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Conserved domains on  [gi|5902134|ref|NP_009005|]
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coronin-1A [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-461 2.54e-114

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 344.95  E-value: 2.54e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134     9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134    88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAM 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421 394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                 ....*..
gi 5902134   455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 2.54e-114

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 344.95  E-value: 2.54e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134     9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134    88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAM 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421 394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                 ....*..
gi 5902134   455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.87e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 1.87e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5902134      4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-302 1.55e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.55e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   76 TVCGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNV 155
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  156 IMVWDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEkdrpHEG-TRPVRAVFVS--EG 232
Cdd:cd00200 117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGE 190

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5902134  233 KILTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200 191 KLLSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
76-293 1.42e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.42e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   76 TVCGHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNV 155
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  156 IMVWDVGTGAAMLTLGPevHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVaekdRPHEG-TRPVRAV-FVSEGK 233
Cdd:COG2319 270 VRLWDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGK 343

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  234 ILTTGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319 344 TLASGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 2.63e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.63e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 5902134      79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 2.54e-114

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 344.95  E-value: 2.54e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134     9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134    88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAM 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421 162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421 239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421 317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421 394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                 ....*..
gi 5902134   455 EETVQAK 461
Cdd:PTZ00421 473 REALQKK 479
PTZ00420 PTZ00420
coronin; Provisional
 18-394 8.58e-67

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 224.06  E-value: 8.58e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134    18 PAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRvdkNAPTVC--GHTAPVLDIAWCPHNDN 95
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSE 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134    96 VIASGSEDCTVMVWEIP-DGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLgpeV 174
Cdd:PTZ00420  89 ILASGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI---N 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   175 HPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVvAEKDRPHEGTRPVRAVFV-----SEGKILTTGFSRMSERQVAL 249
Cdd:PTZ00420 166 MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEI-ASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   250 WDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRGLEV 329
Cdd:PTZ00420 245 WDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDV 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5902134   330 NKCEIARFYK-LHERRCEPIAMTVPRK-SDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKD 394
Cdd:PTZ00420 323 YKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD 389
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.87e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 1.87e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5902134      4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
Trimer_CC pfam08954
trimerization motif; This domain is predominantly found in the structural protein coronin, and ...
 410-461 8.37e-30

trimerization motif; This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins.


Pssm-ID: 462646  Cd Length: 52  Bit Score: 110.02  E-value: 8.37e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 5902134    410 LDTGRRRAAPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 461
Cdd:pfam08954   1 LDSGRRRATPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 52
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-302 1.55e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.55e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   76 TVCGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNV 155
Cdd:cd00200  46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  156 IMVWDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEkdrpHEG-TRPVRAVFVS--EG 232
Cdd:cd00200 117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGE 190

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5902134  233 KILTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200 191 KLLSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
76-293 1.42e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.55  E-value: 1.42e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   76 TVCGHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNV 155
Cdd:COG2319 199 TLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG-------KLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGT 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  156 IMVWDVGTGAAMLTLGPevHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVaekdRPHEG-TRPVRAV-FVSEGK 233
Cdd:COG2319 270 VRLWDLATGELLRTLTG--HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL----RTLTGhTGAVRSVaFSPDGK 343

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  234 ILTTGFsrmSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYLCGkGDSSIR 293
Cdd:COG2319 344 TLASGS---DDGTVRLWDLATGELLRTLT--GHTGAVTSVAFSPDGRTLASGS-ADGTVR 397
WD40 COG2319
WD40 repeat [General function prediction only];
79-303 1.25e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.16  E-value: 1.25e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNVIMV 158
Cdd:COG2319 118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  159 WDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAekdRPHEGTRPVRAVFVS-EGKILTT 237
Cdd:COG2319 189 WDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSpDGRLLAS 263

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5902134  238 GfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVyLCGKGDSSIRYFEITSEAPF 303
Cdd:COG2319 264 G---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-238 3.40e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 3.40e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   79 GHTAPVLDIAWCPHNDnVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQNvLLSAGCDNVIMV 158
Cdd:cd00200 133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  159 WDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRpHEGtrPVRAVFVS-EGKILTT 237
Cdd:cd00200 204 WDLSTGKCLGTL--RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG-HTN--SVTSLAWSpDGKRLAS 278


                .
gi 5902134  238 G 238
Cdd:cd00200 279 G 279
WD40 COG2319
WD40 repeat [General function prediction only];
79-202 3.13e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 3.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNVIMV 158
Cdd:COG2319 286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRL 356

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 5902134  159 WDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:COG2319 357 WDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-202 2.88e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 2.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglmlplrEPVVTLEGHTKRVGIVAWHTTaQNVLLSAGCDNVIMV 158
Cdd:cd00200 175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 5902134  159 WDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:cd00200 246 WDLRTGECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 5.43e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 82.95  E-value: 5.43e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 5902134    345 CEPIAMTVPRKS-DLFQEDLYPPTAGPDPALTAEEWLGGRDAGP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-299 2.09e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 2.09e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  126 TLEGHTKRVGIVAWHTTaQNVLLSAGCDNVIMVWDVGTGAAMLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEP 205
Cdd:cd00200   4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  206 RKGTVVAEKdRPHEGtrPVRAV-FVSEGKILTTGfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVYl 284
Cdd:cd00200  81 ETGECVRTL-TGHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFVA- 151

                       170
                ....*....|....*
gi 5902134  285 CGKGDSSIRYFEITS 299
Cdd:cd00200 152 SSSQDGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
79-163 2.49e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGGLmlplrepVVTLEGHTKRVGIVAWHTTAQnVLLSAGCDNVIMV 158
Cdd:COG2319 328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL-------LRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                ....*
gi 5902134  159 WDVGT 163
Cdd:COG2319 399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 2.63e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.63e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 5902134      79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
76-110 2.78e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.78e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 5902134     76 TVCGHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-160 1.57e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.57e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 5902134     121 REPVVTLEGHTKRVGIVAWHTTaQNVLLSAGCDNVIMVWD 160
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
121-160 1.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 5902134    121 REPVVTLEGHTKRVGIVAWHTTaQNVLLSAGCDNVIMVWD 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-110 1.94e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.94e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 5902134   76 TVCGHTAPVLDIAWCPHNdNVIASGSEDCTVMVWE 110
Cdd:cd00200 256 TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
126-262 1.99e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 1.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5902134  126 TLEGHTKRVGIVAWHTTAQNVLLSAGcDNVIMVWDVGTGAAMLTLGPevHPDTIYSVDWSRDGGLICTSCRDKRVRIIEP 205
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 5902134  206 RKGTVVAEkDRPHEGtrPVRAVFVS-EGKILTTGFsrmSERQVALWDTKHLEEPLSLQ 262
Cdd:COG2319 108 ATGLLLRT-LTGHTG--AVRSVAFSpDGKTLASGS---ADGTVRLWDLATGKLLRTLT 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-202 2.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.77e-04
                           10        20
                   ....*....|....*....|....*...
gi 5902134     175 HPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 pfam00400
WD domain, G-beta repeat;
175-202 5.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.94e-04
                          10        20
                  ....*....|....*....|....*...
gi 5902134    175 HPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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