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Conserved domains on  [gi|157743257|ref|NP_009183|]
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POU domain, class 6, transcription factor 2 isoform 1 [Homo sapiens]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
477-586 4.13e-29

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 451464  Cd Length: 75  Bit Score: 110.22  E-value: 4.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743257   477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48
                           90       100       110
                   ....*....|....*....|....*....|
gi 157743257   557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeobox pfam00046
Homeobox domain;
610-663 5.18e-19

Homeobox domain;


:

Pssm-ID: 425441  Cd Length: 54  Bit Score: 81.02  E-value: 5.18e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157743257  610 RRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
477-586 4.13e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 110.22  E-value: 4.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743257   477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48
                           90       100       110
                   ....*....|....*....|....*....|
gi 157743257   557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
482-586 1.30e-26

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 425490  Cd Length: 69  Bit Score: 103.10  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743257  482 EEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgllypaRF 561
Cdd:pfam00157   1 KELEQFAKEFKQRRITLGYTQADVGSALGALYGKVFSQTTIC------------------------------------RF 44
                          90       100
                  ....*....|....*....|....*
gi 157743257  562 EKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:pfam00157  45 EKLDLSLKNMCKLKPLLEKWLEEAE 69
Homeobox pfam00046
Homeobox domain;
610-663 5.18e-19

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 81.02  E-value: 5.18e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157743257  610 RRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
607-663 8.59e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 80.37  E-value: 8.59e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 157743257   607 KRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
608-665 3.58e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 75.74  E-value: 3.58e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157743257 608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNT 665
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
601-663 5.83e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 5.83e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157743257 601 GSEPSKKRKRRTsfTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:COG5576   47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
477-586 4.13e-29

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 110.22  E-value: 4.13e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743257   477 DGVNLEEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgll 556
Cdd:smart00352   2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTIC--------------------------------- 48
                           90       100       110
                   ....*....|....*....|....*....|
gi 157743257   557 ypaRFEKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:smart00352  49 ---RFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
482-586 1.30e-26

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 425490  Cd Length: 69  Bit Score: 103.10  E-value: 1.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157743257  482 EEIREFAKAFKIRRLSLGLTQTQVGQALSATEGPAYSQSAICrhtilrshfflpqeaqentiassltaklnpgllypaRF 561
Cdd:pfam00157   1 KELEQFAKEFKQRRITLGYTQADVGSALGALYGKVFSQTTIC------------------------------------RF 44
                          90       100
                  ....*....|....*....|....*
gi 157743257  562 EKLDITPKSAQKIKPVLERWMAEAE 586
Cdd:pfam00157  45 EKLDLSLKNMCKLKPLLEKWLEEAE 69
Homeobox pfam00046
Homeobox domain;
610-663 5.18e-19

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 81.02  E-value: 5.18e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 157743257  610 RRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:pfam00046   1 KRTTFTPEQLEELEKEFQENPYPSREEREELAAQLGLTERQVKVWFQNRRAKWK 54
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
607-663 8.59e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 80.37  E-value: 8.59e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 157743257   607 KRKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
608-665 3.58e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 75.74  E-value: 3.58e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 157743257 608 RKRRTSFTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALKNT 665
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
601-663 5.83e-09

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.52  E-value: 5.83e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157743257 601 GSEPSKKRKRRTsfTPQALEILNAHFEKNTHPSGQEMTEIAEKLNYDREVVRVWFCNKRQALK 663
Cdd:COG5576   47 GSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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