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Conserved domains on  [gi|6005948|ref|NP_009118|]
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WW domain-binding protein 4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10533256)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270|GO:0003700
PubMed:  11179890|11361095|10940247|22803940|12665246
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-U1 pfam06220
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 8-44 2.81e-14

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


:

Pssm-ID: 368798  Cd Length: 38  Bit Score: 66.31  E-value: 2.81e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6005948      8 QPKKFCDYCKCWIADNRPSV-EFHERGKNHKENVAKRI 44
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDSPSVrKSHNGGRKHKDNVKDYY 38
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
128-196 8.94e-09

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 57.01  E-value: 8.94e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6005948  128 WVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:COG5104  17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
 
Name Accession Description Interval E-value
zf-U1 pfam06220
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 8-44 2.81e-14

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


Pssm-ID: 368798  Cd Length: 38  Bit Score: 66.31  E-value: 2.81e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6005948      8 QPKKFCDYCKCWIADNRPSV-EFHERGKNHKENVAKRI 44
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDSPSVrKSHNGGRKHKDNVKDYY 38
PRP40 COG5104
Splicing factor [RNA processing and modification];
128-196 8.94e-09

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 57.01  E-value: 8.94e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6005948  128 WVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:COG5104  17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 8-43 1.95e-08

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 49.56  E-value: 1.95e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 6005948       8 QPKKFCDYCKCWIADNrPSVEFHERGKNHKENVAKR 43
Cdd:smart00451   1 TGGFYCKLCNVTFTDE-ISVEAHLKGKKHKKNVKKR 35
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 169-194 5.58e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 48.27  E-value: 5.58e-08
                          10        20
                  ....*....|....*....|....*.
gi 6005948    169 WVEGLSEDGFTYYYNTETGESRWEKP 194
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 169-196 1.31e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.14  E-value: 1.31e-07
                        10        20
                ....*....|....*....|....*...
gi 6005948  169 WVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:cd00201   4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 169-196 1.50e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 1.50e-07
                           10        20
                   ....*....|....*....|....*...
gi 6005948     169 WVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
 
Name Accession Description Interval E-value
zf-U1 pfam06220
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 8-44 2.81e-14

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


Pssm-ID: 368798  Cd Length: 38  Bit Score: 66.31  E-value: 2.81e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6005948      8 QPKKFCDYCKCWIADNRPSV-EFHERGKNHKENVAKRI 44
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDSPSVrKSHNGGRKHKDNVKDYY 38
PRP40 COG5104
Splicing factor [RNA processing and modification];
128-196 8.94e-09

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 57.01  E-value: 8.94e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6005948  128 WVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:COG5104  17 WEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSEEDLDVDPWKECRTADGKVYYYNSITRESRWKIPPE 85
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 8-43 1.95e-08

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 49.56  E-value: 1.95e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 6005948       8 QPKKFCDYCKCWIADNrPSVEFHERGKNHKENVAKR 43
Cdd:smart00451   1 TGGFYCKLCNVTFTDE-ISVEAHLKGKKHKKNVKKR 35
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 169-194 5.58e-08

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 48.27  E-value: 5.58e-08
                          10        20
                  ....*....|....*....|....*.
gi 6005948    169 WVEGLSEDGFTYYYNTETGESRWEKP 194
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 169-196 1.31e-07

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 47.14  E-value: 1.31e-07
                        10        20
                ....*....|....*....|....*...
gi 6005948  169 WVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:cd00201   4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 169-196 1.50e-07

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 47.21  E-value: 1.50e-07
                           10        20
                   ....*....|....*....|....*...
gi 6005948     169 WVEGLSEDGFTYYYNTETGESRWEKPDD 196
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 128-153 7.92e-06

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 42.11  E-value: 7.92e-06
                          10        20
                  ....*....|....*....|....*.
gi 6005948    128 WVEGITSEGYHYYYDLISGASQWEKP 153
Cdd:pfam00397   5 WEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 128-155 1.08e-05

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 41.74  E-value: 1.08e-05
                        10        20
                ....*....|....*....|....*...
gi 6005948  128 WVEGITSEGYHYYYDLISGASQWEKPEG 155
Cdd:cd00201   4 WEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 123-155 2.08e-04

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 38.35  E-value: 2.08e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 6005948     123 PSKGRWVEGITSEGYHYYYDLISGASQWEKPEG 155
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
PRP40 COG5104
Splicing factor [RNA processing and modification];
165-198 7.89e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 41.60  E-value: 7.89e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 6005948  165 VKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFI 198
Cdd:COG5104  13 ARSEWEELKAPDGRIYYYNKRTGKSSWEKPKELL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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