|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
17-335 |
0e+00 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 639.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 17 FLSETAAIKVSPLILGEVSYDGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQIV 96
Cdd:cd19147 1 VLSKTAGIRVSPLILGAMSIGDAWSGFMGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKNRDQIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 97 IATKFIKSDKKYKAGESNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLG 176
Cdd:cd19147 81 IATKFTTDYKAYEVGKGKAVNYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 177 VSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGI 256
Cdd:cd19147 161 VSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQSKKAVEERKKNGEGL 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 257 RSFVGASEQTDAEIKISEALAKIAEEHGTESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19147 241 RSFVGGTEQTPEEVKISEALEKVAEEHGTESVTAIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
16-349 |
5.21e-158 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 446.10 E-value: 5.21e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 16 RFLSETAAIKVSPLILGEVSYDGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQI 95
Cdd:cd19146 1 RQLSPTAGVRVSPLCLGAMSFGEAWKSMMGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGNRDEM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 96 VIATKFIKSdkkYKAGESN--TANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVL 173
Cdd:cd19146 81 VLATKYTTG---YRRGGPIkiKSNYQGNHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 174 YLGVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSkkamEERRKNG 253
Cdd:cd19146 158 YLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRT----EEEFKRR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 254 EGIRSFVGAseQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKY 333
Cdd:cd19146 234 GRSGRKGGP--QTEKERKVSEKLEKVAEEKGT-AITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQE 310
|
330
....*....|....*.
gi 6319951 334 LESIVPFDIGFPNNFI 349
Cdd:cd19146 311 IEDAYPFDVGFPMNFL 326
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
17-335 |
2.38e-157 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 443.58 E-value: 2.38e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 17 FLSETAAIKVSPLILGEVSYDGARSdflKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIV 96
Cdd:cd19080 1 RLLGRSGLRVSPLALGTMTFGTEWG---WGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNR--DRIV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 97 IATKFIKSDKKykagesNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLG 176
Cdd:cd19080 76 LATKYTMNRRP------GDPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 177 VSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGI 256
Cdd:cd19080 150 ISDTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGRAGEAK 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 257 RSFVGASEQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19080 230 GVTVGFGKLTERNWAIVDVVAAVAEELGR-SAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
24-339 |
1.50e-72 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 228.14 E-value: 1.50e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEVSYdgarSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATKFIk 103
Cdd:COG0667 11 LKVSRLGLGTMTF----GGPWGGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRP-RDDVVIATKVG- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 sdkkYKAGESntANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAW 183
Cdd:COG0667 85 ----RRMGPG--PNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 184 VVSAANyyATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRSFVGAS 263
Cdd:COG0667 159 QLRRAL--AIAEGLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPEGDRAATNFVQG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 264 EQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKaknffPSVEG-----GKIEDLKENIKALSIDLTPDNIKYLESIV 338
Cdd:COG0667 237 YLTERNLALVDALRAIAAEHGV-TPAQLALAWLLAQ-----PGVTSvipgaRSPEQLEENLAAADLELSAEDLAALDAAL 310
|
.
gi 6319951 339 P 339
Cdd:COG0667 311 A 311
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
24-335 |
9.86e-72 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 225.93 E-value: 9.86e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEVSYdGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQIVIATKFik 103
Cdd:cd19079 10 LKVSRLCLGCMSF-GDPKWRPWVLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRDEVVIATKV-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 sdkkyKAGESNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAW 183
Cdd:cd19079 87 -----YFPMGDGPNGRGLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYAW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 184 VVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRSFVGAS 263
Cdd:cd19079 162 QFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTTDTAKLKYD 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319951 264 EQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19079 242 YFTEADKEIVDRVEEVAKERGV-SMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
46-338 |
2.25e-70 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 221.80 E-value: 2.25e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 46 SMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRL-RDQIVIATKFIKSDKKYKAGesntanycgNHKR 124
Cdd:pfam00248 14 PISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVkRDKVVIATKVPDGDGPWPSG---------GSKE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 125 SLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSaanyYATSYGKTPFSIYQ 204
Cdd:pfam00248 85 NIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIE----KALTKGKIPIVAVQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 205 GKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRSFVgasEQTDAEIKISEALAKIAEEHG 284
Cdd:pfam00248 161 VEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLK---KGTPLNLEALEALEEIAKEHG 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 6319951 285 tESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLESIV 338
Cdd:pfam00248 238 -VSPAQVALRWALSKPGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
27-320 |
5.94e-68 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 213.53 E-value: 5.94e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 27 SPLILGEVSYDGARSDflksmnkNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQIVIATKFIKSDK 106
Cdd:cd06660 1 SRLGLGTMTFGGDGDE-------EEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGNRDDVVIATKGGHPPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 107 kykagesNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVS 186
Cdd:cd06660 74 -------GDPSRSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 187 AANYYATSYGKTPFSIYQGKWNVLNRDF-ERDIIPMARHFGMALAPWDVMGGGrfqskkameerrkngegirsfvgaseq 265
Cdd:cd06660 147 EALAYAKAHGLPGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARG--------------------------- 199
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 6319951 266 tdaeikisealakiaeehgtesVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIK 320
Cdd:cd06660 200 ----------------------PAQLALAWLLSQPFVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
24-334 |
1.30e-66 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 212.84 E-value: 1.30e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEvsydgarSDFLKSMNKNRAFELLDTFYEAGGNFIDAAN-------NCQNEQSEEWIGEWIQSRRLRDQIV 96
Cdd:cd19081 7 LSVSPLCLGT-------MVFGWTADEETSFALLDAFVDAGGNFIDTADvysawvpGNAGGESETIIGRWLKSRGKRDRVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 97 IATKfiksdkkykAGESNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLG 176
Cdd:cd19081 80 IATK---------VGFPMGPNGPGLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIG 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 177 VSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGG----GRFQSKKAMEERRK 251
Cdd:cd19081 151 ASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGgfltGKYRSEADLPGSTR 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 252 NGEGIRSFVgaseqTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNI 331
Cdd:cd19081 231 RGEAAKRYL-----NERGLRILDALDEVAAEHGA-TPAQVALAWLLARPGVTAPIAGARTVEQLEDLLAAAGLRLTDEEV 304
|
...
gi 6319951 332 KYL 334
Cdd:cd19081 305 ARL 307
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
16-339 |
6.55e-63 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 203.19 E-value: 6.55e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 16 RFLSETAaIKVSPLILGEVSYdGARSDflksmnKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQI 95
Cdd:cd19087 4 RTLGRTG-LKVSRLCLGTMNF-GGRTD------EETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGRR--DDI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 96 VIATKFIksdkkYKAGESNTANycGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYL 175
Cdd:cd19087 74 VLATKVF-----GPMGDDPNDR--GLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 176 GVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEG 255
Cdd:cd19087 147 GVSNFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYGKGKRPESGRL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 256 IRSFVG-ASEQTDAEIKISEALAKIAEEHGtESVTAIAIAYVRSKaknffPSVEG---G--KIEDLKENIKALSIDLTPD 329
Cdd:cd19087 227 VERARYqARYGLEEYRDIAERFEALAAEAG-LTPASLALAWVLSH-----PAVTSpiiGprTLEQLEDSLAALEITLTPE 300
|
330
....*....|
gi 6319951 330 NIKYLESIVP 339
Cdd:cd19087 301 LLAEIDELFP 310
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
14-337 |
1.27e-62 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 202.84 E-value: 1.27e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 14 RLRFLSETAaIKVSPLILGEVSYDGARSDFLK--SMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRl 91
Cdd:cd19091 2 EYRTLGRSG-LKVSELALGTMTFGGGGGFFGAwgGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGRR- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 92 rDQIVIATKFiksdkKYKAGESntANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGK 171
Cdd:cd19091 80 -DDVLIATKV-----RGRMGEG--PNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 172 VLYLGVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRK 251
Cdd:cd19091 152 VRYIGVSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYRRGQPAP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 252 NGEGIRSFVGASEQTDAE--IKISEALAKIAEEHGTeSVTAIAIAYVRSKAknFFPSVEGG--KIEDLKENIKALSIDLT 327
Cdd:cd19091 232 EGSRLRRTGFDFPPVDRErgYDVVDALREIAKETGA-TPAQVALAWLLSRP--TVSSVIIGarNEEQLEDNLGAAGLSLT 308
|
330
....*....|
gi 6319951 328 PDNIKYLESI 337
Cdd:cd19091 309 PEEIARLDKV 318
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
27-323 |
2.73e-50 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 170.04 E-value: 2.73e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 27 SPLILGevsydgaRSDFLKSMNKNRAFELLDTFYEAGGNFIDAA----NNCQNEQSEEWIGEWIQSRRLRDQIVIATKfi 102
Cdd:cd19082 1 SRIVLG-------TADFGTRIDEEEAFALLDAFVELGGNFIDTArvygDWVERGASERVIGEWLKSRGNRDKVVIATK-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 103 ksdkkykaG-----ESNTANYCgnHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGV 177
Cdd:cd19082 72 --------GghpdlEDMSRSRL--SPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 178 SDtpaWV---VSAANYYATSYGKTPFSIYQGKWN--VLNRDFERD--IIPM---ARHF----GMALAPWDVMGGGRFqSK 243
Cdd:cd19082 142 SN---WSterIAEANAYAKAHGLPGFAASSPQWSlaRPNEPPWPGptLVAMdeeMRAWheenQLPVFAYSSQARGFF-SK 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 244 KAMEERRKNGEGIRSFvgaseQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALS 323
Cdd:cd19082 218 RAAGGAEDDSELRRVY-----YSEENFERLERAKELAEEKGV-SPTQIALAYVLNQPFPTVPIIGPRTPEQLRDSLAAAD 291
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
47-329 |
1.35e-45 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 158.88 E-value: 1.35e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 47 MNKNRAFELLDTFYEAGGNFIDAAnncqnEQ------------SEEWIGEWIQSRRLRDQIVIATKFiksdkkykAGESN 114
Cdd:cd19094 15 NTEAEAHEQLDYAFDEGVNFIDTA-----EMypvppspetqgrTEEIIGSWLKKKGNRDKVVLATKV--------AGPGE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 115 TANYCGNHKRSL---HV--SVRDSLRKLQTDWIDILYVHWWD-----------------YMS-SIEEFMDSLHILVQQGK 171
Cdd:cd19094 82 GITWPRGGGTRLdreNIreAVEGSLKRLGTDYIDLYQLHWPDrytplfgggyytepseeEDSvSFEEQLEALGELVKAGK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 172 VLYLGVSDTPAWVVSAANYYATSYGKTPF-SIyQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEERR 250
Cdd:cd19094 162 IRHIGLSNETPWGVMKFLELAEQLGLPRIvSI-QNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGG-VLTGKYLDGAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 251 KNGEGIRS-FVG-----ASEQTDAEIKiseALAKIAEEHGTeSVTAIAIAYVRSKAknFFPSVEGG--KIEDLKENIKAL 322
Cdd:cd19094 240 RPEGGRLNlFPGymaryRSPQALEAVA---EYVKLARKHGL-SPAQLALAWVRSRP--FVTSTIIGatTLEQLKENIDAF 313
|
....*..
gi 6319951 323 SIDLTPD 329
Cdd:cd19094 314 DVPLSDE 320
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
24-335 |
1.77e-45 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 157.30 E-value: 1.77e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEVSYDGARSDflkSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIVIATKF-I 102
Cdd:cd19084 2 LKVSRIGLGTWAIGGTWWG---EVDDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGRR--DDVVIATKCgL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 103 KSDKKYKAGESNTANYcgnhkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPA 182
Cdd:cd19084 77 RWDGGKGVTKDLSPES-------IRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 183 WVVSAANYYAtsygktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGG----RFQSK---KAMEERRKNgeg 255
Cdd:cd19084 150 EQLEEARKYG------PIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGlltgKYKKEptfPPDDRRSRF--- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 256 iRSFVGasEQTDAEIKISEALAKIAEEHGtESVTAIAIAYVRSK---------AKNffpsveggkIEDLKENIKALSIDL 326
Cdd:cd19084 221 -PFFRG--ENFEKNLEIVDKLKEIAEKYG-KSLAQLAIAWTLAQpgvtsaivgAKN---------PEQLEENAGALDWEL 287
|
....*....
gi 6319951 327 TPDNIKYLE 335
Cdd:cd19084 288 TEEELKEID 296
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
29-329 |
8.01e-40 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 142.73 E-value: 8.01e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 29 LILGEVSYDGARSdFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATK--FIKSDK 106
Cdd:cd19074 2 LKVSELSLGTWLT-FGGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWP-RESYVISTKvfWPTGPG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 107 KYKAGESntanycgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVS 186
Cdd:cd19074 80 PNDRGLS---------RKHIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 187 AANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGG----RFQSKKAMEER-RKNGEGIRSFVG 261
Cdd:cd19074 151 EAHDLARQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGlltgKYRDGIPPPSRsRATDEDNRDKKR 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6319951 262 aSEQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPD 329
Cdd:cd19074 231 -RLLTDENLEKVKKLKPIADELGL-TLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
21-334 |
8.07e-37 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 135.04 E-value: 8.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 21 TAAIKVSPLILGEVSYdgarSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIqsRRLRDQIVIATK 100
Cdd:cd19076 7 TQGLEVSALGLGCMGM----SAFYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKAL--KDRRDEVVIATK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 101 F--IKSDKKYKAGESNTANYCgnhkRSlhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19076 81 FgiVRDPGSGFRGVDGRPEYV----RA---ACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 179 D-TPAWVVSAANYYatsygktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMG----GGRFQSKKAMEE---RR 250
Cdd:cd19076 154 EaSADTIRRAHAVH-------PITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGrgflTGAIKSPEDLPEddfRR 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 251 KNGEgirsFVGasEQTDAEIKISEALAKIAEEHGtesVTA--IAIAYVRSKAKNFFPsVEGGK-IEDLKENIKALSIDLT 327
Cdd:cd19076 227 NNPR----FQG--ENFDKNLKLVEKLEAIAAEKG---CTPaqLALAWVLAQGDDIVP-IPGTKrIKYLEENVGALDVVLT 296
|
....*..
gi 6319951 328 PDNIKYL 334
Cdd:cd19076 297 PEELAEI 303
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
27-323 |
2.41e-36 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 133.23 E-value: 2.41e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 27 SPLILGEVsYDGARSDflksmnKNRAFELLDTFYEAGGNFIDAANN-------CQNEQSEEWIGEWIQSRRLRDQIVIAT 99
Cdd:cd19752 1 SELCLGTM-YFGTRTD------EETSFAILDRYVAAGGNFLDTANNyafwtegGVGGESERLIGRWLKDRGNRDDVVIAT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 100 KFiksDKKYKAGESNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD 179
Cdd:cd19752 74 KV---GAGPRDPDGGPESPEGLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASN 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 180 TPAWVVSAANYYATSYGKTPFSIYQGKWNVL----NRDF------ERDIIPMAR-HFGMALAPWDVMGGGRFqSKKAMEE 248
Cdd:cd19752 151 FAAWRLERARQIARQQGWAEFSAIQQRHSYLrprpGADFgvqrivTDELLDYASsRPDLTLLAYSPLLSGAY-TRPDRPL 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319951 249 RrkngegirsfvGASEQTDAEIKISeALAKIAEEHGtesVTA--IAIAYVRSKAKNFFPSVEGGKIEDLKENIKALS 323
Cdd:cd19752 230 P-----------EQYDGPDSDARLA-VLEEVAGELG---ATPnqVVLAWLLHRTPAIIPLLGASTVEQLEENLAALD 291
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
56-337 |
1.50e-34 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 128.47 E-value: 1.50e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 56 LDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIVIATKFiksdkkykagesntaNYCGNHKRSLHVSVRDSLR 135
Cdd:cd19085 29 IHAALDAGINFFDTAEAYGDGHSEEVLGKALKGRR--DDVVIATKV---------------SPDNLTPEDVRKSCERSLK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 136 KLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAANYyatsygkTPFSIYQGKWNVLNRDF 214
Cdd:cd19085 92 RLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNfGPAQLEEALDA-------GRIDSNQLPYNLLWRAI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 215 ERDIIPMARHFGMALAPWDVMG----GGRFQSKKAMEERRKNGEGIRSFvgaseQTDAEIKISEALAK---IAEEHGTeS 287
Cdd:cd19085 165 EYEILPFCREHGIGVLAYSPLAqgllTGKFSSAEDFPPGDARTRLFRHF-----EPGAEEETFEALEKlkeIADELGV-T 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 6319951 288 VTAIAIAYVRSkaKNFFPSVEGG--KIEDLKENIKALSIDLTPDNIKYLESI 337
Cdd:cd19085 239 MAQLALAWVLQ--QPGVTSVIVGarNPEQLEENAAAVDLELSPSVLERLDEI 288
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
11-336 |
2.45e-33 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 125.85 E-value: 2.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 11 KLGRlrflsetAAIKVSPLILGEVSYDGArsDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIqsRR 90
Cdd:cd19149 3 KLGK-------SGIEASVIGLGTWAIGGG--PWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAI--KG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 91 LRDQIVIATKF-----IKSDKKYKAGESNTANYCGNhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHI 165
Cdd:cd19149 72 RRDKVVLATKCglrwdREGGSFFFVRDGVTVYKNLS-PESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 166 LVQQGKVLYLGVSDTPAWVVSAanyyATSYGktPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKA 245
Cdd:cd19149 151 LKRQGKIRAIGASNVSVEQIKE----YVKAG--QLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQG-LLTGKI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 246 MEERRKNGEGIRS----FVGASEQTDAEIKisEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKA 321
Cdd:cd19149 224 TPDREFDAGDARSgipwFSPENREKVLALL--EKWKPLCEKYGC-TLAQLVIAWTLAQPGITSALCGARKPEQAEENAKA 300
|
330
....*....|....*
gi 6319951 322 LSIDLTPDNIKYLES 336
Cdd:cd19149 301 GDIRLSAEDIATMRS 315
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
16-337 |
4.47e-31 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 120.01 E-value: 4.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 16 RFLSETAaIKVSPLilgevSYdGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIqsRRL---R 92
Cdd:cd19143 4 RRLGRSG-LKVSAL-----SF-GSWVTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAI--KELgwpR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 93 DQIVIATKFiksdkkYKAGESNTANYCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKV 172
Cdd:cd19143 75 SDYVVSTKI------FWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 173 LYLGVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRFQSK---KAMEE 248
Cdd:cd19143 149 FYWGTSEWSAQQIEEAHEIADRLGLIPPVMEQPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLASGLLTGKynnGIPEG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 249 RR---KNGEGIRSFVgaSEQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVrskAKNffPSVE-----GGKIEDLKENIK 320
Cdd:cd19143 229 SRlalPGYEWLKDRK--EELGQEKIEKVRKLKPIAEELGC-SLAQLAIAWC---LKN--PNVStvitgATKVEQLEENLK 300
|
330
....*....|....*....
gi 6319951 321 ALSI--DLTPDNIKYLESI 337
Cdd:cd19143 301 ALEVlpKLTPEVMEKIEAI 319
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
52-334 |
1.16e-30 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 118.30 E-value: 1.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 52 AFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATKF-IKSDKKYKAGESNTANYcgnhkrslhvsV 130
Cdd:cd19145 35 GIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALKDGP-REKVQLATKFgIHEIGGSGVEVRGDPAY-----------V 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 131 R----DSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAAnyyatsYGKTPFSIYQGK 206
Cdd:cd19145 103 RaaceASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADTIRRA------HAVHPITAVQLE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 207 WNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRS---FVGasEQTDAEIKISEALAKIAEEH 283
Cdd:cd19145 177 WSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLENSDVRKShprFQG--ENLEKNKVLYERVEALAKKK 254
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 6319951 284 GTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYL 334
Cdd:cd19145 255 GC-TPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
11-338 |
7.55e-30 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 116.36 E-value: 7.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 11 KLGRlrflsetAAIKVSPLILGEVSYDGarSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRR 90
Cdd:cd19083 3 KLGK-------SDIDVNPIGLGTNAVGG--HNLYPNLDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYN 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 91 lRDQIVIATKFIKSDKKYKAGESNTANYcgnhkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQG 170
Cdd:cd19083 74 -RNEVVIATKGAHKFGGDGSVLNNSPEF-------LRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEG 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 171 KVLYLGVSDTPAWVVSAANyyATSYgktpFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEERR 250
Cdd:cd19083 146 KIRAIGVSNFSLEQLKEAN--KDGY----VDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASG-LLAGKYTKDTK 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 251 KNGEGIRSFVG--ASEQTDAEIKISEALAKIAEEHGTEsVTAIAIAYVRSKaknffPSVE----GGK-IEDLKENIKALS 323
Cdd:cd19083 219 FPDNDLRNDKPlfKGERFSENLDKVDKLKSIADEKGVT-VAHLALAWYLTR-----PAIDvvipGAKrAEQVIDNLKALD 292
|
330
....*....|....*
gi 6319951 324 IDLTPDNIKYLESIV 338
Cdd:cd19083 293 VTLTEEEIAFIDALF 307
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
24-335 |
3.09e-29 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 113.48 E-value: 3.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGeVSYDGARSDFLKSmNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIqSRRLRDQIVIATKFIK 103
Cdd:cd19072 2 EEVPVLGLG-TWGIGGGMSKDYS-DDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAI-KGFDREDLFITTKVSP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 SDKKYKAgesntanycgnhkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAW 183
Cdd:cd19072 79 DHLKYDD---------------VIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLE 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 184 VVSAANYYAtsyGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAmeerrkngegirsfvgas 263
Cdd:cd19072 144 ELEEAQSYL---KKGPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNAKG------------------ 202
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319951 264 eqtdaeikiSEALAKIAEEHGtESVTAIAIAYVRSKaKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19072 203 ---------SPLLDEIAKKYG-KTPAQIALNWLISK-PNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
23-336 |
3.84e-29 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 114.25 E-value: 3.84e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 23 AIKVSPLILGEVSYDGARSDFlksMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIVIATKF- 101
Cdd:cd19078 1 GLEVSAIGLGCMGMSHGYGPP---PDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPFR--DQVVIATKFg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 102 --IKSDKKYKAGESNTANycgnHKRSlhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD 179
Cdd:cd19078 76 fkIDGGKPGPLGLDSRPE----HIRK---AVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 180 TpawvvsAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEERRKNGEGIRSF 259
Cdd:cd19078 149 A------GVETIRRAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKG-FLTGKIDENTKFDEGDDRAS 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 260 VG--ASEQTDAEIKISEALAKIAEEHGTESVtAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLES 336
Cdd:cd19078 222 LPrfTPEALEANQALVDLLKEFAEEKGATPA-QIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIED 299
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
25-335 |
7.92e-29 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 113.09 E-value: 7.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 25 KVSPLILGEVSYDGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQIVIATKFiks 104
Cdd:cd19093 1 EVSPLGLGTWQWGDRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRDEVVIATKF--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 105 dkkykAGESNTANycgnhKRSLHVSVRDSLRKLQTDWIDILYVHW-WDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAW 183
Cdd:cd19093 78 -----APLPWRLT-----RRSVVKALKASLERLGLDSIDLYQLHWpGPWYSQIEALMDGLADAVEEGLVRAVGVSNYSAD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 184 VVSAANYYATSYGKTPFSIyQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRSFVGA 262
Cdd:cd19093 148 QLRRAHKALKERGVPLASN-QVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 263 SEQTDAeikISEALAKIAEEHGtESVTAIAIAYVRSK-------AKNffpsveggkIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19093 227 LEKVQP---LLDALEEIAEKYG-KTPAQVALNWLIAKgvvpipgAKN---------AEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
23-327 |
5.93e-28 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 110.72 E-value: 5.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 23 AIKVSPLILGevsydgarsdFLKSMNKN----RAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRR-LRDQIVI 97
Cdd:cd19092 3 GLEVSRLVLG----------CMRLADWGesaeELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPgLREKIEI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 98 ATKF-IKSDKKYKAGESNTANYCGNHKRSlhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLG 176
Cdd:cd19092 73 QTKCgIRLGDDPRPGRIKHYDTSKEHILA---SVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 177 VSDTPAWVVSAANyyatSYGKTPFSIYQGKWNVLNRDF----------ERDIIPMArhfgmalapWDVMGGGRFqskkam 246
Cdd:cd19092 150 VSNFTPSQIELLQ----SYLDQPLVTNQIELSLLHTEAiddgtldycqLLDITPMA---------WSPLGGGRL------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 247 eerrkngegirsfvgASEQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDL 326
Cdd:cd19092 211 ---------------FGGFDERFQRLRAALEELAEEYGV-TIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIEL 274
|
.
gi 6319951 327 T 327
Cdd:cd19092 275 T 275
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
35-338 |
1.22e-26 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 107.91 E-value: 1.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 35 SYDGARSDflksmnkNRAFELLDTFYEAGGNFIDAANNCQNeqSEEWIGEWI-QSRRLRDQIVIATKF-IKSDKKYKAGE 112
Cdd:cd19144 26 FYGPPKPD-------EERFAVLDAAFELGCTFWDTADIYGD--SEELIGRWFkQNPGKREKIFLATKFgIEKNVETGEYS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 113 -SNTANYCGNhkrslhvSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAAnyy 191
Cdd:cd19144 97 vDGSPEYVKK-------ACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSECSAETLRRA--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 192 atsYGKTPFSIYQGKWNVLNRDFER---DIIPMARHFGMALAPWDVMG----GGRFQSKKAMEE---RRKNGEgirsFvg 261
Cdd:cd19144 167 ---HAVHPIAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGrgflTGAIRSPDDFEEgdfRRMAPR----F-- 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 262 ASEQTDAEIKISEALAKIAEEHGtesVTA--IAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLESIV 338
Cdd:cd19144 238 QAENFPKNLELVDKIKAIAKKKN---VTAgqLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIREIA 313
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
24-327 |
3.40e-26 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 106.00 E-value: 3.40e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEVSYDGARsdflksMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRR-LRDQIVIATKFi 102
Cdd:COG4989 11 LSVSRIVLGCMRLGEWD------LSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKLSPsLREKIELQTKC- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 103 ksDKKYKAGESNTA----NYCGNHkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVS 178
Cdd:COG4989 84 --GIRLPSEARDNRvkhyDTSKEH---IIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 179 DTPAWVVSAANyyatSYGKTPFSIYQGKWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRFqskkameerrkngegir 257
Cdd:COG4989 159 NFTPSQFELLQ----SALDQPLVTNQIELSLLHTDaFDDGTLDYCQLNGITPMAWSPLAGGRL----------------- 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 258 sfvgASEQTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLT 327
Cdd:COG4989 218 ----FGGFDEQFPRLRAALDELAEKYGV-SPEAIALAWLLRHPAGIQPVIGTTNPERIKAAAAALDIELT 282
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
52-332 |
3.67e-26 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 106.19 E-value: 3.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 52 AFELLDTFYEAGGNFIDAANNC-QNEQS-EEWIGEWIQS--RRLRDQIVIATK--FIKSDKKYKAGESntanycgnhKRS 125
Cdd:cd19089 31 ARELLRTAFDLGITHFDLANNYgPPPGSaEENFGRILKRdlRPYRDELVISTKagYGMWPGPYGDGGS---------RKY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 126 LHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSYGkTPFSIYQG 205
Cdd:cd19089 102 LLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKARRAIALLRELG-VPLIIHQP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 206 KWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSK-----KAMEERRKNGegirSFVGASEQTDAEIKISEALAKIA 280
Cdd:cd19089 181 RYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKylngiPPDSRRAAES----KFLTEEALTPEKLEQLRKLNKIA 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 6319951 281 EEHGtESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKAL-SIDLTPDNIK 332
Cdd:cd19089 257 AKRG-QSLAQLALSWVLRDPRVTSVLIGASSPSQLEDNVAALkNLDFSEEELA 308
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
54-323 |
1.08e-25 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 104.95 E-value: 1.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrdQIVIATKFiksdkkykagesNTANYCGNHKRSLHVSVRDS 133
Cdd:cd19075 24 ELLDAFLERGHTEIDTARVYPDGTSEELLGELGLGER---GFKIDTKA------------NPGVGGGLSPENVRKQLETS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 134 LRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRD 213
Cdd:cd19075 89 LKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPTVYQGMYNAITRQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 214 FERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEERRKNGEG---IRSFVGASEQT----DAEIKISEALAKIAEEHGtE 286
Cdd:cd19075 169 VETELFPCLRKLGIRFYAYSPLAGG-FLTGKYKYSEDKAGGGrfdPNNALGKLYRDrywkPSYFEALEKVEEAAEKEG-I 246
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 6319951 287 SVTAIAIAYVR--SKAKnffpsVEGG--------KIEDLKENIKALS 323
Cdd:cd19075 247 SLAEAALRWLYhhSALD-----GEKGdgvilgasSLEQLEENLAALE 288
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
41-229 |
2.59e-24 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 99.47 E-value: 2.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 41 SDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRrlRDQIVIATKFIKSDKKYKAGESNTAnycg 120
Cdd:cd19086 15 GDWWGDVDDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKGR--RDKVVIATKFGNRFDGGPERPQDFS---- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 121 nhKRSLHVSVRDSLRKLQTDWIDILYVH-WWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANyyatSYGKtp 199
Cdd:cd19086 89 --PEYIREAVEASLKRLGTDYIDLYQLHnPPDEVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAAL----RRGG-- 160
|
170 180 190
....*....|....*....|....*....|
gi 6319951 200 FSIYQGKWNVLNRDFERDIIPMARHFGMAL 229
Cdd:cd19086 161 IDVVQVIYNLLDQRPEEELFPLAEEHGVGV 190
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
60-338 |
2.82e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 100.83 E-value: 2.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 60 YEAGGNFIDAANNCQNEQSEEWIGEWIqsRRLRDQIVIATKF-IKSDKKYKAGESNTANycgnhkrSLHVSVRDSLRKLQ 138
Cdd:cd19102 36 LDLGINWIDTAAVYGLGHSEEVVGRAL--KGLRDRPIVATKCgLLWDEEGRIRRSLKPA-------SIRAECEASLRRLG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 139 TDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYAT-SYGKTPFSIyqgkwnvLNRDFERD 217
Cdd:cd19102 107 VDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPiASLQPPYSL-------LRRGIEAE 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 218 IIPMARHFGMALAPWDVMGGGRFqSKKAMEERRK----NGEGIRSFVGASEQTDAEIKISEALAKIAEEHGTeSVTAIAI 293
Cdd:cd19102 180 ILPFCAEHGIGVIVYSPMQSGLL-TGKMTPERVAslpaDDWRRRSPFFQEPNLARNLALVDALRPIAERHGR-TVAQLAI 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 6319951 294 AYVRSKaknffPSVEGG-----KIEDLKENIKALSIDLTPDNIKYLESIV 338
Cdd:cd19102 258 AWVLRR-----PEVTSAivgarRPDQIDETVGAADLRLTPEELAEIEALL 302
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
24-251 |
3.25e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 99.58 E-value: 3.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEVSYDGARSDFLKsmnknRAfelldtfYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATKFIK 103
Cdd:cd19105 11 LKVSRLGFGGGGLPRESPELLR-----RA-------LDLGINYFDTAEGYGNGNSEEIIGEALKGLR-RDKVFLATKASP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 SDKKYKAGEsntanycgnhkrsLHVSVRDSLRKLQTDWIDILYVHWWDYMSSI---EEFMDSLHILVQQGKVLYLGVS-- 178
Cdd:cd19105 78 RLDKKDKAE-------------LLKSVEESLKRLQTDYIDIYQLHGVDTPEERllnEELLEALEKLKKEGKVRFIGFSth 144
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319951 179 DTPAWVVSAAnyyATSYgktPFSIYQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSKKAMEERRK 251
Cdd:cd19105 145 DNMAEVLQAA---IESG---WFDVIMVAYNFLNQPAELEeALAAAAEKGIGVVAMKTLAGGYLQPALLSVLKAK 212
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
61-296 |
1.70e-22 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 95.84 E-value: 1.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRDQIVIATKF--IKSDKKYKAGESNTANycgnhkrsLHVSVRDSLRKLQ 138
Cdd:cd19148 36 DLGINLIDTAPVYGFGLSEEIVGKALKEYGKRDRVVIATKVglEWDEGGEVVRNSSPAR--------IRKEVEDSLRRLQ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 139 TDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSdtpawvvsaaNY----YATSYGKTPFSIYQGKWNVLNRDF 214
Cdd:cd19148 108 TDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVS----------NFspeqMETFRKVAPLHTVQPPYNLFEREI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 215 ERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEERRKNGEGIRSFVG--ASEQTDAEIKISEALAKIAEEHGTESVTAIA 292
Cdd:cd19148 178 EKDVLPYARKHNIVTLAYGALCRG-LLSGKMTKDTKFEGDDLRRTDPkfQEPRFSQYLAAVEELDKLAQERYGKSVIHLA 256
|
....
gi 6319951 293 IAYV 296
Cdd:cd19148 257 VRWL 260
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
24-247 |
6.10e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 90.23 E-value: 6.10e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGevsydGARsdfLKSMNKNRAFELLDTFYEAGGNFIDAANNcqNEQSEEWIGEWIQSRRlrDQIVIATKFIK 103
Cdd:cd19100 9 LKVSRLGFG-----GGP---LGRLSQEEAAAIIRRALDLGINYFDTAPS--YGDSEEKIGKALKGRR--DKVFLATKTGA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 SDKKyKAgesntanycgnhKRSLHvsvrDSLRKLQTDWIDILYVHwwdYMSSIEEF---------MDSLHILVQQGKVLY 174
Cdd:cd19100 77 RDYE-GA------------KRDLE----RSLKRLGTDYIDLYQLH---AVDTEEDLdqvfgpggaLEALLEAKEEGKIRF 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6319951 175 LGVSD-TPAWVVSAANYYatsygktPFSIYQGKWNVL---NRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAME 247
Cdd:cd19100 137 IGISGhSPEVLLRALETG-------EFDVVLFPINPAgdhIDSFREELLPLAREKGVGVIAMKVLAGGRLLSGDPLD 206
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
22-337 |
1.73e-20 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 91.07 E-value: 1.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 22 AAIKVSPLILGEVSYDGARSDflksmnkNRAFELLDTFYEAGGNFIDAAN--------NCQNeQSEEWIGEWIQSRRLRD 93
Cdd:PRK10625 9 SSLEVSTLGLGTMTFGEQNSE-------ADAHAQLDYAVAQGINLIDVAEmypvpprpETQG-LTETYIGNWLAKRGSRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 94 QIVIATKFIKSDKKYKAG-ESNTANYCGNHKRSLHvsvrDSLRKLQTDWIDILYVHW--------------WDYMSSIEE 158
Cdd:PRK10625 81 KLIIASKVSGPSRNNDKGiRPNQALDRKNIREALH----DSLKRLQTDYLDLYQVHWpqrptncfgklgysWTDSAPAVS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 159 FMDSLHILVQQ---GKVLYLGVSDTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARHFGMALAPWDVM 235
Cdd:PRK10625 157 LLETLDALAEQqraGKIRYIGVSNETAFGVMRYLHLAEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 236 GGGRFQSK---KAMEERRKNGEGIRSFVGASEQTDAEIKiseALAKIAEEHGTESvTAIAIAYVRSKAknFFPSVEGG-- 310
Cdd:PRK10625 237 AFGTLTGKylnGAKPAGARNTLFSRFTRYSGEQTQKAVA---AYVDIAKRHGLDP-AQMALAFVRRQP--FVASTLLGat 310
|
330 340
....*....|....*....|....*..
gi 6319951 311 KIEDLKENIKALSIDLTPDNIKYLESI 337
Cdd:PRK10625 311 TMEQLKTNIESLHLTLSEEVLAEIEAV 337
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
51-228 |
5.73e-20 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 88.06 E-value: 5.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 51 RAFELLDTFYEAGGNFIDAANNCQNeqSEEWIGEWIQSRRlRDQIVIATKfiksdkkykAGESNtaNYCGNHKRSL--HV 128
Cdd:cd19095 21 EAARLLNTALDLGINLIDTAPAYGR--SEERLGRALAGLR-RDDLFIATK---------VGTHG--EGGRDRKDFSpaAI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 129 --SVRDSLRKLQTDWIDILYVHwwdyMSSIEEF----MDSLHILVQQGKVLYLGVS-DTPawvvsAANYYATSygkTPFS 201
Cdd:cd19095 87 raSIERSLRRLGTDYIDLLQLH----GPSDDELtgevLETLEDLKAAGKVRYIGVSgDGE-----ELEAAIAS---GVFD 154
|
170 180
....*....|....*....|....*..
gi 6319951 202 IYQGKWNVLNRDfERDIIPMARHFGMA 228
Cdd:cd19095 155 VVQLPYNVLDRE-EEELLPLAAEAGLG 180
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
54-335 |
6.77e-20 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 88.07 E-value: 6.77e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIVIATKFIKSDkkykAGESNTANYCGNhkrslhvsvrdS 133
Cdd:cd19138 33 EALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGRR--DKVFLVSKVLPSN----ASRQGTVRACER-----------S 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 134 LRKLQTDWIDILYVHWwdyMSSI--EEFMDSLHILVQQGKVLYLGVS--DTP----AWVVSAANYYATSygktpfsiyQG 205
Cdd:cd19138 96 LRRLGTDYLDLYLLHW---RGGVplAETVAAMEELKKEGKIRAWGVSnfDTDdmeeLWAVPGGGNCAAN---------QV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 206 KWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEerrkngegirsfvgaseqtdaeikiSEALAKIAEEHGT 285
Cdd:cd19138 164 LYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRRGLLE-------------------------NPTLKEIAARHGA 218
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 6319951 286 eSVTAIAIAYV-RSkaKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19138 219 -TPAQVALAWVlRD--GNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
47-327 |
2.67e-19 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 86.12 E-value: 2.67e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 47 MNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlrDQIVIATK--FIKSDkkykaGESNTANycgNHKR 124
Cdd:cd19088 21 ADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYP--DDVVIATKggLVRTG-----PGWWGPD---GSPE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 125 SLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAANYyatsygkTPFSIY 203
Cdd:cd19088 91 YLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNvTVAQIEEARAI-------VRIVSV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 204 QGKWNVLNRDFErDIIPMARHFGMALAPWDVMGGGRFqskkameerRKNGegirsfvgaseqtdaeikisEALAKIAEEH 283
Cdd:cd19088 164 QNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDL---------AQPG--------------------GLLAEVAARL 213
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 6319951 284 GTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLT 327
Cdd:cd19088 214 GA-TPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
52-335 |
2.76e-19 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 86.09 E-value: 2.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 52 AFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATKFIKSDKKYKagesntanycgnhkrSLHVSVR 131
Cdd:cd19137 28 MVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFP-REDLFIVTKVWPTNLRYD---------------DLLRSLQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 132 DSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAanyyATSYGKTPFSIYQGKWNVLN 211
Cdd:cd19137 92 NSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEE----AISKSQTPIVCNQVKYNLED 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 212 RDFERD-IIPMARHFG---MALAPWDvmgggrfqskkameerrkngEGIrsfvgaseqtdaeIKISEALAKIAEEHGtES 287
Cdd:cd19137 168 RDPERDgLLEYCQKNGitvVAYSPLR--------------------RGL-------------EKTNRTLEEIAKNYG-KT 213
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 6319951 288 VTAIAIAYVRSKaKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19137 214 IAQIALAWLIQK-PNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
54-323 |
5.89e-18 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 83.22 E-value: 5.89e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNCQNE--QSEEWIGEWIQS--RRLRDQIVIATKfiksdkkykAGESNTANYCGNH--KRSLH 127
Cdd:cd19151 34 AMLRRAFDLGITHFDLANNYGPPpgSAEENFGRILKEdlKPYRDELIISTK---------AGYTMWPGPYGDWgsKKYLI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 128 VSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYATSYGkTPFSIYQGKW 207
Cdd:cd19151 105 ASLDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAILKDLG-TPCLIHQPKY 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 208 NVLNRDFERDIIPMARHFGMALAPWDVMGGGRFQSK--KAMEERRKNGEGiRSFVGASEQTDAEIKISEALAKIAEEHGt 285
Cdd:cd19151 184 SMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRylNGIPEDSRAAKG-SSFLKPEQITEEKLAKVRRLNEIAQARG- 261
|
250 260 270
....*....|....*....|....*....|....*...
gi 6319951 286 ESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALS 323
Cdd:cd19151 262 QKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGALD 299
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
51-329 |
2.21e-17 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 81.06 E-value: 2.21e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 51 RAFELLDTFYEAGGNFIDAANNCQNeqSEEWIGEWIQSRRlRDQIVIATKfiksdkkykagesntanyCGNHKR------ 124
Cdd:cd19090 21 EAVATIRAALDLGINYIDTAPAYGD--SEERLGLALAELP-REPLVLSTK------------------VGRLPEdtadys 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 125 --SLHVSVRDSLRKLQTDWIDILYVH------WWDYMsSIEEFMDSLHILVQQGKVLYLGVSDTPAWVvsAANYYATsyG 196
Cdd:cd19090 80 adRVRRSVEESLERLGRDRIDLLMIHdpervpWVDIL-APGGALEALLELKEEGLIKHIGLGGGPPDL--LRRAIET--G 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 197 KTPFSIYQGKWNVLNRDFERDIIPMARHFGMAlapwdVMGGGRFQ----SKKAMEERRKNGEGIrsfvgaseqTDAEIKI 272
Cdd:cd19090 155 DFDVVLTANRYTLLDQSAADELLPAAARHGVG-----VINASPLGmgllAGRPPERVRYTYRWL---------SPELLDR 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319951 273 SEALAKIAEEHGtESVTAIAIAYVRSkaknfFPSVEG-----GKIEDLKENIKALSIDLTPD 329
Cdd:cd19090 221 AKRLYELCDEHG-VPLPALALRFLLR-----DPRISTvlvgaSSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
60-332 |
2.76e-16 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 77.31 E-value: 2.76e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 60 YEAGGNFIDAANNCQNEqseEWIGEWIQ-SRRLRDQIVIATKFIKSDKKYKagesntanycgnhkrSLHVSVRDSLRKLQ 138
Cdd:cd19073 24 LELGYRHIDTAEIYNNE---AEVGEAIAeSGVPREDLFITTKVWRDHLRPE---------------DLKKSVDRSLEKLG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 139 TDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAANYYAT--SYGKTPFSIYQGKWNVLNRDFE 215
Cdd:cd19073 86 TDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNfTIELLEEALDISPLpiAVNQVEFHPFLYQAELLEYCRE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 216 RDIIPMARhfgMALApwdvmgggrfqskkameerrkNGEGIRsfvgaseqtdaeikiSEALAKIAEEHGTESVTaIAIAY 295
Cdd:cd19073 166 NDIVITAY---SPLA---------------------RGEVLR---------------DPVIQEIAEKYDKTPAQ-VALRW 205
|
250 260 270
....*....|....*....|....*....|....*..
gi 6319951 296 VRSKAKNFFPSveGGKIEDLKENIKALSIDLTPDNIK 332
Cdd:cd19073 206 LVQKGIVVIPK--ASSEDHLKENLAIFDWELTSEDVA 240
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
54-240 |
6.91e-16 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 77.94 E-value: 6.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNcqNEQSEEWIGEWIQSRRlrDQIVIATKFiksdkkykAGESNTANycgNHKRSLHvsvrDS 133
Cdd:COG1453 33 ALIRRAIDNGINYIDTARG--YGDSEEFLGKALKGPR--DKVILATKL--------PPWVRDPE---DMRKDLE----ES 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 134 LRKLQTDWIDILYVHWWDYMSSIEEFMDSLHIL------VQQGKVLYLGVS--DTPAWVVSAANYYatsygktPFSIYQG 205
Cdd:COG1453 94 LKRLQTDYIDLYLIHGLNTEEDLEKVLKPGGALealekaKAEGKIRHIGFSthGSLEVIKEAIDTG-------DFDFVQL 166
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 6319951 206 KWNVLNRDF--ERDIIPMARHFGMALApwdVM---GGGRF 240
Cdd:COG1453 167 QYNYLDQDNqaGEEALEAAAEKGIGVI---IMkplKGGRL 203
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
38-178 |
5.86e-15 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 74.81 E-value: 5.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 38 GARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRL-RDQIVIATKFIksdkkYKAGESNta 116
Cdd:cd19142 19 GTWSTFSTAISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGWkRSSYIVSTKIY-----WSYGSEE-- 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319951 117 nyCGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19142 92 --RGLSRKHIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTS 151
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
22-338 |
1.26e-13 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 70.78 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 22 AAIKVSPLILGE-VSYDGARSDflksmnkNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLRdqiviATK 100
Cdd:cd19160 11 SGLRVSCLGLGTwVTFGSQISD-------ETAEDLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWR-----RSS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 101 FIKSDKKYKAGESNTANycGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDT 180
Cdd:cd19160 79 YVVTTKIYWGGQAETER--GLSRKHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 181 PAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMGGGRFQSK---KAMEERRKNGEG- 255
Cdd:cd19160 157 SAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREKVEMQLPELYHkIGVGSVTWSPLACGLITGKydgRVPDTCRAAVKGy 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 256 --IRSFVGASEQTDAEIKISEaLAKIAEEHGTeSVTAIAIAY-VRSKAknfFPSVEGG--KIEDLKENIKALSI--DLTP 328
Cdd:cd19160 237 qwLKEKVQSEEGKKQQAKVKE-LHPIADRLGC-TVAQLAIAWcLRSEG---VSSVLLGvsSAEQLIENLGSIQVlsQLTP 311
|
330
....*....|
gi 6319951 329 DNIKYLESIV 338
Cdd:cd19160 312 QTVMEIDALL 321
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
45-338 |
3.20e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 69.55 E-value: 3.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 45 KSMNKNRAFELLDTFYEAGGNFIDAANNCQNeqSEEWIGE----WIQSRRLRDQIVIATKFIKSDKKYKAGESNTANYcg 120
Cdd:cd19101 18 GIRDEDAAVRAMAAYVDAGLTTFDCADIYGP--AEELIGEfrkrLRRERDAADDVQIHTKWVPDPGELTMTRAYVEAA-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 121 nhkrslhvsVRDSLRKLQTDWIDILYVHWWDY-MSSIEEFMDSLHILVQQGKVLYLGVS--DTP--AWVVSAanyyatsy 195
Cdd:cd19101 94 ---------IDRSLKRLGVDRLDLVQFHWWDYsDPGYLDAAKHLAELQEEGKIRHLGLTnfDTErlREILDA-------- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 196 GKTPFSiYQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGrFQSKKAMEER------------RKNGEGIRSFVGas 263
Cdd:cd19101 157 GVPIVS-NQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGG-LLSEKYLGVPeptgpaletrslQKYKLMIDEWGG-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 264 eqTDAEIKISEALAKIAEEHGTeSVTAIAIAYVRSKaknffPSVeGGKI------EDLKENIKALSIDLTPDNIKYLESI 337
Cdd:cd19101 233 --WDLFQELLRTLKAIADKHGV-SIANVAVRWVLDQ-----PGV-AGVIvgarnsEHIDDNVRAFSFRLDDEDRAAIDAV 303
|
.
gi 6319951 338 V 338
Cdd:cd19101 304 L 304
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
54-332 |
4.67e-13 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 69.02 E-value: 4.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNCQNE--QSEEWIGEWIQS--RRLRDQIVIATKfiksdkkykAGESNTANYCGN--HKRSLH 127
Cdd:cd19150 34 AILRTAFDLGITHFDLANNYGPPpgSAEENFGRILREdfAGYRDELIISTK---------AGYDMWPGPYGEwgSRKYLL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 128 VSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAANYYATSygKTPFSIYQGK 206
Cdd:cd19150 105 ASLDQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSySPERTREAAAILREL--GTPLLIHQPS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 207 WNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSK--KAMEERRKNGEGiRSFvGASEQTDAEIKISEALAKIAEEH 283
Cdd:cd19150 183 YNMLNRWVEESgLLDTLQELGVGCIAFTPLAQGLLTDKylNGIPEGSRASKE-RSL-SPKMLTEANLNSIRALNEIAQKR 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 6319951 284 GtESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKAL-SIDLTPDNIK 332
Cdd:cd19150 261 G-QSLAQMALAWVLRDGRVTSALIGASRPEQLEENVGALdNLTFSADELA 309
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
48-324 |
9.20e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 67.55 E-value: 9.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 48 NKNRAFELLDTFYEAGGNFIDAANNCQNeqSEEWIGEWIQSRrlrDQIVIATKFiksdkkykageSNTANYCGNHKRSLH 127
Cdd:cd19097 24 SEKEAKKILEYALKAGINTLDTAPAYGD--SEKVLGKFLKRL---DKFKIITKL-----------PPLKEDKKEDEAAIE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 128 VSVRDSLRKLQTDWIDILYVHWWDYMSSI-EEFMDSLHILVQQGKVLYLGVS-DTPAWVVSAANYYatsygktPFSIYQG 205
Cdd:cd19097 88 ASVEASLKRLKVDSLDGLLLHNPDDLLKHgGKLVEALLELKKEGLIRKIGVSvYSPEELEKALESF-------KIDIIQL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 206 KWNVLNRdferdiipmarhfgmalapwdvmgggRFQSKKAMEERRKNGEGI--RS-------FVGASEQTD--AEIK-IS 273
Cdd:cd19097 161 PFNILDQ--------------------------RFLKSGLLAKLKKKGIEIhaRSvflqgllLMEPDKLPAkfAPAKpLL 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 6319951 274 EALAKIAEEHGTeSVTAIAIAYVRSkaknfFPSVEG---G--KIEDLKENIKALSI 324
Cdd:cd19097 215 KKLHELAKKLGL-SPLELALGFVLS-----LPEIDKivvGvdSLEQLKEIIAAFKK 264
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
43-323 |
1.33e-12 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 68.09 E-value: 1.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 43 FLKSMNKNRAfeLLDTFYEAGGNFIDAANNCQNE--QSEEWIGEWIQS--RRLRDQIVIATK--FIKSDKKYKAGESnta 116
Cdd:PRK09912 38 HVNALESQRA--ILRKAFDLGITHFDLANNYGPPpgSAEENFGRLLREdfAAYRDELIISTKagYDMWPGPYGSGGS--- 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 117 nycgnhKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAANYYATsy 195
Cdd:PRK09912 113 ------RKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSySPERTQKMVELLRE-- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 196 GKTPFSIYQGKWNVLNRDFERD-IIPMARHFGMALAPWDVMGGGRFQSK---KAMEERRKNGEGiRSFVGASEQ--TDAE 269
Cdd:PRK09912 185 WKIPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLLTGKylnGIPQDSRMHREG-NKVRGLTPKmlTEAN 263
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 6319951 270 IKISEALAKIAEEHGtESVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALS 323
Cdd:PRK09912 264 LNSLRLLNEMAQQRG-QSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQALN 316
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
61-337 |
6.27e-12 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 65.08 E-value: 6.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEqseEWIGEWI-QSRRLRDQIVIATKFIKSDKKYkagesntanycgnhkRSLHVSVRDSLRKLQT 139
Cdd:COG0656 29 EAGYRHIDTAAMYGNE---EGVGEAIaASGVPREELFVTTKVWNDNHGY---------------DDTLAAFEESLERLGL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVHW---WDYMSSIEEFMDslhiLVQQGKVLYLGVSD-TPA---WVVSAAnyyatsyGKTP------FSIYQGK 206
Cdd:COG0656 91 DYLDLYLIHWpgpGPYVETWRALEE----LYEEGLIRAIGVSNfDPEhleELLAET-------GVKPavnqveLHPYLQQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 207 WNVLNRDFERDIIPMArhfgmalapWDVMGGGrfqskKAMEErrkngegirsfvgaseqtdaeikisEALAKIAEEHGTe 286
Cdd:COG0656 160 RELLAFCREHGIVVEA---------YSPLGRG-----KLLDD-------------------------PVLAEIAEKHGK- 199
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 6319951 287 SVTAIAIAYVRskAKNFFP---SVeggKIEDLKENIKALSIDLTPDNIKYLESI 337
Cdd:COG0656 200 TPAQVVLRWHL--QRGVVVipkSV---TPERIRENLDAFDFELSDEDMAAIDAL 248
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
61-335 |
7.68e-12 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 64.81 E-value: 7.68e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWIQSRRL-RDQIVIATKFIKSDKKYKagesNTANycgnhkrslhvSVRDSLRKLQT 139
Cdd:cd19071 25 EAGYRHIDTAAAYGNEAE---VGEAIRESGVpREELFITTKLWPTDHGYE----RVRE-----------ALEESLKDLGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVHW---WDYMSSIEEFMDS---LHILVQQGKVLYLGVSdtpawvvsaaNYYAT------SYGKTPFSIYQGKW 207
Cdd:cd19071 87 DYLDLYLIHWpvpGKEGGSKEARLETwraLEELVDEGLVRSIGVS----------NFNVEhleellAAARIKPAVNQIEL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 208 NVLN-----RDF--ERDIIPMArhfgmalapWDVMGGGRFQSKKameerrkngegirsfvgaseqtdaeikiSEALAKIA 280
Cdd:cd19071 157 HPYLqqkelVEFckEHGIVVQA---------YSPLGRGRRPLLD----------------------------DPVLKEIA 199
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 6319951 281 EEHGTeSVTAIAIAYVRSkaKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19071 200 KKYGK-TPAQVLLRWALQ--RGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
21-330 |
9.16e-12 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 65.16 E-value: 9.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 21 TAAIKVSPLILGE-VSYDGARSDFLksmnknrAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRL-RDQIVIA 98
Cdd:cd19141 7 KSGLRVSCLGLGTwVTFGSQISDEV-------AEELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGWrRSSYVIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 99 TKFiksdkkYKAGESNTANycGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19141 80 TKI------FWGGKAETER--GLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTS 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 179 DTPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMGGG----------RFQSKKAME 247
Cdd:cd19141 152 RWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQREKVEMQLPELFHkIGVGAMTWSPLACGilsgkyddgvPEYSRASLK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 248 ERRKNGEGIRSFVGASEQTdaeiKISEaLAKIAEEHGTeSVTAIAIAY-VRSKAKNffpSVEGG--KIEDLKENIKALSI 324
Cdd:cd19141 232 GYQWLKEKILSEEGRRQQA----KLKE-LQIIADRLGC-TLPQLAIAWcLKNEGVS---SVLLGasSTEQLYENLQAIQV 302
|
....*...
gi 6319951 325 --DLTPDN 330
Cdd:cd19141 303 lpKLTPNI 310
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
20-185 |
3.71e-11 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 63.32 E-value: 3.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 20 ETAAIKVSPLILGEVSYDGARSDFLKSMnknrafELLDTFYEA---GGNFIDAANNCQNEQSEEWIGEWIQSRRL-RDQI 95
Cdd:cd19153 6 EIALGNVSPVGLGTAALGGVYGDGLEQD------EAVAIVAEAfaaGINHFDTSPYYGAESSEAVLGKALAALQVpRSSY 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 96 VIATKFiksdKKYKAGESNTAnycgnhKRSLHVSVRDSLRKLQTDWIDILYVH---WWDYMSSIEEFMDSLHILVQQGKV 172
Cdd:cd19153 80 TVATKV----GRYRDSEFDYS------AERVRASVATSLERLHTTYLDVVYLHdieFVDYDTLVDEALPALRTLKDEGVI 149
|
170
....*....|....*..
gi 6319951 173 LYLGVS----DTPAWVV 185
Cdd:cd19153 150 KRIGIAgyplDTLTRAT 166
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
25-178 |
4.74e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 63.11 E-value: 4.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 25 KVSPLILGevSYDGARSDFLKSmnknRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIG----EWIQSRRL-RDQIVIAT 99
Cdd:cd19099 2 TLSSLGLG--TYRGDSDDETDE----EYREALKAALDSGINVIDTAINYRGGRSERLIGkalrELIEKGGIkRDEVVIVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 100 K--FIKSD------------KKYKAGESNTANYCGN----HKRSLHVSVRDSLRKLQTDWIDILYVH----------WWD 151
Cdd:cd19099 76 KagYIPGDgdeplrplkyleEKLGRGLIDVADSAGLrhciSPAYLEDQIERSLKRLGLDTIDLYLLHnpeeqllelgEEE 155
|
170 180
....*....|....*....|....*..
gi 6319951 152 YMSSIEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19099 156 FYDRLEEAFEALEEAVAEGKIRYYGIS 182
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
24-178 |
5.95e-11 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 62.57 E-value: 5.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 24 IKVSPLILGEvsydGARSDFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRlRDQIVIATKFik 103
Cdd:cd19163 11 LKVSKLGFGA----SPLGGVFGPVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGIP-RDSYYLATKV-- 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 104 sdKKYKAGESNTANYcgNHKRSLHvSVRDSLRKLQTDWIDILYVHWWDYMSS----IEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19163 84 --GRYGLDPDKMFDF--SAERITK-SVEESLKRLGLDYIDIIQVHDIEFAPSldqiLNETLPALQKLKEEGKVRFIGIT 157
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
57-336 |
7.38e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 62.35 E-value: 7.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 57 DTFYEAGGNFIDAANNCQNEQSEEWIGEWIQsRRLRDQIVIATKFiksdkkykagesnTANYCGNHKRSLHVSVRDSLRK 136
Cdd:cd19103 39 DKAMAAGLNLWDTAAVYGMGASEKILGEFLK-RYPREDYIISTKF-------------TPQIAGQSADPVADMLEGSLAR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 137 LQTDWIDILYVHwwdYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYatsYGKTPFSIY--QGKWNVLNRDF 214
Cdd:cd19103 105 LGTDYIDIYWIH---NPADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEI---LAKAGVSLSavQNHYSLLYRSS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 215 ERD-IIPMARHFGMALAPWDV----MGGGRFQSKKAMEERRKNGEGIRSFVGASEqtdaeiKISEALAKIAEEHGTeSVT 289
Cdd:cd19103 179 EEAgILDYCKENGITFFAYMVleqgALSGKYDTKHPLPEGSGRAETYNPLLPQLE------ELTAVMAEIGAKHGA-SIA 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 6319951 290 AIAIAYVRskAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLES 336
Cdd:cd19103 252 QVAIAWAI--AKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQ 296
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
61-332 |
1.72e-10 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 60.44 E-value: 1.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWI-QSRRLRDQIVIATKfIKSDkkykagesntaNYcgnHKRSLHVSVRDSLRKLQT 139
Cdd:cd19139 25 ELGYRHIDTAQIYDNEAA---VGQAIaESGVPRDELFITTK-IWID-----------NL---SKDKLLPSLEESLEKLRT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVHW--WDYMSSIEEFMDSLHILVQQGKVLYLGVSDtpawvvsaanyyatsygktpFSIYQ--------GKWNV 209
Cdd:cd19139 87 DYVDLTLIHWpsPNDEVPVEEYIGALAEAKEQGLTRHIGVSN--------------------FTIALldeaiavvGAGAI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 210 LNRDFErdiipmarhfgmaLAPWdvmgggrFQSKKAMEERRKNGEGIRSFvgaseQTDAEIKI--SEALAKIAEEHGTeS 287
Cdd:cd19139 147 ATNQIE-------------LSPY-------LQNRKLVAHCKQHGIHVTSY-----MTLAYGKVldDPVLAAIAERHGA-T 200
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 6319951 288 VTAIAIAYVRSKAKNFFPSveGGKIEDLKENIKALSIDLTPDNIK 332
Cdd:cd19139 201 PAQIALAWAMARGYAVIPS--STKREHLRSNLLALDLTLDADDMA 243
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
61-337 |
2.56e-10 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 60.35 E-value: 2.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAAnncQNEQSEEWIGEWI-QSRRLRDQIVIATKFIksdkkykagesnTANYcgnHKRSLHVSVRDSLRKLQT 139
Cdd:cd19140 32 ELGYRHIDTA---QMYGNEAQVGEAIaASGVPRDELFLTTKVW------------PDNY---SPDDFLASVEESLRKLRT 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAanyyATSYGKTPFSIYQGKWNVLNRdfERDII 219
Cdd:cd19140 94 DYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLRE----AVELSEAPLFTNQVEYHPYLD--QRKLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 220 PMARHFGMALAPWDVMGGGrfqskkameerrkngegirsfvgaseqtdaEIKISEALAKIAEEHGtESVTAIAIAY---- 295
Cdd:cd19140 168 DAAREHGIALTAYSPLARG------------------------------EVLKDPVLQEIGRKHG-KTPAQVALRWllqq 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 6319951 296 ----VRSKAKNFfpsveggkiEDLKENIKALSIDLTPDNIKYLESI 337
Cdd:cd19140 217 egvaAIPKATNP---------ERLEENLDIFDFTLSDEEMARIAAL 253
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
22-324 |
9.36e-10 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 59.29 E-value: 9.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 22 AAIKVSPLILGE-VSYDGARSDflksmnkNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLR-DQIVIAT 99
Cdd:cd19159 9 SGLRVSCLGLGTwVTFGGQISD-------EVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRrSSLVITT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 100 KFiksdkkYKAGESNTANycGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD 179
Cdd:cd19159 82 KL------YWGGKAETER--GLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 180 TPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMG----GGRFQ------SKKAMEE 248
Cdd:cd19159 154 WSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHkIGVGAMTWSPLAcgiiSGKYGngvpesSRASLKC 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 249 RRKNGEGIRSFVGASEQTdaeiKISEaLAKIAEEHGTeSVTAIAIAY-VRSKAknfFPSVEGG--KIEDLKENIKALSI 324
Cdd:cd19159 234 YQWLKERIVSEEGRKQQN----KLKD-LSPIAERLGC-TLPQLAVAWcLRNEG---VSSVLLGssTPEQLIENLGAIQV 303
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
51-335 |
1.85e-09 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 58.02 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 51 RAFELLDTFYEAGGNFIDAA---NNCQNEQSEEWIGEWIQSR-RLRDQIVIATKFIKSDKKYKAGESntanycgnhKRSL 126
Cdd:cd19077 26 EAFETMKAALDAGSNLWNGGefyGPPDPHANLKLLARFFRKYpEYADKVVLSVKGGLDPDTLRPDGS---------PEAV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 127 HVSVRDSLRKL-QTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSDTPAWVVSAANYYAtsygktPFSIYQG 205
Cdd:cd19077 97 RKSIENILRALgGTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAETIRRAHAVH------PIAAVEV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 206 KWNVLNRD-FERDIIPMARHFGMALAPWDVMGGGRFQSKKAMEERRKNGEGIRSFVGASEQT-DAEIKISEALAKIAEEH 283
Cdd:cd19077 171 EYSLFSREiEENGVLETCAELGIPIIAYSPLGRGLLTGRIKSLADIPEGDFRRHLDRFNGENfEKNLKLVDALQELAEKK 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 6319951 284 GTeSVTAIAIAYVRSKAKN-FFPSVEGGKIEDLKENIKALSIDLTPDNIKYLE 335
Cdd:cd19077 251 GC-TPAQLALAWILAQSGPkIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
61-337 |
2.17e-09 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 58.05 E-value: 2.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSEEWIGEWIQSrrLRDQIVIATKfiksdkkYKAGESNTANYCGNHKRSLHvsvrDSLRKLQTD 140
Cdd:cd19104 43 DLGINFFDTAPSYGDGKSEENLGRALKG--LPAGPYITTK-------VRLDPDDLGDIGGQIERSVE----KSLKRLKRD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 141 WIDILYVH------------------WWDYMssiEEFMDSLHILVQQGKVLYLGVS------------DTPAWvvSAANY 190
Cdd:cd19104 110 SVDLLQLHnrigderdkpvggtlsttDVLGL---GGVADAFERLRSEGKIRFIGITglgnppairellDSGKF--DAVQV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 191 YATSYGKTPFSIYQGKWNvlNRDFeRDIIPMARHFGMALAPWDVMGGGrfqskkAMEERRKNGEGIRSFVGASEQTDAEi 270
Cdd:cd19104 185 YYNLLNPSAAEARPRGWS--AQDY-GGIIDAAAEHGVGVMGIRVLAAG------ALTTSLDRGREAPPTSDSDVAIDFR- 254
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 271 kISEALAKIAEEHGtESVTAIAIAYVRSKAKnfFPSVEGG--KIEDLKENIKALSI-DLTPDNIKYLESI 337
Cdd:cd19104 255 -RAAAFRALAREWG-ETLAQLAHRFALSNPG--VSTVLVGvkNREELEEAVAAEAAgPLPAENLARLEAL 320
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
45-240 |
3.97e-09 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 56.80 E-value: 3.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 45 KSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIqSRRLRDQIVIATKF-IKSDKKYKAGESNtanycgnhk 123
Cdd:cd19096 16 DSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEAL-KEGPREKFYLATKLpPWSVKSAEDFRRI--------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 124 rslhvsVRDSLRKLQTDWIDILYVHWWDyMSSIEEFMDSLHIL------VQQGKVLYLGVS--DTPAWVVSAANYYatsy 195
Cdd:cd19096 86 ------LEESLKRLGVDYIDFYLLHGLN-SPEWLEKARKGGLLeflekaKKEGLIRHIGFSfhDSPELLKEILDSY---- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 6319951 196 gktPFSIYQGKWNVLNRDFERDI--IPMARHFGMALApwdVM---GGGRF 240
Cdd:cd19096 155 ---DFDFVQLQYNYLDQENQAGRpgIEYAAKKGMGVI---IMeplKGGGL 198
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
22-324 |
6.41e-08 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 53.55 E-value: 6.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 22 AAIKVSPLILGE-VSYDGARSDFLksmnknrAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQSRRLR-DQIVIAT 99
Cdd:cd19158 9 SGLRVSCLGLGTwVTFGGQITDEM-------AEHLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRrSSLVITT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 100 KFiksdkkYKAGESNTANycGNHKRSLHVSVRDSLRKLQTDWIDILYVHWWDYMSSIEEFMDSLHILVQQGKVLYLGVSD 179
Cdd:cd19158 82 KI------FWGGKAETER--GLSRKHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 180 TPAWVVSAANYYATSYGKTPFSIYQGKWNVLNRDFERDIIPMARH-FGMALAPWDVMG----GGRFQSKKAMEERR--KN 252
Cdd:cd19158 154 WSSMEIMEAYSVARQFNLIPPICEQAEYHMFQREKVEVQLPELFHkIGVGAMTWSPLAcgivSGKYDSGIPPYSRAslKG 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6319951 253 GEGIRSFVGASEQTDAEIKISEaLAKIAEEHGTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSI 324
Cdd:cd19158 234 YQWLKDKILSEEGRRQQAKLKE-LQAIAERLGC-TLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQV 303
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
51-296 |
2.28e-07 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 51.59 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 51 RAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQsRRLRDQIVIATKfiksdkkykAG---ESNTANYCGNHKRSLH 127
Cdd:cd19162 20 EAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALA-RHPRAEYVVSTK---------VGrllEPGAAGRPAGADRRFD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 128 V-------SVRDSLRKLQTDWIDILYVHWWD--YMSSIEEFMDSLHILVQQGKVLYLGVSDTpawVVSAANYYATSYGKT 198
Cdd:cd19162 90 FsadgirrSIEASLERLGLDRLDLVFLHDPDrhLLQALTDAFPALEELRAEGVVGAIGVGVT---DWAALLRAARRADVD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 199 PFSIyQGKWNVLNRDFERDIIPMARHFGMALAPWDVMGGGRFqskkAMEERrkngEGIRSFVGASeqTDAEIKISEALAK 278
Cdd:cd19162 167 VVMV-AGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGIL----ATDDP----AGDRYDYRPA--TPEVLARARRLAA 235
|
250
....*....|....*...
gi 6319951 279 IAEEHGTESVTAiAIAYV 296
Cdd:cd19162 236 VCRRYGVPLPAA-ALQFP 252
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
27-296 |
4.51e-07 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 50.79 E-value: 4.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 27 SPLILGEVSYDGarsdFLKSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSEEWIGEWIQsRRLRDQIVIATKFIKsdK 106
Cdd:cd19161 1 SELGLGTAGLGN----LYTAVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLR-EKPRDEFVLSTKVGR--L 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 107 KYKAGESNTANYCGNHK----------------RSlhvsVRDSLRKLQTDWIDILYVHWWDYMSSIEEF--------MDS 162
Cdd:cd19161 74 LKPAREGSVPDPNGFVDplpfeivydysydgimRS----FEDSLQRLGLNRIDILYVHDIGVYTHGDRKerhhfaqlMSG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 163 ----LHILVQQG--KVLYLGVSDTPAwVVSAANYYatsygktPFSIY--QGKWNVLNRDFERDIIPMARHFGMALAPwdv 234
Cdd:cd19161 150 gfkaLEELKKAGviKAFGLGVNEVQI-CLEALDEA-------DLDCFllAGRYSLLDQSAEEEFLPRCEQRGTSLVI--- 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6319951 235 mgGGRFQSkkameerrkngeGIRSFVGASEQT------DAEI-KISEALAKIAEEHGTESVTAiAIAYV 296
Cdd:cd19161 219 --GGVFNS------------GILATGTKSGAKfnygdaPAEIiSRVMEIEKICDAYNVPLAAA-ALQFP 272
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
61-179 |
1.45e-06 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 48.91 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEqseEWIGEWIQSRRL-RDQIVIATKFIKSDKKYKAGESntanycgnhkrslhvSVRDSLRKLQT 139
Cdd:cd19131 34 EVGYRSIDTAAIYGNE---EGVGKAIRASGVpREELFITTKLWNSDQGYDSTLR---------------AFDESLRKLGL 95
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6319951 140 DWIDILYVHWwdYMSSIEEFMDSLHILVQ---QGKVLYLGVSD 179
Cdd:cd19131 96 DYVDLYLIHW--PVPAQDKYVETWKALIElkkEGRVKSIGVSN 136
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
27-181 |
6.07e-06 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 47.47 E-value: 6.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 27 SPL--ILGEVSYDGARSDFlksmnkNRAFELldtfyeaGGNFIDAANNCQNEQSEEWIGEWIQSRRL-RDQIVIATKFik 103
Cdd:PLN02587 19 SPLgsVFGPVSEEDAIASV------REAFRL-------GINFFDTSPYYGGTLSEKVLGKALKALGIpREKYVVSTKC-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 104 sdKKYKAGESNTAnycgnhKRSLHvSVRDSLRKLQTDWIDILYVHWWDYMS---SIEEFMDSLHILVQQGKVLYLGVSDT 180
Cdd:PLN02587 84 --GRYGEGFDFSA------ERVTK-SVDESLARLQLDYVDILHCHDIEFGSldqIVNETIPALQKLKESGKVRFIGITGL 154
|
.
gi 6319951 181 P 181
Cdd:PLN02587 155 P 155
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
45-179 |
7.83e-06 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 46.66 E-value: 7.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 45 KSMNKNRAFELLDTFYEAGGNFIDAANNCQNEQSeewIGEWIQSRRL-RDQIVIATKFIKSDKKYKAGESntanycgnhk 123
Cdd:cd19126 18 QTPDGDETERAVQTALENGYRSIDTAAIYKNEEG---VGEAIRESGVpREELFVTTKLWNDDQRARRTED---------- 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6319951 124 rslhvSVRDSLRKLQTDWIDILYVHW---------WDYMssiEEFMDSlhilvqqGKVLYLGVSD 179
Cdd:cd19126 85 -----AFQESLDRLGLDYVDLYLIHWpgkdkfidtWKAL---EKLYAS-------GKVKAIGVSN 134
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
61-332 |
1.54e-05 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 46.07 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWI-QSRRLRDQIVIATKFIKSDKKYKAgesntanycgnhkrslhvSVRDSLRKLQT 139
Cdd:cd19120 36 KAGFRHIDTAEMYGNEKE---VGEALkESGVPREDLFITTKVSPGIKDPRE------------------ALRKSLAKLGV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVH--WWDYMS--SIEEFMDSLHILVQQGKVLYLGVSdtpawvvsaaNYYAT------SYGKTPFSIYQGKWNV 209
Cdd:cd19120 95 DYVDLYLIHspFFAKEGgpTLAEAWAELEALKDAGLVRSIGVS----------NFRIEdleellDTAKIKPAVNQIEFHP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 210 LNRDFERDIIPMARHFGMALApwdvmgggrfqskkameerrkngegirSFVGASEQT-DAEIKISEALAKIAEEHGtESV 288
Cdd:cd19120 165 YLYPQQPALLEYCREHGIVVS---------------------------AYSPLSPLTrDAGGPLDPVLEKIAEKYG-VTP 216
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 6319951 289 TAIAIAYVRskAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIK 332
Cdd:cd19120 217 AQVLLRWAL--QKGIVVVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
61-179 |
1.64e-05 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 45.79 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWIQ-SRRLRDQIVIATKFIksdkkykagesnTANYCgnhKRSLHVSVRDSLRKLQT 139
Cdd:PRK11172 27 ELGYRAIDTAQIYDNEAA---VGQAIAeSGVPRDELFITTKIW------------IDNLA---KDKLIPSLKESLQKLRT 88
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 6319951 140 DWIDILYVHW--WDYMSSIEEFMDSLHILVQQGKVLYLGVSD 179
Cdd:PRK11172 89 DYVDLTLIHWpsPNDEVSVEEFMQALLEAKKQGLTREIGISN 130
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
127-197 |
2.61e-05 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 45.35 E-value: 2.61e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6319951 127 HVSVRDSLRKLQTDWIDILYVHWWDYMSSiEEFMDSLHILVQ---QGKVLYLGVSDTPAWV-VSAANYYATSYGK 197
Cdd:cd19164 102 RASVERSLRRLHTDYLDLVYLHDVEFVAD-EEVLEALKELFKlkdEGKIRNVGISGYPLPVlLRLAELARTTAGR 175
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
61-178 |
3.38e-05 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 44.87 E-value: 3.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEqseEWIGEWI-QSRRLRDQIVIATKFIKSDKKYKagesntanycgNHKRSLHvsvrDSLRKLQT 139
Cdd:cd19133 34 KAGYRLIDTAAAYGNE---EAVGRAIkKSGIPREELFITTKLWIQDAGYE-----------KAKKAFE----RSLKRLGL 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 6319951 140 DWIDILYVHW--------WDYMssiEEfmdslhiLVQQGKVLYLGVS 178
Cdd:cd19133 96 DYLDLYLIHQpfgdvygaWRAM---EE-------LYKEGKIRAIGVS 132
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
56-148 |
1.64e-04 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 42.90 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 56 LDTFYEAGGNFIDAANNCQNEQSeewIG----EWIQSRRL-RDQIVIATKFIKSdkkykagesntanycGNHKRSLHVSV 130
Cdd:cd19155 31 VDTALEAGYRHIDTAYVYRNEAA---IGnvlkKWIDSGKVkREELFIVTKLPPG---------------GNRREKVEKFL 92
|
90
....*....|....*...
gi 6319951 131 RDSLRKLQTDWIDILYVH 148
Cdd:cd19155 93 LKSLEKLQLDYVDLYLIH 110
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
79-178 |
2.56e-04 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 42.31 E-value: 2.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 79 EEWIGEWI-QSRRLRDQIVIATKFIKSDKKYKagesNTANYCgnhkrslhvsvRDSLRKLQTDWIDILYVHWWDYMSS-- 155
Cdd:cd19135 52 EELLGKAIkESGVPREDLFLTTKLWPSDYGYE----STKQAF-----------EASLKRLGVDYLDLYLLHWPDCPSSgk 116
|
90 100
....*....|....*....|....*...
gi 6319951 156 -----IEEFMDSLHILVQQGKVLYLGVS 178
Cdd:cd19135 117 nvketRAETWRALEELYDEGLCRAIGVS 144
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
61-178 |
3.42e-04 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 41.87 E-value: 3.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWIQSRRL-RDQIVIATKFIKSDKKYKAGESntanycgnhkrslhvSVRDSLRKLQT 139
Cdd:cd19132 31 QAGYRLLDTAFNYENEGA---VGEAVRRSGVpREELFVTTKLPGRHHGYEEALR---------------TIEESLYRLGL 92
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 6319951 140 DWIDILYVHWWD-----YMSSIEEFMDslhiLVQQGKVLYLGVS 178
Cdd:cd19132 93 DYVDLYLIHWPNpsrdlYVEAWQALIE----AREEGLVRSIGVS 132
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
61-179 |
4.08e-04 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 41.73 E-value: 4.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEQSeewIGEWI-QSRRLRDQIVIATKFIKSDKKYkagESNTANYcgnhkrslhvsvRDSLRKLQT 139
Cdd:cd19156 34 EAGYRHIDTAAIYKNEEG---VGQGIrESGVPREEVFVTTKLWNSDQGY---ESTLAAF------------EESLEKLGL 95
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6319951 140 DWIDILYVHWwdymSSIEEFMDS---LHILVQQGKVLYLGVSD 179
Cdd:cd19156 96 DYVDLYLIHW----PVKGKFKDTwkaFEKLYKEKKVRAIGVSN 134
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
61-179 |
4.45e-04 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 41.60 E-value: 4.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEqseEWIGEWIQSRRL-RDQIVIATKFIKSDKKykagesntanycgNHKRSLHvsvrDSLRKLQT 139
Cdd:PRK11565 39 EVGYRSIDTAAIYKNE---EGVGKALKEASVaREELFITTKLWNDDHK-------------RPREALE----ESLKKLQL 98
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 6319951 140 DWIDILYVHWwdYMSSIEEFMDS---LHILVQQGKVLYLGVSD 179
Cdd:PRK11565 99 DYVDLYLMHW--PVPAIDHYVEAwkgMIELQKEGLIKSIGVCN 139
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
61-148 |
5.47e-04 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 41.24 E-value: 5.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNE-QSEEWIGEWIQSRRL-RDQIVIATKFiksdkkykagesntanYCGNHKRS-LHVSVRDSLRKL 137
Cdd:cd19154 36 KAGYRLIDTAFLYQNEeAIGEALAELLEEGVVkREDLFITTKL----------------WTHEHAPEdVEEALRESLKKL 99
|
90
....*....|.
gi 6319951 138 QTDWIDILYVH 148
Cdd:cd19154 100 QLEYVDLYLIH 110
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
62-179 |
6.52e-04 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 40.94 E-value: 6.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 62 AGGNFIDAANNCQNEqseEWIGEWIQSRRL-RDQIVIATKFiksdkkykagesntanYCGNHKRsLHVSVRDSLRKLQTD 140
Cdd:cd19117 39 AGYRHIDTAAIYGNE---EEVGQGIKDSGVpREEIFITTKL----------------WCTWHRR-VEEALDQSLKKLGLD 98
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319951 141 WIDILYVHW-------------------------WDYMSSIEEFMDslhiLVQQGKVLYLGVSD 179
Cdd:cd19117 99 YVDLYLMHWpvpldpdgndflfkkddgtkdhepdWDFIKTWELMQK----LPATGKVKAIGVSN 158
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
130-337 |
7.48e-04 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 40.72 E-value: 7.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 130 VRDSLRKLQTDWIDILYVH-WWDYMS----SIEEFMDSLHILVQQGKVLYLGVSD-TPAWVVSAAnyyatsyGKTPFSIY 203
Cdd:PRK10376 112 VHDNLRNLGLDVLDVVNLRlMGDGHGpaegSIEEPLTVLAELQRQGLVRHIGLSNvTPTQVAEAR-------KIAEIVCV 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 204 QGKWNVLNRDFERDIIPMARHfGMALAPWDVMGGgrFQSKKameerrkngegirsfvgaseqtdaeikiSEALAKIAEEH 283
Cdd:PRK10376 185 QNHYNLAHRADDALIDALARD-GIAYVPFFPLGG--FTPLQ----------------------------SSTLSDVAASL 233
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 6319951 284 GTeSVTAIAIAYVRSKAKNFFPSVEGGKIEDLKENIKALSIDLTPDNIKYLESI 337
Cdd:PRK10376 234 GA-TPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDGI 286
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
54-337 |
1.34e-03 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 40.17 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 54 ELLDTFYEAGGNFIDAANNCQNEQS-EEWIGEWIQSRRL-RDQIVIATKfiksdkkykagesntANYCGNHKRSLHVSVR 131
Cdd:cd19111 21 AAVDYALFVGYRHIDTALSYQNEKAiGEALKWWLKNGKLkREEVFITTK---------------LPPVYLEFKDTEKSLE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 132 DSLRKLQTDWIDILYVHW-W------------DYMSSIEEFMDSLHILVQQGKVLYLGVSDtpaWVVSAANyYATSYGKT 198
Cdd:cd19111 86 KSLENLKLPYVDLYLIHHpCgfvnkkdkgereLASSDVTSVWRAMEALVSEGKVKSIGLSN---FNPRQIN-KILAYAKV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 199 PFSIYQGKWNVLNRdfERDIIPMARHFGMALAPWDVMGggrfqskkameerrknGEGIRSFVGASEQTDaeIKISEALAK 278
Cdd:cd19111 162 KPSNLQLECHAYLQ--QRELRKFCNKKNIVVTAYAPLG----------------SPGRANQSLWPDQPD--LLEDPTVLA 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 279 IAEEHGtESVTAIAIAYVRSKAKNFFP-SVEGGKIEdlkENIKALSIDLTPDNIKYLESI 337
Cdd:cd19111 222 IAKELD-KTPAQVLLRFVLQRGTGVLPkSTNKERIE---ENFEVFDFELTEEHFKKLKTL 277
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
62-179 |
2.26e-03 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 39.31 E-value: 2.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 62 AGGNFIDAANNCQNEQSeewIGEWI-QSRRLRDQIVIATKFIKSDKKYKAGEsntanycgnhkrslhVSVRDSLRKLQTD 140
Cdd:cd19127 34 DGYRLIDTAAAYGNERE---VGEGIrRSGVDRSDIFVTTKLWISDYGYDKAL---------------RGFDASLRRLGLD 95
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 6319951 141 WIDILYVHW-----WDymSSIEEFMDSLHILVqQGKVLYLGVSD 179
Cdd:cd19127 96 YVDLYLLHWpvpndFD--RTIQAYKALEKLLA-EGRVRAIGVSN 136
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
61-179 |
6.47e-03 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 37.76 E-value: 6.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319951 61 EAGGNFIDAANNCQNEqseEWIGEWIQ-SRRLRDQIVIATKFIKSDKKYkagESNTANYcgnhkrslhvsvRDSLRKLQT 139
Cdd:cd19157 35 KNGYRSIDTAAIYGNE---EGVGKGIKeSGIPREELFITSKVWNADQGY---DSTLKAF------------EASLERLGL 96
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 6319951 140 DWIDILYVHWWDYMSSIEEFmDSLHILVQQGKVLYLGVSD 179
Cdd:cd19157 97 DYLDLYLIHWPVKGKYKETW-KALEKLYKDGRVRAIGVSN 135
|
|
| |
