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Conserved domains on  [gi|24307929|ref|NP_009211|]
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protein Mis18-beta isoform 1 [Homo sapiens]

Protein Classification

yippee/mis18 family protein( domain architecture ID 10505208)

yippee/mis18 family protein may be involved in protein/nucleic acid binding, similar to human Mis18-alpha, which is required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis

Gene Ontology:  GO:0046872
PubMed:  11240639|15556292

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Yippee-Mis18 pfam03226
Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both ...
 76-176 7.10e-35

Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon.


:

Pssm-ID: 427204  Cd Length: 99  Bit Score: 119.73  E-value: 7.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307929    76 AVFQCAQCHAVLADSVHLaWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKgSTYNLLFCGSCGIPVGFHLYSTHAAL 155
Cdd:pfam03226   1 LVFQCKRCNTILGDSLAL-VSSGRELNTIVLKKVTRNVVVGKELVTSESGFDD-CTYSPLFCAGCGAVLGRKYRSTPEEL 78

                          90       100
                  ....*....|....*....|.
gi 24307929   156 AALRGHFCLSSDKMVCYLLKT 176
Cdd:pfam03226  79 DYKRGLFCLETDAISSYQLGS 99
 
Name Accession Description Interval E-value
Yippee-Mis18 pfam03226
Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both ...
 76-176 7.10e-35

Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon.


Pssm-ID: 427204  Cd Length: 99  Bit Score: 119.73  E-value: 7.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307929    76 AVFQCAQCHAVLADSVHLaWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKgSTYNLLFCGSCGIPVGFHLYSTHAAL 155
Cdd:pfam03226   1 LVFQCKRCNTILGDSLAL-VSSGRELNTIVLKKVTRNVVVGKELVTSESGFDD-CTYSPLFCAGCGAVLGRKYRSTPEEL 78

                          90       100
                  ....*....|....*....|.
gi 24307929   156 AALRGHFCLSSDKMVCYLLKT 176
Cdd:pfam03226  79 DYKRGLFCLETDAISSYQLGS 99
 
Name Accession Description Interval E-value
Yippee-Mis18 pfam03226
Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both ...
 76-176 7.10e-35

Yippee zinc-binding/DNA-binding /Mis18, centromere assembly; This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus. This entry also includes the CULT domain proteins such as Cereblon.


Pssm-ID: 427204  Cd Length: 99  Bit Score: 119.73  E-value: 7.10e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24307929    76 AVFQCAQCHAVLADSVHLaWDLSRSLGAVVFSRVTNNVVLEAPFLVGIEGSLKgSTYNLLFCGSCGIPVGFHLYSTHAAL 155
Cdd:pfam03226   1 LVFQCKRCNTILGDSLAL-VSSGRELNTIVLKKVTRNVVVGKELVTSESGFDD-CTYSPLFCAGCGAVLGRKYRSTPEEL 78

                          90       100
                  ....*....|....*....|.
gi 24307929   156 AALRGHFCLSSDKMVCYLLKT 176
Cdd:pfam03226  79 DYKRGLFCLETDAISSYQLGS 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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