NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398366657|ref|NP_010791|]
View 

phosphatidate phosphatase LPP1 [Saccharomyces cerevisiae S288C]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 52-258 5.57e-65

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 201.29  E-value: 5.57e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  52 PSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKdllkknrvkrlrerpdgisNDFHFMHTSILCLMLIISINAAL 131
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFR-------------------RSLWDLHTSLLGLLLSVSLNGVI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 132 TGALKLIIGNLRPDFVDRCIPDLQKMSDsdsLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRN 211
Cdd:cd03390   62 TNVLKNYAGRPRPDFLARCFPDGGTPSD---TLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398366657 212 TRS--------CIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWT 258
Cdd:cd03390  139 DPRgsswrlllALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 52-258 5.57e-65

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 201.29  E-value: 5.57e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  52 PSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKdllkknrvkrlrerpdgisNDFHFMHTSILCLMLIISINAAL 131
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFR-------------------RSLWDLHTSLLGLLLSVSLNGVI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 132 TGALKLIIGNLRPDFVDRCIPDLQKMSDsdsLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRN 211
Cdd:cd03390   62 TNVLKNYAGRPRPDFLARCFPDGGTPSD---TLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398366657 212 TRS--------CIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWT 258
Cdd:cd03390  139 DPRgsswrlllALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
122-255 2.12e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 97.03  E-value: 2.12e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657   122 MLIISINAALTGALKLIIGNLRPDFVDRCipdlqkmsdsdslvfglDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTY 201
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIG-----------------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 398366657   202 LWQRVFTtRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:smart00014  64 LYLPARA-GRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PLN02250 PLN02250
lipid phosphate phosphatase
 107-255 1.30e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.91  E-value: 1.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 107 ISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSD---SDSLVFGLdickqtnKWILYEGLK 183
Cdd:PLN02250  89 IRRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHpvtTDVLCTGA-------KSVIKEGHK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 184 STPSGHSSFIVSTMGFTYLWQ----RVFTTRN--TRSCI-WCPLL-ALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:PLN02250 162 SFPSGHTSWSFAGLGFLSLYLsgkiRVFDRRGhvAKLCIvFLPLLvAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCY 241
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 118-260 2.70e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 81.31  E-value: 2.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  118 ILCLMLIISInaALTGALKLIIGNLRPDFVDRCIPDlqkmsdsdslvfgldickQTNKWILYEGLKSTPSGHSSFIVSTM 197
Cdd:pfam01569   1 ILLLALALAG--LLSSVLKDYFGRPRPFFLLLEGGL------------------VPAPSTLPGLGYSFPSGHSATAFALA 60

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366657  198 GF-TYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFT 260
Cdd:pfam01569  61 LLlALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 121-257 5.60e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 45.80  E-value: 5.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 121 LMLIISINAALTGALKLIIGNLRPdFVDRCIPDLQKMSDSDSLvfgldickqtnkwilyeglkstPSGHS--SFIVSTMG 198
Cdd:COG0671   78 AALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAGGYSF----------------------PSGHAaaAFALALVL 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 398366657 199 FTYLWQRVFTtrntrscIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKW 257
Cdd:COG0671  135 ALLLPRRWLA-------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 52-258 5.57e-65

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 201.29  E-value: 5.57e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  52 PSISKRYVPNELVGPLECLILSVGLSNMVVFWTCMFDKdllkknrvkrlrerpdgisNDFHFMHTSILCLMLIISINAAL 131
Cdd:cd03390    1 PSISYPFAESETVPTWLLVIISVGIPLLVIILISLFFR-------------------RSLWDLHTSLLGLLLSVSLNGVI 61

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 132 TGALKLIIGNLRPDFVDRCIPDLQKMSDsdsLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLWQRVFTTRN 211
Cdd:cd03390   62 TNVLKNYAGRPRPDFLARCFPDGGTPSD---TLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIF 138

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398366657 212 TRS--------CIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWT 258
Cdd:cd03390  139 DPRgsswrlllALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
122-255 2.12e-25

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 97.03  E-value: 2.12e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657   122 MLIISINAALTGALKLIIGNLRPDFVDRCipdlqkmsdsdslvfglDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTY 201
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIG-----------------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLL 63

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 398366657   202 LWQRVFTtRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:smart00014  64 LYLPARA-GRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 127-250 3.50e-22

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 89.61  E-value: 3.50e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 127 INAALTGALKLIIGNLRPDFVDRCIPDLQKMS-DSDSLVFGLDICKQTNKWILYEGLKSTPSGHSSFIVSTMGFTYLW-Q 204
Cdd:cd03384   15 ATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTcSLDHQYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYlQ 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398366657 205 RVFTTRNTRS-----CIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLV 250
Cdd:cd03384   95 ARLKLRGSRLlrpllQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVI 145
PLN02250 PLN02250
lipid phosphate phosphatase
 107-255 1.30e-21

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 91.91  E-value: 1.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 107 ISNDFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSD---SDSLVFGLdickqtnKWILYEGLK 183
Cdd:PLN02250  89 IRRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHpvtTDVLCTGA-------KSVIKEGHK 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 184 STPSGHSSFIVSTMGFTYLWQ----RVFTTRN--TRSCI-WCPLL-ALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:PLN02250 162 SFPSGHTSWSFAGLGFLSLYLsgkiRVFDRRGhvAKLCIvFLPLLvAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCY 241
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 115-255 6.90e-20

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 82.89  E-value: 6.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 115 HTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKmsdsdslvfgldickqtnkWILYEGLKSTPSGHSSFIV 194
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDP-------------------LLLTEGGYSFPSGHAAFAF 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398366657 195 STMGFTYLWQRVFTTRnTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:cd01610   63 ALALFLALLLPRRLLR-LLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 118-260 2.70e-19

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 81.31  E-value: 2.70e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  118 ILCLMLIISInaALTGALKLIIGNLRPDFVDRCIPDlqkmsdsdslvfgldickQTNKWILYEGLKSTPSGHSSFIVSTM 197
Cdd:pfam01569   1 ILLLALALAG--LLSSVLKDYFGRPRPFFLLLEGGL------------------VPAPSTLPGLGYSFPSGHSATAFALA 60

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366657  198 GF-TYLWQRVFTTRNTRSCIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFT 260
Cdd:pfam01569  61 LLlALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 110-255 2.49e-18

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 83.15  E-value: 2.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 110 DFHFMHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSdslvFGLDICkQTNKWILYEGLKSTPSGH 189
Cdd:PLN02731 111 DVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDS----LGDVIC-HGDKSVIREGHKSFPSGH 185

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366657 190 SSFIVSTMGFTYLWQ----RVFTTRN--TRSCI-WCPLL-ALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:PLN02731 186 TSWSFSGLGFLSLYLsgkiQAFDGKGhvAKLCIvILPLLfAALVGISRVDDYWHHWQDVFAGGLLGLAISTICY 259
PLN02715 PLN02715
lipid phosphate phosphatase
 114-261 1.86e-15

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 75.09  E-value: 1.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 114 MHTSILCLMLIISINAALTGALKLIIGNLRPDFVDRCIPDLQKMSDSdslvFGLDICKQTNKWIlYEGLKSTPSGHSSFI 193
Cdd:PLN02715 121 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDA----LGGVICHGKAAEV-KEGHKSFPSGHTSWS 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366657 194 VSTMGFT--YLWQRVFTTRN----TRSC-IWCPLLA-LVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKWTFTN 261
Cdd:PLN02715 196 FAGLTFLslYLSGKIKAFNGeghvAKLClVIFPLLAaCLVGISRVDDYWHHWQDVFAGALIGILVAAFCYRQFYPN 271
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 125-250 2.52e-08

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 50.79  E-value: 2.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 125 ISINAALTGALKLIIGNLRPDFVDRcipdlqkmsdsdslvfgldickqtnkwilyeGLKSTPSGHSS--FIVSTM-GFTY 201
Cdd:cd03394   12 AALTAAVTEGLKFAVGRARPDGSNN-------------------------------GYRSFPSGHTAsaFAAATFlQYRY 60

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 398366657 202 LWQRVFttrntrscIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLV 250
Cdd:cd03394   61 GWRWYG--------IPAYALASLVGASRVVANRHWLSDVLAGAAIGILV 101
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 121-257 5.60e-06

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 45.80  E-value: 5.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 121 LMLIISINAALTGALKLIIGNLRPdFVDRCIPDLQKMSDSDSLvfgldickqtnkwilyeglkstPSGHS--SFIVSTMG 198
Cdd:COG0671   78 AALLLLLLLLLLLLLKYLFGRPRP-FVVPDLELLLGTAGGYSF----------------------PSGHAaaAFALALVL 134

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 398366657 199 FTYLWQRVFTtrntrscIWCPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCWKW 257
Cdd:COG0671  135 ALLLPRRWLA-------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLAL 186
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 129-255 7.23e-06

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 45.29  E-value: 7.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 129 AALTGALKLIIGNLRPDFVDrcipdlqkmsdsdslvfgldickqtnkwILYEGLKSTPSGHSSFIVSTMGFT--YLWQRV 206
Cdd:cd03392   75 GALNTLLKLLVQRPRPPLHL----------------------------LVPEGGYSFPSGHAMGATVLYGFLayLLARRL 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 398366657 207 FTTRNTRSCIW-CPLLALVVMVSRVIDHRHHWYDVVSGAVLAFLVIYCCW 255
Cdd:cd03392  127 PRRRVRILLLIlAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLI 176
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 91-257 2.34e-04

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 41.15  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657  91 LLKKNRVKRLRERPDGISNDfhfmHTSILCLMLIISINAA--LTGALKLIIGNLRPDFVdrcipdlqkmsdSDSLVFGLD 168
Cdd:cd03389   46 LLFRFGDLRGLSAPSRARFP----KAAWAGLFLFATVALSgiLVNLLKFIIGRARPKLL------------FDDGLYGFD 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 169 ICKQTNKWilyeglKSTPSGHSSFIVSTMG-FTYLWQRVFttrntrsciWCPL-LALVVMVSRVIDHRHHWYDVVSGAVL 246
Cdd:cd03389  110 PFHADYAF------TSFPSGHSATAGAAAAaLALLFPRYR---------WAFIlLALLIAFSRVIVGAHYPSDVIAGSLL 174

                        170
                 ....*....|.
gi 398366657 247 AFLVIYCCWKW 257
Cdd:cd03389  175 GAVTALALYQR 185
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 130-249 1.91e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 38.07  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366657 130 ALTGALKLIIGNLRPdfvdrcipdlQKMSDSDSLVFGLDickqtnKWilyeglkSTPSGHSSFIVstMGFTYLWQRVFTT 209
Cdd:cd03391   61 ITVAILKALVRRRRP----------AYNSPDMLDYVAVD------KY-------SFPSGHASRAA--FVARFLLNHLVLA 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 398366657 210 RNTRSCIWcpLLALVVMVSRVIDHRHHWYDVVSGAVLAFL 249
Cdd:cd03391  116 VPLRVLLV--LWATVVGISRVLLGRHHVLDVLAGAFLGYL 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH