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Conserved domains on  [gi|5921465|ref|NP_008915|]
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claudin-10 isoform b [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 10467089)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
4-179 4.55e-48

PMP-22/EMP/MP20/Claudin family;


:

Pssm-ID: 395662  Cd Length: 162  Bit Score: 155.61  E-value: 4.55e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465      4 TASEIIAFMVSISGWV--LVSSTLPtDYWKVSTIDGtvittATYWANLWKACVTDS-TGVSNCKdfpsMLALDGYIQACR 80
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVilLFVATIP-DQWKVSRYVG-----AAASAGLWRNCTTQScTGQISCK----VLELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465     81 GLMIAAVSLGFFGSIFALFGMKCTKVGGSDKakakiacLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGA 160
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNRKYSFGY 143

                         170
                  ....*....|....*....
gi 5921465    161 ALFIGWAGASLCIIGGVIF 179
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
4-179 4.55e-48

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 155.61  E-value: 4.55e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465      4 TASEIIAFMVSISGWV--LVSSTLPtDYWKVSTIDGtvittATYWANLWKACVTDS-TGVSNCKdfpsMLALDGYIQACR 80
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVilLFVATIP-DQWKVSRYVG-----AAASAGLWRNCTTQScTGQISCK----VLELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465     81 GLMIAAVSLGFFGSIFALFGMKCTKVGGSDKakakiacLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGA 160
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNRKYSFGY 143

                         170
                  ....*....|....*....
gi 5921465    161 ALFIGWAGASLCIIGGVIF 179
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
 
Name Accession Description Interval E-value
PMP22_Claudin pfam00822
PMP-22/EMP/MP20/Claudin family;
4-179 4.55e-48

PMP-22/EMP/MP20/Claudin family;


Pssm-ID: 395662  Cd Length: 162  Bit Score: 155.61  E-value: 4.55e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465      4 TASEIIAFMVSISGWV--LVSSTLPtDYWKVSTIDGtvittATYWANLWKACVTDS-TGVSNCKdfpsMLALDGYIQACR 80
Cdd:pfam00822   1 MLVLLLGFIVSHIAWVilLFVATIP-DQWKVSRYVG-----AAASAGLWRNCTTQScTGQISCK----VLELNDALQAVQ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465     81 GLMIAAVSLGFFGSIFALFGMKCTKVGGSDKakakiacLAGIVFILSGLCSMTGCSLYANKITTEFFDPLFVEQKYELGA 160
Cdd:pfam00822  71 ALMILSIILGIISLIVFFFQLFTMRKGGRFK-------LAGIIFLVSGLCVLVGASIYTSRIATDFGNPFTPNRKYSFGY 143

                         170
                  ....*....|....*....
gi 5921465    161 ALFIGWAGASLCIIGGVIF 179
Cdd:pfam00822 144 SFILGWVAFALAFIGGVLY 162
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 15-179 1.25e-03

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 38.56  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465     15 ISGWVLVSSTLPTDYWKVSTIDGTVITTATY---WANLWKAC-----VTDS----------TGVSNCKDFPSMLALDGYI 76
Cdd:pfam13903   1 ILAFALLLIAFATDYWLVLDVALTGINNYTClfaHLGLWRHCfksevDVDSdnqtrffgclNQVPNPFPTFEEEIVSFSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5921465     77 QACRGLMIAAVSLGFFGSIFALFGMKCTKVGGSDKaKAKIACLAGIVFILSGLCSMTGCSLYANK---ITTEFFDPLFVE 153
Cdd:pfam13903  81 TSLPGLTRFVQAFAILSLVLIVCGVVCGLLALPKQ-SVFLLLAAGILFLLSGVLGLLGVIVFGQSvklVFEEYFRQWMPE 159

                         170       180       190
                  ....*....|....*....|....*....|
gi 5921465    154 Q----KYELGAALFIGWAGASLCIIGGVIF 179
Cdd:pfam13903 160 HqnnvRISFGWSFALAWAGVVLSLLAGLLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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