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Conserved domains on  [gi|6320575|ref|NP_010655|]
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Kei1p [Saccharomyces cerevisiae S288C]

Protein Classification

inositol phosphorylceramide synthase regulatory subunit KEI1( domain architecture ID 10554078)

inositol phosphorylceramide synthase regulatory subunit KEI1 is a regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kei1 pfam08552
Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces ...
 11-182 2.04e-61

Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase. It is localized to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2. Kei1 is essential for both the activity and the Golgi localization of IPC synthase.


:

Pssm-ID: 430069  Cd Length: 181  Bit Score: 189.69  E-value: 2.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     11 SFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPN-LLVFSQIcVLY 89
Cdd:pfam08552   1 SFLGFMSLQTGVELILLFALLNKVSGVYGLLALFTGYPLSFLQLSMYIYSLLALVLLAWGLPHIRKQSpLQCLALA-WLY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     90 TIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQS---------NPISTGKLTERGIDISKQSATESYEYTMTILITLVS 160
Cdd:pfam08552  80 LIDTVINTAYTAAFAVTWFLVLAPHDGRRSASGSAtqedtagftSPKAAGGSLTAAARAALASAVWQQESAFSIAIIVLL 159

                         170       180
                  ....*....|....*....|..
gi 6320575    161 LIFRFYFNFILASFVQELLHHP 182
Cdd:pfam08552 160 WLVRIYFALVVYSFARQLLRQY 181
 
Name Accession Description Interval E-value
Kei1 pfam08552
Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces ...
 11-182 2.04e-61

Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase. It is localized to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2. Kei1 is essential for both the activity and the Golgi localization of IPC synthase.


Pssm-ID: 430069  Cd Length: 181  Bit Score: 189.69  E-value: 2.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     11 SFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPN-LLVFSQIcVLY 89
Cdd:pfam08552   1 SFLGFMSLQTGVELILLFALLNKVSGVYGLLALFTGYPLSFLQLSMYIYSLLALVLLAWGLPHIRKQSpLQCLALA-WLY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     90 TIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQS---------NPISTGKLTERGIDISKQSATESYEYTMTILITLVS 160
Cdd:pfam08552  80 LIDTVINTAYTAAFAVTWFLVLAPHDGRRSASGSAtqedtagftSPKAAGGSLTAAARAALASAVWQQESAFSIAIIVLL 159

                         170       180
                  ....*....|....*....|..
gi 6320575    161 LIFRFYFNFILASFVQELLHHP 182
Cdd:pfam08552 160 WLVRIYFALVVYSFARQLLRQY 181
 
Name Accession Description Interval E-value
Kei1 pfam08552
Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces ...
 11-182 2.04e-61

Inositolphosphorylceramide synthase subunit Kei1; Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase. It is localized to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2. Kei1 is essential for both the activity and the Golgi localization of IPC synthase.


Pssm-ID: 430069  Cd Length: 181  Bit Score: 189.69  E-value: 2.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     11 SFLGFMPLYLAVEIVLGISILNKCSGAYGILALFTGHPLDFMQWIAYLWSVFTLIVFSQGLYLIHKPN-LLVFSQIcVLY 89
Cdd:pfam08552   1 SFLGFMSLQTGVELILLFALLNKVSGVYGLLALFTGYPLSFLQLSMYIYSLLALVLLAWGLPHIRKQSpLQCLALA-WLY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320575     90 TIDTISTCFFTLWFTTQWFTLEDTANIDGNNALQS---------NPISTGKLTERGIDISKQSATESYEYTMTILITLVS 160
Cdd:pfam08552  80 LIDTVINTAYTAAFAVTWFLVLAPHDGRRSASGSAtqedtagftSPKAAGGSLTAAARAALASAVWQQESAFSIAIIVLL 159

                         170       180
                  ....*....|....*....|..
gi 6320575    161 LIFRFYFNFILASFVQELLHHP 182
Cdd:pfam08552 160 WLVRIYFALVVYSFARQLLRQY 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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