NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6320144|ref|NP_010224|]
View 

Rad59p [Saccharomyces cerevisiae S288C]

Protein Classification

RAD52 family DNA repair protein( domain architecture ID 10513695)

RAD52 family DNA repair protein similar to DNA repair and recombination protein RAD52 that is involved in DNA double-strand break (DSB) repair and recombination, by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 47-187 1.21e-49

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


:

Pssm-ID: 367812  Cd Length: 140  Bit Score: 159.03  E-value: 1.21e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320144     47 RIGLLQSKIERYTYNIYHNNKYGKHNLS-KLIPGHALIQFANETFGYDGWRMDVIDVEARECQPFTAVNngentntsevK 125
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKvAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERPEGG----------K 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320144    126 YTVVAEAQVKVTLKDGTNTQCGGLGRIT-LSSRGECYNRSKKEAVGDALKKALLSFEKIILDY 187
Cdd:pfam04098  71 YSVGYTAVVRVTLKDGTYREDIGYGSIEnAPSKGEAFEKAKKEAVTDALKRALRQFGNVLGNC 133
 
Name Accession Description Interval E-value
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 47-187 1.21e-49

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 159.03  E-value: 1.21e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320144     47 RIGLLQSKIERYTYNIYHNNKYGKHNLS-KLIPGHALIQFANETFGYDGWRMDVIDVEARECQPFTAVNngentntsevK 125
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKvAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERPEGG----------K 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320144    126 YTVVAEAQVKVTLKDGTNTQCGGLGRIT-LSSRGECYNRSKKEAVGDALKKALLSFEKIILDY 187
Cdd:pfam04098  71 YSVGYTAVVRVTLKDGTYREDIGYGSIEnAPSKGEAFEKAKKEAVTDALKRALRQFGNVLGNC 133
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 77-180 2.24e-14

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 68.30  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320144     77 IPGHALIQFANETFGYDGWRMDVIDVEArecqPFTAVNNGentntsevKYTVVAEAQVKVTLKDGTNTQCGGLGRI-TLS 155
Cdd:TIGR00607  29 IEGWKVINLANEIFGYNGWSHSITQQNV----DFVDENNG--------KFSVGVCAIVRVTLKDGSYHEDVGYGVSeNLR 96

                          90       100
                  ....*....|....*....|....*
gi 6320144    156 SRGECYNRSKKEAVGDALKKALLSF 180
Cdd:TIGR00607  97 SKALAFEKAKKEAVTDALKRALRNF 121
 
Name Accession Description Interval E-value
Rad52_Rad22 pfam04098
Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins ...
 47-187 1.21e-49

Rad52/22 family double-strand break repair protein; The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways. This family includes proteins related to Rad52. These proteins contain two helix-hairpin-helix motifs.


Pssm-ID: 367812  Cd Length: 140  Bit Score: 159.03  E-value: 1.21e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320144     47 RIGLLQSKIERYTYNIYHNNKYGKHNLS-KLIPGHALIQFANETFGYDGWRMDVIDVEARECQPFTAVNngentntsevK 125
Cdd:pfam04098   1 EIGTLQAKLEKPLGPEYISWRPGPGGQKvAYIEGWKVINLANEVFGFNGWSSEIISIEVDFIDERPEGG----------K 70

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320144    126 YTVVAEAQVKVTLKDGTNTQCGGLGRIT-LSSRGECYNRSKKEAVGDALKKALLSFEKIILDY 187
Cdd:pfam04098  71 YSVGYTAVVRVTLKDGTYREDIGYGSIEnAPSKGEAFEKAKKEAVTDALKRALRQFGNVLGNC 133
rad52 TIGR00607
recombination protein rad52; All proteins in this family for which functions are known are ...
 77-180 2.24e-14

recombination protein rad52; All proteins in this family for which functions are known are involved in recombination and recombination repair. Their exact biochemical activity is not yet known.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129695  Cd Length: 161  Bit Score: 68.30  E-value: 2.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320144     77 IPGHALIQFANETFGYDGWRMDVIDVEArecqPFTAVNNGentntsevKYTVVAEAQVKVTLKDGTNTQCGGLGRI-TLS 155
Cdd:TIGR00607  29 IEGWKVINLANEIFGYNGWSHSITQQNV----DFVDENNG--------KFSVGVCAIVRVTLKDGSYHEDVGYGVSeNLR 96

                          90       100
                  ....*....|....*....|....*
gi 6320144    156 SRGECYNRSKKEAVGDALKKALLSF 180
Cdd:TIGR00607  97 SKALAFEKAKKEAVTDALKRALRNF 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH