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Conserved domains on  [gi|5803165|ref|NP_006799|]
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protein transport protein Sec61 subunit beta [Homo sapiens]

Protein Classification

SEC61-beta family protein( domain architecture ID 10511259)

SEC61-beta family protein similar to Homo sapiens protein transport protein Sec61 subunit beta, which is a component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sec61_beta pfam03911
Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61 ...
 54-91 9.46e-18

Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane.


:

Pssm-ID: 427582  Cd Length: 38  Bit Score: 69.71  E-value: 9.46e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 5803165    54 GMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWG 91
Cdd:pfam03911  1 GLLRYYEEDAPGIKIDPKVVLVLSLAFIASVILLHILA 38
 
Name Accession Description Interval E-value
Sec61_beta pfam03911
Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61 ...
 54-91 9.46e-18

Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane.


Pssm-ID: 427582  Cd Length: 38  Bit Score: 69.71  E-value: 9.46e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 5803165    54 GMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWG 91
Cdd:pfam03911  1 GLLRYYEEDAPGIKIDPKVVLVLSLAFIASVILLHILA 38
PRK01253 PRK01253
preprotein translocase subunit Sec61beta;
54-89 5.59e-05

preprotein translocase subunit Sec61beta;


Pssm-ID: 179263  Cd Length: 54  Bit Score: 37.59  E-value: 5.59e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 5803165   54 GMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHI 89
Cdd:PRK01253 15 GLIRYFEEETEAIKIDPKTVIAIGLALGIFVLVLNA 50
SBH1 COG4023
Preprotein translocase subunit SecG (Sec61beta) [Intracellular trafficking, secretion, and ...
 40-91 2.71e-04

Preprotein translocase subunit SecG (Sec61beta) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443201  Cd Length: 55  Bit Score: 35.59  E-value: 2.71e-04
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 5803165  40 GTRSAGRTTSAGtggMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWG 91
Cdd:COG4023  4 KKKGGGLMSSAG---LVRYFEEDTKGIKIDPKTVVAIGIALGVIVIILNILL 52
 
Name Accession Description Interval E-value
Sec61_beta pfam03911
Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61 ...
 54-91 9.46e-18

Sec61beta family; This family consists of homologs of Sec61beta - a component of the Sec61/SecYEG protein secretory system. The domain is found in eukaryotes and archaea and is possibly homologous to the bacterial SecG. It consists of a single putative transmembrane helix, preceded by a short stretch containing various charged residues; this arrangement may help determine orientation in the cell membrane.


Pssm-ID: 427582  Cd Length: 38  Bit Score: 69.71  E-value: 9.46e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 5803165    54 GMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWG 91
Cdd:pfam03911  1 GLLRYYEEDAPGIKIDPKVVLVLSLAFIASVILLHILA 38
PRK01253 PRK01253
preprotein translocase subunit Sec61beta;
54-89 5.59e-05

preprotein translocase subunit Sec61beta;


Pssm-ID: 179263  Cd Length: 54  Bit Score: 37.59  E-value: 5.59e-05
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 5803165   54 GMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHI 89
Cdd:PRK01253 15 GLIRYFEEETEAIKIDPKTVIAIGLALGIFVLVLNA 50
SBH1 COG4023
Preprotein translocase subunit SecG (Sec61beta) [Intracellular trafficking, secretion, and ...
 40-91 2.71e-04

Preprotein translocase subunit SecG (Sec61beta) [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443201  Cd Length: 55  Bit Score: 35.59  E-value: 2.71e-04
                       10        20        30        40        50
               ....*....|....*....|....*....|....*....|....*....|..
gi 5803165  40 GTRSAGRTTSAGtggMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWG 91
Cdd:COG4023  4 KKKGGGLMSSAG---LVRYFEEDTKGIKIDPKTVVAIGIALGVIVIILNILL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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