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Conserved domains on  [gi|6319795|ref|NP_009876|]
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Kar4p [Saccharomyces cerevisiae S288C]

Protein Classification

methyltransferase-A70 family protein( domain architecture ID 5277)

methyltransferase-A70 (MT-A70) family protein similar to Caenorhabditis elegans DNA N6-methyl methyltransferase that methylates DNA on the 6th position of adenine (N(6)-methyladenosine)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MT-A70 super family cl01947
MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A ...
138-293 7.40e-11

MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs.


The actual alignment was detected with superfamily member pfam05063:

Pssm-ID: 470404  Cd Length: 174  Bit Score: 60.14  E-value: 7.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319795    138 LTQLPLDRLISKPGFLFIW-ANSQKINELTKLLNNeiWAkkFRRSEELVFVPIDKKSPfyPGLDQDDETLMEKMQWHCWM 216
Cdd:pfam05063  31 LLALPIPELLDPGSLIFLWcTNREGELGGRECLKK--WG--YRLVETITWIKTNTLGE--PIHTLRSGHWLKHPKEHLLV 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6319795    217 CITGTVRRSTDGHLIHCNVDTDLSIETKDTTNGAvPSHLYRIAENFS-TATRRLHIIpARTgyetpvkVRPGWVIVSP 293
Cdd:pfam05063 105 GVKGNVKRSYGGDFINANIDTDLIISPEREHSRK-PPELFHIIEHFClPGTRKLELF-GRD-------LRPGWLTVGN 173
 
Name Accession Description Interval E-value
MT-A70 pfam05063
MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A ...
138-293 7.40e-11

MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs.


Pssm-ID: 368270  Cd Length: 174  Bit Score: 60.14  E-value: 7.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319795    138 LTQLPLDRLISKPGFLFIW-ANSQKINELTKLLNNeiWAkkFRRSEELVFVPIDKKSPfyPGLDQDDETLMEKMQWHCWM 216
Cdd:pfam05063  31 LLALPIPELLDPGSLIFLWcTNREGELGGRECLKK--WG--YRLVETITWIKTNTLGE--PIHTLRSGHWLKHPKEHLLV 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6319795    217 CITGTVRRSTDGHLIHCNVDTDLSIETKDTTNGAvPSHLYRIAENFS-TATRRLHIIpARTgyetpvkVRPGWVIVSP 293
Cdd:pfam05063 105 GVKGNVKRSYGGDFINANIDTDLIISPEREHSRK-PPELFHIIEHFClPGTRKLELF-GRD-------LRPGWLTVGN 173
 
Name Accession Description Interval E-value
MT-A70 pfam05063
MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A ...
138-293 7.40e-11

MT-A70; MT-A70 is the S-adenosylmethionine-binding subunit of human mRNA:m6A methyl-transferase (MTase), an enzyme that sequence-specifically methylates adenines in pre-mRNAs.


Pssm-ID: 368270  Cd Length: 174  Bit Score: 60.14  E-value: 7.40e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319795    138 LTQLPLDRLISKPGFLFIW-ANSQKINELTKLLNNeiWAkkFRRSEELVFVPIDKKSPfyPGLDQDDETLMEKMQWHCWM 216
Cdd:pfam05063  31 LLALPIPELLDPGSLIFLWcTNREGELGGRECLKK--WG--YRLVETITWIKTNTLGE--PIHTLRSGHWLKHPKEHLLV 104
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6319795    217 CITGTVRRSTDGHLIHCNVDTDLSIETKDTTNGAvPSHLYRIAENFS-TATRRLHIIpARTgyetpvkVRPGWVIVSP 293
Cdd:pfam05063 105 GVKGNVKRSYGGDFINANIDTDLIISPEREHSRK-PPELFHIIEHFClPGTRKLELF-GRD-------LRPGWLTVGN 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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