NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|5902152|ref|NP_008884|]
View 

uroplakin-3a isoform 1 precursor [Homo sapiens]

Protein Classification

UP_IIIa domain-containing protein( domain architecture ID 10177859)

UP_IIIa domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 17-228 3.15e-139

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


:

Pssm-ID: 197379  Cd Length: 212  Bit Score: 390.88  E-value: 3.15e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 96
Cdd:cd09970   1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   97 TGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLV 176
Cdd:cd09970  81 TGPYKAAAFDLPPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFKGLCNPPLSAATEYRFKYVLVNMSTGLV 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 5902152  177 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228
Cdd:cd09970 161 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
 
Name Accession Description Interval E-value
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 17-228 3.15e-139

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 390.88  E-value: 3.15e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 96
Cdd:cd09970   1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   97 TGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLV 176
Cdd:cd09970  81 TGPYKAAAFDLPPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFKGLCNPPLSAATEYRFKYVLVNMSTGLV 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 5902152  177 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228
Cdd:cd09970 161 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
 
Name Accession Description Interval E-value
UP_IIIa cd09970
Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is ...
 17-228 3.15e-139

Uroplakin IIIa; Uroplakin IIIa, mayor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197379  Cd Length: 212  Bit Score: 390.88  E-value: 3.15e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   17 SAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 96
Cdd:cd09970   1 SAVNLQPQLASVTFATNNPTLTTITLEKPFCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   97 TGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLV 176
Cdd:cd09970  81 TGPYKAAAFDLPPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFKGLCNPPLSAATEYRFKYVLVNMSTGLV 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 5902152  177 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228
Cdd:cd09970 161 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILSTLPFFLLVGFAG 212
UP_III cd09968
Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a ...
 17-228 9.59e-82

Uroplakin III; Uroplakin IIIa and IIIb, the dimerization partners of uroplakin Ib, are a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197377  Cd Length: 187  Bit Score: 244.21  E-value: 9.59e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   17 SAVNLQPQLASvTFATNNPTLTTVALEKPLCMFDSKEalTGTHEVYLYVLVDSAISRNASVQDSTNTplGSTFLQTEGGR 96
Cdd:cd09968   1 EAVSYVPQLAS-TFLEGNPTSTTFTLEQPRCVFDSSA--SDTDDVWLVVAVSNATNNFNAPQNSTDP--ISTYSQFSGGQ 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   97 TGPYKAVAFDLIPCSDLPsldaigdvskasqiLNAYLVRVGANGTCLWDPNfqglCNAPLSAATEYRFKYVLVNMSTglV 176
Cdd:cd09968  76 YYLTLRASRDLYPCGNPS--------------LNAYVLRVGADGNCTDNGN----CNGPLPGPGPYRVKYLVMNGSG--V 135

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 5902152  177 EDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228
Cdd:cd09968 136 VAQTNWSDPIRLNQAKSYQTIDTWPGRRSGGMIVITSILSVLLALLLLALLA 187
UP_III_II cd09966
Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with ...
 19-228 6.24e-64

Uroplakin IIIb, IIIa and II; Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains separating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers; six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197375  Cd Length: 181  Bit Score: 198.80  E-value: 6.24e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   19 VNLQPQLASVTFAtNNPTLTTVALEKPLCMFDSkealTGTHEVYLYVLVDSAISRNASVQDSTNTPlgsTFLQTEGGRTG 98
Cdd:cd09966   1 LSYVPQLTASTGA-GNPTLSTFTLEQPPCMFDS----SSTDDVWLVVALPNATLAFQNVTLSTDIS---TYLTFTTGNYY 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   99 PYKAVAFDLIPCSDLPSldaigdvskasqILNAYLVRVGANGTCLWDpnfqgLCNAPLSAATEYRFKYVLVNMStgLVED 178
Cdd:cd09966  73 KTLRASFDLPPCRNRRD------------IVSAYVLRVGNTTTCLSG-----YCNTPLPGPGPYRVKYLVMNGS--GPSA 133

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 5902152  179 QTLWSDPIRTNQLTPYSTidTWPGRRSGGMIVITSILGSLPFFLLVGFAG 228
Cdd:cd09966 134 QTEWSTPIRLNQNKIYST--TWPGARSGGMIVITVILSVLMFLLLVALIA 181
UP_IIIb cd09969
Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is ...
 19-226 1.45e-29

Uroplakin IIIb; Uroplakin IIIb, minor isoform of the dimerization partner of uroplakin Ib, is a members of the uroplakin family. Uroplakins (UPs) are a family of proteins that associate with each other to form plaques on the apical surface of the urothelium, the pseudo-stratified epithelium lining the urinary tract from renal pelvis to the bladder outlet. UPs are classified into 3 types: UPIa and UPIb, UPII, and UPIIIa and IIIb. UPIs are tetraspanins that have four transmembrane domains seperating one large and one small extracellular domain while UPII and UPIIIs are single-pass transmembrane proteins. UPIa and UPIb form specific heterodimers with UPII and UPIII, respectively, which allows them to exit the endoplasmatic rediculum. UPII/UPIa and UPIIIs/UPIb form heterotetramers and six of these tetramers form the 16nm particle, seen in the hexagonal array of the asymmetric unit membrane, which is believed to form a urinary tract barrier. Uroplakins are also believed to play a role during urinary tract morphogenesis.


Pssm-ID: 197378  Cd Length: 184  Bit Score: 110.56  E-value: 1.45e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   19 VNLQPQLASVTFAtNNPTLTTVALEKPLCMFDSKEAltgTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTG 98
Cdd:cd09969   3 ISYVPQLTPAPLE-GRITSSTFVLEQPRCVFSSSSD---GDDIWLVVALSNATQNFNAPVKSSDIPTASSFSTKGYYLTL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902152   99 PykaVAFDLIPCSDLPSldaigdvskasqilNAYLVRVGANGTClwDPNFqglCNAPLSAATEYRFKYVLVNMSTglVED 178
Cdd:cd09969  79 R---ASRALYPCGNPSM--------------GLPVLRVGADTGC--TDNN---CNGPLPGPGPYRVKFLVMNNRG--PVA 134

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 5902152  179 QTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGF 226
Cdd:cd09969 135 ETNWSDPITLRTGKSPQTIDTWPGRRSGGMIVITTILSVLLALLLLAL 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH