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Conserved domains on  [gi|133922600|ref|NP_008987|]
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CLK4-associating serine/arginine rich protein isoform 1 [Homo sapiens]

Protein Classification

CLK4-associating serine/arginine rich family protein( domain architecture ID 10560954)

CLK4-associating serine/arginine rich family protein probably functions as an alternative splicing regulator and may act by regulating members of the CLK kinase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 41-169 5.91e-48

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 164.80  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133922600   41 LQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTP---PLLTTISPEQESDERKCNYERYR 117
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgrsARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 133922600  118 GLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDekkKLAEKKASIGYTYED 169
Cdd:pfam09750  81 DLIKNEFEGVSEEEELKRIYQEEQFGAKRLSAAK---KSSGSYAAIGFSYDD 129
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 41-169 5.91e-48

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 164.80  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133922600   41 LQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTP---PLLTTISPEQESDERKCNYERYR 117
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgrsARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 133922600  118 GLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDekkKLAEKKASIGYTYED 169
Cdd:pfam09750  81 DLIKNEFEGVSEEEELKRIYQEEQFGAKRLSAAK---KSSGSYAAIGFSYDD 129
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 41-169 5.91e-48

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 164.80  E-value: 5.91e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133922600   41 LQVHGRACKVHLDSAVALAAESPVNMMPWQGDTNNMIDRFDVRAHLDHIPDYTP---PLLTTISPEQESDERKCNYERYR 117
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEAgrsARLSELTSEEEEEERECNYERYR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 133922600  118 GLVQNDFAGISEEQCLYQIYIDELYGGLQRPSEDekkKLAEKKASIGYTYED 169
Cdd:pfam09750  81 DLIKNEFEGVSEEEELKRIYQEEQFGAKRLSAAK---KSSGSYAAIGFSYDD 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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