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Conserved domains on  [gi|6320272|ref|NP_010352|]
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protein-tyrosine-phosphatase [Saccharomyces cerevisiae S288C]

Protein Classification

protein-tyrosine phosphatase family protein( domain architecture ID 13026123)

protein-tyrosine phosphatase family protein, similar to Saccharomyces cerevisiae OCA6 that is required for replication of Brome mosaic virus, but may be inactive as a protein-tyrosine phosphatase as it lacks the CxxxxxR catalytic motif

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PFA-DSP_Oca6 cd17663
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; ...
 4-181 1.02e-85

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; Oxidant-induced cell-cycle arrest protein 6 (Oca6) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca6 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


:

Pssm-ID: 350501 [Multi-domain]  Cd Length: 162  Bit Score: 251.07  E-value: 1.02e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    4 VTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLmvKFCEENNIKTIHIKCQSERKADktkpkikr 83
Cdd:cd17663   1 IPPFRFATVEPGLYRGAYPRLKNFRFLRRLKLKTIVSLTPEPPTEDLA--NFCEAENITLIHISAEKFKKGK-------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   84 kkktVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNS 163
Cdd:cd17663  71 ----VPLSYSTVIQILQLLIDKDNLPVYIHCLDGRHVTGLVVACLRKLQFWSSIAIFAEFLRFARTISSEERAFIENFKG 146

                       170
                ....*....|....*...
gi 6320272  164 EIEVddLDIKDKVPWITV 181
Cdd:cd17663 147 EIEV--PANKPKWLWGGV 162
 
Name Accession Description Interval E-value
PFA-DSP_Oca6 cd17663
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; ...
 4-181 1.02e-85

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; Oxidant-induced cell-cycle arrest protein 6 (Oca6) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca6 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350501 [Multi-domain]  Cd Length: 162  Bit Score: 251.07  E-value: 1.02e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    4 VTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLmvKFCEENNIKTIHIKCQSERKADktkpkikr 83
Cdd:cd17663   1 IPPFRFATVEPGLYRGAYPRLKNFRFLRRLKLKTIVSLTPEPPTEDLA--NFCEAENITLIHISAEKFKKGK-------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   84 kkktVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNS 163
Cdd:cd17663  71 ----VPLSYSTVIQILQLLIDKDNLPVYIHCLDGRHVTGLVVACLRKLQFWSSIAIFAEFLRFARTISSEERAFIENFKG 146

                       170
                ....*....|....*...
gi 6320272  164 EIEVddLDIKDKVPWITV 181
Cdd:cd17663 147 EIEV--PANKPKWLWGGV 162
Y_phosphatase2 pfam03162
Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 ...
 3-165 9.97e-68

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 families.


Pssm-ID: 397328 [Multi-domain]  Cd Length: 150  Bit Score: 204.91  E-value: 9.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272      3 LVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMvkFCEENNIKTIHIKCQSERKADktkpkik 82
Cdd:pfam03162   1 LVPPLNFSPVEPGLYRSSYPRANNFSFLRSLRLKTIISLSPEPYPQDNLQ--FLESEHIKLYHIHMEGNKDPF------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272     83 rkkktVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSS-INIHERNFIENF 161
Cdd:pfam03162  72 -----VNIPSHLLRRALKLLLNKDNYPVLIHCNRGKHRTGLVIGCLRKLQKWSLASILNEYRRFSGSkARIVDEEFIEIF 146


                  ....
gi 6320272    162 NSEI 165
Cdd:pfam03162 147 DSEL 150
 
Name Accession Description Interval E-value
PFA-DSP_Oca6 cd17663
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; ...
 4-181 1.02e-85

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; Oxidant-induced cell-cycle arrest protein 6 (Oca6) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca6 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350501 [Multi-domain]  Cd Length: 162  Bit Score: 251.07  E-value: 1.02e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    4 VTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLmvKFCEENNIKTIHIKCQSERKADktkpkikr 83
Cdd:cd17663   1 IPPFRFATVEPGLYRGAYPRLKNFRFLRRLKLKTIVSLTPEPPTEDLA--NFCEAENITLIHISAEKFKKGK-------- 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   84 kkktVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSINIHERNFIENFNS 163
Cdd:cd17663  71 ----VPLSYSTVIQILQLLIDKDNLPVYIHCLDGRHVTGLVVACLRKLQFWSSIAIFAEFLRFARTISSEERAFIENFKG 146

                       170
                ....*....|....*...
gi 6320272  164 EIEVddLDIKDKVPWITV 181
Cdd:cd17663 147 EIEV--PANKPKWLWGGV 162
Y_phosphatase2 pfam03162
Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 ...
 3-165 9.97e-68

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 families.


Pssm-ID: 397328 [Multi-domain]  Cd Length: 150  Bit Score: 204.91  E-value: 9.97e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272      3 LVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMvkFCEENNIKTIHIKCQSERKADktkpkik 82
Cdd:pfam03162   1 LVPPLNFSPVEPGLYRSSYPRANNFSFLRSLRLKTIISLSPEPYPQDNLQ--FLESEHIKLYHIHMEGNKDPF------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272     83 rkkktVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSS-INIHERNFIENF 161
Cdd:pfam03162  72 -----VNIPSHLLRRALKLLLNKDNYPVLIHCNRGKHRTGLVIGCLRKLQKWSLASILNEYRRFSGSkARIVDEEFIEIF 146


                  ....
gi 6320272    162 NSEI 165
Cdd:pfam03162 147 DSEL 150
PFA-DSP cd14501
plant and fungi atypical dual-specificity phosphatase; Plant and fungi atypical ...
 4-161 8.57e-63

plant and fungi atypical dual-specificity phosphatase; Plant and fungi atypical dual-specificity phosphatases (PFA-DSPs) are a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds. They share structural similarity with atypical- and lipid phosphatase DSPs from mammals. The PFA-DSP group is composed of active as well as inactive phosphatases. The best characterized member is Saccharomyces Siw14, also known as Oca3, which plays a role in actin filament organization and endocytosis. Siw14 has been shown to be an inositol pyrophosphate phosphatase, hydrolyzing the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5or IP7).


Pssm-ID: 350351 [Multi-domain]  Cd Length: 149  Bit Score: 192.51  E-value: 8.57e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    4 VTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLmvKFCEENNIKTIHIKCQSERKADKTKpkikr 83
Cdd:cd14501   1 VPPLNFSIVEPGLYRSAYPTPANFPFLKTLGLKTIILLSPEPPPKPVL--SFLTENGIKLIHLGMLSSKRADSVP----- 73

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320272   84 kkkTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSI-NIHERNFIENF 161
Cdd:cd14501  74 ---WDPLAYELVKRALEILLDKTNYPVLVHCSLGEHRTGVVVGCLRKLQGWSLASILDEYRLFAGSKeRYVDEQFIELF 149
PFA-DSP_Siw14 cd14528
atypical dual specificity phosphatases similar to yeast Siw14; This subfamily contains ...
 2-162 1.31e-26

atypical dual specificity phosphatases similar to yeast Siw14; This subfamily contains Saccharomyces Siw14 and a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000. Siw14, also known as Oca3, plays a role in actin filament organization and endocytosis. Siw14 has been shown to be an inositol pyrophosphate phosphatase, hydrolyzing the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5or IP7). The At1g05000 protein, also called AtPFA-DSP1, has been shown to have highest activity toward olyphosphate (poly-P(12-13)) and deoxyribo- and ribonucleoside triphosphates, and less activity toward phosphoenolpyruvate, phosphotyrosine, phosphotyrosine-containing peptides, and phosphatidylinositols. This subfamily belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs).


Pssm-ID: 350377 [Multi-domain]  Cd Length: 148  Bit Score: 99.72  E-value: 1.31e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    2 TLVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLmvKFCEENNIKTIHIKCQSERKAdktkpki 81
Cdd:cd14528   1 LLIPPLNFSMVDKGVYRSGYPNKKNFPFLRTLGLRSILYLCPEDYPESNL--EFLKENGIKLFQFGIEGNKEP------- 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   82 krkkkTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVY-NSSINIHERNFIEN 160
Cdd:cd14528  72 -----FVDIPEELIRDALKVLLDPRNHPVLIHCNKGKHRTGCLVGCLRKLQNWSLTSIFDEYRRFaGPKARMLDQQFIEL 146


                ..
gi 6320272  161 FN 162
Cdd:cd14528 147 FD 148
PFA-DSP_unk cd18538
unknown subfamily of atypical dual-specificity phosphatases from fungi; This uncharacterized ...
 6-161 6.51e-26

unknown subfamily of atypical dual-specificity phosphatases from fungi; This uncharacterized subfamily belongs to the plant and fungi atypical dual-specificity phosphatases (PFA-DSPs) group of atypical DSPs that present in plants, fungi, kinetoplastids, and slime molds. They share structural similarity with atypical- and lipid phosphatase DSPs from mammals. The PFA-DSP group is composed of active as well as inactive phosphatases. This unknown subgroup contains the conserved the CxxxxxR catalytic motif present in active cysteine phosphatases.


Pssm-ID: 350514 [Multi-domain]  Cd Length: 145  Bit Score: 97.83  E-value: 6.51e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    6 PLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMvkFCEENNIKTIHIKCQSERKadktkpkikrkk 85
Cdd:cd18538   3 PPNFGVVVPGVYRSSFPKPENFGFLKSLGLRTILTLVQEEYSPEFLN--FLRENGIQHFHIAMLGNKD------------ 68

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320272   86 KTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNS-SINIHERNFIENF 161
Cdd:cd18538  69 PKVSIPDHTMNRILRIILDKENHPILVHCNKGKHRTGCVIACFRKLQGWDVENVLEEYLSYAHpKSRDLDEEYIENF 145
PFA-DSP_Oca1 cd14531
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1; ...
 3-161 7.34e-25

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1; Oxidant-induced cell-cycle arrest protein 1 (Oca1) is an atypical dual specificity phosphatase whose gene is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide. It may function in linking growth, stress responses, and the cell cycle. Oca1 belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs).


Pssm-ID: 350379 [Multi-domain]  Cd Length: 149  Bit Score: 95.44  E-value: 7.34e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    3 LVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLStdPLMVKFCEENNIKTIHIKCQSERKADktkpkik 82
Cdd:cd14531   2 FIPPLNFGMVEEDLYRSGQPTPINFPFLERLKLKTIIYLAPDEPS--DQFLEFCEDQNINLVHLGGDDSTESR------- 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   83 rkkkTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFLVYNSSI-NIHERNFIENF 161
Cdd:cd14531  73 ----QNPLSEELVLAALHIILDPDNYPLLVMCNLGRHRTGTVVGCLRKLQRWNLSSIFEEYRRFAGSKvRLLNEQFIELF 148
PFA-DSP_Oca2 cd17661
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 2; ...
 4-161 3.57e-15

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 2; Oxidant-induced cell-cycle arrest protein 2 (Oca2) is an atypical dual specificity phosphatase of unknown function. It has been identified as a putative negative regulator acting on cell wall integrity and mating MAPK pathways in yeast. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca2 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350499 [Multi-domain]  Cd Length: 146  Bit Score: 69.74  E-value: 3.57e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    4 VTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLSTDPLMvKFCEENNIKTIHIKCQSERKadktkpkikr 83
Cdd:cd17661   1 VPPLNFSLVADGIYRSGHPMPINYPFLKQLNLKTIIYLGDKDPYRQDYL-DFLQSQGIELYYFDFSSSSE---------- 69

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320272   84 kkKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKF-SYWSTVSILNEFLVYNSSINIHERNFIENF 161
Cdd:cd17661  70 --PFTEEDQERMEQALKLLLDKRNYPILVHSNKGKHRVGVLVGIMRKLlQGWCLAGIFDEYGRFAGGKGETDLEFIETF 146
PFA-DSP_Oca4 cd17662
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; ...
 3-162 3.02e-12

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; Oxidant-induced cell-cycle arrest protein 4 (Oca4) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca4 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350500 [Multi-domain]  Cd Length: 177  Bit Score: 62.59  E-value: 3.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272    3 LVTPLQFSTVQPNLYRGSYPREINLPFLRTLRLKYILSLTPEPLStdPLMVKFCEENNIKTIHI---------------- 66
Cdd:cd17662   1 LVPPANFGIVEPGIYRCSKLSTLNFSFLETLNLKTIVFVGGQEPS--KFFKEFFERNNIELIVLrdadfsnhhhpgknss 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320272   67 --KCQSERKADKTKPKIKRKKKTVPIEYDVVVRCVKFLIDKGHYPCYMHCTNGELIISLVVACMRKFSYWSTVSILNEFL 144
Cdd:cd17662  79 sgKLQGNTDVNDLEPINTNYHLWKNDLDMLIKSTLLQRIFEKNLPVLNHNKLLVDKTSTVIGCLRRIQKWNFSSIINEYR 158

                       170
                ....*....|....*....
gi 6320272  145 VYNSSI-NIHERNFIENFN 162
Cdd:cd17662 159 RFAGKSsNYFAETFLELFD 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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