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Conserved domains on  [gi|6320255|ref|NP_010335|]
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triose-phosphate isomerase TPI1 [Saccharomyces cerevisiae S288C]

Protein Classification

triose-phosphate isomerase( domain architecture ID 10085182)

triose-phosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.1
Gene Ontology:  GO:0004807|GO:0006096|GO:0031625|GO:0042803
PubMed:  12206759|11257493

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-245 2.65e-124

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


:

Pssm-ID: 238190  Cd Length: 242  Bit Score: 352.61  E-value: 2.65e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    5 FFVGGNFKLNGSKQSIKEIVERLNTASI-PENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:cd00311   1 PLVAGNWKMNGTLAEALELAKALNAVLKdESGVEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   84 KDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVA 163
Cdd:cd00311  81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255  164 YEPVWAIGTGLAATPEDAQDIHASIRKFLAsKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-FVD 242
Cdd:cd00311 161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLA-ELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                ...
gi 6320255  243 IIN 245
Cdd:cd00311 240 IIK 242
 
Name Accession Description Interval E-value
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-245 2.65e-124

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 352.61  E-value: 2.65e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    5 FFVGGNFKLNGSKQSIKEIVERLNTASI-PENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:cd00311   1 PLVAGNWKMNGTLAEALELAKALNAVLKdESGVEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   84 KDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVA 163
Cdd:cd00311  81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255  164 YEPVWAIGTGLAATPEDAQDIHASIRKFLAsKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-FVD 242
Cdd:cd00311 161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLA-ELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                ...
gi 6320255  243 IIN 245
Cdd:cd00311 240 IIK 242
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 3-246 2.73e-122

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 347.81  E-value: 2.73e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    3 RTFFVGGNFKLNGSKQSIKEIVERL-NTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVD 81
Cdd:COG0149   2 RKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEISAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   82 QIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEV--KDWTN 159
Cdd:COG0149  82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLsaEQAAN 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255  160 VVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE 239
Cdd:COG0149 162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                ....*...
gi 6320255  240 -FVDIINS 246
Cdd:COG0149 242 dFLAIVRA 249
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 7.59e-121

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 344.59  E-value: 7.59e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     1 MARTFFVGGNFKLNGSKQSIKEIVERLNTASI-PENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENS 79
Cdd:PTZ00333   2 MKRKPFVGGNWKCNGTKASIKELIDSFNKLKFdPNNVDVVVAPPSLHIPLVQEKLKNKNFKISSQNVSLTGSGAFTGEIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    80 VDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKD--W 157
Cdd:PTZ00333  82 AEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDeaW 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   158 TNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLK 237
Cdd:PTZ00333 162 DNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASLK 241


                 ....*....
gi 6320255   238 PEFVDIINS 246
Cdd:PTZ00333 242 PDFVDIIKS 250
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-246 3.12e-117

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 334.86  E-value: 3.12e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255      5 FFVGGNFKLNGSKQSIKEIVERLNTASIPEN-VEVVICPPATYLDYSVSLVKKPqVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESgVEVVVAPPFTYLSAVAELLGSN-IKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     84 KDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWT-NVVV 162
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQkNLVI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    163 AYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDkAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-FV 241
Cdd:pfam00121 160 AYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKE-VAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFL 238


                  ....*
gi 6320255    242 DIINS 246
Cdd:pfam00121 239 DIINA 243
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 6-239 1.10e-48

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 159.20  E-value: 1.10e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255      6 FVGGNFK-LNGSKQSIKEIVERLN-TASIPENVEVVICPPATYLDysvSLVKKPQVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:TIGR00419   1 LVIGNWKtYNESRGMRALEVAKIAeEVASEAGVAVAVAPPFVDLP---MIKREVEIPVYAQHVDAVLSGAHTGEISAEML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     84 KDVGAKWVILGHSERRsyFHEDDkfIADKTKFALGQGVGVILCIGETLEEKKAGKtldvverqlnavleevkdWTNVVVA 163
Cdd:TIGR00419  78 KDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCTNNVLTTAAAAA------------------LEPDVVA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320255    164 YEPVWAIGTGLAATPEDAQDIHASIRkflASKlgdKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE 239
Cdd:TIGR00419 136 VEPPELIGTGIPVSPAQPEVVHGSVR---AVK---EVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
 
Name Accession Description Interval E-value
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 5-245 2.65e-124

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 352.61  E-value: 2.65e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    5 FFVGGNFKLNGSKQSIKEIVERLNTASI-PENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:cd00311   1 PLVAGNWKMNGTLAEALELAKALNAVLKdESGVEVVVAPPFTYLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISAEML 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   84 KDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVA 163
Cdd:cd00311  81 KDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGVEDLAPVVIA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255  164 YEPVWAIGTGLAATPEDAQDIHASIRKFLAsKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-FVD 242
Cdd:cd00311 161 YEPVWAIGTGKTASPEQAQEVHAFIRKLLA-ELYGEVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKAEsFLD 239


                ...
gi 6320255  243 IIN 245
Cdd:cd00311 240 IIK 242
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 3-246 2.73e-122

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 347.81  E-value: 2.73e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    3 RTFFVGGNFKLNGSKQSIKEIVERL-NTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVD 81
Cdd:COG0149   2 RKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALAGSPIALGAQNVHWEDSGAYTGEISAA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   82 QIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEV--KDWTN 159
Cdd:COG0149  82 MLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLsaEQAAN 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255  160 VVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE 239
Cdd:COG0149 162 VVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGASLDAE 241


                ....*...
gi 6320255  240 -FVDIINS 246
Cdd:COG0149 242 dFLAIVRA 249
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-246 7.59e-121

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 344.59  E-value: 7.59e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     1 MARTFFVGGNFKLNGSKQSIKEIVERLNTASI-PENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENS 79
Cdd:PTZ00333   2 MKRKPFVGGNWKCNGTKASIKELIDSFNKLKFdPNNVDVVVAPPSLHIPLVQEKLKNKNFKISSQNVSLTGSGAFTGEIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    80 VDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKD--W 157
Cdd:PTZ00333  82 AEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDeaW 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   158 TNVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLK 237
Cdd:PTZ00333 162 DNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGASLK 241


                 ....*....
gi 6320255   238 PEFVDIINS 246
Cdd:PTZ00333 242 PDFVDIIKS 250
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 5-246 3.12e-117

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 334.86  E-value: 3.12e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255      5 FFVGGNFKLNGSKQSIKEIVERLNTASIPEN-VEVVICPPATYLDYSVSLVKKPqVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELAEALADESgVEVVVAPPFTYLSAVAELLGSN-IKVGAQNVDPEESGAFTGEISAEML 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     84 KDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWT-NVVV 162
Cdd:pfam00121  80 KDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQkNLVI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    163 AYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDkAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-FV 241
Cdd:pfam00121 160 AYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYKE-VAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKAEdFL 238


                  ....*
gi 6320255    242 DIINS 246
Cdd:pfam00121 239 DIINA 243
tpiA PRK00042
triosephosphate isomerase; Provisional
 3-245 1.09e-116

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 333.63  E-value: 1.09e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     3 RTFFVGGNFKLNGSKQSIKEIVERLNTA-SIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVD 81
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELKAAlPDADGVEVAVAPPFTALASVKEALKGSNIKLGAQNVHPEDSGAFTGEISAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    82 QIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEV--KDWTN 159
Cdd:PRK00042  81 MLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLsaEQFAN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   160 VVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDkAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE 239
Cdd:PRK00042 161 LVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYGE-VAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASLKAE 239


                 ....*..
gi 6320255   240 -FVDIIN 245
Cdd:PRK00042 240 dFLAIVK 246
PLN02561 PLN02561
triosephosphate isomerase
 1-246 1.69e-103

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 300.59  E-value: 1.69e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     1 MARTFFVGGNFKLNGSKQSIKEIVERLNTASIP--ENVEVVICPPATYLDYSVSLVKkPQVTVGAQNAYLKASGAFTGEN 78
Cdd:PLN02561   1 MARKFFVGGNWKCNGTVEEVKKIVTTLNEAEVPseDVVEVVVSPPFVFLPLVKSLLR-PDFQVAAQNCWVKKGGAFTGEI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    79 SVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWT 158
Cdd:PLN02561  80 SAEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVSDWA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   159 NVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKP 238
Cdd:PLN02561 160 NVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGASLKP 239


                 ....*...
gi 6320255   239 EFVDIINS 246
Cdd:PLN02561 240 EFIDIIKS 247
PLN02429 PLN02429
triosephosphate isomerase
 14-246 9.73e-82

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 247.40  E-value: 9.73e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    14 NGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKpQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVIL 93
Cdd:PLN02429  75 NGTKDSIAKLISDLNSATLEADVDVVVSPPFVYIDQVKSSLTD-RIDISGQNSWVGKGGAFTGEISVEQLKDLGCKWVIL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    94 GHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTNVVVAYEPVWAIGTG 173
Cdd:PLN02429 154 GHSERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVPSWDNIVVAYEPVWAIGTG 233

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320255   174 LAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLK-PEFVDIINS 246
Cdd:PLN02429 234 KVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKgPEFATIVNS 307
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 2-246 2.97e-80

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 253.11  E-value: 2.97e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     2 ARTFFVGGNFKLNGSKQSIKEIVERLNTASIPENVEVVICPPATYLDYSVSLVKKPQVTVGAQNAYLKASGAFTGENSVD 81
Cdd:PRK13962 396 PRKPIIAGNWKMNKTPAEAKEFVNELKKYVKDAQAEVVVCPPFTALPSVKEAVDGSNIKLGAQNVFYEEKGAYTGEISGP 475

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    82 QIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVL-----EEVKD 156
Cdd:PRK13962 476 MLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALnglsaEQVKK 555

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   157 wtnVVVAYEPVWAIGTGLAATPEDAQDIHASIRKFLASKLGDKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASL 236
Cdd:PRK13962 556 ---VVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGASL 632

                        250
                 ....*....|.
gi 6320255   237 KP-EFVDIINS 246
Cdd:PRK13962 633 KAqEFAAIANY 643
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 4-246 3.22e-53

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 171.87  E-value: 3.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     4 TFFVGGNFKLNGSKQSIKEIVERLNT--ASIPENVEVVICPPATYLDYSVSLVkkPQVTVGAQNAYLKASGAFTGENSVD 81
Cdd:PRK14565   2 SFLIVANWKMNGDFSLFSSFLKELSNklANNEITLKLVICPPFTAMSSFVECN--PNIKLGAQNCFYGSSGGYTGEISAK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    82 QIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEVKDWTnvv 161
Cdd:PRK14565  80 MLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCLPKHGEFI--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   162 VAYEPVWAIGTGlaATPedaqDIHASIRKFLASKLGDkaaSELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE-F 240
Cdd:PRK14565 157 IAYEPVWAIGGS--TIP----SNDAIAEAFEIIRSYD---SKSHIIYGGSVNQENIRDLKSINQLSGVLVGSASLDVDsF 227


                 ....*.
gi 6320255   241 VDIINS 246
Cdd:PRK14565 228 CKIIQQ 233
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 6-239 1.10e-48

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 159.20  E-value: 1.10e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255      6 FVGGNFK-LNGSKQSIKEIVERLN-TASIPENVEVVICPPATYLDysvSLVKKPQVTVGAQNAYLKASGAFTGENSVDQI 83
Cdd:TIGR00419   1 LVIGNWKtYNESRGMRALEVAKIAeEVASEAGVAVAVAPPFVDLP---MIKREVEIPVYAQHVDAVLSGAHTGEISAEML 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     84 KDVGAKWVILGHSERRsyFHEDDkfIADKTKFALGQGVGVILCIGETLEEKKAGKtldvverqlnavleevkdWTNVVVA 163
Cdd:TIGR00419  78 KDIGAKGTLINHSERR--MKLAD--IEKKIARLKELGLTSVVCTNNVLTTAAAAA------------------LEPDVVA 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320255    164 YEPVWAIGTGLAATPEDAQDIHASIRkflASKlgdKAASELRILYGGSANGSNAVTFKDKADVDGFLVGGASLKPE 239
Cdd:TIGR00419 136 VEPPELIGTGIPVSPAQPEVVHGSVR---AVK---EVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKAD 205
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 1-232 4.26e-39

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 138.63  E-value: 4.26e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     1 MARTFFVGGNFKL-NGSKQSIKEIVERLNTASIPE---NVEVVICPPATYLDYSVSLVK----KPQVTVGAQNAYLKASG 72
Cdd:PRK14905   1 MAKKIYFGTNLKMyKGNAETVDYLSELLAFAEKFKsdyDIELFVIPSYIALKDAVEAAAsetgHPKIKIGAQNMNAKDKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    73 AFTGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLE 152
Cdd:PRK14905  81 QFTGEISPLMLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGLH 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   153 --EVKDWTNVVVAYEPVWAIGT-GLAATPEDAQDIHASIRKFLASKLGDKaASELRILYGGSANGSNAVTFKDKADVDGF 229
Cdd:PRK14905 161 gvSAEQLPHLFIAYEPVWAIGEgGIPASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLENANELIMKPHIDGL 239


                 ...
gi 6320255   230 LVG 232
Cdd:PRK14905 240 FIG 242
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 3-232 2.24e-35

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 126.65  E-value: 2.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255     3 RTFFVGGNFKL-NGSKQSIK---EIVERLNTASIPENVEVVICPPATYLDYSVSLVK----KPQVTVGAQNAYLKASGAF 74
Cdd:PRK15492   2 KKIYFGTNLKMyKGIADATDflaKLSELADDIPADKDIELFVIPSFTAIQDAIAATLaiphDHPIIIGAQNMNPNDNGQF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    75 TGENSVDQIKDVGAKWVILGHSERRSYFHEDDKFIADKTKFALGQGVGVILCIGETLEEKKAGKTLDVVERQLNAVLEEV 154
Cdd:PRK15492  82 TGDISPLMLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKIGLHGI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255   155 --KDWTNVVVAYEPVWAIGT-GLAATPEDAQDIHASIRKFLASKLGDkAASELRILYGGSANGSNAVTFKDKADVDGFLV 231
Cdd:PRK15492 162 npDQLAKLRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIELFGD-AGDDIPVFYGGSVNAENANELFGQPHIDGLFI 240


                 .
gi 6320255   232 G 232
Cdd:PRK15492 241 G 241
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 35-179 7.04e-05

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 42.55  E-value: 7.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320255    35 NVEVVICPPATYLdYSVSlvKKPQVTVGAQNAYLKASGAFTGENSVDQIKDVGAKWVILGHSERRSYFHEddkfIADKTK 114
Cdd:PRK04302  36 GVRIAVAPQALDI-RRVA--EEVDIPVYAQHVDPVEPGSHTGHILPEAVKDAGAVGTLINHSERRLTLAD----IEAVVE 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320255   115 FALGQGVGVILCIgETLEEKKAGKTLDvverqlnavleevKDWtnvvVAYEPVWAIGTGLA---ATPE 179
Cdd:PRK04302 109 RAKKLGLESVVCV-NNPETSAAAAALG-------------PDY----VAVEPPELIGTGIPvskAKPE 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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