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Conserved domains on  [gi|398364677|ref|NP_011033|]
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RNA export factor GLE2 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-333 3.38e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQGRAQHESSsPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-T 114
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 115 QQIGMHSAPIKVLRFVQCGpsntECIVTGSWDKTIKYWDMRQPQPVSTVMMPER-----VYSMDNKqsLLVVATAERHIA 189
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDG----KLLASGSADGTVRLWDLATGKLLRTLTGHSGsvrsvAFSPDGR--LLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 190 IINLANPTTIfkATTSPLKWQTRCVACYneADGY--AIGSVEGRCSIRYIDDGmqkKSGFSFKCHrqtnpnrapgsngqs 267
Cdd:COG2319  272 LWDLATGELL--RTLTGHSGGVNSVAFS--PDGKllASGSDDGTVRLWDLATG---KLLRTLTGH--------------- 329

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398364677 268 lVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYAlSYD 333
Cdd:COG2319  330 -TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG-SAD 393
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-333 3.38e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQGRAQHESSsPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-T 114
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 115 QQIGMHSAPIKVLRFVQCGpsntECIVTGSWDKTIKYWDMRQPQPVSTVMMPER-----VYSMDNKqsLLVVATAERHIA 189
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDG----KLLASGSADGTVRLWDLATGKLLRTLTGHSGsvrsvAFSPDGR--LLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 190 IINLANPTTIfkATTSPLKWQTRCVACYneADGY--AIGSVEGRCSIRYIDDGmqkKSGFSFKCHrqtnpnrapgsngqs 267
Cdd:COG2319  272 LWDLATGELL--RTLTGHSGGVNSVAFS--PDGKllASGSDDGTVRLWDLATG---KLLRTLTGH--------------- 329

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398364677 268 lVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYAlSYD 333
Cdd:COG2319  330 -TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG-SAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-333 5.99e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.19  E-value: 5.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASSwDGKVRIWDVQNGVPQgRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-T 114
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 115 QQIGMHSAPIKVLRFVQcgpsNTECIVTGSWDKTIKYWDMRQPQ----------PVSTVmmperVYSMDNKqsLLVVATA 184
Cdd:cd00200   87 RTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKclttlrghtdWVNSV-----AFSPDGT--FVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 185 ERHIAIINLANPTTI--FKATTSPLkwqtRCVACYNEADGYAIGSVEGRCSIRYIDDGMQKKsgfSFKCHRQtnpnrapg 262
Cdd:cd00200  156 DGTIKLWDLRTGKCVatLTGHTGEV----NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRGHEN-------- 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398364677 263 sngqslvyPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKgypTLQASipvcsfnrNGSVFAYALSYD 333
Cdd:cd00200  221 --------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ---TLSGH--------TNSVTSLAWSPD 272
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 36-154 1.71e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASSWDGKVRIWDVQNGVPQGRAQHESSspVLCTRWSND-GTKVASGGCDNALKLYDIASGQT 114
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKL 652

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 398364677 115 QQIGM--HSAPIKVLRFVqcgpsNTECIVTGSWDKTIKYWDM 154
Cdd:PLN00181 653 PLCTMigHSKTVSYVRFV-----DSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 36-65 2.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 398364677    36 EDSISDIAFSPQQDFMFSASsWDGKVRIWD 65
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
36-65 3.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.75e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 398364677   36 EDSISDIAFSPQQDFMFSASsWDGKVRIWD 65
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-333 3.38e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.77  E-value: 3.38e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQGRAQHESSsPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-T 114
Cdd:COG2319  120 TGAVRSVAFSPDGKTLASGS-ADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlL 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 115 QQIGMHSAPIKVLRFVQCGpsntECIVTGSWDKTIKYWDMRQPQPVSTVMMPER-----VYSMDNKqsLLVVATAERHIA 189
Cdd:COG2319  198 RTLTGHTGAVRSVAFSPDG----KLLASGSADGTVRLWDLATGKLLRTLTGHSGsvrsvAFSPDGR--LLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 190 IINLANPTTIfkATTSPLKWQTRCVACYneADGY--AIGSVEGRCSIRYIDDGmqkKSGFSFKCHrqtnpnrapgsngqs 267
Cdd:COG2319  272 LWDLATGELL--RTLTGHSGGVNSVAFS--PDGKllASGSDDGTVRLWDLATG---KLLRTLTGH--------------- 329

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398364677 268 lVYPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNRNGSVFAYAlSYD 333
Cdd:COG2319  330 -TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG-SAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-333 5.99e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.19  E-value: 5.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASSwDGKVRIWDVQNGVPQgRAQHESSSPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-T 114
Cdd:cd00200    9 TGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELL-RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEcV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 115 QQIGMHSAPIKVLRFVQcgpsNTECIVTGSWDKTIKYWDMRQPQ----------PVSTVmmperVYSMDNKqsLLVVATA 184
Cdd:cd00200   87 RTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKclttlrghtdWVNSV-----AFSPDGT--FVASSSQ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 185 ERHIAIINLANPTTI--FKATTSPLkwqtRCVACYNEADGYAIGSVEGRCSIRYIDDGMQKKsgfSFKCHRQtnpnrapg 262
Cdd:cd00200  156 DGTIKLWDLRTGKCVatLTGHTGEV----NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRGHEN-------- 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398364677 263 sngqslvyPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKgypTLQASipvcsfnrNGSVFAYALSYD 333
Cdd:cd00200  221 --------GVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ---TLSGH--------TNSVTSLAWSPD 272
WD40 COG2319
WD40 repeat [General function prediction only];
2-333 2.03e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677   2 SFFNRSNTTSALGTSTAMANEKDLANDIVINSPAEDSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQgRAQHESSS 81
Cdd:COG2319   44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS-ADGTVRLWDLATGLLL-RTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  82 PVLCTRWSNDGTKVASGGCDNALKLYDIASGQT-QQIGMHSAPIKVLRFvqcGPSNTEcIVTGSWDKTIKYWDMRQPQPV 160
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAF---SPDGKL-LASGSDDGTVRLWDLATGKLL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 161 STVMMPER-----VYSMDNKqsLLVVATAERHIAIINLANPTTIfkATTSPLKWQTRCVAcYNeADGY--AIGSVEGRCS 233
Cdd:COG2319  198 RTLTGHTGavrsvAFSPDGK--LLASGSADGTVRLWDLATGKLL--RTLTGHSGSVRSVA-FS-PDGRllASGSADGTVR 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677 234 IRYIDDGMQKKsgfsfkchrqtnpnRAPGSNGqslvyPVNSIAFHPLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQAS 313
Cdd:COG2319  272 LWDLATGELLR--------------TLTGHSG-----GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                        330       340
                 ....*....|....*....|
gi 398364677 314 IPVCSFNRNGSVFAYAlSYD 333
Cdd:COG2319  333 VRSVAFSPDGKTLASG-SDD 351
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-185 1.33e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 1.33e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSaSSWDGKVRIWDVQNGVPQGR-AQHESssPVLCTRWSNDGTKVASGGCDNALKLYDIASGQT 114
Cdd:cd00200  135 TDWVNSVAFSPDGTFVAS-SSQDGTIKLWDLRTGKCVATlTGHTG--EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398364677 115 -QQIGMHSAPIkvlRFVQCGPSNtECIVTGSWDKTIKYWDMRQPQPVSTVMMPE-RVYSMDNKQSLLVVATAE 185
Cdd:cd00200  212 lGTLRGHENGV---NSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTnSVTSLAWSPDGKRLASGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
37-155 1.52e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 1.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  37 DSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQGRAQHESSsPVLCTRWSNDGTKVASGGCDNALKLYDIASGQ-TQ 115
Cdd:COG2319  289 GGVNSVAFSPDGKLLASGS-DDGTVRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLATGElLR 366

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 398364677 116 QIGMHSAPIKVLRFvqcgPSNTECIVTGSWDKTIKYWDMR 155
Cdd:COG2319  367 TLTGHTGAVTSVAF----SPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
36-111 1.26e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 62.24  E-value: 1.26e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398364677  36 EDSISDIAFSPQQDFMFSASsWDGKVRIWDVQNGVPQGR-AQHesSSPVLCTRWSNDGTKVASGGCDNALKLYDIAS 111
Cdd:COG2319  330 TGAVRSVAFSPDGKTLASGS-DDGTVRLWDLATGELLRTlTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 36-154 1.71e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  36 EDSISDIAFSPQQDFMFSASSWDGKVRIWDVQNGVPQGRAQHESSspVLCTRWSND-GTKVASGGCDNALKLYDIASGQT 114
Cdd:PLN00181 575 EKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKL 652

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 398364677 115 QQIGM--HSAPIKVLRFVqcgpsNTECIVTGSWDKTIKYWDM 154
Cdd:PLN00181 653 PLCTMigHSKTVSYVRFV-----DSSTLVSSSTDNTLKLWDL 689
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 3-164 2.77e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677   3 FFNRSNTTSALGT-------STAMANEK-------DLAND------IVINSPAEDSISDIAFSPQQDFMFSASSWDGKVR 62
Cdd:PLN00181 479 LLNSSNLVCAIGFdrdgeffATAGVNKKikifeceSIIKDgrdihyPVVELASRSKLSGICWNSYIKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364677  63 IWDV-QNGVPQGRAQHESSSpvlctrW-----SNDGTKVASGGCDNALKLYDIASGQTQQIGMHSAPIKVLRFvqcgPSN 136
Cdd:PLN00181 559 VWDVaRSQLVTEMKEHEKRV------WsidysSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQF----PSE 628

                        170       180       190
                 ....*....|....*....|....*....|
gi 398364677 137 T-ECIVTGSWDKTIKYWDMRQPQ-PVSTVM 164
Cdd:PLN00181 629 SgRSLAFGSADHKVYYYDLRNPKlPLCTMI 658
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 36-65 2.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.11e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 398364677    36 EDSISDIAFSPQQDFMFSASsWDGKVRIWD 65
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGS-DDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
36-65 3.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.75e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 398364677   36 EDSISDIAFSPQQDFMFSASsWDGKVRIWD 65
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGS-DDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-108 1.59e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.59e-03
                           10        20
                   ....*....|....*....|....*....
gi 398364677    80 SSPVLCTRWSNDGTKVASGGCDNALKLYD 108
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 271-297 2.86e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.86e-03
                           10        20
                   ....*....|....*....|....*..
gi 398364677   271 PVNSIAFHPLYGTFVTAGGDGTFNFWD 297
Cdd:smart00320  14 PVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 120-153 8.23e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 8.23e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 398364677   120 HSAPIKVLRFVQCGPsnteCIVTGSWDKTIKYWD 153
Cdd:smart00320  11 HTGPVTSVAFSPDGK----YLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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