGRLEKELEQAEEELD 730
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146219843 2304 ALVEQLTPIERYAMKFLEASLEEVSREEL---------KQAEEQVEAARKDLDQAKEEVFRL 2356
Cdd:COG4913 731 ELQDRLEAAEDLARLELRALLEERFAAALgdaverelrENLEERIDALRARLNRAEEELERA 792
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1380-1503 |
1.15e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 44.71 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1380 SPSPEVSASAPGAAPLTISSPlhVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPlSSSLPISVPTTLPAPASAPLTIPI 1459
Cdd:PRK14951 373 AAPAEKKTPARPEAAAPAAAP--VAQAAAAPAPAAAPAAAASAPAAPPAAAPPAP-VAAPAAAAPAAAPAAAPAAVALAP 449
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 146219843 1460 SAPLTVSASGPALLTSVTPPLAPVVPAApgppslAPSGASPSAS 1503
Cdd:PRK14951 450 APPAQAAPETVAIPVRVAPEPAVASAAP------APAAAPAAAR 487
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1339-1471 |
1.27e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 44.32 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1339 PAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPllklVHSPSPEVSASAPGAAPltissPLHVPSSLPGPASSPMPIP 1418
Cdd:PRK14951 378 KKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAAS----APAAPPAAAPPAPVAAP-----AAAAPAAAPAAAPAAVALA 448
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 146219843 1419 NSSPLASPvSSTVSVPLSSSLPISVPTTLPAPASApltiPISAPLTVSASGPA 1471
Cdd:PRK14951 449 PAPPAQAA-PETVAIPVRVAPEPAVASAAPAPAAA----PAAARLTPTEEGDV 496
|
|
| PRK11901 |
PRK11901 |
hypothetical protein; Reviewed |
1635-1793 |
1.53e-03 |
|
hypothetical protein; Reviewed
Pssm-ID: 237015 [Multi-domain] Cd Length: 327 Bit Score: 43.52 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1635 SSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPV------PSPLPSPASTQTLALAPALAPTLggsspSQTLSLGTGNPQ 1708
Cdd:PRK11901 91 NQSSPSAANNTSDGHDASGVKNTAPPQDISAPPIsptptqAAPPQTPNGQQRIELPGNISDAL-----SQQQGQVNAASQ 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1709 GpfptqtlSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSS----------AS 1778
Cdd:PRK11901 166 N-------AQGNTSTLPTAPATVAPSKGAKVPATAETHPTPPQKPATKKPAVNHHKTATVAVPPATSGkpksgaasarAL 238
|
170
....*....|....*
gi 146219843 1779 LLAPASVQTLTLSPA 1793
Cdd:PRK11901 239 SSAPASHYTLQLSSA 253
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
2109-2158 |
1.66e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.61 E-value: 1.66e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 146219843 2109 KRIFCFILSTRSGGVGVNLTGADTVVFYDSDWNPTMDAQAQDRCHRIGQT 2158
Cdd:cd18785 20 ASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKD 69
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1218-1577 |
1.69e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 44.29 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1218 LTGAQVRQLAVGQPRPLQRNvvHLVSAGGQHHliSQPAHVALIQAV-APTPGPTPVSVLPSSTPSTTPAP---TGLSLPL 1293
Cdd:PHA03378 577 LTSPTTSQLASSAPSYAQTP--WPVPHPSQTP--EPPTTQSHIPETsAPRQWPMPLRPIPMRPLRMQPITfnvLVFPTPH 652
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1294 AANQVPPTMVNNTGVVKIVVRQAPRdgltpvpPLAPAPRPPSSGLPAVLNPrPTLTPGRLPTPTL--GTARAPMPTPTLV 1371
Cdd:PHA03378 653 QPPQVEITPYKPTWTQIGHIPYQPS-------PTGANTMLPIQWAPGTMQP-PPRAPTPMRPPAAppGRAQRPAAATGRA 724
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1372 RPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSsplASPVSSTVSVPLSSSLPISVPTTLPAPA 1451
Cdd:PHA03378 725 RPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGA---PTPQPPPQAPPAPQQRPRGAPTPQPPPQ 801
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1452 SAPLTIPISAPLTVSASGPA------LLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTlglatapslsSSQTPGHPL 1525
Cdd:PHA03378 802 AGPTSMQLMPRAAPGQQGPTkqilrqLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGT----------SDKIVQAPV 871
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 146219843 1526 LLAP--TSSHVPGLNSTVAPACspvlvpasalASPFPSAPNPAPAQASLLAPAS 1577
Cdd:PHA03378 872 FYPPvlQPIQVMRQLGSVRAAA----------ASTVTQAPTEYTGERRGVGPMH 915
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
1542-1698 |
1.96e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 43.70 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1542 APACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPlaPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPV 1621
Cdd:PRK07994 367 EPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAP--AVPLPETTSQLLAARQQLQRAQGATKAKKSEPA 444
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 146219843 1622 LASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLAL--APALAPTLGGSSPSQ 1698
Cdd:PRK07994 445 AASRARPVNSALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHekTPELAAKLAAEAIER 523
|
|
| PRK02292 |
PRK02292 |
V-type ATP synthase subunit E; Provisional |
2231-2352 |
2.06e-03 |
|
V-type ATP synthase subunit E; Provisional
Pssm-ID: 235026 [Multi-domain] Cd Length: 188 Bit Score: 41.91 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2231 ETVASKqthILEQALCRAEDeedIRAATQAKAEQVAELAEfnendgfpagegEEAGRPGAEDEEmsRAEQEIAALVEQ-L 2309
Cdd:PRK02292 4 ETVVED---IRDEARARASE---IRAEADEEAEEIIAEAE------------ADAEEILEDREA--EAEREIEQLREQeL 63
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 146219843 2310 TPIEryamkfLEASLE--EVSREELKQAEEQVEAARKDLDQAKEE 2352
Cdd:PRK02292 64 SSAK------LEAKRErlNARKEVLEDVRNQVEDEIASLDGDKRE 102
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
1543-1700 |
2.07e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 42.93 E-value: 2.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1543 PACSPVLVPASALASPFPSAPNPAPAqasllAPASSASQALATPLAPMAAPQTAilapspapplaplpvlaPSPGAAPVL 1622
Cdd:PHA02682 76 PSGQSPLAPSPACAAPAPACPACAPA-----APAPAVTCPAPAPACPPATAPTC-----------------PPPAVCPAP 133
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 1623 ASSqtpvpvmAPSSTPGTSLASASPvPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTL 1700
Cdd:PHA02682 134 ARP-------APACPPSTRQCPPAP-PLPTPKPAPAAKPIFLHNQLPPPDYPAASCPTIETAPAASPVLEPRIPDKII 203
|
|
| SAP130_C |
pfam16014 |
Histone deacetylase complex subunit SAP130 C-terminus; |
1335-1500 |
2.39e-03 |
|
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain] Cd Length: 371 Bit Score: 43.38 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1335 SSGLPAVLNPRPTlTPGRLPTPTLGTARAPMPTPTLvrPLLKLVHSPSPEVSASAPGAAPltissPLHVPSSLPGPASSP 1414
Cdd:pfam16014 4 SSPRPSILRKKPA-TEGAKPKPDIHVAVAPPVTVAV--EALPGQNSEQQTASASPPSQHP-----AQAIPTILAPAAPPS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1415 MPIPNSSPLASPVSSTVSVPLSSSlPISVPTTLPAPASAPLTIPISA-----------PLTVSASGPAL-LTSVTPPLAP 1482
Cdd:pfam16014 76 QPSVVLSTLPAAMAVTPPIPASMA-NVVAPPTQPAASSTAACAVSSVlpeikikqeaePMDTSQSVPPLtPTSISPALTS 154
|
170
....*....|....*...
gi 146219843 1483 VVPAAPGPPSLAPSGASP 1500
Cdd:pfam16014 155 LANNLSVPAGDLLPGASP 172
|
|
| motB |
PRK12799 |
flagellar motor protein MotB; Reviewed |
1550-1677 |
2.63e-03 |
|
flagellar motor protein MotB; Reviewed
Pssm-ID: 183756 [Multi-domain] Cd Length: 421 Bit Score: 43.17 E-value: 2.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1550 VPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVlasSQTPV 1629
Cdd:PRK12799 301 VAAVTPSSAVTQSSAITPSSAAIPSPAVIPSSVTTQSATTTQASAVALSSAGVLPSDVTLPGTVALPAAEPV---NMQPQ 377
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 146219843 1630 PVMAPSSTPGTSLASASPVPAPTpvlapsstqTMLP-APVPSPLPSPAS 1677
Cdd:PRK12799 378 PMSTTETQQSSTGNITSTANGPT---------TSLPaAPASNIPVSPTS 417
|
|
| Med25_SD1 |
pfam11235 |
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is ... |
1561-1714 |
2.80e-03 |
|
Mediator complex subunit 25 synapsin 1; The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, this SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This The function of the SD domains is unclear.
Pssm-ID: 463244 [Multi-domain] Cd Length: 157 Bit Score: 41.31 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1561 SAPNP-APAQASLLAPASSASQALAtplapmAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPvMAPSSTPG 1639
Cdd:pfam11235 7 SAPGPlQSKQPVPLPPAAPSGATLS------AAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAG-LGPRFSPI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 1640 TSLASASPVPAPTPVLAPSSTQTMLP---APVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQ 1714
Cdd:pfam11235 80 TPLQQAAPGVGPPFSQAPAPQLPPGPpgaPKPVPPASQPSLVSTVAPGSGLAPTAQPGAPSMAGTVAPGGVSGPSPAQ 157
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
2297-2362 |
2.87e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 42.97 E-value: 2.87e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 2297 RAEQEIAALVEQLtpieRYAMKFLEASLEEVS--REELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG4372 21 KTGILIAALSEQL----RKALFELDKLQEELEqlREELEQAREELEQLEEELEQARSELEQLEEELEE 84
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
2234-2362 |
3.09e-03 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 43.37 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2234 ASKQTHILEQALCRAEDE-----------EDIRAATQAKAEQVAELAEFNEndgfpagegeeagrpgaEDEEMSRAEQEI 2302
Cdd:COG4913 608 NRAKLAALEAELAELEEElaeaeerlealEAELDALQERREALQRLAEYSW-----------------DEIDVASAEREI 670
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 146219843 2303 AALVEQLtpiERyamkfLEASLEEVS--REELKQAEEQVEAARKDLDQAKEEVFRLPQEEEE 2362
Cdd:COG4913 671 AELEAEL---ER-----LDASSDDLAalEEQLEELEAELEELEEELDELKGEIGRLEKELEQ 724
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1252-1461 |
3.39e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1252 SQPAHVALIQAVAPTPG---PTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLA 1328
Cdd:PRK12323 372 AGPATAAAAPVAQPAPAaaaPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1329 PAPRPPSSGL--PAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKL-VHSPSPEVSASAPGAAPLtissplhVPS 1405
Cdd:PRK12323 452 PAPAAAPAAAarPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELpPEFASPAPAQPDAAPAGW-------VAE 524
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 146219843 1406 SLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTtlPAPASAPLTIPISA 1461
Cdd:PRK12323 525 SIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPR--PPRASASGLPDMFD 578
|
|
| TALPID3 |
pfam15324 |
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ... |
1252-1475 |
3.65e-03 |
|
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.
Pssm-ID: 434634 [Multi-domain] Cd Length: 1288 Bit Score: 43.34 E-value: 3.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1252 SQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTMVNNtgvVKIVVRQAPRDgltpvpplapap 1331
Cdd:pfam15324 972 SVPGDLPTKETLLPTPVPTPQPTPPCSPPSPLKEPSPVKTPDSSPCVSEHDFFP---VKEIPPEKGAD------------ 1036
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1332 rppssGLPAVLnprPTLTPGRLPTPTlgTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAA-PLTISSPlHVPSSLPGP 1410
Cdd:pfam15324 1037 -----TGPAVS---LVITPTVTPIAT--PPPAATPTPPLSENSIDKLKSPSPELPKPWEDSDlPLEEENP-NSEQEELHP 1105
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 1411 ASSPMPIPNSsplaspvSSTVSVPLSSSLPISVPTTLPAPASAPltipiSAPLTVSASGPALLTS 1475
Cdd:pfam15324 1106 RAVVMSVARD-------EEPESVVLPASPPEPKPLAPPPLGAAP-----PSPPQSPSSSSSTLES 1158
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1316-1649 |
3.83e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 42.64 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1316 APRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGrLPTPTLGTARAPMP-TPTLVRPLLKLVHSPSPEVSASAP--GA 1392
Cdd:pfam17823 101 ATREGAADGAASRALAAAASSSPSSAAQSLPAAIAA-LPSEAFSAPRAAACrANASAAPRAAIAAASAPHAASPAPrtAA 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1393 APLTISSPLHVPSSLP--GPASSPMPIPNSSPLASPVSSTVSvPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGP 1470
Cdd:pfam17823 180 SSTTAASSTTAASSAPttAASSAPATLTPARGISTAATATGH-PAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAA 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1471 ALLTsVTPPLAPVVPAAPGPPSLAPSGASPSAsalTLGLATAPSlSSSQTPGhplLLAPTSSHVPGLNSTVAPACSP--- 1547
Cdd:pfam17823 259 AAGT-VASAAGTINMGDPHARRLSPAKHMPSD---TMARNPAAP-MGAQAQG---PIIQVSTDQPVHNTAGEPTPSPsnt 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1548 VLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPmaapqtAILAPSPAPPLAPLPVLAPSPGAAPVLASSQt 1627
Cdd:pfam17823 331 TLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIP------EVEATSPTTQPSPLLPTQGAAGPGILLAPEQ- 403
|
330 340
....*....|....*....|..
gi 146219843 1628 pvpvMAPSSTPGTslASASPVP 1649
Cdd:pfam17823 404 ----VATEATAGT--ASAGPTP 419
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1464-1694 |
4.12e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.05 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1464 TVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAP 1543
Cdd:PRK07764 587 VVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGG 666
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1544 ACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPlpvlapSPGAAPVLA 1623
Cdd:PRK07764 667 DGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP------SPAADDPVP 740
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 146219843 1624 SSQTPVPVMAPSSTPGTSLASASPVPAPTPVlapsstqtmlPAPVPSPLPSPASTQTLALAPALAPTLGGS 1694
Cdd:PRK07764 741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPA----------AAPPPSPPSEEEEMAEDDAPSMDDEDRRDA 801
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1252-1674 |
5.03e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.75 E-value: 5.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1252 SQPAHVALIqavaPTPGPTPVSVLPSSTPST----TPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPL 1327
Cdd:PHA03378 556 TEPVHDQLL----PAPGLGPLQIQPLTSPTTsqlaSSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRPI 631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1328 APAPRPPSsglPAVLN----PRPTLTPGRLPTPTLGTARAPMPTPtlvrpllklvHSPSPEVSASA--PGAAPLTISSPL 1401
Cdd:PHA03378 632 PMRPLRMQ---PITFNvlvfPTPHQPPQVEITPYKPTWTQIGHIP----------YQPSPTGANTMlpIQWAPGTMQPPP 698
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1402 HVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVTPPLA 1481
Cdd:PHA03378 699 RAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQP 778
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1482 PVVPAAPGPPSlaPSGAsPSASALTLGLATAPSLSSSQTPGHPlllAPTSSHVPGLNSTVAPACSPVLVPASALASPFPS 1561
Cdd:PHA03378 779 PPQAPPAPQQR--PRGA-PTPQPPPQAGPTSMQLMPRAAPGQQ---GPTKQILRQLLTGGVKRGRPSLKKPAALERQAAA 852
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1562 APNPAPaQASLLAPASSASQALATPLAPMAAPQTAilapspapplaplpvlapsPGAAPVLASSQTPVPVMAPSSTPGTS 1641
Cdd:PHA03378 853 GPTPSP-GSGTSDKIVQAPVFYPPVLQPIQVMRQL-------------------GSVRAAAASTVTQAPTEYTGERRGVG 912
|
410 420 430
....*....|....*....|....*....|...
gi 146219843 1642 LASASPVPAPTPVLAPSSTQTMLPAPVPSPLPS 1674
Cdd:PHA03378 913 PMHPTDIPPSKRAKTDAYVESQPPHGGQSHSFS 945
|
|
| PTZ00436 |
PTZ00436 |
60S ribosomal protein L19-like protein; Provisional |
1551-1678 |
5.17e-03 |
|
60S ribosomal protein L19-like protein; Provisional
Pssm-ID: 185616 [Multi-domain] Cd Length: 357 Bit Score: 42.24 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1551 PASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVP 1630
Cdd:PTZ00436 222 PAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAPPAKAAAAPAK 301
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 146219843 1631 VMAPSSTPGTSLASASPVPAPTPvlAPSSTQTMLPAPVPSPlPSPAST 1678
Cdd:PTZ00436 302 AAAAPAKAAAAPAKAAAPPAKAA--APPAKAATPPAKAAAP-PAKAAA 346
|
|
| PHA03269 |
PHA03269 |
envelope glycoprotein C; Provisional |
1700-1858 |
5.93e-03 |
|
envelope glycoprotein C; Provisional
Pssm-ID: 165527 [Multi-domain] Cd Length: 566 Bit Score: 42.41 E-value: 5.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1700 LSLGTGNPQGPFPTQTLSLTPASSL---VPTPAQTLSLAPGPPLGPTQTLSLApapplapaspvgPAPAhtltlapasss 1776
Cdd:PHA03269 15 INLIIANLNTNIPIPELHTSAATQKpdpAPAPHQAASRAPDPAVAPTSAASRK------------PDLA----------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1777 aslLAPASVQTLTLSPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKDEPDTLTLRSG 1856
Cdd:PHA03269 72 ---QAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLAAAPKPDAAEAFTSAAQAHEAPADAGTSAASKKPDPAAHTQHSP 148
|
..
gi 146219843 1857 PP 1858
Cdd:PHA03269 149 PP 150
|
|
| TolA |
COG3064 |
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; |
2228-2409 |
6.72e-03 |
|
Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442298 [Multi-domain] Cd Length: 485 Bit Score: 41.95 E-value: 6.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2228 EEEETVASKQTHILEQALCRAEDEEDIRAATQAKAEQVAELAEFNENDGFPAGEGEEAGRPGAEDEEMSRAEQEIA---- 2303
Cdd:COG3064 19 EQAEAEKRAAAEAEQKAKEEAEEERLAELEAKRQAEEEAREAKAEAEQRAAELAAEAAKKLAEAEKAAAEAEKKAAaeka 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 2304 ---ALVEQLTPIERYAMKFLEASLEEVSREELKQAEEQVEAARKDLDQAKEEVFRLPQEEEEGPGAGDESSCGTGGGTHR 2380
Cdd:COG3064 99 kaaKEAEAAAAAEKAAAAAEKEKAEEAKRKAEEEAKRKAEEERKAAEAEAAAKAEAEAARAAAAAAAAAAAAAARAAAGA 178
|
170 180
....*....|....*....|....*....
gi 146219843 2381 RSKKAKAPERPGTRVSERLRGARAETQGA 2409
Cdd:COG3064 179 AAALVAAAAAAVEAADTAAAAAAALAAAA 207
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1276-1596 |
6.78e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 41.87 E-value: 6.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1276 PSSTPSTTPAPTGLSLPLAANQVPPTMVNNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSglPAVLNPRPTLTPGRLPT 1355
Cdd:pfam17823 92 PHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRA--NASAAPRAAIAAASAPH 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1356 PTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPL 1435
Cdd:pfam17823 170 AASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVT 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1436 SSSLPiSVPTTLPAPASAPLTIPISAPLTVSASgpalltsvtpPLAPVVPAAPGPPSLAPSGASPSASAL---------- 1505
Cdd:pfam17823 250 PAALA-TLAAAAGTVASAAGTINMGDPHARRLS----------PAKHMPSDTMARNPAAPMGAQAQGPIIqvstdqpvhn 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1506 TLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVA--PACSPVLVPASALaSPFPSAPNPApAQASLLAPassaSQAL 1583
Cdd:pfam17823 319 TAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAkePSASPVPVLHTSM-IPEVEATSPT-TQPSPLLP----TQGA 392
|
330
....*....|...
gi 146219843 1584 ATPLAPMAAPQTA 1596
Cdd:pfam17823 393 AGPGILLAPEQVA 405
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1466-1693 |
7.44e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 7.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1466 SASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVAPAC 1545
Cdd:PRK07764 599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1546 SPVlVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASS 1625
Cdd:PRK07764 679 AAP-PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQ 757
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 146219843 1626 QTPVPVMAPsstpgtslasASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGG 1693
Cdd:PRK07764 758 PPPPPAPAP----------AAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGA 815
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1315-1528 |
8.40e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1315 QAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGTARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAP 1394
Cdd:PRK12323 379 AAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAP 458
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1395 LTISSPlHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLT 1474
Cdd:PRK12323 459 AAAARP-AAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDA 537
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 146219843 1475 SVTPPLAPVVPAAPgppslAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLA 1528
Cdd:PRK12323 538 FETLAPAPAAAPAP-----RAAAATEPVVAPRPPRASASGLPDMFDGDWPALAA 586
|
|
| PRK04654 |
PRK04654 |
sec-independent translocase; Provisional |
1615-1704 |
8.61e-03 |
|
sec-independent translocase; Provisional
Pssm-ID: 135173 [Multi-domain] Cd Length: 214 Bit Score: 40.57 E-value: 8.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1615 SPGAAPV---LASSQTPVPVMAPSSTPGTSLASASPVPAPTPV------LAPSSTQTMLPAPVPSPLPSPASTQtLALAP 1685
Cdd:PRK04654 106 TPVATPLelaHADLSASAQVDAAAGAEPGAGQAHTPVPAPAPViaqaqpIAPAPHQTLVPAPHDTIVPAPHAAH-LPSAP 184
|
90 100
....*....|....*....|...
gi 146219843 1686 A----LAPTLGGSSPSQTLSLGT 1704
Cdd:PRK04654 185 AtpvsVAPVDAGTSASPTPSEPT 207
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
1542-1651 |
8.95e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 41.62 E-value: 8.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1542 APACSPVLVPASALAsPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAilAPSPAPPLAPLPVLAPSPGAAPV 1621
Cdd:PRK14951 388 APAAAPVAQAAAAPA-PAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAA--PAAVALAPAPPAQAAPETVAIPV 464
|
90 100 110
....*....|....*....|....*....|
gi 146219843 1622 LASSQTPVPVMAPSSTPGTslASASPVPAP 1651
Cdd:PRK14951 465 RVAPEPAVASAAPAPAAAP--AAARLTPTE 492
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
1440-1675 |
9.09e-03 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 41.84 E-value: 9.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1440 PISVPTTLPAPASaPLTIPISAPLTVSASGPALLTSVTP-PLAPVVPAAPGPPSLAPSGASPSASAltlglATAPSLSSS 1518
Cdd:PLN03209 331 KESDAADGPKPVP-TKPVTPEAPSPPIEEEPPQPKAVVPrPLSPYTAYEDLKPPTSPIPTPPSSSP-----ASSKSVDAV 404
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1519 QTPGhplllAPTSSHVPGLNSTVaPACSPVLVPASALA--SPF--------PSAPNPAPAQASLLaPASSASQALATPLA 1588
Cdd:PLN03209 405 AKPA-----EPDVVPSPGSASNV-PEVEPAQVEAKKTRplSPYaryedlkpPTSPSPTAPTGVSP-SVSSTSSVPAVPDT 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1589 PMAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAPT--------PVLAPSST 1660
Cdd:PLN03209 478 APATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALadeqhhaqPKPRPLSP 557
|
250
....*....|....*..
gi 146219843 1661 QTMLP--APVPSPLPSP 1675
Cdd:PLN03209 558 YTMYEdlKPPTSPTPSP 574
|
|
| Med13_C |
pfam06333 |
Mediator complex subunit 13 C-terminal domain; Mediator is a large complex of up to 33 ... |
1341-1473 |
9.15e-03 |
|
Mediator complex subunit 13 C-terminal domain; Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Med13 is part of the ancillary kinase module, together with Med12, CDK8 and CycC, which in yeast is implicated in transcriptional repression, though most of this activity is likely attributable to the CDK8 kinase. The large Med12 and Med13 proteins are required for specific developmental processes in Drosophila, zebrafish, and Caenorhabditis elegans but their biochemical functions are not understood. This domain is also identified as an RNaseH domain of the medPIWI PIWI/Argonaute module. medPIWI is the core domain found in the Med13 protein. The medPIWI module in Med13 is predicted to bind double-stranded nucleic acids, triggering the experimentally-observed conformational switch in the CDK8 subcomplex which regulates the Mediator complex.
Pssm-ID: 461879 Cd Length: 322 Bit Score: 41.11 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146219843 1341 VLNPRPTLTPGRLPTPTLGTaraPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMPIPNS 1420
Cdd:pfam06333 146 RLMPPAPTPPSVFGQQSSST---PVSTPQDSSCTHILVFSPSATGQSTPPSGPNEPANAPTTPTDSSPEPDPDALLIDIT 222
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 146219843 1421 splaspvSSTVSVPLSSSLPISVPTT--LPAPASAPLtipISAPLTVSASGPALL 1473
Cdd:pfam06333 223 -------DETWGVILSHRLNNSPSLTelQPPLASGYL---VKRPGTADNDCPVFL 267
|
|
| |
