GPI-anchor transamidase [Saccharomyces cerevisiae S288C]
Protein Classification
caspase family protein( domain architecture ID 1724)
caspase family protein similar to caspases which are cysteine class enzymes that drive the terminal stages of apoptosis as well as other cellular remodeling and inflammatory events
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| CASc super family | cl00042 | Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent ... |
38-277 | 5.74e-50 | |||||
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs. The actual alignment was detected with superfamily member pfam01650: Pssm-ID: 444667 Cd Length: 257 Bit Score: 169.39 E-value: 5.74e-50
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidase_C13 | pfam01650 | Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke ... |
38-277 | 5.74e-50 | |||||
Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified. This has formerly been characterized as a 'haemoglobinase', but this term is probably incorrect. Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue. Both forms have been recombinantly expressed. Pssm-ID: 396290 Cd Length: 257 Bit Score: 169.39 E-value: 5.74e-50
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| Name | Accession | Description | Interval | E-value | |||||
| Peptidase_C13 | pfam01650 | Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke ... |
38-277 | 5.74e-50 | |||||
Peptidase C13 family; Members of this family are asparaginyl peptidases. The blood fluke parasite Schistosoma mansoni has at least five Clan CA cysteine peptidases in its digestive tract including cathepsins B (2 isoforms), C, F and L. All have been recombinantly expressed as active enzymes, albeit in various stages of activation. In addition, a Clan CD peptidase, termed asparaginyl endopeptidase or 'legumain' has been identified. This has formerly been characterized as a 'haemoglobinase', but this term is probably incorrect. Two cDNAs have been described for Schistosoma mansoni legumain; one encodes an active enzyme whereas the active site cysteine residue encoded by the second cDNA is substituted by an asparagine residue. Both forms have been recombinantly expressed. Pssm-ID: 396290 Cd Length: 257 Bit Score: 169.39 E-value: 5.74e-50
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