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Conserved domains on  [gi|28376656|ref|NP_009088|]
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zinc finger X-linked protein ZXDB [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11986654)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
344-539 9.26e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 9.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 344 SFTTVYNLKAHMKGHEQENSFKC--------EVCEESFPTQAKLSA-HQRSHFEPER----PYQCafSGCKKTFITVSAL 410
Cdd:COG5048 228 PLTTNSQLSPKSLLSQSPSSLSSsdssssasESPRSSLPTASSQSSsPNESDSSSEKgfslPIKS--KQCNISFSRSSPL 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 411 FSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMS-----KLLRHKRKHDDDR 482
Cdd:COG5048 306 TRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDK 385

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28376656 483 RFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHL 539
Cdd:COG5048 386 KSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-747 1.98e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 466 TSMSKLLRHKRKHDDDRRFMCPveGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTW 545
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 546 KSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDT 625
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 626 ALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSS---LNMDEVSSVS 702
Cdd:COG5048 174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqSPSSLSSSDS 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 28376656 703 VGPlgSLDSLAMKNSSPEPQALTPSSKLTVDTDALT--PSSTLCENS 747
Cdd:COG5048 254 SSS--ASESPRSSLPTASSQSSSPNESDSSSEKGFSlpIKSKQCNIS 298
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 304-328 3.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*
gi 28376656   304 FKCPlgGCGWTFTTSYKLKRHLQSH 328
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
344-539 9.26e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 9.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 344 SFTTVYNLKAHMKGHEQENSFKC--------EVCEESFPTQAKLSA-HQRSHFEPER----PYQCafSGCKKTFITVSAL 410
Cdd:COG5048 228 PLTTNSQLSPKSLLSQSPSSLSSsdssssasESPRSSLPTASSQSSsPNESDSSSEKgfslPIKS--KQCNISFSRSSPL 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 411 FSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMS-----KLLRHKRKHDDDR 482
Cdd:COG5048 306 TRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDK 385

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28376656 483 RFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHL 539
Cdd:COG5048 386 KSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 336-413 1.24e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 47.41  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656   336 CPAEGCGKSFTTVYNLKAHMKGH------EQENSFKCEV--CEESFPTQAKLSAHQRSHFEPERPYQCafSGCKKTFITV 407
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKC--ENCLLRFRTH 79


                  ....*.
gi 28376656   408 SALFSH 413
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-747 1.98e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 466 TSMSKLLRHKRKHDDDRRFMCPveGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTW 545
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 546 KSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDT 625
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 626 ALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSS---LNMDEVSSVS 702
Cdd:COG5048 174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqSPSSLSSSDS 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 28376656 703 VGPlgSLDSLAMKNSSPEPQALTPSSKLTVDTDALT--PSSTLCENS 747
Cdd:COG5048 254 SSS--ASESPRSSLPTASSQSSSPNESDSSSEKGFSlpIKSKQCNIS 298
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 304-328 3.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*
gi 28376656   304 FKCPlgGCGWTFTTSYKLKRHLQSH 328
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 522-573 7.25e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 7.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 28376656 522 CAR-FSARSSLYIHSK-KHLqdvdtwksRCPIssCNKLFTSKHSMKTHMVKRHK 573
Cdd:cd20908   7 CDReFDDEKILIQHQKaKHF--------KCHI--CHKKLYTAGGLAVHCLQVHK 50
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
344-539 9.26e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 9.26e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 344 SFTTVYNLKAHMKGHEQENSFKC--------EVCEESFPTQAKLSA-HQRSHFEPER----PYQCafSGCKKTFITVSAL 410
Cdd:COG5048 228 PLTTNSQLSPKSLLSQSPSSLSSsdssssasESPRSSLPTASSQSSsPNESDSSSEKgfslPIKS--KQCNISFSRSSPL 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 411 FSHNRA---HFREQELFSCSFPGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMS-----KLLRHKRKHDDDR 482
Cdd:COG5048 306 TRHLRSvnhSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnneppQSLQQYKDLKNDK 385

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28376656 483 RFMCPVEGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHL 539
Cdd:COG5048 386 KSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-478 8.77e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 8.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 270 LYLCPEAQCGQTFAKKHQLKVHL-LTHSSSQGQRPFKCPLGGCGWTFTTSYKLKRHLQSHDKLRPFGCPAEGCGKSFttv 348
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF--- 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 349 yNLKAHMKGHEqensfkcevceesfptqaklSAHQRSHFEPERPYQCAFSGCKKTFITVSALFSHNRAHFREQELfSCSF 428
Cdd:COG5048 364 -SPLLNNEPPQ--------------------SLQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPY-NCKN 421

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 28376656 429 PGCSKQYDKACRLKIHLRSHTGERPFLCdfdgCGWNFTSMSKLLRHKRKH 478
Cdd:COG5048 422 PPCSKSFNRHYNLIPHKKIHTNHAPLLC----SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
441-572 8.78e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 8.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 441 LKIHLRS--HTGE--RPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEGCGKSFTRAEHLKGHSITH-----LGT 511
Cdd:COG5048 305 LTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQqykdlKND 384

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28376656 512 KPFVCPVAGCCARFSARSSLYIHSKKHLQDvdtWKSRCPISSCNKLFTSKHSMKTHMVKRH 572
Cdd:COG5048 385 KKSETLSNSCIRNFKRDSNLSLHIITHLSF---RPYNCKNPPCSKSFNRHYNLIPHKKIHT 442
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 336-413 1.24e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 47.41  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656   336 CPAEGCGKSFTTVYNLKAHMKGH------EQENSFKCEV--CEESFPTQAKLSAHQRSHFEPERPYQCafSGCKKTFITV 407
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKC--ENCLLRFRTH 79


                  ....*.
gi 28376656   408 SALFSH 413
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
466-747 1.98e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.98e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 466 TSMSKLLRHKRKHDDDRRFMCPveGCGKSFTRAEHLKGHSITHLGTKPFVCPVAGCCARFSARSSLYIHSKKHLQDVDTW 545
Cdd:COG5048  16 LSSTPKSTLKSLSNAPRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 546 KSRCPISSCNKLFTSKHSMKTHMVKRHKVGQDLLAQLEAANSLTPSSELTSQRQNDLSDAEIVSLFSDVPDSTSAALLDT 625
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 626 ALVNSGILTIDVASVSSTLAGHLPANNNNSVGQAVDPPSLMATSDPPQSLDTSLFFGTAATGFQQSS---LNMDEVSSVS 702
Cdd:COG5048 174 NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLlsqSPSSLSSSDS 253

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 28376656 703 VGPlgSLDSLAMKNSSPEPQALTPSSKLTVDTDALT--PSSTLCENS 747
Cdd:COG5048 254 SSS--ASESPRSSLPTASSQSSSPNESDSSSEKGFSlpIKSKQCNIS 298
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-387 7.60e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 7.60e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28376656 332 RPFGCPAEGCGKSFTTVYNLKAHMK-GH-----------EQENSF-------KCEVCEESFPTQAKLSAHqRSHF 387
Cdd:COG5189 348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHqnqklhenpspEKMNIFsakdkpyRCEVCDKRYKNLNGLKYH-RKHS 421
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 306-382 9.35e-04

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 39.32  E-value: 9.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656   306 CPLGGCGWTFTTSYKLKRHLQSHD------KLRPFGCPAEGCGKSFTTVYNLKAHMKGHEQENS-FKCEVCEESFPTQAK 378
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRyFKCENCLLRFRTHRS 81


                  ....
gi 28376656   379 LSAH 382
Cdd:pfam15909  82 LFKH 85
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 369-426 2.29e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.17  E-value: 2.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28376656   369 CEESFPTQAKLSAHQRSHFEPERP-----YQCAFSGCKKTFITVSALFSHNRAHFREQELFSC 426
Cdd:pfam15909   7 CCLSFPSVRDLAQHLRTHCPPTQSlegklFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKC 69
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-373 2.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....
gi 28376656   350 NLKAHMKGHEQENSFKCEVCEESF 373
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 304-328 3.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.14e-03
                          10        20
                  ....*....|....*....|....*
gi 28376656   304 FKCPlgGCGWTFTTSYKLKRHLQSH 328
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 364-386 3.30e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|...
gi 28376656   364 FKCEVCEESFPTQAKLSAHQRSH 386
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 522-573 7.25e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 7.25e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 28376656 522 CAR-FSARSSLYIHSK-KHLqdvdtwksRCPIssCNKLFTSKHSMKTHMVKRHK 573
Cdd:cd20908   7 CDReFDDEKILIQHQKaKHF--------KCHI--CHKKLYTAGGLAVHCLQVHK 50
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
412-703 7.72e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 7.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 412 SHNRAHFREQELFSCSF-PGCSKQYDKACRLKIHLRSHTGERPFLCDFDGCGWNFTSMSKLLRHKRKHDDDRRFMCPVEG 490
Cdd:COG5048  19 TPKSTLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 491 CGKSFTRAEHLKGHSITHlgtkpfvcpvagccarFSARSSLYIHSKKHLQDVdtwKSRCPISSCNKLFTSKHSMKTHMVK 570
Cdd:COG5048  99 PLSNSKASSSSLSSSSSN----------------SNDNNLLSSHSLPPSSRD---PQLPDLLSISNLRNNPLPGNNSSSV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28376656 571 RHKVGQDLLAQLEAANSLTPSSELTSqrqndlsdaeiVSLFSDVPDSTSAALLDTALVNSGILTIDV-ASVSSTLAGHLP 649
Cdd:COG5048 160 NTPQSNSLHPPLPANSLSKDPSSNLS-----------LLISSNVSTSIPSSSENSPLSSSYSIPSSSsDQNLENSSSSLP 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28376656 650 ANNNNSVGQAVDP---PSLMATSDPPQSLDTSLFFGTAATGFQQSSLNMDEVSSVSV 703
Cdd:COG5048 229 LTTNSQLSPKSLLsqsPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKG 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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