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Conserved domains on  [gi|6005723|ref|NP_009151|]
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carbonic anhydrase 5B, mitochondrial precursor [Homo sapiens]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 275)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

CATH:  3.10.200.10
Gene Ontology:  GO:0004089|GO:0008270|GO:0006730
PubMed:  10978542|18336305
SCOP:  4002732

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
alpha_CA super family cl00012
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 61-296 1.51e-173

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


The actual alignment was detected with superfamily member cd03118:

Pssm-ID: 469577  Cd Length: 236  Bit Score: 480.11  E-value: 1.51e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd03118   1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSGISGGPLENHYRLKQFHFHWGANNEWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCL 220
Cdd:cd03118  81 SEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSF 296
Cdd:cd03118 161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
 
Name Accession Description Interval E-value
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 61-296 1.51e-173

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 480.11  E-value: 1.51e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd03118   1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSGISGGPLENHYRLKQFHFHWGANNEWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCL 220
Cdd:cd03118  81 SEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSF 296
Cdd:cd03118 161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
52-296 2.32e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 340.78  E-value: 2.32e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723     52 WESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTIS-YD-PATCLHVWNNGYSFLVEFEDStDKSVIKGGPLEHNYRLKQF 129
Cdd:pfam00194   6 WGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQgYDvPPGKNTLTNNGHTVQVSLDDG-DPSTISGGPLATRYRLVQF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    130 HFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRfENFEDAALEENGLAVIGVFLKLGKHH-KELQKLVDTLPSIKHKDA 208
Cdd:pfam00194  85 HFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKY-KSFDEAAKHPDGLAVLGVFFEVGDENnPYLQPIVSALDNIKYKGK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    209 LVEFGSFDPSCLMPTCP-DYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPL 287
Cdd:pfam00194 164 SVLLPPFDLSDLLPEDLtSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNFRPTQPL 243


                  ....*....
gi 6005723    288 MNRTVRSSF 296
Cdd:pfam00194 244 NGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 60-291 1.81e-111

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 323.11  E-value: 1.81e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723      60 GGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDstDKSVIKGGPLEHNYRLKQFHFHWGAIDAW 139
Cdd:smart01057  21 GGKRQSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDD--DGSTLSGGPLPGRYRLKQFHFHWGGSDSE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723     140 GSEHTVDSKCFPAELHLVHWNAVrfENFEDAALEENGLAVIGVFLKLGKHH-KELQKLVDTLPSIKHKDALVEFGSFDPS 218
Cdd:smart01057  99 GSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDHLPLIKYKGQETELTPFDLS 176

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005723     219 CLMPT-CPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEkekRMVDNFRPLQPLMNRT 291
Cdd:smart01057 177 SLLPAsTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGNE---PLVNNARPLQPLNGRV 247
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
61-295 2.42e-61

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 195.49  E-value: 2.42e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRwrdSVYDPGLKPLTISYDPATcLHVWNNGYSFLVEFEDstdksvikGGPLE---HNYRLKQFHFHWGaid 137
Cdd:COG3338  52 GKNQSPIDIR---TAIKADLPPLKFDYKPTP-LEIVNNGHTIQVNVDP--------GSTLTvdgKRYELKQFHFHTP--- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  138 awgSEHTVDSKCFPAELHLVHWNAvrfenfedaaleENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGsFDP 217
Cdd:COG3338 117 ---SEHTINGKSYPMEAHLVHKDA------------DGELAVVGVLFEEGAENPALAKLWANLPLEAGEEVALDAT-IDL 180

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005723  218 SCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLlftsegekekrMVDNFRPLQPLMNRTVRSS 295
Cdd:COG3338 181 NDLLPEDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL-----------YPNNARPVQPLNGRLILES 247
PLN02179 PLN02179
carbonic anhydrase
 48-250 7.77e-17

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 78.10  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    48 LHPLWEsvdLVPGGDRQSPINIR-WRDS-VYDpglKPLTISYDPATCLhVWNNGYSFLVEFEDSTDKSVIKggplEHNYR 125
Cdd:PLN02179  53 LNPQWK---VCSTGKYQSPIDLTdERVSlIHD---QALSRHYKPAPAV-IQSRGHDVMVSWKGDAGKITIH----QTDYK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   126 LKQFHFHWGaidawgSEHTVDSKCFPAELHLVHWNAvrfenfedaaleENGLAVIGVFLKLGKHHKELQKLVDTLPSIKH 205
Cdd:PLN02179 122 LVQCHWHSP------SEHTINGTSYDLELHMVHTSA------------SGKTAVVGVLYKLGEPDEFLTKLLNGIKGVGK 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 6005723   206 KDalVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQ 250
Cdd:PLN02179 184 KE--INLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTVVKR 226
 
Name Accession Description Interval E-value
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
 61-296 1.51e-173

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 480.11  E-value: 1.51e-173
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd03118   1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIWNNGYSFQVEFDDSTDKSGISGGPLENHYRLKQFHFHWGANNEWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCL 220
Cdd:cd03118  81 SEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAHHEGLQKLVDALPEVRHKDTVVEFNPFDPSCL 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSF 296
Cdd:cd03118 161 LPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSSF 236
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
 61-296 2.77e-123

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 352.99  E-value: 2.77e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd03149   1 GNRQSPIDIVSSEAVYDPKLKPLSLSYDPCTSLSISNNGHSVMVEFDDSDDKTVITGGPLENPYRLKQFHFHWGAKHGSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCL 220
Cdd:cd03149  81 SEHTVDGKTFPSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGDEHPGLNRLTDALYMVRFKGTKAQFLDFNPKCL 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSF 296
Cdd:cd03149 161 LPKSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNHMVNNFRPPQPLKGRTVRASF 236
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
 61-296 2.39e-120

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 346.35  E-value: 2.39e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd03119  25 GDRQSPIDIKTKDAKHDPSLKPLSVSYDPATAKTILNNGHSFNVEFDDTDDRSVLRGGPLTGSYRLRQFHFHWGSSDDHG 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNaVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCL 220
Cdd:cd03119 105 SEHTVDGVKYAAELHLVHWN-SKYGSFGEAAKQPDGLAVVGVFLKVGEANPELQKVLDALDSIKTKGKQAPFTNFDPSCL 183

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSF 296
Cdd:cd03119 184 LPASLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNAEGEPPCPMVDNWRPPQPLKGRKVRASF 259
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
52-296 2.32e-118

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 340.78  E-value: 2.32e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723     52 WESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTIS-YD-PATCLHVWNNGYSFLVEFEDStDKSVIKGGPLEHNYRLKQF 129
Cdd:pfam00194   6 WGKVYPSCGGKRQSPINIDTRKVRYDPSLPPLTFQgYDvPPGKNTLTNNGHTVQVSLDDG-DPSTISGGPLATRYRLVQF 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    130 HFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRfENFEDAALEENGLAVIGVFLKLGKHH-KELQKLVDTLPSIKHKDA 208
Cdd:pfam00194  85 HFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSKY-KSFDEAAKHPDGLAVLGVFFEVGDENnPYLQPIVSALDNIKYKGK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    209 LVEFGSFDPSCLMPTCP-DYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPL 287
Cdd:pfam00194 164 SVLLPPFDLSDLLPEDLtSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRPLVNNFRPTQPL 243


                  ....*....
gi 6005723    288 MNRTVRSSF 296
Cdd:pfam00194 244 NGRVVFASF 252
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
 60-291 1.81e-111

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 323.11  E-value: 1.81e-111
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723      60 GGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDstDKSVIKGGPLEHNYRLKQFHFHWGAIDAW 139
Cdd:smart01057  21 GGKRQSPIDIVTAEAQYDPSLKPLKLSYDQPTAKRILNNGHTVQVNFDD--DGSTLSGGPLPGRYRLKQFHFHWGGSDSE 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723     140 GSEHTVDSKCFPAELHLVHWNAVrfENFEDAALEENGLAVIGVFLKLGKHH-KELQKLVDTLPSIKHKDALVEFGSFDPS 218
Cdd:smart01057  99 GSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEnPALQAILDHLPLIKYKGQETELTPFDLS 176

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6005723     219 CLMPT-CPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEkekRMVDNFRPLQPLMNRT 291
Cdd:smart01057 177 SLLPAsTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLPMEGNE---PLVNNARPLQPLNGRV 247
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
 61-293 2.50e-106

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 309.60  E-value: 2.50e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDstDKSVIKGGPLEHNYRLKQFHFHWGAIDAWG 140
Cdd:cd00326   1 GKRQSPINIVTSAVVYDPSLPPLNFDYYPTTSLTLVNNGHTVQVNFDD--DGGTLSGGGLPGRYKLVQFHFHWGSENSPG 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNAVRFENfeDAALEENGLAVIGVFLKLG-KHHKELQKLVDTLPSIKHKDALVEFGSFDPSC 219
Cdd:cd00326  79 SEHTIDGKRYPLELHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGeKENPFLKKILDALPKIKYKGKETTLPPFDLSD 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6005723  220 LMPTCP-DYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSegekEKRMVDNFRPLQPLMNRTVR 293
Cdd:cd00326 157 LLPSSLrDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDRE----GKPLVNNYRPVQPLNGRVVY 227
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
 61-296 1.53e-64

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 203.93  E-value: 1.53e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLK--PLTISYDPATCLHVWNNGYSFLVEFEDstdKSVIKGGPL--EHNYRLKQFHFHWGAI 136
Cdd:cd03120  13 GEYQSPINLNSREARYDPSLLevRLSPNYVVCRDCEVINDGHTIQIILKS---KSVLSGGPLpqGHEFELAEVRFHWGRE 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  137 DAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFD 216
Cdd:cd03120  90 NQRGSEHTVNFKAFPMELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKEHVGLKAVTEILQDIQYKGKSKTIPCFN 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  217 PSCLM--PTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEK-----EKRMVDNFRPLQPLMN 289
Cdd:cd03120 170 PNTLLpdPLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAElvegcDGLLGDNFRPTQPLSD 249


                ....*..
gi 6005723  290 RTVRSSF 296
Cdd:cd03120 250 RVIRAAF 256
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
 61-292 1.25e-63

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 200.96  E-value: 1.25e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPGLKPLT-ISYD-PATCLHVWNNGYSFLVEFEDSTDksvIKGGPLEHNYRLKQFHFHWGAIDA 138
Cdd:cd03117   1 GKRQSPINIVTKKVQYDENLTPFTfTGYDdTTTNWTITNNGHTVQVTLPDGAK---ISGGGLPGTYKALQFHFHWGSNGS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  139 WGSEHTVDSKCFPAELHLVHWNAvRFENFEDAALEENGLAVIGVFLKLGK-HHKELQKLVDTLPSIKHKDALVEFGSFDP 217
Cdd:cd03117  78 PGSEHTIDGERYPMELHIVHIKE-SYNSLLEALKDSDGLAVLGFFIEEGEeENTNFDPLISALSNIPQKGGSTNLTPFSL 156

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6005723  218 SCLMPtcPD----YWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKeKRMVDNFRPLQPLMNRTV 292
Cdd:cd03117 157 RSLLP--SVlltkYYRYNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDTDNG-QPMVNNFRPVQPLNGRVV 232
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
 60-296 1.76e-61

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 195.99  E-value: 1.76e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   60 GGDRQSPINIRWRDSVYDPGLKPLTIS-YD--PATCLHVWNNGYSFLVEFEDSTdksVIKGGPLEHnYRLKQFHFHWGAI 136
Cdd:cd03123  13 GGKRQSPIDIQTDIVQFDPSLPPLELVgYDlpGTEEFTLTNNGHTVQLSLPPTM---HIRGGPGTE-YTAAQLHLHWGGR 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  137 D-AWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKE-LQKLVDTLPSIKHKDALVEFGS 214
Cdd:cd03123  89 GsLSGSEHTIDGIRFAAELHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGYPENTyYEKIISHLHEIKYKGQETTVPG 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  215 FDPSCLMPTCPD-YWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEgekEKRMVDNFRPLQPLMNRTVR 293
Cdd:cd03123 169 FNVRELLPEDLShYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLETLENTLMDTH---NKTLQNNYRATQPLNGRVVE 245


                ...
gi 6005723  294 SSF 296
Cdd:cd03123 246 ASF 248
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
61-295 2.42e-61

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 195.49  E-value: 2.42e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRwrdSVYDPGLKPLTISYDPATcLHVWNNGYSFLVEFEDstdksvikGGPLE---HNYRLKQFHFHWGaid 137
Cdd:COG3338  52 GKNQSPIDIR---TAIKADLPPLKFDYKPTP-LEIVNNGHTIQVNVDP--------GSTLTvdgKRYELKQFHFHTP--- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  138 awgSEHTVDSKCFPAELHLVHWNAvrfenfedaaleENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGsFDP 217
Cdd:COG3338 117 ---SEHTINGKSYPMEAHLVHKDA------------DGELAVVGVLFEEGAENPALAKLWANLPLEAGEEVALDAT-IDL 180

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6005723  218 SCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLlftsegekekrMVDNFRPLQPLMNRTVRSS 295
Cdd:COG3338 181 NDLLPEDRSYYRYSGSLTTPPCSEGVLWIVLKQPITVSAEQIEAFARL-----------YPNNARPVQPLNGRLILES 247
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
 48-293 6.16e-59

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 189.55  E-value: 6.16e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   48 LHPLWesvDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGY--SFLVEFEDSTDksvIKGGPLEHNYR 125
Cdd:cd03121   8 VNSAW---NLCSKGRRQSPVDIEPSRLLFDPFLTPLRIDTGRKVSGTFYNTGRhvSFRPDKDPVVN---ISGGPLSYRYR 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  126 LKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGK-HHKELQKLV--DTLPS 202
Cdd:cd03121  82 LEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGEtSNPELRRLTnrDTITS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  203 IKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFR 282
Cdd:cd03121 162 IRYKGDAYFLQDLSIELLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPMSPNFR 241

                       250
                ....*....|.
gi 6005723  283 PLQPLMNRTVR 293
Cdd:cd03121 242 PVQPLNNRPVR 252
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
 61-292 1.74e-56

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 182.09  E-value: 1.74e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   61 GDRQSPINIRWRDSVYDPgLKPLTISYDPATcLHVWNNGYSFLVEFEDSTDKSVIKGgpleHNYRLKQFHFHWGaidawg 140
Cdd:cd03124  18 GKNQSPIDITTKAVVSDK-LPPLNYNYKPTS-ATLVNNGHTIQVNFEGNGGTLTIDG----ETYQLLQFHFHSP------ 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  141 SEHTVDSKCFPAELHLVHWNavrfenfedaalEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEfGSFDPSCL 220
Cdd:cd03124  86 SEHLINGKRYPLEAHLVHKS------------KDGQLAVVAVLFEEGKENPFLKKILDNMPKKEGTEVNLP-AILDPNEL 152

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6005723  221 MPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTsegekekrmvDNFRPLQPLMNRTV 292
Cdd:cd03124 153 LPESRSYYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYP----------NNARPVQPLNGREV 214
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
 60-296 9.04e-54

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 176.18  E-value: 9.04e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   60 GGDRQSPINIRwRDSV-YDPGLKPLT-ISYD--PATCLHVWNNGYSflVEFEDSTDKSvIKGGPLEhnYRLKQFHFHWGA 135
Cdd:cd03126  13 GGVAQSPIDIH-TDILqYDSSLPPLEfHGYNvsGTEQFTLTNNGHT--VQLSLPPTMH-IGGLPFK--YTASQLHLHWGQ 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  136 I-DAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGS 214
Cdd:cd03126  87 RgSPEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGPFNPSYEKIFSHLHEVKYKDQKVSVPG 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  215 FDPSCLMPTCPD-YWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVR 293
Cdd:cd03126 167 FNVQELLPKRLDeYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQPFNERLVF 246


                ...
gi 6005723  294 SSF 296
Cdd:cd03126 247 ASF 249
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 50-296 1.08e-50

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 168.21  E-value: 1.08e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   50 PLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTI-SYD--PATCLHVWNNGYSFLVEFEDSTDksvIKGGPlEHNYRL 126
Cdd:cd03150   3 PPWPSVSPACAGRFQSPVDIRPHLVAFCPALRPLELlGFDlpPSPSLRLLNNGHTVQLSLPSGLR---MALGP-GQEYRA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  127 KQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAvRFENFEDAALEENGLAVIGVFLKLGKHHKE-LQKLVDTLPSIKH 205
Cdd:cd03150  79 LQLHLHWGAAGRPGSEHTVDGHRFPAEIHVVHLST-AFANLDEALGRPGGLAVLAAFLAEGLHENSaYEQLLSRLSEISE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  206 KDALVEFGSFDPSCLMPT-CPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEqfrTLLFTSEGEKEKRMVDNFRPL 284
Cdd:cd03150 158 EESETVVPGLDVSALLPSdLSRYFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLH---TLSDSLWGPHDSRLQLNFRAT 234

                       250
                ....*....|..
gi 6005723  285 QPLMNRTVRSSF 296
Cdd:cd03150 235 QPLNGRKIEASF 246
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
 52-294 9.71e-50

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 165.99  E-value: 9.71e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   52 WESVDLVPG-GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVW--NNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQ 128
Cdd:cd03122   5 WAKKYPACGeGRQQSPIDIVEDTQVQRQGLQPLHFDGYEELTASTTleNTGKTVILRLEGNSSDPFVSGGPLLGRYKFSE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  129 FHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEdAALEENGLAVIGVFLKLGKHHKE-LQKLVDTLPSIKHKD 207
Cdd:cd03122  85 ITFHWGTCNSDGSEHSIDGHKFPLEMQILHRNTDFFDSFE-AIKSPGGVLALAYLFELSHEDNPfLDPIIEGLRNVSRPG 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  208 ALVEFGSFDPSCLMPTCPD-YWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFT--SEGEKEKRMVDNFRPL 284
Cdd:cd03122 164 KEVELPPFPLSDLLPPFTDkYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFRELLTRrqDGVMSGDYLPNNGRPQ 243

                       250
                ....*....|
gi 6005723  285 QPLMNRTVRS 294
Cdd:cd03122 244 QPLGSRTVFS 253
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
 60-296 4.67e-42

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 145.70  E-value: 4.67e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   60 GGDRQSPINIRWRDSVYDPGLKPLTIS-YD-PATCLHVWNNGYSFLVEFEDSTDKSVIKGGPlehnYRLKQFHFHWGAID 137
Cdd:cd03125  13 GGKRQSPIDIQRREVRFNPSLLQLELVgYEkEQGEFTMTNNGHTVQIDLPPTMSITTGDGTV----YTAVQMHFHWGGRD 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  138 --AWGSEHTVDSKCFPAELHLVHWNAvRFENFEDAALEENGLAVIGVFLKLGkHHKE---LQKLVDTLPSIKHKDALVEF 212
Cdd:cd03125  89 seISGSEHTIDGMRYVAELHIVHYNS-KYKSYEEAKDKPDGLAVLAFLYKVG-HYAEntyYSDFISKLAKIKYAGQTTTL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723  213 GSFDPSCLMP-TCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTsegEKEKRMVDNFRPLQPLMNRT 291
Cdd:cd03125 167 TSLDVRDMLPeNLHHYYTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLMD---HHNKTIRNDYRRTQPLNHRV 243


                ....*
gi 6005723  292 VRSSF 296
Cdd:cd03125 244 VEANF 248
PLN02179 PLN02179
carbonic anhydrase
 48-250 7.77e-17

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 78.10  E-value: 7.77e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    48 LHPLWEsvdLVPGGDRQSPINIR-WRDS-VYDpglKPLTISYDPATCLhVWNNGYSFLVEFEDSTDKSVIKggplEHNYR 125
Cdd:PLN02179  53 LNPQWK---VCSTGKYQSPIDLTdERVSlIHD---QALSRHYKPAPAV-IQSRGHDVMVSWKGDAGKITIH----QTDYK 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   126 LKQFHFHWGaidawgSEHTVDSKCFPAELHLVHWNAvrfenfedaaleENGLAVIGVFLKLGKHHKELQKLVDTLPSIKH 205
Cdd:PLN02179 122 LVQCHWHSP------SEHTINGTSYDLELHMVHTSA------------SGKTAVVGVLYKLGEPDEFLTKLLNGIKGVGK 183

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 6005723   206 KDalVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQ 250
Cdd:PLN02179 184 KE--INLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTVVKR 226
PLN02202 PLN02202
carbonate dehydratase
 61-301 4.85e-16

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 77.02  E-value: 4.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723    61 GDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVwNNGYSFLVEFEDSTDKSVIKggplEHNYRLKQFHFHWGaidawg 140
Cdd:PLN02202  55 GKLQSPIDIQRRQIFYNHKLESIHRDYYFTNATLV-NHVCNVAMFFGEGAGDVIID----NKNYTLLQMHWHTP------ 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   141 SEHTVDSKCFPAELHLVHwnavrfenfedaALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHK------DALVEFGS 214
Cdd:PLN02202 124 SEHHLHGVQYAAELHMVH------------QAKDGSFAVVASLFKIGTEEPFLSQMKDKLVKLKEErfkgnhTAQVEVGK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6005723   215 FDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLftsegekEKRMVDNFRPLQPLMNRTVRS 294
Cdd:PLN02202 192 IDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVELLRSPL-------DKSFKNNSRPCQPLNGRRVEM 264


                 ....*..
gi 6005723   295 SFRHDYV 301
Cdd:PLN02202 265 FHDHERV 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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