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Conserved domains on  [gi|6320583|ref|NP_010663|]
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bifunctional AAA family ATPase chaperone/translocase BCS1 [Saccharomyces cerevisiae S288C]

Protein Classification

mitochondrial chaperone BCS1( domain architecture ID 16123122)

mitochondrial chaperone BCS1, an AAA (ATPases Associated with diverse cellular Activities) protein of the mitochondria with a role in the biogenesis of the respiratory chain

CATH:  3.40.50.300
Gene Ontology:  GO:0016020|GO:0005524|GO:0016887
PubMed:  31988523|24361883|22575765|31988523
TCDB:  3.A.28

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 238-386 6.70e-92

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 275.00  E-value: 6.70e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  238 ILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILL 317
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320583  318 LEDIDAAFNKRSQTGEQ----GFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19510  81 LEDIDAAFESREHNKKNpsayGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 59-228 1.62e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


:

Pssm-ID: 214980  Cd Length: 170  Bit Score: 259.47  E-value: 1.62e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583      59 MILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQR-VSRHLSVRTNYIQHDNGSVSTKFSLVPG 137
Cdd:smart01024   1 MLLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQPFRqRSRHLSVETSYTQHDNGKSSTSFSFVPG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     138 PGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSFGPEWRKFg 217
Cdd:smart01024  81 PGTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF- 159

                          170
                   ....*....|.
gi 6320583     218 QPKAKRMLPSV 228
Cdd:smart01024 160 APRRKRPLSSV 170
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 238-386 6.70e-92

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 275.00  E-value: 6.70e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  238 ILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILL 317
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320583  318 LEDIDAAFNKRSQTGEQ----GFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19510  81 LEDIDAAFESREHNKKNpsayGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 59-228 1.62e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 259.47  E-value: 1.62e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583      59 MILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQR-VSRHLSVRTNYIQHDNGSVSTKFSLVPG 137
Cdd:smart01024   1 MLLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQPFRqRSRHLSVETSYTQHDNGKSSTSFSFVPG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     138 PGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSFGPEWRKFg 217
Cdd:smart01024  81 PGTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF- 159

                          170
                   ....*....|.
gi 6320583     218 QPKAKRMLPSV 228
Cdd:smart01024 160 APRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 61-228 1.96e-58

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 189.77  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     61 LGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQ-RVSRHLSVRTNYIQH------DNGSVSTKFS 133
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQPFwRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    134 LVPGPGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTS----F 209
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAwrdgY 160

                         170
                  ....*....|....*....
gi 6320583    210 GPEWRKFGQpKAKRMLPSV 228
Cdd:pfam08740 161 GGSWRRVGS-RPKRPLSTV 178
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 230-387 7.08e-26

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 107.40  E-value: 7.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  230 LDSGIKEgILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSEnnLTD-------DR 302
Cdd:COG1222  83 LDEQIEE-IREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSE--LVSkyigegaRN 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  303 LNHLMNNMPER--SILLLEDIDAAFNKRSQTGEQGFHSSvTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRI 380
Cdd:COG1222 160 VREVFELAREKapSIIFIDEIDAIAARRTDDGTSGEVQR-TVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRF 238


                ....*..
gi 6320583  381 DYKVFVG 387
Cdd:COG1222 239 DRVIEVP 245
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 263-387 2.67e-25

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 100.36  E-value: 2.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    263 YLLYGPPGSGKTSFIQALAGELDYNICILNLSEnnLTD-------DRLNHLMNNMPER--SILLLEDIDAAFNKRSQTGE 333
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSE--LVSkyvgeseKRLRELFEAAKKLapCVIFIDEIDALAGSRGSGGD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6320583    334 QgfHSSVTFSGLLNALDGVTSSEETITF-MTTNHPEKLDAAIMrpGRIDYKVFVG 387
Cdd:pfam00004  79 S--ESRRVVNQLLTELDGFTSSNSKVIViAATNRPDKLDPALL--GRFDRIIEFP 129
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 246-387 3.77e-15

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 78.03  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    246 MKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE-----NNLTDDRLNHLMNNMPER--SILLL 318
Cdd:TIGR01243 198 MKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEimskyYGESEERLREIFKEAEENapSIIFI 277

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    319 EDIDAAFNKRSQ-TGEQgfhSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVG 387
Cdd:TIGR01243 278 DEIDAIAPKREEvTGEV---EKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFDREIVIR 344
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
216-408 4.26e-14

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 74.30  E-value: 4.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   216 FGQPKAkRMLPsvilDSGIKEGILD------------DVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGE 283
Cdd:PRK10733 134 FGKSKA-RMLT----EDQIKTTFADvagcdeakeevaELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGE 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   284 LdyNICILNLSENNLTD-------DRLNHLMNNMPERS--ILLLEDIDAAFNKRSqTGEQGFHSS--VTFSGLLNALDGV 352
Cdd:PRK10733 209 A--KVPFFTISGSDFVEmfvgvgaSRVRDMFEQAKKAApcIIFIDEIDAVGRQRG-AGLGGGHDEreQTLNQMLVEMDGF 285

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320583   353 TSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVGnaTP-----YQVEKMFMKFYPGETDI 408
Cdd:PRK10733 286 EGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG--LPdvrgrEQILKVHMRRVPLAPDI 344
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 260-390 1.76e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.15  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     260 RRGYLLYGPPGSGKTSFIQALAGELDYN---ICILNLSENNLTDDRLNHLMNNMPE---------------------RSI 315
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlalalarklkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320583     316 LLLEDIDAAFNKRSQTGEQgfhssvtFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPgRIDYKVFVGNAT 390
Cdd:smart00382  82 LILDEITSLLDAEQEALLL-------LLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 259-327 9.39e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.70  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   259 YRRGYLLYGPPGSGKTSFIQALAGELDYNICILN--LSEN--NLTDD----RLNHLMNNMP---ERSILLLEDIDAAFNK 327
Cdd:NF033453  15 YYKLILLVGPPGSGKTALLRELAAKRGAPVINVNleLSRRllELPEKqralRAPRLLDEIAeksSGDVVLLDNIEILFDK 94
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 238-386 6.70e-92

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 275.00  E-value: 6.70e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  238 ILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILL 317
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320583  318 LEDIDAAFNKRSQTGEQ----GFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19510  81 LEDIDAAFESREHNKKNpsayGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 59-228 1.62e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 259.47  E-value: 1.62e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583      59 MILGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQR-VSRHLSVRTNYIQHDNGSVSTKFSLVPG 137
Cdd:smart01024   1 MLLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQPFRqRSRHLSVETSYTQHDNGKSSTSFSFVPG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     138 PGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTSFGPEWRKFg 217
Cdd:smart01024  81 PGTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF- 159

                          170
                   ....*....|.
gi 6320583     218 QPKAKRMLPSV 228
Cdd:smart01024 160 APRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 61-228 1.96e-58

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 189.77  E-value: 1.96e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     61 LGTGLAVARSGIIKASRVLYRQMIVDLEIQSKDKSYAWFLTWMAKHPQ-RVSRHLSVRTNYIQH------DNGSVSTKFS 133
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQPFwRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    134 LVPGPGNHWIRYKGAFILIKRERSAKMIDIANGSPFETVTLTTLYRDKHLFDDILNEAKDIALKTTEGKTVIYTS----F 209
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAwrdgY 160

                         170
                  ....*....|....*....
gi 6320583    210 GPEWRKFGQpKAKRMLPSV 228
Cdd:pfam08740 161 GGSWRRVGS-RPKRPLSTV 178
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 238-386 4.36e-35

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 127.78  E-value: 4.36e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  238 ILDDVYDFMKNGKWYSD---RGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE-----NNLTDDRLNHLMNN 309
Cdd:cd19481   1 LKASLREAVEAPRRGSRlrrYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSllskyVGESEKNLRKIFER 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320583  310 MPER--SILLLEDIDAAFNKRSQTGEQGfHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19481  81 ARRLapCILFIDEIDAIGRKRDSSGESG-ELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 230-387 7.08e-26

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 107.40  E-value: 7.08e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  230 LDSGIKEgILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSEnnLTD-------DR 302
Cdd:COG1222  83 LDEQIEE-IREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSE--LVSkyigegaRN 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  303 LNHLMNNMPER--SILLLEDIDAAFNKRSQTGEQGFHSSvTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRI 380
Cdd:COG1222 160 VREVFELAREKapSIIFIDEIDAIAARRTDDGTSGEVQR-TVNQLLAELDGFESRGDVLIIAATNRPDLLDPALLRPGRF 238


                ....*..
gi 6320583  381 DYKVFVG 387
Cdd:COG1222 239 DRVIEVP 245
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 263-387 2.67e-25

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 100.36  E-value: 2.67e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    263 YLLYGPPGSGKTSFIQALAGELDYNICILNLSEnnLTD-------DRLNHLMNNMPER--SILLLEDIDAAFNKRSQTGE 333
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSE--LVSkyvgeseKRLRELFEAAKKLapCVIFIDEIDALAGSRGSGGD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6320583    334 QgfHSSVTFSGLLNALDGVTSSEETITF-MTTNHPEKLDAAIMrpGRIDYKVFVG 387
Cdd:pfam00004  79 S--ESRRVVNQLLTELDGFTSSNSKVIViAATNRPDKLDPALL--GRFDRIIEFP 129
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 223-398 2.43e-22

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 98.44  E-value: 2.43e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  223 RMLPSVILDSGIKEGILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLS-------- 294
Cdd:COG0464 154 AILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSdlvskyvg 233

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  295 --ENNLtDDRLNHLMNNMPerSILLLEDIDAAFNKRSQTGEQgfHSSVTFSGLLNALDGVTSseETITFMTTNHPEKLDA 372
Cdd:COG0464 234 etEKNL-REVFDKARGLAP--CVLFIDEADALAGKRGEVGDG--VGRRVVNTLLTEMEELRS--DVVVIAATNRPDLLDP 306

                       170       180
                ....*....|....*....|....*.
gi 6320583  373 AIMRpgRIDYKVFVGNATPYQVEKMF 398
Cdd:COG0464 307 ALLR--RFDEIIFFPLPDAEERLEIF 330
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 233-386 3.37e-20

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 87.29  E-value: 3.37e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  233 GIKEGI--LDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELdyNICILNLSENNLTD-------DRL 303
Cdd:cd19501   8 GCEEAKeeLKEVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEA--GVPFFSISGSDFVEmfvgvgaSRV 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  304 NHLMNNMPE--RSILLLEDIDAAFNKRSqTGEQGFHSSV--TFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGR 379
Cdd:cd19501  86 RDLFEQAKKnaPCIVFIDEIDAVGRKRG-AGLGGGHDEReqTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPALLRPGR 164


                ....*..
gi 6320583  380 IDYKVFV 386
Cdd:cd19501 165 FDRQVYV 171
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 234-386 1.61e-18

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 82.33  E-value: 1.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  234 IKEGILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNIC------ILNL----SENNLTD--D 301
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFIsvkgpeLFSKyvgeSERAVREifQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  302 RLNhlmNNMPerSILLLEDIDAAFNKRSQTGEQGFHSSVtFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRID 381
Cdd:cd19511  81 KAR---QAAP--CIIFFDEIDSLAPRRGQSDSSGVTDRV-VSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLD 154


                ....*
gi 6320583  382 YKVFV 386
Cdd:cd19511 155 KLIYV 159
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 230-384 3.80e-18

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 81.61  E-value: 3.80e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  230 LDSGIKEgILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSEnnLTDD------RL 303
Cdd:cd19502   8 LDEQIRE-IREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSE--LVQKyigegaRL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  304 NHLMNNMPER---SILLLEDIDAAFNKRSQTGEQGfHSSV--TFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPG 378
Cdd:cd19502  85 VRELFEMAREkapSIIFIDEIDAIGAKRFDSGTGG-DREVqrTMLELLNQLDGFDPRGNIKVIMATNRPDILDPALLRPG 163


                ....*.
gi 6320583  379 RIDYKV 384
Cdd:cd19502 164 RFDRKI 169
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 256-384 6.04e-18

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 80.80  E-value: 6.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  256 GIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILN----------LSENNLtDDRLNHLMNNMPerSILLLEDIDAAF 325
Cdd:cd19503  30 GLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISgpsivskylgESEKNL-REIFEEARSHAP--SIIFIDEIDALA 106

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6320583  326 NKRSQTGEQgFHSSVTfSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKV 384
Cdd:cd19503 107 PKREEDQRE-VERRVV-AQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGRFDREV 163
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 246-387 5.40e-16

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 75.55  E-value: 5.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  246 MKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILN----------LSENNLTdDRLNHLMNNMPerSI 315
Cdd:cd19519  20 LRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINgpeimsklagESESNLR-KAFEEAEKNAP--AI 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320583  316 LLLEDIDAAFNKRSQTgeQGFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVG 387
Cdd:cd19519  97 IFIDEIDAIAPKREKT--HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREIDIG 166
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 256-386 1.27e-15

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 74.08  E-value: 1.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  256 GIPYRRGYLLYGPPGSGKTSFIQALAGELDYNIC------ILNL----SENNLTD--DRLNhlmnnMPERSILLLEDIDA 323
Cdd:cd19528  23 GMTPSKGVLFYGPPGCGKTLLAKAIANECQANFIsvkgpeLLTMwfgeSEANVRDifDKAR-----AAAPCVLFFDELDS 97

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320583  324 AFNKR-SQTGEQGFHSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19528  98 IAKARgGNIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIYI 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 234-386 1.87e-15

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 73.70  E-value: 1.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  234 IKEGILDDVYDFMKNGKWYSDrGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNIC------ILNL----SENNLTdDRL 303
Cdd:cd19527   1 VKKEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLsvkgpeLINMyigeSEANVR-EVF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  304 NHLMNNMPerSILLLEDIDAAFNKRSQTGEQGFHSSVTFSGLLNALDGVTSSEETITFM-TTNHPEKLDAAIMRPGRIDY 382
Cdd:cd19527  79 QKARDAKP--CVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSGQDVFVIgATNRPDLLDPALLRPGRFDK 156


                ....
gi 6320583  383 KVFV 386
Cdd:cd19527 157 LLYL 160
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 246-387 3.77e-15

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 78.03  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    246 MKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE-----NNLTDDRLNHLMNNMPER--SILLL 318
Cdd:TIGR01243 198 MKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEimskyYGESEERLREIFKEAEENapSIIFI 277

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    319 EDIDAAFNKRSQ-TGEQgfhSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVG 387
Cdd:TIGR01243 278 DEIDAIAPKREEvTGEV---EKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRRPGRFDREIVIR 344
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
225-384 4.58e-15

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 74.54  E-value: 4.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  225 LPSVILDSGIKEgILDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE--------- 295
Cdd:COG1223   1 LDDVVGQEEAKK-KLKLIIKELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSligsylget 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  296 -NNLTD--DRLNHlmnnmpERSILLLEDIDAAFNKRSQTGEQGFHSSVTfSGLLNALDGVTSseETITFMTTNHPEKLDA 372
Cdd:COG1223  80 aRNLRKlfDFARR------APCVIFFDEFDAIAKDRGDQNDVGEVKRVV-NALLQELDGLPS--GSVVIAATNHPELLDS 150

                       170
                ....*....|..
gi 6320583  373 AIMRpgRIDYKV 384
Cdd:COG1223 151 ALWR--RFDEVI 160
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
216-408 4.26e-14

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 74.30  E-value: 4.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   216 FGQPKAkRMLPsvilDSGIKEGILD------------DVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGE 283
Cdd:PRK10733 134 FGKSKA-RMLT----EDQIKTTFADvagcdeakeevaELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGE 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   284 LdyNICILNLSENNLTD-------DRLNHLMNNMPERS--ILLLEDIDAAFNKRSqTGEQGFHSS--VTFSGLLNALDGV 352
Cdd:PRK10733 209 A--KVPFFTISGSDFVEmfvgvgaSRVRDMFEQAKKAApcIIFIDEIDAVGRQRG-AGLGGGHDEreQTLNQMLVEMDGF 285

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320583   353 TSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVGnaTP-----YQVEKMFMKFYPGETDI 408
Cdd:PRK10733 286 EGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVG--LPdvrgrEQILKVHMRRVPLAPDI 344
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 246-386 4.88e-14

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 69.44  E-value: 4.88e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  246 MKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGEldynicilnlSENNLTDDRLNHLMNNM---PERSI------- 315
Cdd:cd19530  16 IKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANE----------SGANFISVKGPELLNKYvgeSERAVrqvfqra 85

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320583  316 -------LLLEDIDAAFNKRSQTGEQGfhSSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19530  86 rasapcvIFFDEVDALVPKRGDGGSWA--SERVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTLYV 161
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 252-384 9.45e-14

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 72.88  E-value: 9.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   252 YSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE---------NNLTDDRLNHLMNNMPerSILLLEDID 322
Cdd:PTZ00361 209 YDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSEliqkylgdgPKLVRELFRVAEENAP--SIVFIDEID 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320583   323 AAFNKRSQT---GEQGFHSsvTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKV 384
Cdd:PTZ00361 287 AIGTKRYDAtsgGEKEIQR--TMLELLNQLDGFDSRGDVKVIMATNRIESLDPALIRPGRIDRKI 349
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 252-386 1.74e-13

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 67.91  E-value: 1.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  252 YSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYN-ICI---------LNLSENNLtddRLNHLMNNMPERSILLLEDI 321
Cdd:cd19529  19 FKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANfISVkgpellskwVGESEKAI---REIFRKARQVAPCVIFFDEI 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320583  322 DAAFNKRSQTGEQGFHSSVTfSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:cd19529  96 DSIAPRRGTTGDSGVTERVV-NQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 258-387 1.81e-13

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 67.56  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  258 PYRRGYLLYGPPGSGKTSFIQALAGEL---DYNICILNLSEN----------NLTDDRLNHLMNNMPERSILLLEDIDaA 324
Cdd:cd00009  17 PPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLleglvvaelfGHFLVRLLFELAEKAKPGVLFIDEID-S 95

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320583  325 FNKRSQTGEQGFhssvtfsgLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVG 387
Cdd:cd00009  96 LSRGAQNALLRV--------LETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 252-384 2.64e-13

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 67.81  E-value: 2.64e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  252 YSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDynICILNLSENNL-------TDDRLNHLMNNMPERS--ILLLEDID 322
Cdd:cd19518  26 FQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELK--VPFLKISATEIvsgvsgeSEEKIRELFDQAISNApcIVFIDEID 103

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320583  323 AAFNKRsQTGEQGFHSSVTfSGLLNALDGV----TSSEETITFMTTNHPEKLDAAIMRPGRIDYKV 384
Cdd:cd19518 104 AITPKR-ESAQREMERRIV-SQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALRRAGRFDREI 167
ftsH CHL00176
cell division protein; Validated
 239-428 5.93e-13

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 70.85  E-value: 5.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   239 LDDVYDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE---------NNLTDDRLNHLMNN 309
Cdd:CHL00176 195 FEEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEfvemfvgvgAARVRDLFKKAKEN 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   310 MPerSILLLEDIDAAFNKRSqTGEQGFH--SSVTFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVG 387
Cdd:CHL00176 275 SP--CIVFIDEIDAVGRQRG-AGIGGGNdeREQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLRPGRFDRQITVS 351

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 6320583   388 natpyqvekmfMKFYPGETDICKKFVNSvKELDITVSTAQL 428
Cdd:CHL00176 352 -----------LPDREGRLDILKVHARN-KKLSPDVSLELI 380
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 247-385 7.80e-12

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 63.22  E-value: 7.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  247 KNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNIC------ILN----LSENNLtddRLNHLMNNMPERSIL 316
Cdd:cd19526  14 KYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFIsvkgpeLLNkyigASEQNV---RDLFSRAQSAKPCIL 90

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320583  317 LLEDIDAAFNKRSQTgeqgfHSSVT---FSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVF 385
Cdd:cd19526  91 FFDEFDSIAPKRGHD-----STGVTdrvVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 252-384 8.42e-12

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 66.71  E-value: 8.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   252 YSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE---------NNLTDDRLNHLMNNMPerSILLLEDID 322
Cdd:PTZ00454 171 YEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEfvqkylgegPRMVRDVFRLARENAP--SIIFIDEVD 248

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320583   323 AAFNKR--SQTGEQGFHSSVTFSgLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKV 384
Cdd:PTZ00454 249 SIATKRfdAQTGADREVQRILLE-LLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKI 311
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 246-386 3.32e-11

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 65.31  E-value: 3.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583    246 MKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE-----NNLTDDRLNHLMNNMPERS--ILLL 318
Cdd:TIGR01243 473 LKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEilskwVGESEKAIREIFRKARQAApaIIFF 552

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320583    319 EDIDAAFNKRSQTgeqgFHSSVT---FSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFV 386
Cdd:TIGR01243 553 DEIDAIAPARGAR----FDTSVTdriVNQLLTEMDGIQELSNVVVIAATNRPDILDPALLRPGRFDRLILV 619
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 261-381 5.35e-11

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 60.99  E-value: 5.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  261 RGYLLYGPPGSGKTSFIQALAGEL---DYNICILN------LSENNLTDDRLNHLMNNMPER---SILLLEDIDAAFNKR 328
Cdd:cd19517  35 RGVLFHGPPGTGKTLMARALAAECskgGQKVSFFMrkgadcLSKWVGEAERQLRLLFEEAYRmqpSIIFFDEIDGLAPVR 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320583  329 SQTGEQgFHSSVTfSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRID 381
Cdd:cd19517 115 SSKQEQ-IHASIV-STLLALMDGLDNRGQVVVIGATNRPDALDPALRRPGRFD 165
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 256-384 5.74e-11

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 61.35  E-value: 5.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  256 GIPYRRGYLLYGPPGSGKTSFIQALAGEL---DYNIC----ILN----LSENNLTD-----DRLNHLMNNMPERSILLLE 319
Cdd:cd19504  31 GCKHVKGILLYGPPGTGKTLMARQIGKMLnarEPKIVngpeILNkyvgESEANIRKlfadaEEEQRRLGANSGLHIIIFD 110

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320583  320 DIDAAFNKR-SQTGEQGFHSSVTfSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKV 384
Cdd:cd19504 111 EIDAICKQRgSMAGSTGVHDTVV-NQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLEVQM 175
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 251-376 1.90e-10

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 59.29  E-value: 1.90e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  251 WYSDRGIPyrRGYLLYGPPGSGKTSFIQALAGELDynICILNLSENNLTDD---------RLNHLMNNMPERSILLLEDI 321
Cdd:cd19509  25 FPGLRGPP--RGILLYGPPGTGKTLLARAVASESG--STFFSISASSLVSKwvgesekivRALFALARELQPSIIFIDEI 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6320583  322 DAAFNKRSQtGEQGfHSSVTFSGLLNALDGVTSSEETITFM--TTNHPEKLDAAIMR 376
Cdd:cd19509 101 DSLLSERGS-GEHE-ASRRVKTEFLVQMDGVLNKPEDRVLVlgATNRPWELDEAFLR 155
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 261-386 1.14e-08

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 54.09  E-value: 1.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  261 RGYLLYGPPGSGKTSFIQALAGEldYNICILNLSENNLT-------DDRLNHLMNNMPER--SILLLEDIDAAFNKRSQT 331
Cdd:cd19524  34 RGLLLFGPPGNGKTMLAKAVAAE--SNATFFNISAASLTskyvgegEKLVRALFAVARELqpSIIFIDEVDSLLSERSEG 111

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6320583  332 GEQGfhSSVTFSGLLNALDGVTS-SEETITFM-TTNHPEKLDAAIMRpgRIDYKVFV 386
Cdd:cd19524 112 EHEA--SRRLKTEFLIEFDGVQSnGDDRVLVMgATNRPQELDDAVLR--RFTKRVYV 164
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 251-386 1.26e-08

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 54.22  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  251 WYSD--RGI--PYRrGYLLYGPPGSGKTSFIQALAGELdyNICILNLSENNLT------DDRLNHLMNNMPE---RSILL 317
Cdd:cd19522  21 WMPEffKGIrrPWK-GVLMVGPPGTGKTLLAKAVATEC--GTTFFNVSSSTLTskyrgeSEKLVRLLFEMARfyaPTTIF 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320583  318 LEDIDAAFNKRSQTGEQGFHSSVTfSGLLNALDGVTSSEE-------TITFMTTNHPEKLDAAIMRpgRIDYKVFV 386
Cdd:cd19522  98 IDEIDSICSRRGTSEEHEASRRVK-SELLVQMDGVGGASEnddpskmVMVLAATNFPWDIDEALRR--RLEKRIYI 170
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 261-376 1.54e-08

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 53.97  E-value: 1.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  261 RGYLLYGPPGSGKTSFIQALAGELDYNicILNLSENNLTD----------DRLNHLMNNMpERSILLLEDIDAAFNKRSQ 330
Cdd:cd19520  36 KGVLLYGPPGCGKTMLAKATAKEAGAR--FINLQVSSLTDkwygesqklvAAVFSLASKL-QPSIIFIDEIDSFLRQRSS 112

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6320583  331 TGEQGFHSSVT-FSGLLNALDgvTSSEETITFM-TTNHPEKLDAAIMR 376
Cdd:cd19520 113 TDHEATAMMKAeFMSLWDGLS--TDGNCRVIVMgATNRPQDLDEAILR 158
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 260-390 1.76e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 53.15  E-value: 1.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583     260 RRGYLLYGPPGSGKTSFIQALAGELDYN---ICILNLSENNLTDDRLNHLMNNMPE---------------------RSI 315
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDILEEVLDQLLLIIVGGKkasgsgelrlrlalalarklkPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320583     316 LLLEDIDAAFNKRSQTGEQgfhssvtFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPgRIDYKVFVGNAT 390
Cdd:smart00382  82 LILDEITSLLDAEQEALLL-------LLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 255-376 4.89e-07

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 49.99  E-value: 4.89e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  255 RGIPyrRGYLLYGPPGSGKTSFIQALAGELdyNICILNLSENNLTDD---------RLNHLMNNMPERSILLLEDIDAAF 325
Cdd:cd19525  52 RGPP--KGILLFGPPGTGKTLIGKCIASQS--GATFFSISASSLTSKwvgegekmvRALFSVARCKQPAVIFIDEIDSLL 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320583  326 NKRSQTGEQGfhSSVTFSGLLNALDGV-TSSEETITFM-TTNHPEKLDAAIMR 376
Cdd:cd19525 128 SQRGEGEHES--SRRIKTEFLVQLDGAtTSSEDRILVVgATNRPQEIDEAARR 178
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 237-386 1.65e-06

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 47.75  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  237 GILDDVYDFM-KNGKWYSDR----GIPYRRGYLLYGPPGSGKTSFIQALAGEldYNICILNLSENNL-------TDDRLN 304
Cdd:cd19507   3 GGLDNLKDWLkKRKAAFSKQasayGLPTPKGLLLVGIQGTGKSLTAKAIAGV--WQLPLLRLDMGRLfgglvgeSESRLR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  305 HLMNNMPERS--ILLLEDIDAAFNKRSQTGEQGFHSSVtFSGLLNALDGVTSseETITFMTTNHPEKLDAAIMRPGRIDY 382
Cdd:cd19507  81 QMIQTAEAIApcVLWIDEIEKGFSNADSKGDSGTSSRV-LGTFLTWLQEKKK--PVFVVATANNVQSLPPELLRKGRFDE 157


                ....
gi 6320583  383 KVFV 386
Cdd:cd19507 158 IFFV 161
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 233-386 4.41e-06

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 46.78  E-value: 4.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  233 GIKEGILDDVYDFMKNGKWYSDRGIPYRrGYLLYGPPGSGKTSFIQALAGELdyNICILNLSENNLTDDRLNH---LMNN 309
Cdd:cd19521  14 GAKEALKEAVILPVKFPHLFTGNRKPWS-GILLYGPPGTGKSYLAKAVATEA--NSTFFSVSSSDLVSKWMGEsekLVKQ 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  310 MPER------SILLLEDIDAAFNKRSQTGEQGFHSSVTfsGLLNALDGVTSSEETITFM-TTNHPEKLDAAIMRpgRIDY 382
Cdd:cd19521  91 LFAMarenkpSIIFIDEVDSLCGTRGEGESEASRRIKT--ELLVQMNGVGNDSQGVLVLgATNIPWQLDSAIRR--RFEK 166


                ....
gi 6320583  383 KVFV 386
Cdd:cd19521 167 RIYI 170
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
216-388 5.43e-06

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 48.88  E-value: 5.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  216 FGQPKAKRMLPS---VILD--SGIKEGI--LDDVYDFMKNGKWYSDRG--IPyrRGYLLYGPPGSGKTSFIQALAGELD- 285
Cdd:COG0465 124 FGKSKAKLYDEDkpkVTFDdvAGVDEAKeeLQEIVDFLKDPEKFTRLGakIP--KGVLLVGPPGTGKTLLAKAVAGEAGv 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  286 --YNI-----------------------------CILNLSEnnltddrlnhlmnnmpersillledIDAAFNKRS----- 329
Cdd:COG0465 202 pfFSIsgsdfvemfvgvgasrvrdlfeqakknapCIIFIDE-------------------------IDAVGRQRGaglgg 256

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320583  330 ------QTgeqgfhssvtfsglLNAL----DGVTSSEETITFMTTNHPEKLDAAIMRPGRIDYKVFVGN 388
Cdd:COG0465 257 ghdereQT--------------LNQLlvemDGFEGNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVDL 311
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 256-381 1.51e-05

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 47.13  E-value: 1.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   256 GIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSE----------------NNLTDDRlnhlmnnmpERSILLLE 319
Cdd:PRK03992 161 GIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSElvqkfigegarlvrelFELAREK---------APSIIFID 231

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320583   320 DIDAAFNKRSQTGEQGFHSsV--TFSGLLNALDGVTSSEETITFMTTNHPEKLDAAIMRPGRID 381
Cdd:PRK03992 232 EIDAIAAKRTDSGTSGDRE-VqrTLMQLLAEMDGFDPRGNVKIIAATNRIDILDPAILRPGRFD 294
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 261-381 2.59e-05

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 44.05  E-value: 2.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  261 RGYLLYGPPGSGKTSFIQALA--GELDYNIC----ILNLSENNLTddRLNHLMN--NMPERSILLLED-IDAAFNKRSQT 331
Cdd:cd19512  23 RNILFYGPPGTGKTLFAKKLAlhSGMDYAIMtggdVAPMGREGVT--AIHKVFDwaNTSRRGLLLFVDeADAFLRKRSTE 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320583  332 GeqgfhSSVTFSGLLNALDGVTS--SEETITFMTTNHPEKLDAAIMrpGRID 381
Cdd:cd19512 101 K-----ISEDLRAALNAFLYRTGeqSNKFMLVLASNQPEQFDWAIN--DRID 145
PRK04195 PRK04195
replication factor C large subunit; Provisional
 250-294 2.94e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.45  E-value: 2.94e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 6320583   250 KWysDRGIPyRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLS 294
Cdd:PRK04195  32 SW--LKGKP-KKALLLYGPPGVGKTSLAHALANDYGWEVIELNAS 73
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 227-284 4.09e-05

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 44.36  E-value: 4.09e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320583  227 SVILDSGIKEGILDDVYDFMKngkwYSDRG-----IPYRRGYLLYGPPGSGKTSFIQALAGEL 284
Cdd:cd19508  18 SLIYDSNLKSRLLDYVTTTLL----FSDKNvntnlITWNRLVLLHGPPGTGKTSLCKALAQKL 76
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 264-292 1.15e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 44.31  E-value: 1.15e-04
                         10        20
                 ....*....|....*....|....*....
gi 6320583   264 LLYGPPGSGKTSFIQALAGELDYNICILN 292
Cdd:PRK13342  40 ILWGPPGTGKTTLARIIAGATDAPFEALS 68
ycf46 CHL00195
Ycf46; Provisional
 253-404 3.55e-04

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 42.70  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   253 SDRGIPYRRGYLLYGPPGSGKTSFIQALAGelDYNICILNLSENNL-------TDDRLNHlMNNMPERS---ILLLEDID 322
Cdd:CHL00195 252 SNYGLPTPRGLLLVGIQGTGKSLTAKAIAN--DWQLPLLRLDVGKLfggivgeSESRMRQ-MIRIAEALspcILWIDEID 328

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   323 AAFNKRSQTGEQGFHSSVtFSGLLNALdgvtsSEET---ITFMTTNHPEKLDAAIMRPGRIDYKVFVGNATPYQVEKMF- 398
Cdd:CHL00195 329 KAFSNSESKGDSGTTNRV-LATFITWL-----SEKKspvFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFk 402


                 ....*....
gi 6320583   399 ---MKFYPG 404
Cdd:CHL00195 403 ihlQKFRPK 411
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
239-284 1.20e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 40.73  E-value: 1.20e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 6320583  239 LDDVYDFMKngKWYSDRGIPyrRGYLLYGPPGSGKTSFIQALAGEL 284
Cdd:COG0470   1 QEEAWEQLL--AAAESGRLP--HALLLHGPPGIGKTTLALALARDL 42
PRK08116 PRK08116
hypothetical protein; Validated
 261-323 1.85e-03

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 40.00  E-value: 1.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320583   261 RGYLLYGPPGSGKTSFIQALAGEL---DYNICILNLSE--NNLT--------DDRlNHLMNNMPERSILLLEDIDA 323
Cdd:PRK08116 115 VGLLLWGSVGTGKTYLAACIANELiekGVPVIFVNFPQllNRIKstykssgkEDE-NEIIRSLVNADLLILDDLGA 189
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 261-376 1.99e-03

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 38.71  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  261 RGYLLYGPPGSGKTSFIQALAGELdyNICILNLSENNLT------DDRLNH---LMNNMPERSILLLEDIDAAFNkrSQT 331
Cdd:cd19523  34 RSILLFGPRGTGKTLLGRCLASQL--GATFLRLRGSTLVakwageGEKILQasfLAARCRQPSVLFISDLDALLS--SQD 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6320583  332 GEqgfHSSVTF--SGLLNALDGVTSS--EETITFMTTNHPEKLDAAIMR 376
Cdd:cd19523 110 DE---ASPVGRlqVELLAQLDGVLGSgeDGVLVVCTTSKPEEIDESLRR 155
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
264-349 3.58e-03

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 39.40  E-value: 3.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583  264 LLYGPPGSGKTSFIQALA---GELDYNICILNLSENNLTDDRLNHLMNN-MPE-----RSI--LLLEDIDaAFNKRSQTG 332
Cdd:COG0593  38 FLYGGVGLGKTHLLHAIGneaLENNPGARVVYLTAEEFTNDFINAIRNNtIEEfkekyRSVdvLLIDDIQ-FLAGKEATQ 116

                        90
                ....*....|....*..
gi 6320583  333 EQGFHssvtfsgLLNAL 349
Cdd:COG0593 117 EEFFH-------TFNAL 126
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 264-292 4.68e-03

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 39.27  E-value: 4.68e-03
                        10        20
                ....*....|....*....|....*....
gi 6320583  264 LLYGPPGSGKTSFIQALAGELDYNICILN 292
Cdd:COG2256  53 ILWGPPGTGKTTLARLIANATDAEFVALS 81
PRK13764 PRK13764
ATPase; Provisional
 260-281 5.07e-03

ATPase; Provisional


Pssm-ID: 184311 [Multi-domain]  Cd Length: 602  Bit Score: 39.44  E-value: 5.07e-03
                         10        20
                 ....*....|....*....|..
gi 6320583   260 RRGYLLYGPPGSGKTSFIQALA 281
Cdd:PRK13764 257 AEGILIAGAPGAGKSTFAQALA 278
PLN03140 PLN03140
ABC transporter G family member; Provisional
 238-285 7.94e-03

ABC transporter G family member; Provisional


Pssm-ID: 215599 [Multi-domain]  Cd Length: 1470  Bit Score: 39.06  E-value: 7.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6320583    238 ILDDVYDFMKNGkwysdrgipyrRGYLLYGPPGSGKTSFIQALAGELD 285
Cdd:PLN03140  180 ILKDASGIIKPS-----------RMTLLLGPPSSGKTTLLLALAGKLD 216
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 264-294 9.34e-03

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 38.05  E-value: 9.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 6320583   264 LLYGPPGSGKTSFIQALAGEL-----DYNICILNLS 294
Cdd:PRK12402  40 LVQGPPGSGKTAAVRALARELygdpwENNFTEFNVA 75
BREX_3_BrxF NF033453
BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino ...
 259-327 9.39e-03

BREX-3 system P-loop-containing protein BrxF; This family of proteins that are about 150 amino acids in length includes BrxF from type 3 BREX (bacteriophage exclusion) systems. Most members have the P-loop motif GxxGxGKT, but the region is surprisingly poorly conserved in a sizable fraction of otherwise strongly similar proteins.


Pssm-ID: 468038  Cd Length: 149  Bit Score: 36.70  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320583   259 YRRGYLLYGPPGSGKTSFIQALAGELDYNICILN--LSEN--NLTDD----RLNHLMNNMP---ERSILLLEDIDAAFNK 327
Cdd:NF033453  15 YYKLILLVGPPGSGKTALLRELAAKRGAPVINVNleLSRRllELPEKqralRAPRLLDEIAeksSGDVVLLDNIEILFDK 94
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 264-290 9.81e-03

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 36.06  E-value: 9.81e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 6320583  264 LLYGPPGSGKTSFI-----QALAGELDYNICI 290
Cdd:cd17934   3 LIQGPPGTGKTTTIaaivlQLLKGLRGKRVLV 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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