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Conserved domains on  [gi|56550061|ref|NP_009192|]
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CMRF35-like molecule 8 isoform 1 precursor [Homo sapiens]

Protein Classification

Ig_pIgR_like and SIT domain-containing protein( domain architecture ID 10146063)

Ig_pIgR_like and SIT domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-117 4.70e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.11  E-value: 4.70e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061  22 RTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPpQIFLCDKIVETKGSagKRNGRVSIRDSPANLSFTVTLENLTEEDAGTY 101
Cdd:cd05716   5 EVVTGVEGGSVTIQCPYPPKYASSRKYWCKW-GSEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81

                        90
                ....*....|....*.
gi 56550061 102 WCGVDTPWLRDFHDPV 117
Cdd:cd05716  82 WCGVGDDGDRGLTVQV 97
SIT super family cl21173
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 199-273 1.45e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


The actual alignment was detected with superfamily member pfam15330:

Pssm-ID: 464650  Cd Length: 114  Bit Score: 52.00  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061   199 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 262
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 56550061   263 EELHYASVVFD 273
Cdd:pfam15330 100 EEISYASLSLD 110
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-117 4.70e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.11  E-value: 4.70e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061  22 RTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPpQIFLCDKIVETKGSagKRNGRVSIRDSPANLSFTVTLENLTEEDAGTY 101
Cdd:cd05716   5 EVVTGVEGGSVTIQCPYPPKYASSRKYWCKW-GSEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81

                        90
                ....*....|....*.
gi 56550061 102 WCGVDTPWLRDFHDPV 117
Cdd:cd05716  82 WCGVGDDGDRGLTVQV 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-108 2.08e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.48  E-value: 2.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061    22 RTVAGPVGGSLSVQCPY--EKEHRTLNKYWCRPPQIFLCDKIV---ETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEE 96
Cdd:pfam07686   4 REVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90
                  ....*....|..
gi 56550061    97 DAGTYWCGVDTP 108
Cdd:pfam07686  84 DSGTYTCAVIPS 95
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 199-273 1.45e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 52.00  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061   199 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 262
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 56550061   263 EELHYASVVFD 273
Cdd:pfam15330 100 EEISYASLSLD 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-105 1.79e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 1.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061     22 RTVAGPVGGSLSVQCPYeKEHRTLNKYWCRPPQIFLCDKivetkgsagkrnGRVSIRDSpaNLSFTVTLENLTEEDAGTY 101
Cdd:smart00410   2 PSVTVKEGESVTLSCEA-SGSPPPEVTWYKQGGKLLAES------------GRFSVSRS--GSTSTLTISNVTPEDSGTY 66


                   ....
gi 56550061    102 WCGV 105
Cdd:smart00410  67 TCAA 70
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 22-117 4.70e-31

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 112.11  E-value: 4.70e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061  22 RTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPpQIFLCDKIVETKGSagKRNGRVSIRDSPANLSFTVTLENLTEEDAGTY 101
Cdd:cd05716   5 EVVTGVEGGSVTIQCPYPPKYASSRKYWCKW-GSEGCQTLVSSEGV--VPGGRISLTDDPDNGVFTVTLNQLRKEDAGWY 81

                        90
                ....*....|....*.
gi 56550061 102 WCGVDTPWLRDFHDPV 117
Cdd:cd05716  82 WCGVGDDGDRGLTVQV 97
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 22-108 2.08e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 62.48  E-value: 2.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061    22 RTVAGPVGGSLSVQCPY--EKEHRTLNKYWCRPPQIFLCDKIV---ETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEE 96
Cdd:pfam07686   4 REVTVALGGSVTLPCTYssSMSEASTSVYWYRQPPGKGPTFLIayySNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90
                  ....*....|..
gi 56550061    97 DAGTYWCGVDTP 108
Cdd:pfam07686  84 DSGTYTCAVIPS 95
SIT pfam15330
SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane ...
 199-273 1.45e-08

SHP2-interacting transmembrane adaptor protein, SIT; SIT, or SHP2-interacting transmembrane adaptor protein, is a disulfide-linked dimer that regulates human T Cell activation.


Pssm-ID: 464650  Cd Length: 114  Bit Score: 52.00  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061   199 LAWRMFQKWIKAGDHSELSQNPKQAATQ---SELHYANLELLMW-----PLQEK-------PAPPREVEVEYSTVAS-PR 262
Cdd:pfam15330  20 LAWRMMKRQKKAAGYSPEQVIPREYYLQpieGDLCYANLTLQQTgtspgSSDEKayeqmssSAQRSQNEVEYVTMAPfPR 99

                          90
                  ....*....|.
gi 56550061   263 EELHYASVVFD 273
Cdd:pfam15330 100 EEISYASLSLD 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 22-105 1.79e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.19  E-value: 1.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061     22 RTVAGPVGGSLSVQCPYeKEHRTLNKYWCRPPQIFLCDKivetkgsagkrnGRVSIRDSpaNLSFTVTLENLTEEDAGTY 101
Cdd:smart00410   2 PSVTVKEGESVTLSCEA-SGSPPPEVTWYKQGGKLLAES------------GRFSVSRS--GSTSTLTISNVTPEDSGTY 66


                   ....
gi 56550061    102 WCGV 105
Cdd:smart00410  67 TCAA 70
IGv smart00406
Immunoglobulin V-Type;
73-105 3.35e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.52  E-value: 3.35e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 56550061     73 GRVSIRDSPANLSFTVTLENLTEEDAGTYWCGV 105
Cdd:smart00406  49 GRFTISKDTSKNDVSLTISNLRVEDTGTYYCAV 81
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 22-103 8.17e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 38.47  E-value: 8.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56550061  22 RTVAGPVGGSLSVQCPYEKEHRTLNKYWCR--PPQ--IFLcdkiVETKGSAGKRNGRVSIRDS---PANLSFTVTLENLT 94
Cdd:cd00099   6 RSLSVQEGESVTLSCEVSSSFSSTYIYWYRqkPGQgpEFL----IYLSSSKGKTKGGVPGRFSgsrDGTSSFSLTISNLQ 81


                ....*....
gi 56550061  95 EEDAGTYWC 103
Cdd:cd00099  82 PEDSGTYYC 90
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 68-103 4.48e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 36.19  E-value: 4.48e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 56550061  68 AGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWC 103
Cdd:cd04982  59 SGKTKNKFEARKDVGKSTSTLTITNLEKEDSATYYC 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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