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Conserved domains on  [gi|6320324|ref|NP_010404|]
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Vba4p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 259-414 3.13e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17502:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 337  Bit Score: 95.71  E-value: 3.13e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDSSIILVIASKIASEFHELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGG---YLSWSSa 335
Cdd:cd17502   5 LFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSllcGLAPNM- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  336 hfWTFIFARCVTGFGGGSLIALKSTIMN-RFSQKNDSRYSlSASMITFAMGVVIGPFMMNLFdsSHGSGWRNAFLIPVPF 414
Cdd:cd17502  84 --TMLIVGRAIQGIGGGGLMSLAFIIIAdLVPPRERGKYQ-GYIGAVFGIASVAGPLIGGAF--TDHLSWRWCFYINLPI 158
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
246-665 6.62e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


:

Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 6.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  246 TRRRIFSSCMCTyLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSF 324
Cdd:COG2814   7 RRWLALLALALG-AFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  325 ILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFdsSHGSGW 404
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--ADLFGW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  405 RNAFLIPVPFCLVNASIMLADMYSVKSTLYGRPTPTLWKRFKNtllspdlyeiltltlfllcfvqvtsldltglknntmi 484
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR------------------------------------- 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  485 qallfsviivcgilfflietsdtymnsvismslqgdKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLAERLS 564
Cdd:COG2814 207 ------------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  565 PFFFSIVLGYFSVSYFwkskGQNFLLKFVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHE 644
Cdd:COG2814 251 LFGLGGVLGALLAGRL----ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                       410       420
                ....*....|....*....|.
gi 6320324  645 QRKSPISGSIVYCFGAVGGTV 665
Cdd:COG2814 327 PEARGRASGLYNSAFFLGGPL 347
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 259-414 3.13e-21

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 95.71  E-value: 3.13e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDSSIILVIASKIASEFHELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGG---YLSWSSa 335
Cdd:cd17502   5 LFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSllcGLAPNM- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  336 hfWTFIFARCVTGFGGGSLIALKSTIMN-RFSQKNDSRYSlSASMITFAMGVVIGPFMMNLFdsSHGSGWRNAFLIPVPF 414
Cdd:cd17502  84 --TMLIVGRAIQGIGGGGLMSLAFIIIAdLVPPRERGKYQ-GYIGAVFGIASVAGPLIGGAF--TDHLSWRWCFYINLPI 158
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
246-665 6.62e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 6.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  246 TRRRIFSSCMCTyLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSF 324
Cdd:COG2814   7 RRWLALLALALG-AFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  325 ILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFdsSHGSGW 404
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--ADLFGW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  405 RNAFLIPVPFCLVNASIMLADMYSVKSTLYGRPTPTLWKRFKNtllspdlyeiltltlfllcfvqvtsldltglknntmi 484
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR------------------------------------- 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  485 qallfsviivcgilfflietsdtymnsvismslqgdKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLAERLS 564
Cdd:COG2814 207 ------------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  565 PFFFSIVLGYFSVSYFwkskGQNFLLKFVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHE 644
Cdd:COG2814 251 LFGLGGVLGALLAGRL----ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                       410       420
                ....*....|....*....|.
gi 6320324  645 QRKSPISGSIVYCFGAVGGTV 665
Cdd:COG2814 327 PEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
255-666 1.19e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    255 MCTYLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWS 333
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    334 SAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHgsGWRNAFLIPVP 413
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    414 FCLVNASIMladmysvkstLYGRPTPTLWKrfkntllspdlyeiltltlfllcfvqvtsldLTGLKNNTMIQALLFSVII 493
Cdd:pfam07690 160 LSLLAAVLL----------LLPRPPPESKR-------------------------------PKPAEEARLSLIVAWKALL 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    494 VCGILfflietsdtymnsvismslqgdkRLIWTMIGISFCFAALMCIIPFgttyFIIVLNLSTLQLAERLSPFFFSIVLG 573
Cdd:pfam07690 199 RDPVL-----------------------WLLLALLLFGFAFFGLLTYLPL----YQEVLGLSALLAGLLLGLGGLLGAIG 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    574 YFSVSYFWKSKGQNFLLKFVLSGAtLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHEQRKSPISGS 653
Cdd:pfam07690 252 RLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASG 330

                         410
                  ....*....|...
gi 6320324    654 IVYCFGAVGGTVG 666
Cdd:pfam07690 331 LYNTAGSLGGALG 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 236-423 2.21e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 80.63  E-value: 2.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  236 TSSDELVHDLTRRRIFSSCMCTylFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLS-LISSV 313
Cdd:COG0477   2 SSTDAAPTRRRRRALLALALGT--FLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGdRYGRK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  314 K-LLLCIAQFS-FILGGYLSWSsahFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPF 391
Cdd:COG0477  80 RvLLIGLLLFGlASLLCGLAPS---PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156

                       170       180       190
                ....*....|....*....|....*....|..
gi 6320324  392 MMNLFdsSHGSGWRNAFLIPVPFCLVNASIML 423
Cdd:COG0477 157 LGGLL--VAALGWRWIFLINAPLGLLALVLRL 186
emrD PRK11652
multidrug transporter EmrD;
276-451 5.93e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.89  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324   276 IASEFH----ELWRlslVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGG 351
Cdd:PRK11652  34 MARDLNvregAVQA---VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324   352 GSLIALKSTIMNRFSQKNDSRYslSASMITfaMGVVIGPFMMNLFDS--SHGSGWRNAFLIPVPFClvnASIMLADMYSV 429
Cdd:PRK11652 111 GVGGVMARTLPRDLYEGTQLRH--ANSLLN--MGILVSPLLAPLIGGllTTLFGWRACYLFLLLLG---AGVTFSMARWM 183

                        170       180
                 ....*....|....*....|...
gi 6320324   430 KSTL-YGRPTPTLWKRFKnTLLS 451
Cdd:PRK11652 184 PETRpADARRTRVLASYR-TLLS 205
 
Name Accession Description Interval E-value
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 259-414 3.13e-21

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 95.71  E-value: 3.13e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDSSIILVIASKIASEFHELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGG---YLSWSSa 335
Cdd:cd17502   5 LFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSllcGLAPNM- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  336 hfWTFIFARCVTGFGGGSLIALKSTIMN-RFSQKNDSRYSlSASMITFAMGVVIGPFMMNLFdsSHGSGWRNAFLIPVPF 414
Cdd:cd17502  84 --TMLIVGRAIQGIGGGGLMSLAFIIIAdLVPPRERGKYQ-GYIGAVFGIASVAGPLIGGAF--TDHLSWRWCFYINLPI 158
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
246-665 6.62e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 95.04  E-value: 6.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  246 TRRRIFSSCMCTyLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSF 324
Cdd:COG2814   7 RRWLALLALALG-AFLSGLGIGIVLPALPLIAADLGaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  325 ILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFdsSHGSGW 404
Cdd:COG2814  86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--ADLFGW 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  405 RNAFLIPVPFCLVNASIMLADMYSVKSTLYGRPTPTLWKRFKNtllspdlyeiltltlfllcfvqvtsldltglknntmi 484
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRR------------------------------------- 206

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  485 qallfsviivcgilfflietsdtymnsvismslqgdKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLAERLS 564
Cdd:COG2814 207 ------------------------------------PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  565 PFFFSIVLGYFSVSYFwkskGQNFLLKFVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHE 644
Cdd:COG2814 251 LFGLGGVLGALLAGRL----ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                       410       420
                ....*....|....*....|.
gi 6320324  645 QRKSPISGSIVYCFGAVGGTV 665
Cdd:COG2814 327 PEARGRASGLYNSAFFLGGPL 347
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 255-674 1.38e-17

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 1.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  255 MCTYLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWS 333
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGlSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  334 SAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHGSGWRNAFLIPVP 413
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  414 FCLVNASIMLADMYSVKSTLYGRPTPTLWKRFKNTLLspdlyeiltltlfllcfvqvtsldltglknntmiqallfsvii 493
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK------------------------------------------- 197

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  494 vcgilfflietsdtymnsvismSLQGDKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLAERLSPFFFSIVLG 573
Cdd:cd06174 198 ----------------------RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALG 255

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  574 YFsVSYFWKSKGQNFLLKFVLSGATLLLYVALMGVSLNLPVWkqYICLSLPFLGSSMILTLLSNLYHEYHEQRKSPISGS 653
Cdd:cd06174 256 SL-LLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL--LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332

                       410       420
                ....*....|....*....|.
gi 6320324  654 IVYCFGAVGGTVGISLGGYVF 674
Cdd:cd06174 333 LLNTFGFLGGAIGPLLAGFLL 353
MFS_1 pfam07690
Major Facilitator Superfamily;
255-666 1.19e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.08  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    255 MCTYLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWS 333
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    334 SAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHgsGWRNAFLIPVP 413
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--GWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    414 FCLVNASIMladmysvkstLYGRPTPTLWKrfkntllspdlyeiltltlfllcfvqvtsldLTGLKNNTMIQALLFSVII 493
Cdd:pfam07690 160 LSLLAAVLL----------LLPRPPPESKR-------------------------------PKPAEEARLSLIVAWKALL 198

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    494 VCGILfflietsdtymnsvismslqgdkRLIWTMIGISFCFAALMCIIPFgttyFIIVLNLSTLQLAERLSPFFFSIVLG 573
Cdd:pfam07690 199 RDPVL-----------------------WLLLALLLFGFAFFGLLTYLPL----YQEVLGLSALLAGLLLGLGGLLGAIG 251

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    574 YFSVSYFWKSKGQNFLLKFVLSGAtLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNLYHEYHEQRKSPISGS 653
Cdd:pfam07690 252 RLLLGRLSDRLGRRRRLLLALLLL-ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASG 330

                         410
                  ....*....|...
gi 6320324    654 IVYCFGAVGGTVG 666
Cdd:pfam07690 331 LYNTAGSLGGALG 343
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 236-423 2.21e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 80.63  E-value: 2.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  236 TSSDELVHDLTRRRIFSSCMCTylFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLS-LISSV 313
Cdd:COG0477   2 SSTDAAPTRRRRRALLALALGT--FLEGLDFTIVNVALPSIAADLGaSSAQLGWIVSAYLLGRAIGLLLFGRLGdRYGRK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  314 K-LLLCIAQFS-FILGGYLSWSsahFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPF 391
Cdd:COG0477  80 RvLLIGLLLFGlASLLCGLAPS---PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPL 156

                       170       180       190
                ....*....|....*....|....*....|..
gi 6320324  392 MMNLFdsSHGSGWRNAFLIPVPFCLVNASIML 423
Cdd:COG0477 157 LGGLL--VAALGWRWIFLINAPLGLLALVLRL 186
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 255-417 2.21e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 75.67  E-value: 2.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  255 MCTYLFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLS-LISSVKLLLcIAQFSFILGGYLSW 332
Cdd:cd17321   1 LLLAVFLAALDVTIVNVALPTIARDLGaSPSQLQWVVNAYLLAFAALLLLAGRLGdRFGRKRVFL-IGLALFGLASLLCA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  333 SSAHFWTFIFARCVTGFGGGSLIALKSTIMNR-FSQKNDSRySLSASMITFAMGVVIGP----FMMNLFdsshgsGWRNA 407
Cdd:cd17321  80 LAPSLAFLIAARALQGIGAAAIMPASLALIAAtFPGERRGR-ALGLWGAVVGIGAALGPllggLLLELF------GWRWI 152

                       170
                ....*....|
gi 6320324  408 FLIPVPFCLV 417
Cdd:cd17321 153 FLINVPIGLV 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
247-677 1.27e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 69.90  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  247 RRRIFSSCMCTYlFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFI 325
Cdd:COG2271   8 RWRILALLFLAY-FLNYLDRSNLSVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  326 LGGYLSWSSAHFWTFIFARCVTGFG-GGSLIALKSTIMNRFSQKNDSRYS---LSASMITFAMGVVIGPFMMNLFdsshg 401
Cdd:COG2271  87 LATLLFGFATSFWQLLLLRFLLGLGeAGFFPAALKLIAEWFPPKERGRALgifNAGGPLGGALAPPLLGWLLAAF----- 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  402 sGWRNAFLIPVPFCLVnasimladmysvkstlygrptptlwkrfkntllspdlyeiltltlfllcfvqvtsldltglknn 481
Cdd:COG2271 162 -GWRAAFLILGLPGLL---------------------------------------------------------------- 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  482 tmiqALLFSVIIVCGILFFlietsdtymnsvismslqgdkrLIWTMIGISFcfaalmciipFGTTYFIIVLNLSTLQLAE 561
Cdd:COG2271 177 ----LALLRFWLLALAYFL----------------------VYFALYGFLT----------WLPTYLVEVRGLSLAQAGL 220

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  562 RLSPFFFSIVLGYFSVSYF---WKSKGqnfllKFVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMILTLLSNL 638
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLsdrLGRRR-----KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWAL 295

                       410       420       430
                ....*....|....*....|....*....|....*....
gi 6320324  639 YHEYHEQRKSPISGSIVYCFGAVGGTVGISLGGYVFHKT 677
Cdd:COG2271 296 AAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
247-677 1.15e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.21  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  247 RRRIFSSCmCTYLFFIAMDSSIILVIASKIASEFHelW---RLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFS 323
Cdd:COG2223   3 RWRVLLLA-TLAFFLAFGVWYLWSVLAPPLAEEFG--LsaaQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  324 FILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNdsRYSLsASMIT---FAMGVVIGPFMMNLFDSSH 400
Cdd:COG2223  80 LGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPD--RRGL-ALGLAaggGNLGAAVAAFLAPLLIAAF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  401 gsGWRNAFLIPVPFCLVNASIMLadmysvkstLYGRPTPTLWKRFKNTLLSpdlyeiltltlfllcfvqvtsldltglkn 480
Cdd:COG2223 157 --GWRNAFLILGILLLVVAVLAW---------LFLRDPPAGAAAAAKASLR----------------------------- 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  481 nTMIQALlfsviivcgilfflietsdtymnsvismslqGDKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQLA 560
Cdd:COG2223 197 -DQLEAL-------------------------------RDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  561 ERLSPF-----FFSIVLGYFSvSYFWKSKGqnFLLKFVLSGATLLLYVALMGvslnlPVWKQYICLSLPFLGSSMILTLL 635
Cdd:COG2223 245 LLAALFallgaLGRPLGGWLS-DRIGGRRV--LLIVFALMALGLLLLALALG-----SLWLFLVLFLLLGLALGGGNGAV 316

                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 6320324  636 SNLYHEYHEQRKSPISGSIVYCFGAVGGTVGISLGGYVFHKT 677
Cdd:COG2223 317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 260-417 5.16e-11

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 65.29  E-value: 5.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  260 FFIA-MDSSIILVIASKIASEFHE-LWRLSLVISAYLLSNAIgqlvFLKLS--LIS--SVKLLLCIAQFSFILGGYLSWS 333
Cdd:cd17503   5 AFMAiLDTTIVNVALPTIMGDLGAsLDTVQWVITSYLLALAI----MIPLSgwLADrfGTRRLFLTALALFTLGSLLCGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  334 SAHFWTFIFARCVTGFGGGSLIAL-KSTIMNRFsqkndSRYSLSASMITFAMGVVIGP--------FMMNLFdsshgsGW 404
Cdd:cd17503  81 APNLASLIIFRILQGFGGGVLIPLaQTILLRIY-----PPEKRGAAMGLVGLVILLAPaigptlggWLTDNL------SW 149

                       170
                ....*....|...
gi 6320324  405 RNAFLIPVPFCLV 417
Cdd:cd17503 150 RWIFYINLPIGIL 162
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 276-552 4.55e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 59.10  E-value: 4.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  276 IASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSL 354
Cdd:cd17324  25 IARDFGvSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  355 IALKSTIMNRFSQKNDSRYSLS--ASMITFAM--GVVIGPFMMNLFdsshgsGWRNAFLIpvpFCLVNASIMLADMYSVK 430
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGlvFSGLTLGLvlGRPLGGLLGQLL------GWRAAFLA---IAVLALLAALLLWRLLP 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  431 STLYGRPTPT-LWKRFKNTLLSPDLYEILTltlfllcfvqVTSLDLTGLKN-----NTMIQALLFSVIIVCGILFFLIet 504
Cdd:cd17324 176 SLPPKKPGSLgLLSSLLLLLRNPRLRLAYL----------ITFLLFGGFFAlytylAPFLTDVPGFSSSAIIGLLLLF-- 243

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 6320324  505 sdtYMNSVISMSLQG---DKRLIWTMIGISFCFAALMCIIPFGTTYFIIVL 552
Cdd:cd17324 244 ---GVAGVVGSPLAGrlaDRGGRRALLIALLLLAAALLLLTLLGPSPLLLL 291
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
246-677 1.48e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.56  E-value: 1.48e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  246 TRRRIFSSCMCTYlFFIAMDSSIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSF 324
Cdd:COG0738   5 NYRRALIAIYLLF-FLWGFATALWGPLIPALKDAFGlSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  325 ILGGYLSWSSAHFWTFIFARCVTGFGGGSL-IALKSTIMNRFSQKNDSRYSLSASMitFAMGVVIGPFMMNLF-DSSHGS 402
Cdd:COG0738  84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAALGPETAASRLNLLHAF--FSLGALLGPLLGGLLiLLGLSL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  403 GWRNAFLIpvpfclvnasimladmysvkstlygrptptlwkrfkntllspdlyeiltltlfllcfvqvtsldltglknnt 482
Cdd:COG0738 162 SWHLPYLI------------------------------------------------------------------------ 169

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  483 miqALLFSVIIVCGILFFLI-----ETSDTYMNSVISMSLQGDKRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTL 557
Cdd:COG0738 170 ---LAVLLLLLALLFLRSKLpeieeEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA 246

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  558 QLAERLSPFFFSIVLGYFSVSYFWKSKGQNFLLKFVLSGATLLLYVALMGVSLNLPVWkqyiCLSLPFLGSS----MILT 633
Cdd:COG0738 247 TAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALI----GLALVGLGLSlmfpTIFS 322

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 6320324  634 LLSNLYHEYHEQRkspisGSIVYCFGAVGGTVGISLGGYVFHKT 677
Cdd:COG0738 323 LALDGLGKRTAAA-----VSAVLIMGIVGGAIGPPLIGFLADAF 361
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 260-417 7.29e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.30  E-value: 7.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  260 FFIAMDSSIILVIASKIASEFHE---LWRLSLVISAYLLSNAIGQLVF--------LKLSLISSvklLLCIAQFSFILGg 328
Cdd:cd17316   9 FFDAYDFFLIGFVAPVLAAEFSLglsLLQTGLLFAAGFLGRPIGALLFgylgdrigRKKALILT---LLLFGLATLLIG- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  329 yLSWSsahFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHGS--GWRN 406
Cdd:cd17316  85 -LLPT---PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwGWRI 160

                       170
                ....*....|.
gi 6320324  407 AFLIPVPFCLV 417
Cdd:cd17316 161 LFLIGALPALL 171
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 259-445 1.43e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 54.50  E-value: 1.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDssIILVIASKIASEFH-ELWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHF 337
Cdd:cd17320  10 LGPLAID--MYLPALPAIARDLGaSASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSI 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  338 WTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGP----FMMNLFdsshgsGWRNAFLIpvp 413
Cdd:cd17320  88 EQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPllggLLLLFF------GWRAIFVF--- 158

                       170       180       190
                ....*....|....*....|....*....|..
gi 6320324  414 FCLVNASIMLADMYSVKSTLYGRPTPTLWKRF 445
Cdd:cd17320 159 LALLGLLLLLLVLLFLPETLPEEKRKPLLSSL 190
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 259-417 6.64e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 6.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIA----MDSSIILVIASKIASEFHE-LWRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWS 333
Cdd:cd17474   4 VFFATllavLGVSIVDPILPAIAEALGAsPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  334 SAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLS--ASMITFAMGV--VIGPFMMnlfdsshGSGWRNAFL 409
Cdd:cd17474  84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGlyEAALGLGIAVgpLLGGLLA-------AISWRYPFF 156


                ....*...
gi 6320324  410 IPVPFCLV 417
Cdd:cd17474 157 LLAALIPV 164
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 260-405 7.52e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 49.11  E-value: 7.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  260 FFIAMDSSIILVIASKIASEFHELWRLS-LVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFW 338
Cdd:cd17323   9 FVVTFGSSIYSPALPQIAEDFHVSEEVAnLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320324  339 TFIFARCVTGFGGGSLIALKS-TIMNRFSQKNDSRYslsasMITFAMGVVIGPF---MMNLFDSSHgSGWR 405
Cdd:cd17323  89 MLIILRFLQGFFGSSPLAIGAgTIADLFTPEERGKA-----MGVYSLGPLLGPAlgpIIGGFITQS-LGWR 153
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 259-410 9.78e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 48.76  E-value: 9.78e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDSSIILVIASKIASEFHELWRLSLVISAYLLS--NAIGQLVFL----KLSLISSVKLLLCIAQFSFILggyLSW 332
Cdd:cd17353 222 FFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSifNGGGRPFWGwlsdKIGRKNTLSIAFLIQGVAMFL---LPF 298

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  333 SSAHFWTFIFARCVTGFGGGSLIAL-KSTIMNRFSQKNDSR-YSLsasMIT-FAMGVVIGPFMMNLFDSSHgsGWRNAFL 409
Cdd:cd17353 299 IGSVAVLFVLGVALIGFCYGGGFALfPALTADFFGTKNAGTnYGL---LYTaKGVGGLIGPIIAAYVLYTG--GYNAAFI 373


                .
gi 6320324  410 I 410
Cdd:cd17353 374 I 374
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 286-455 1.84e-05

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 47.63  E-value: 1.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  286 LSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAH-FWTFIFARCVTGFGGGSLiALKSTIMNR 364
Cdd:cd17341  36 IGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVLGFLLGFAGANF-ASGQPWASF 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  365 FSQKNDSRyslSASMITFA---MGVVIGPFMM-----NLFDSSHGSGWRNAFLIPVPFCLVNASIMLADMYSVksTLYGR 436
Cdd:cd17341 115 WFPKEKIG---GAAGGIAGagnMGVAVSQLLApliagAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDL--PTGKA 189

                       170
                ....*....|....*....
gi 6320324  437 PTPTLWKRFKNTLLSPDLY 455
Cdd:cd17341 190 SALEFLKVQLAVLKNYRTW 208
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 287-417 2.29e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.19  E-value: 2.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  287 SLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSL-IALkstIMNRF 365
Cdd:cd17504  34 SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFpLAF---ALVRE 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6320324  366 SQKNDSRYS----LSASM-ITFAMGVVIGPFMMNLFdsshgsGWRNAFLIPVPFCLV 417
Cdd:cd17504 111 EFPPERVPVaqgiLSATFgIGAGIGLPLGGWIVQHL------GWRWIFWTAAPVAVL 161
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 259-410 9.87e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 9.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIAMDSSIILVIASKIASEFH--ELWrLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAH 336
Cdd:cd17325   5 LFLDMLGYGIIIPILPLYAESLGasVAQ-IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS 83

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320324  337 FWTFIFARCVTGFGGGSLIALKST-IMNRFSQKNDSRYSLSASMITFaMGVVIGPFMMNLFDSSHgsGWRNAFLI 410
Cdd:cd17325  84 YWQLLLARFLQGLASAAVWPAAMAlIADIAPPEERGRAMGIFSSAIG-LGFLIGPLLGGLLADAL--GYRAPFLV 155
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
287-423 1.08e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.25  E-value: 1.08e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  287 SLVISAYLLSNAIGQLVFLKLS--LISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMNR 364
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAE 298

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  365 FSQKNdSRYSLSASMITFAM-GVVIGPFMMNLFdsSHGSGWRNAFLIPVPFCLVNASIML 423
Cdd:COG2271 299 LFPKK-ARGTASGLVNTFGFlGGALGPLLVGYL--LDATGYQAAFLLLAALALLAALLAL 355
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 233-424 4.66e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 4.66e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  233 VENTSSDELVHDLTRRRIFSSCMCTYLFFIAMDSSII----LVIASKIASEFhelwRLSLVISAYLLSNAIGQLVFLKLS 308
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqlpfLLQERGGGSAA----LIGLALAIASLAGAIGALLFGRLK 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  309 LISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSLI-ALKSTIMNRFSQKNDSRySLSASMITFAMGVV 387
Cdd:cd17473 258 RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLpTLNSWAMSLVPPELRGR-AMGIVTSAFFLGQF 336

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6320324  388 IGPFMMNLFDSSHGSGWRnAFLIPVPFCLVNASIMLA 424
Cdd:cd17473 337 LSPLVLGPLVNLTGGLSG-AFLILGVLALVLAIVLLL 372
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 284-417 5.82e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 42.95  E-value: 5.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  284 WRLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGGGSLIALKSTIMN 363
Cdd:cd17317  25 WLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGM 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6320324  364 RFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSshgsgWRN-AFLIPVPFCLV 417
Cdd:cd17317 105 EIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----WRWlQLAISLPGLLF 154
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
486-673 8.45e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.58  E-value: 8.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  486 ALLFSVIIVCGILFFLIETSDTYMNSVISMSLQGD-------KRLIWTMIGISFCFAALMCIIPFGTTYFIIVLNLSTLQ 558
Cdd:COG2211 186 ALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESlkallknRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAAL 265

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  559 laerLSPFFFSIVLGYFSVSYFWkskgqNFLLK-------FVLSGATLLLYVALMGVSLNLPVWKQYICLSLPFLGSSMI 631
Cdd:COG2211 266 ----VGLLLALYFLAALLGAPLW-----PRLAKrfgkkkaFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAI 336

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 6320324  632 LTLLSNL------YHEY-HEQRKSPISGSIVYCFGAVGGTVGISLGGYV 673
Cdd:COG2211 337 LVLPWAMladvvdYDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 260-410 9.46e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.19  E-value: 9.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  260 FFIAMDSSIILVIASKIASEFHELWRLS-----LVISAYLLSNAIGQLVFLKLSLISSVK--LLLCIAQFS-FILGGYLS 331
Cdd:cd17365   5 FLIIVLDGFDLAVMGFVAPALAQDWGLSpaqlgPVGSAALFGMAIGALLAGPLADRFGRKrvLLVSVALFGlFTLLTAFA 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320324  332 WSsahFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRYSLSASMITFAMGVVIGPFMMNLFDSSHgsGWRNAFLI 410
Cdd:cd17365  85 QS---VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAF--GWRSVFLL 158
Sugar_tr pfam00083
Sugar (and other) transporter;
285-544 1.74e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 41.49  E-value: 1.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    285 RLSLVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSS---AHFWTFIFARCVTGFGGGSLIALKSTI 361
Cdd:pfam00083  47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMY 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    362 MNRFSQKNdSRY---SLSASMITFamGVVIGPFMMNLFDSSHGS-GWRnaflIPVPFCLVNASIMLADM--------YSV 429
Cdd:pfam00083 127 ISEIAPKK-LRGalgSLYQLAITF--GILLAYIFGLGLNKTSNSdGWR----IPLGLQLVPALLLIIGLlflpesprWLV 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324    430 KSTLYGRPTPTLWKRFKNTLLSPDLYEILTLTLFLLCFVQVTSLDLTGLKNN---TMIQALLFSVIIVCGILFFlietsd 506
Cdd:pfam00083 200 EKGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRrqrLLIGVMLQIFQQLTGINAI------ 273

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 6320324    507 TYMNSVISMSLQGDKRLIWTMI----GISFCFAALMCIIPFG 544
Cdd:pfam00083 274 FYYSTTIFENLGLSDSFLVTIIvgvvNFVFTFIAIFLVDRFG 315
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 257-419 4.32e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.00  E-value: 4.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  257 TYLFFIAMDSSIILVIASkIASeFHELWRLSLV-ISAYLLSNAIGQLVFL----KLSLISSVKLLLCIAQFSFILGGYLS 331
Cdd:cd17333   1 LYISFFSNGLTDALLGIL-GPS-LEEAFNLNVAdVSVIFSSQNAGYLIGSllagFLMKRLGRRRTLILGLLLISLALALI 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  332 WSSAHFWTFIFARCVTGFGGGSLIALKSTIMNRFSQKNDSRySLSASMITFAMGVVIGPFMMNLFDSSHGSgWRNAFLIP 411
Cdd:cd17333  79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSAT-RLNVLHGFFGLGALIGPLIATSLLTSELS-WSWAYLII 156


                ....*...
gi 6320324  412 VPFCLVNA 419
Cdd:cd17333 157 GLIYLLLA 164
emrD PRK11652
multidrug transporter EmrD;
276-451 5.93e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 39.89  E-value: 5.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324   276 IASEFH----ELWRlslVISAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWSSAHFWTFIFARCVTGFGG 351
Cdd:PRK11652  34 MARDLNvregAVQA---VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGT 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324   352 GSLIALKSTIMNRFSQKNDSRYslSASMITfaMGVVIGPFMMNLFDS--SHGSGWRNAFLIPVPFClvnASIMLADMYSV 429
Cdd:PRK11652 111 GVGGVMARTLPRDLYEGTQLRH--ANSLLN--MGILVSPLLAPLIGGllTTLFGWRACYLFLLLLG---AGVTFSMARWM 183

                        170       180
                 ....*....|....*....|...
gi 6320324   430 KSTL-YGRPTPTLWKRFKnTLLS 451
Cdd:PRK11652 184 PETRpADARRTRVLASYR-TLLS 205
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 259-411 8.47e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 39.14  E-value: 8.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  259 LFFIA----MDSSIILVIASKIASEFHELWRLSLVI-SAYLLSNAIGQLVFLKLSLISSVKLLLCIAQFSFILGGYLSWS 333
Cdd:cd17328   4 LFLINllnyMDRFTIAGVLPDIQSDFLIDDSLAGLLqTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320324  334 SAHFWTFIFARCVTGFGGGSLIALKSTIMNRfSQKNDSRySLSASMITFA------MGVVIGPFMmnlfdSSHGSGWRNA 407
Cdd:cd17328  84 APNFWQLLLFRALVGIGEASYSPIAPTIIAD-LFPKEKR-TRALGVFYFAiplgsgLGYVVGGLV-----AQATGGWRWA 156


                ....
gi 6320324  408 FLIP 411
Cdd:cd17328 157 FRVT 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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