|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
100-346 |
2.14e-120 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 355.15 E-value: 2.14e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 100 FDQLLILPPVRDAVKEIISKESLKlqdsrkkTSENIIPSPIQTVAIKRISKNLM----------DPKLQIHAIAAETGSG 169
Cdd:cd17965 1 FDQLKLLPSVREAIIKEILKGSNK-------TDEEIKPSPIQTLAIKKLLKTLMrkvtkqtsneEPKLEVFLLAAETGSG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 170 KTMAYLIPLIDYLKRQELETPEL----WETLRKNVLIRSIILVPTHELVDQVYETVSKTKTL--LGLNSFKWDKATSYRD 243
Cdd:cd17965 74 KTLAYLAPLLDYLKRQEQEPFEEaeeeYESAKDTGRPRSVILVPTHELVEQVYSVLKKLSHTvkLGIKTFSSGFGPSYQR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 244 LLENIKNRIDILVTTPGKLLNLFSIRMitrpdKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQ 323
Cdd:cd17965 154 LQLAFKGRIDILVTTPGKLASLAKSRP-----KILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPK 228
|
250 260
....*....|....*....|...
gi 6321374 324 EFNKTMQRLFPTVVPIMTPRLHK 346
Cdd:cd17965 229 EFDKTLRKLFPDVVRIATPRLHA 251
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
97-556 |
8.42e-51 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 179.96 E-value: 8.42e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 97 ISNFDQLLILPPVRDAVKEI-ISKeslklqdsrkktseniiPSPIQTVAIKRI--SKNLMdpklqihAIAaETGSGKTMA 173
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELgYTT-----------------PTPIQAQAIPLIlaGRDVL-------GQA-QTGTGKTAA 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 174 YLIPLIDYLKRQELETPelwetlrknvliRSIILVPTHELVDQVYETVSKTKTLLGLNSfkwdkAT-----SYRDLLENI 248
Cdd:COG0513 56 FLLPLLQRLDPSRPRAP------------QALILAPTRELALQVAEELRKLAKYLGLRV-----ATvyggvSIGRQIRAL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 249 KNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKT 328
Cdd:COG0513 119 KRGVDIVVATPGRLLDLIERGALD-----LSGVETLVLDEADRMLDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 329 MQRLF--P---------TVVPIMTPRLHKLPfaldfkvinsalspfKGSKIKALAQTLyaisnDDTEPGfekRCIIFVNE 397
Cdd:COG0513 194 AKRYLknPvrievapenATAETIEQRYYLVD---------------KRDKLELLRRLL-----RDEDPE---RAIVFCNT 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 398 KKNVPEIVNLLNKKfGHNAIGLTGEDTFEERsEKIMpflspprplsevvaqstspptslKKFeipdsnivigklkntnsn 477
Cdd:COG0513 251 KRGADRLAEKLQKR-GISAAALHGDLSQGQR-ERAL-----------------------DAF------------------ 287
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321374 478 gtapSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTDSKTKSWAKALPKIIKK 556
Cdd:COG0513 288 ----RNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLIGQ 362
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
137-337 |
3.96e-40 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 144.51 E-value: 3.96e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIS--KNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQELetpelwetlRKNVLIRSIILVPTHELV 214
Cdd:cd00268 13 PTPIQAQAIPLILsgRDVI--------GQAQTGSGKTLAFLLPILEKLLPEPK---------KKGRGPQALVLAPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLfsirmITRPDKVLSKVGFVVLDEADTLLD 294
Cdd:cd00268 76 MQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDL-----IERGKLDLSNVKYLVLDEADRMLD 150
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6321374 295 RSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVV 337
Cdd:cd00268 151 MGFEEDVEKILSALPKDRQTLLFSATLPEEVKELAKKFLKNPV 193
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
138-324 |
3.86e-33 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 124.28 E-value: 3.86e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 138 SPIQTVAIKRIS--KNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRqeletpelwetlrKNVLIRSIILVPTHELVD 215
Cdd:pfam00270 1 TPIQAEAIPAILegRDVL--------VQAPTGSGKTLAFLLPALEALDK-------------LDNGPQALVLAPTRELAE 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNrIDILVTTPGKLLNLFSIRmitrpdKVLSKVGFVVLDEADTLLDR 295
Cdd:pfam00270 60 QIYEELKKLGKGLGLKVASLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQER------KLLKNLKLLVLDEAHRLLDM 132
|
170 180
....*....|....*....|....*....
gi 6321374 296 SWLEETHSAIKRIPNINHLIFCSATIPQE 324
Cdd:pfam00270 133 GFGPDLEEILRRLPKKRQILLLSATLPRN 161
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
137-349 |
6.48e-33 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 124.91 E-value: 6.48e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNLMDpklqiHAIAAETGSGKTMAYLIPLIDYLKRQELetpelwetlrknvlIRSIILVPTHELVDQ 216
Cdd:smart00487 9 LRPYQKEAIEALLSGLRD-----VILAAPTGSGKTLAALLPALEALKRGKG--------------GRVLVLVPTRELAEQ 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 VYETVSKTKTLLGLNSFKWDKATSYRDLLENI-KNRIDILVTTPGKLLnlfsiRMITRPDKVLSKVGFVVLDEADTLLDR 295
Cdd:smart00487 70 WAEELKKLGPSLGLKVVGLYGGDSKREQLRKLeSGKTDILVTTPGRLL-----DLLENDKLSLSNVDLVILDEAHRLLDG 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 6321374 296 SWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPIMTPRLHKLPF 349
Cdd:smart00487 145 GFGDQLEKLLKLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGFTPLEPI 198
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
384-538 |
5.95e-28 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 108.36 E-value: 5.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 384 EPGFEKRCIIFVNEKKNVPEIVNLLnKKFGHNAIGLTGEDTFEERSEkimpflspprplsevvaqstspptSLKKFeipd 463
Cdd:cd18787 23 EKLKPGKAIIFVNTKKRVDRLAELL-EELGIKVAALHGDLSQEERER------------------------ALKKF---- 73
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321374 464 snivigklkntnsngtapSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFML 538
Cdd:cd18787 74 ------------------RSGKVRVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITF 130
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
136-324 |
7.42e-27 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 107.68 E-value: 7.42e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 136 IPSPIQTVAIKrisknLMDPKLQIHAIAAeTGSGKTMAYLIPLIDYLKRQeletpelwetlRKNVLIRSIILVPTHELVD 215
Cdd:cd17957 12 EPTPIQMQAIP-----ILLHGRDLLACAP-TGSGKTLAFLIPILQKLGKP-----------RKKKGLRALILAPTRELAS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKtktLLGLNSFKW---DKATSYR-DLLENIKNRIDILVTTPGKLLNLfsirmITRPDKVLSKVGFVVLDEADT 291
Cdd:cd17957 75 QIYRELLK---LSKGTGLRIvllSKSLEAKaKDGPKSITKYDILVSTPLRLVFL-----LKQGPIDLSSVEYLVLDEADK 146
|
170 180 190
....*....|....*....|....*....|....*.
gi 6321374 292 LLDRSWLEEThSAIKRI---PNINHLIFcSATIPQE 324
Cdd:cd17957 147 LFEPGFREQT-DEILAActnPNLQRSLF-SATIPSE 180
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
135-347 |
1.27e-26 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 108.22 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 135 IIPSPIQTVAIKRISKNlmdpklQIHAIAAETGSGKTMAYLIPLIDYLKRQELETpelweTLRKNVlIRSIILVPTHELV 214
Cdd:cd17948 11 TKPTTVQKQGIPSILRG------RNTLCAAETGSGKTLTYLLPIIQRLLRYKLLA-----EGPFNA-PRGLVITPSRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLD 294
Cdd:cd17948 79 EQIGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYS-----LEQLRHLVLDEADTLLD 153
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321374 295 RSW-------LEETHSAIKRIPNIN------HLIFCSATIPQEFNKTMQRLFP--TVVPIMTPRLHKL 347
Cdd:cd17948 154 DSFneklshfLRRFPLASRRSENTDgldpgtQLVLVSATMPSGVGEVLSKVIDvdSIETVTSDKLHRL 221
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
137-555 |
7.68e-24 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 105.70 E-value: 7.68e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMDpklqihaiAAETGSGKTMAYLIPLIDYLKrQELETPELwetlrknvlirsIILVPTHELV 214
Cdd:PRK11634 29 PSPIQAECIPHLlnGRDVLG--------MAQTGSGKTAAFSLPLLHNLD-PELKAPQI------------LVLAPTRELA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSK-TKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNlfsirMITRPDKVLSKVGFVVLDEADTLL 293
Cdd:PRK11634 88 VQVAEAMTDfSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLD-----HLKRGTLDLSKLSGLVLDEADEML 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 294 DRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLF--PTVVPI---MTPRlhklPfaldfKVINSALSPFKGSKI 368
Cdd:PRK11634 163 RMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMkePQEVRIqssVTTR----P-----DISQSYWTVWGMRKN 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 369 KALAQTLYAISNDDTepgfekrcIIFVNEKKNVPEIVNLLNKKfGHNAIGLTGEdtfeersekimpflspprpLSEVVAQ 448
Cdd:PRK11634 234 EALVRFLEAEDFDAA--------IIFVRTKNATLEVAEALERN-GYNSAALNGD-------------------MNQALRE 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 449 STspptslkkfeipdsnivIGKLKNTNsngtapsnksLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTAR 528
Cdd:PRK11634 286 QT-----------------LERLKDGR----------LDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGR 338
|
410 420
....*....|....*....|....*..
gi 6321374 529 MKQGGRVFMLTDSKTKSWAKALPKIIK 555
Cdd:PRK11634 339 AGRAGRALLFVENRERRLLRNIERTMK 365
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
139-333 |
2.43e-23 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 98.86 E-value: 2.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 139 PIQTVAIKRISKNLMDPKLQIH---AIAAETGSGKTMAYLIPLIdylkrqeletpelwETLRKNVL--IRSIILVPTHEL 213
Cdd:cd17956 15 PVQAAVIPWLLPSSKSTPPYRPgdlCVSAPTGSGKTLAYVLPIV--------------QALSKRVVprLRALIVVPTKEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 214 VDQVYE--------TVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLN-LFSIRMITrpdkvLSKVGFV 284
Cdd:cd17956 81 VQQVYKvfeslckgTGLKVVSLSGQKSFKKEQKLLLVDTSGRYLSRVDILVATPGRLVDhLNSTPGFT-----LKHLRFL 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6321374 285 VLDEADTLLDRS---WLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLF 333
Cdd:cd17956 156 VIDEADRLLNQSfqdWLETVMKALGRPTAPDLGSFGDANLLERSVRPLQKLL 207
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
136-552 |
3.34e-22 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 100.25 E-value: 3.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 136 IPSPIQTVAIKR--ISKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQELETPelweTLRKNVLirSIILVPTHEL 213
Cdd:PLN00206 143 FPTPIQMQAIPAalSGRSLL--------VSADTGSGKTASFLVPIISRCCTIRSGHP----SEQRNPL--AMVLTPTREL 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 214 VDQVYETVS--------KTKTLLGLNSFkwdKATSYRdllenIKNRIDILVTTPGKLLNLFSirmitRPDKVLSKVGFVV 285
Cdd:PLN00206 209 CVQVEDQAKvlgkglpfKTALVVGGDAM---PQQLYR-----IQQGVELIVGTPGRLIDLLS-----KHDIELDNVSVLV 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 286 LDEADTLLDRSWLEETHSAIKRIPNINHLIFcSATIPQEFNKTMQRLF--PTVVPIMTPR-----LHKLPFALDFKvins 358
Cdd:PLN00206 276 LDEVDCMLERGFRDQVMQIFQALSQPQVLLF-SATVSPEVEKFASSLAkdIILISIGNPNrpnkaVKQLAIWVETK---- 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 359 alspfkgSKIKALAQTLYAISNddtepgFEKRCIIFVNEKKNVPEIVNLLNKKFGHNAIGLTGEDTFEERSEKIMPFLSP 438
Cdd:PLN00206 351 -------QKKQKLFDILKSKQH------FKPPAVVFVSSRLGADLLANAITVVTGLKALSIHGEKSMKERREVMKSFLVG 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 439 prplsevvaqstspptslkkfEIPdsnivigklkntnsngtapsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSID 518
Cdd:PLN00206 418 ---------------------EVP-------------------------VIVATGVLGRGVDLLRVRQVIIFDMPNTIKE 451
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 6321374 519 LIHRVGRTARMKQGGR--VFMLTDSKT---------KSWAKALPK 552
Cdd:PLN00206 452 YIHQIGRASRMGEKGTaiVFVNEEDRNlfpelvallKSSGAAIPR 496
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
136-329 |
7.09e-22 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 93.91 E-value: 7.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 136 IPSPIQTVAIKRIsknlMDPKlQIHAIAaETGSGKTMAYLIPLIDYLKRQEletpelwetlrKNVLIRSIILVPTHELVD 215
Cdd:cd17959 23 VPTPIQRKTIPLI----LDGR-DVVAMA-RTGSGKTAAFLIPMIEKLKAHS-----------PTVGARALILSPTRELAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLfsirmITRPDKVLSKVGFVVLDEADTLLDR 295
Cdd:cd17959 86 QTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHL-----LVEMNLKLSSVEYVVFDEADRLFEM 160
|
170 180 190
....*....|....*....|....*....|....*...
gi 6321374 296 SWLEETHSAIKRIP-NINHLIFcSATIPQ---EFNKTM 329
Cdd:cd17959 161 GFAEQLHEILSRLPeNRQTLLF-SATLPKllvEFAKAG 197
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
137-309 |
1.08e-21 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 93.54 E-value: 1.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKrISKNLMDpklqIHAIAaETGSGKTMAYLIPLIDYLKRQeletPELweTLRKNVLI-RSIILVPTHELVD 215
Cdd:cd17945 13 PTPIQRQAIP-IGLQNRD----IIGIA-ETGSGKTAAFLIPLLVYISRL----PPL--DEETKDDGpYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMItrpdkVLSKVGFVVLDEADTLLDR 295
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLL-----VLNQCTYVVLDEADRMIDM 155
|
170
....*....|....
gi 6321374 296 SWLEETHSAIKRIP 309
Cdd:cd17945 156 GFEPQVTKILDAMP 169
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
164-533 |
3.29e-21 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 96.91 E-value: 3.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLkrqeLETPELWETLRKNVliRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRD 243
Cdd:PRK01297 131 AQTGTGKTAAFLISIINQL----LQTPPPKERYMGEP--RALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDK 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 244 LLENIKNR-IDILVTTPGKLLNLfsirmITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINH---LIFcSA 319
Cdd:PRK01297 205 QLKQLEARfCDILVATPGRLLDF-----NQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEErqtLLF-SA 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 320 TIPQE-FNKTMQRLF-PTVVPImtprlhklpfaldfKVINSALSpfkgskikALAQTLYAISNDD---------TEPGFE 388
Cdd:PRK01297 279 TFTDDvMNLAKQWTTdPAIVEI--------------EPENVASD--------TVEQHVYAVAGSDkykllynlvTQNPWE 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 389 kRCIIFVNEKKNVPEIVNLLnKKFGHNAIGLTGEdtfeersekimpflspprplsevVAQSTSPPTsLKKFEipdsnivI 468
Cdd:PRK01297 337 -RVMVFANRKDEVRRIEERL-VKDGINAAQLSGD-----------------------VPQHKRIKT-LEGFR-------E 383
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321374 469 GKLKntnsngtapsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGG 533
Cdd:PRK01297 384 GKIR---------------VLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASG 433
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
164-555 |
2.66e-20 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 94.45 E-value: 2.66e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQELetpelwetLRKNVLIRSIILVPTHELVDQVYETVSKTKtllglNSFKWDKATSY-- 241
Cdd:PTZ00110 174 AETGSGKTLAFLLPAIVHINAQPL--------LRYGDGPIVLVLAPTRELAEQIREQCNKFG-----ASSKIRNTVAYgg 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 242 ---RDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWLEETHSAIKRI-PNINHLIFc 317
Cdd:PTZ00110 241 vpkRGQIYALRRGVEILIACPGRLIDFLESNVTN-----LRRVTYLVLDEADRMLDMGFEPQIRKIVSQIrPDRQTLMW- 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 318 SATIPQEFNKTMQRLFPTVVpimtprLHKLPFALDFKVINSALSPF----KGSKIKALAQTLYAISNDDTepgfekRCII 393
Cdd:PTZ00110 315 SATWPKEVQSLARDLCKEEP------VHVNVGSLDLTACHNIKQEVfvveEHEKRGKLKMLLQRIMRDGD------KILI 382
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 394 FVNEKKNVPEIVNLLNKKfGHNAIGLTGEDTFEERsekimpflspprplsevvaqstspptslkkfeipdsNIVIGKLKn 473
Cdd:PTZ00110 383 FVETKKGADFLTKELRLD-GWPALCIHGDKKQEER------------------------------------TWVLNEFK- 424
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 474 tnsNGTAPsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVF-MLTDSKTKSwAKALPK 552
Cdd:PTZ00110 425 ---TGKSP------IMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAGAKGASYtFLTPDKYRL-ARDLVK 494
|
...
gi 6321374 553 IIK 555
Cdd:PTZ00110 495 VLR 497
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
164-321 |
3.10e-20 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 89.18 E-value: 3.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQEletpelwETLRKNVLIRSIILVPTHELVDQVYETVSK-----TKTLLGLNSFKWDKA 238
Cdd:cd17961 38 ARTGSGKTAAYALPIIQKILKAK-------AESGEEQGTRALILVPTRELAQQVSKVLEQltaycRKDVRVVNLSASSSD 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 239 TSYRDLLENIKnriDILVTTPGKLLNLFSirmiTRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCS 318
Cdd:cd17961 111 SVQRALLAEKP---DIVVSTPARLLSHLE----SGSLLLLSTLKYLVIDEADLVLSYGYEEDLKSLLSYLPKNYQTFLMS 183
|
...
gi 6321374 319 ATI 321
Cdd:cd17961 184 ATL 186
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
164-553 |
4.13e-20 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 93.86 E-value: 4.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLkrqeLETPELWEtlRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRD 243
Cdd:PRK04537 53 AQTGTGKTLAFLVAVMNRL----LSRPALAD--RKPEDPRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDK 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 244 LLENIKNRIDILVTTPGKLLNLfsirmiTRPDKVLS--KVGFVVLDEADTLLDRSWLEETHSAIKRIP---NINHLIFcS 318
Cdd:PRK04537 127 QRELLQQGVDVIIATPGRLIDY------VKQHKVVSlhACEICVLDEADRMFDLGFIKDIRFLLRRMPergTRQTLLF-S 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 319 ATIPqefnktmqrlfptvvpimtprlHKLpFALDFKVINSAlspfkgSKIKALAQTLyaisnddTEPGFEKRcIIFVNEK 398
Cdd:PRK04537 200 ATLS----------------------HRV-LELAYEHMNEP------EKLVVETETI-------TAARVRQR-IYFPADE 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 399 KNVPEIVNLLNKKFGHNAIGLTGEDTFEERSEKIMpflspPRPLSEVVAQSTSPPTslKKFEipdsnivigKLKNTNSNG 478
Cdd:PRK04537 243 EKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTL-----ERHGYRVGVLSGDVPQ--KKRE---------SLLNRFQKG 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321374 479 tapsnkSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTdskTKSWAKALPKI 553
Cdd:PRK04537 307 ------QLEILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFA---CERYAMSLPDI 372
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
133-332 |
4.61e-20 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 89.08 E-value: 4.61e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 133 ENI------IPSPIQTVAIKRIS--KNLMdpklqihaiA-AETGSGKTMAYLIPLIDYLKRQEletPELWETLRKNVLIR 203
Cdd:cd17967 13 ENIkragytKPTPVQKYAIPIILagRDLM---------AcAQTGSGKTAAFLLPIISKLLEDG---PPSVGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 204 SIILVPTHELVDQVYE--------TVSKTKTLLGlnsfkwdkATSYRDLLENIKNRIDILVTTPGKLLNlfsirMITRpD 275
Cdd:cd17967 81 ALILAPTRELAIQIYEearkfsyrSGVRSVVVYG--------GADVVHQQLQLLRGCDILVATPGRLVD-----FIER-G 146
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321374 276 KV-LSKVGFVVLDEADTLLDRSWLEEthsaIKRIpnINH-----------LIFcSATIPQEfnktMQRL 332
Cdd:cd17967 147 RIsLSSIKFLVLDEADRMLDMGFEPQ----IRKI--VEHpdmppkgerqtLMF-SATFPRE----IQRL 204
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
138-533 |
1.00e-19 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 91.57 E-value: 1.00e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 138 SPIQTVAIKrisknlmdPKLQIHAIA--AETGSGKTMAYLIPLIDYLkrqeLETPElwETLRKNVLIRSIILVPTHELVD 215
Cdd:PRK04837 32 TPIQALALP--------LTLAGRDVAgqAQTGTGKTMAFLTATFHYL----LSHPA--PEDRKVNQPRALIMAPTRELAV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVY---ETVSKTKTL-LGLnSFKWDkatSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADT 291
Cdd:PRK04837 98 QIHadaEPLAQATGLkLGL-AYGGD---GYDKQLKVLESGVDILIGTTGRLIDYAKQNHIN-----LGAIQVVVLDEADR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 292 LLDRSWLEETHSAIKRIPNINH---LIFcSATIP---QEfnktmqrlfptvvpimtprlhklpfaLDFKVINSA----LS 361
Cdd:PRK04837 169 MFDLGFIKDIRWLFRRMPPANQrlnMLF-SATLSyrvRE--------------------------LAFEHMNNPeyveVE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 362 PFK--GSKIKalaQTLYAISNDDT--------EPGFEKRCIIFVNEKKNVPEIVNLLNKKfGHNAIGLTGeDTFEERSEK 431
Cdd:PRK04837 222 PEQktGHRIK---EELFYPSNEEKmrllqtliEEEWPDRAIIFANTKHRCEEIWGHLAAD-GHRVGLLTG-DVAQKKRLR 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 432 ImpflspprplsevvaqstspptsLKKFeipdsnivigklkntnSNGTapsnksLHVLVTTDLMARGLNFKGVRNVVLYD 511
Cdd:PRK04837 297 I-----------------------LEEF----------------TRGD------LDILVATDVAARGLHIPAVTHVFNYD 331
|
410 420
....*....|....*....|..
gi 6321374 512 VPKTSIDLIHRVGRTARMKQGG 533
Cdd:PRK04837 332 LPDDCEDYVHRIGRTGRAGASG 353
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
137-331 |
2.91e-19 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 86.20 E-value: 2.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQELEtpelwetlrknvlIRSIILVPTHELV 214
Cdd:cd17940 22 PSPIQEESIPIAlsGRDIL--------ARAKNGTGKTGAYLIPILEKIDPKKDV-------------IQALILVPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMItrpdkVLSKVGFVVLDEADTLLD 294
Cdd:cd17940 81 LQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVA-----DLSHCKTLVLDEADKLLS 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 6321374 295 RSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQR 331
Cdd:cd17940 156 QDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDR 192
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
136-321 |
3.75e-19 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 85.84 E-value: 3.75e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 136 IPSPIQTVAIKRI---SKNLMdpklqihaiAAETGSGKTMAYLIPLIDylkrqeletpelwetlrknvLIRSIILVPTHE 212
Cdd:cd17938 21 LPTDIQAEAIPLIlggGDVLM---------AAETGSGKTGAFCLPVLQ--------------------IVVALILEPSRE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 213 LVDQVYETVSKTKTLL---GLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEA 289
Cdd:cd17938 72 LAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLD-----LSSVRFFVLDEA 146
|
170 180 190
....*....|....*....|....*....|....*...
gi 6321374 290 DTLLDRSWLEETHSAIKRIPNIN------HLIFCSATI 321
Cdd:cd17938 147 DRLLSQGNLETINRIYNRIPKITsdgkrlQVIVCSATL 184
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
164-324 |
1.01e-18 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 84.55 E-value: 1.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQELETpelwetlrKNVLIRSIILVPTHELVDQVYETVS----------KTKTLLGLNSf 233
Cdd:cd17960 34 AVTGSGKTLAFLIPVLEILLKRKANL--------KKGQVGALIISPTRELATQIYEVLQsflehhlpklKCQLLIGGTN- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 234 kwdkatSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITRPDKVLSkvgFVVLDEADTLLDRSWLEETHSAIKRIPNINH 313
Cdd:cd17960 105 ------VEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVKVKSLE---VLVLDEADRLLDLGFEADLNRILSKLPKQRR 175
|
170
....*....|.
gi 6321374 314 LIFCSATIPQE 324
Cdd:cd17960 176 TGLFSATQTDA 186
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
137-538 |
1.07e-18 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 88.71 E-value: 1.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQELETPElwetlRKNVliRSIILVPTHELV 214
Cdd:PRK10590 24 PTPIQQQAIPAVleGRDLM--------ASAQTGTGKTAGFTLPLLQHLITRQPHAKG-----RRPV--RALILTPTRELA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLD 294
Cdd:PRK10590 89 AQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVK-----LDQVEILVLDEADRMLD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 295 RSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLfptvvpimtprLHKlPFALDFKVINSALSPF--------KGS 366
Cdd:PRK10590 164 MGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKL-----------LHN-PLEIEVARRNTASEQVtqhvhfvdKKR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 367 KIKALAQTLyaisnddtEPGFEKRCIIFVNEKKNVPEIVNLLNKKfGHNAIGLTGEDTFEERSEKIMPFLSpprplsevv 446
Cdd:PRK10590 232 KRELLSQMI--------GKGNWQQVLVFTRTKHGANHLAEQLNKD-GIRSAAIHGNKSQGARTRALADFKS--------- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 447 aqstspptslkkfeipdsniviGKLKntnsngtapsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRT 526
Cdd:PRK10590 294 ----------------------GDIR---------------VLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRT 336
|
410
....*....|..
gi 6321374 527 ARMKQGGRVFML 538
Cdd:PRK10590 337 GRAAATGEALSL 348
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
164-324 |
1.07e-18 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 84.94 E-value: 1.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLkrqeLETPELwetlRKNVLIRSIILVPTHELVDQVYETVSK---------TKTLLGLNSFK 234
Cdd:cd17964 39 AKTGTGKTLAFLLPAIQSL----LNTKPA----GRRSGVSALIISPTRELALQIAAEAKKllqglrklrVQSAVGGTSRR 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 235 wdkatsyRDLLENIKNRIDILVTTPGKLLNLFSIrmiTRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINH- 313
Cdd:cd17964 111 -------AELNRLRRGRPDILVATPGRLIDHLEN---PGVAKAFTDLDYLVLDEADRLLDMGFRPDLEQILRHLPEKNAd 180
|
170
....*....|....*
gi 6321374 314 ----LIFcSATIPQE 324
Cdd:cd17964 181 prqtLLF-SATVPDE 194
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
110-332 |
2.06e-18 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 85.40 E-value: 2.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 110 RDAVKEIISKESLKLQDSrkkTSENII------PSPIQTVAIKRIS--KNLMDpklqihaiAAETGSGKTMAYLIPLIDY 181
Cdd:cd18052 36 RNPPPAILTFEEANLCET---LLKNIRkagyekPTPVQKYAIPIILagRDLMA--------CAQTGSGKTAAFLLPVLTG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 182 LKRQELETPELWETlrknVLIRSIILVPTHELVDQVYE--------TVSKTKTLLGLNSfkwdkaTSYRdlLENIKNRID 253
Cdd:cd18052 105 MMKEGLTASSFSEV----QEPQALIVAPTRELANQIFLearkfsygTCIRPVVVYGGVS------VGHQ--IRQIEKGCH 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 254 ILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWleetHSAIKRIpnINH-----------LIFcSATIP 322
Cdd:cd18052 173 ILVATPGRLLDFIGRGKIS-----LSKLKYLILDEADRMLDMGF----GPEIRKL--VSEpgmpskedrqtLMF-SATFP 240
|
250
....*....|
gi 6321374 323 QEfnktMQRL 332
Cdd:cd18052 241 EE----IQRL 246
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
162-528 |
4.99e-18 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 86.78 E-value: 4.99e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 162 IA-AETGSGKTMAYLIPLIdylkrQELETpelwetlrKNVLIRSIILVPTHELVDQVyetvsktktllglnsfkwdkATS 240
Cdd:PRK11776 45 IAqAKTGSGKTAAFGLGLL-----QKLDV--------KRFRVQALVLCPTRELADQV--------------------AKE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 241 YRDL---LENIK-----------NRID-------ILVTTPGKLLNLFSIRMItrpdkVLSKVGFVVLDEADTLLDRSWLE 299
Cdd:PRK11776 92 IRRLarfIPNIKvltlcggvpmgPQIDslehgahIIVGTPGRILDHLRKGTL-----DLDALNTLVLDEADRMLDMGFQD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 300 ETHSAIKRIP-NINHLIFcSATIPQEFNKTMQRlfptvvpIMTPrlhklpfALDFKVInsalSPFKGSKIKalaQTLYAI 378
Cdd:PRK11776 167 AIDAIIRQAPaRRQTLLF-SATYPEGIAAISQR-------FQRD-------PVEVKVE----STHDLPAIE---QRFYEV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 379 SNDDTEPGFEK--------RCIIFVNEKKNVPEIVNLLNKkFGHNAIGLTGEDTFEERSEKIMPFlspprplsevvaqst 450
Cdd:PRK11776 225 SPDERLPALQRlllhhqpeSCVVFCNTKKECQEVADALNA-QGFSALALHGDLEQRDRDQVLVRF--------------- 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321374 451 spptslkkfeipdsnivigklkntnsngtapSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTAR 528
Cdd:PRK11776 289 -------------------------------ANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGR 335
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
164-528 |
9.46e-18 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 85.76 E-value: 9.46e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLkrqeLETPElwetlRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKWDKATSYRD 243
Cdd:PRK11192 45 APTGTGKTAAFLLPALQHL----LDFPR-----RKSGPPRILILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMN 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 244 LLENIKNRIDILVTTPGKLLNL-----FSIRMItrpdKVLskvgfvVLDEADTLLDRSWLE--ETHSAIKRIPNINhLIF 316
Cdd:PRK11192 116 HAEVFSENQDIVVATPGRLLQYikeenFDCRAV----ETL------ILDEADRMLDMGFAQdiETIAAETRWRKQT-LLF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 317 cSATIP----QEFNktmQRLF--PTVVPIMTPRLHKlpfaldfKVINS--ALSPFKGSKIKALAQTLyaiSNDDTEpgfe 388
Cdd:PRK11192 185 -SATLEgdavQDFA---ERLLndPVEVEAEPSRRER-------KKIHQwyYRADDLEHKTALLCHLL---KQPEVT---- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 389 kRCIIFVNEKKNVPEIVNLLNKKfGHNAIGLTGEdtfeersekiMPflspprplsevvaQStspptslKKFEIpdsnivI 468
Cdd:PRK11192 247 -RSIVFVRTRERVHELAGWLRKA-GINCCYLEGE----------MV-------------QA-------KRNEA------I 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 469 GKLKNTNSNgtapsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTAR 528
Cdd:PRK11192 289 KRLTDGRVN----------VLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGR 338
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
137-332 |
1.43e-17 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 81.48 E-value: 1.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIS--KNLMdpklqihaIAAETGSGKTMAYLIPLIDYLkrQELETPelwetLRKNVLIRSIILVPTHELV 214
Cdd:cd17949 14 PTAIQKLAIPVLLqgRDVL--------VRSQTGSGKTLAYLLPIIQRL--LSLEPR-----VDRSDGTLALVLVPTRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSK---------TKTLLGLNSFKWDKAtsyrdlleNIKNRIDILVTTPGKLL----NLFSIRmitrpdkvLSKV 281
Cdd:cd17949 79 LQIYEVLEKllkpfhwivPGYLIGGEKRKSEKA--------RLRKGVNILIATPGRLLdhlkNTQSFD--------VSNL 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321374 282 GFVVLDEADTLLDRSWlEETHSAI-----KRIPNINHL---------IFCSATIpqefNKTMQRL 332
Cdd:cd17949 143 RWLVLDEADRLLDMGF-EKDITKIlelldDKRSKAGGEkskpsrrqtVLVSATL----TDGVKRL 202
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
137-322 |
4.66e-17 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 80.50 E-value: 4.66e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIsknlMDPKLQIHAiaAETGSGKTMAYLIPLIDYLKRQELETPELWETlrknvlirSIILVPTHELVDQ 216
Cdd:cd17953 35 PTPIQAQALPAI----MSGRDVIGI--AKTGSGKTLAFLLPMFRHIKDQRPVKPGEGPI--------GLIMAPTRELALQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 VYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSI--RMITRpdkvLSKVGFVVLDEADTLLD 294
Cdd:cd17953 101 IYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTAnnGRVTN----LRRVTYVVLDEADRMFD 176
|
170 180
....*....|....*....|....*...
gi 6321374 295 RSWLEETHSAIKRIPNINHLIFCSATIP 322
Cdd:cd17953 177 MGFEPQIMKIVNNIRPDRQTVLFSATFP 204
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
135-332 |
5.57e-17 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 79.64 E-value: 5.57e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 135 IIPSPIQTVAIKrisknlmdPKLQIHAI--AAETGSGKTMAYLIPLIDYLKRqeletpELWETLRKnvlIRSIILVPTHE 212
Cdd:cd17941 11 IKMTEIQRDSIP--------HALQGRDIlgAAKTGSGKTLAFLVPLLEKLYR------ERWTPEDG---LGALIISPTRE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 213 LVDQVYETVSKTKT--------LLGLNSFKWDKatsyrdllENIkNRIDILVTTPGKLLNlfsiRMITRPDKVLSKVGFV 284
Cdd:cd17941 74 LAMQIFEVLRKVGKyhsfsaglIIGGKDVKEEK--------ERI-NRMNILVCTPGRLLQ----HMDETPGFDTSNLQML 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6321374 285 VLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIpqefNKTMQRL 332
Cdd:cd17941 141 VLDEADRILDMGFKETLDAIVENLPKSRQTLLFSATQ----TKSVKDL 184
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
137-324 |
9.78e-17 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 78.91 E-value: 9.78e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKnlmdpKLQIHAiAAETGSGKTMAYLIplidyLKRQELETpelweTLRKnvlIRSIILVPTHELVDQ 216
Cdd:cd17939 20 PSAIQQRAIVPIIK-----GRDVIA-QAQSGTGKTATFSI-----GALQRIDT-----TVRE---TQALVLAPTRELAQQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 VYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMItRPDKVlskvGFVVLDEADTLLDRS 296
Cdd:cd17939 81 IQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSL-RTDKI----KMFVLDEADEMLSRG 155
|
170 180
....*....|....*....|....*...
gi 6321374 297 WLEETHSAIKRIPNINHLIFCSATIPQE 324
Cdd:cd17939 156 FKDQIYDIFQFLPPETQVVLFSATMPHE 183
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
164-323 |
6.87e-16 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 76.42 E-value: 6.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQEletpelwETLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSFKwdKATSYRD 243
Cdd:cd17944 34 ARTGTGKTFSFAIPLIEKLQEDQ-------QPRKRGRAPKVLVLAPTRELANQVTKDFKDITRKLSVACFY--GGTPYQQ 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 244 LLENIKNRIDILVTTPGKllnlfsIRMITRPDKV-LSKVGFVVLDEADTLLDRSWLEET----HSAIKRIP--NINHLIF 316
Cdd:cd17944 105 QIFAIRNGIDILVGTPGR------IKDHLQNGRLdLTKLKHVVLDEVDQMLDMGFAEQVeeilSVSYKKDSedNPQTLLF 178
|
....*..
gi 6321374 317 cSATIPQ 323
Cdd:cd17944 179 -SATCPD 184
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
164-324 |
1.04e-15 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 75.87 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQELetpelwetLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSF----KWDKAT 239
Cdd:cd17966 34 AQTGSGKTLAFLLPAIVHINAQPP--------LERGDGPIVLVLAPTRELAQQIQQEANKFGGSSRLRNTcvygGAPKGP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 240 SYRDLLENiknrIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWLEETHSAIKRI-PNINHLIFcS 318
Cdd:cd17966 106 QIRDLRRG----VEICIATPGRLIDFLDQGKTN-----LRRVTYLVLDEADRMLDMGFEPQIRKIVDQIrPDRQTLMW-S 175
|
....*.
gi 6321374 319 ATIPQE 324
Cdd:cd17966 176 ATWPKE 181
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
137-533 |
1.17e-15 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 79.10 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNlMDPKLQihaiaAETGSGKTMAYLIP---LIDYlkrqeletpelwetlrKNVLIRSIILVPTHEL 213
Cdd:PTZ00424 51 PSAIQQRGIKPILDG-YDTIGQ-----AQSGTGKTATFVIAalqLIDY----------------DLNACQALILAPTREL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 214 VDQVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNlfsirMITRPDKVLSKVGFVVLDEADTLL 293
Cdd:PTZ00424 109 AQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYD-----MIDKRHLRVDDLKLFILDEADEML 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 294 DRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPIMtprlhklpfaldfkVINSALSpfkgskIKALAQ 373
Cdd:PTZ00424 184 SRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRIL--------------VKKDELT------LEGIRQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 374 TLYAISNDDTEpgFEKRC-----------IIFVNEKKNVPEIVNLLNKKfGHNAIGLTGEDTFEERsEKIMpflspprpl 442
Cdd:PTZ00424 244 FYVAVEKEEWK--FDTLCdlyetltitqaIIYCNTRRKVDYLTKKMHER-DFTVSCMHGDMDQKDR-DLIM--------- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 443 sevvaqstspptslKKFEipdsnivigklkntnsngtapsNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHR 522
Cdd:PTZ00424 311 --------------REFR----------------------SGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHR 354
|
410
....*....|.
gi 6321374 523 VGRTARMKQGG 533
Cdd:PTZ00424 355 IGRSGRFGRKG 365
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
137-321 |
1.65e-15 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 76.12 E-value: 1.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNLMDpklqihaI--AAETGSGKTMAYLIPLIDYLKRQeLETPELWETLRKnvlIRSIILVPTHELV 214
Cdd:cd17946 13 PTPIQALALPAAIRDGKD-------VigAAETGSGKTLAFGIPILERLLSQ-KSSNGVGGKQKP---LRALILTPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQV---------YETVSKTKTLLGLNSFKWDKatsyrdLLeniKNRIDILVTTPGKLLNLfsirmITRPDKVLS---KVG 282
Cdd:cd17946 82 VQVkdhlkaiakYTNIKIASIVGGLAVQKQER------LL---KKRPEIVVATPGRLWEL-----IQEGNEHLAnlkSLR 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6321374 283 FVVLDEADTLLDRSWLEETHSAIKRIPNINH--------LIFcSATI 321
Cdd:cd17946 148 FLVLDEADRMLEKGHFAELEKILELLNKDRAgkkrkrqtFVF-SATL 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
137-337 |
7.60e-15 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 73.07 E-value: 7.60e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKrISKNLMDPKLQihaiaAETGSGKTMAYLIPLIDYLKRQeletpelwetlrkNVLIRSIILVPTHELVDQ 216
Cdd:cd17943 13 PSPIQLAAIP-LGLAGHDLIVQ-----AKSGTGKTLVFVVIALESLDLE-------------RRHPQVLILAPTREIAVQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 VYETVSK-TKTLLGLNsfkwdkaTSY----RDLLENIK--NRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEA 289
Cdd:cd17943 74 IHDVFKKiGKKLEGLK-------CEVfiggTPVKEDKKklKGCHIAVGTPGRIKQLIELGALN-----VSHVRLFVLDEA 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 6321374 290 DTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLF--PTVV 337
Cdd:cd17943 142 DKLMEGSFQKDVNWIFSSLPKNKQVIAFSATYPKNLDNLLARYMrkPVLV 191
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
137-324 |
1.97e-14 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 72.09 E-value: 1.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNLmdpklqiHAIA-AETGSGKTMAYLIPLidyLKRQELETPElwetlrknvlIRSIILVPTHELVD 215
Cdd:cd18046 22 PSAIQQRAIMPCIKGY-------DVIAqAQSGTGKTATFSISI---LQQIDTSLKA----------TQALVLAPTRELAQ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNlfsirMITRPDKVLSKVGFVVLDEADTLLDR 295
Cdd:cd18046 82 QIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFD-----MINRRYLRTDYIKMFVLDEADEMLSR 156
|
170 180
....*....|....*....|....*....
gi 6321374 296 SWLEETHSAIKRIPNINHLIFCSATIPQE 324
Cdd:cd18046 157 GFKDQIYDIFQKLPPDTQVVLLSATMPND 185
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
162-320 |
2.24e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.51 E-value: 2.24e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 162 IAAETGSGKTMAYLIPLIDYLKRQeletpelwetlRKNVLirsiILVPTHELVDQVYETVsktKTLLGLNS--FKWDKAT 239
Cdd:cd00046 6 ITAPTGSGKTLAALLAALLLLLKK-----------GKKVL----VLVPTKALALQTAERL---RELFGPGIrvAVLVGGS 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 240 SYRDLLENIKNRIDILVTTPGKLLNLfsirmITRPDK-VLSKVGFVVLDEADTLLD--RSWLEETHSAIKRIPNINHLIF 316
Cdd:cd00046 68 SAEEREKNKLGDADIIIATPDMLLNL-----LLREDRlFLKDLKLIIVDEAHALLIdsRGALILDLAVRKAGLKNAQVIL 142
|
....
gi 6321374 317 CSAT 320
Cdd:cd00046 143 LSAT 146
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
137-334 |
2.30e-14 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 71.87 E-value: 2.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKrqelETPelwetlrknVLIRSIILVPTHELV 214
Cdd:cd17955 22 PTPIQKLCIPEIlaGRDVI--------GGAKTGSGKTAAFALPILQRLS----EDP---------YGIFALVLTPTRELA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSfkwDKATSYRDLLENIK---NRIDILVTTPGKLLNLFSIRMITRpdKVLSKVGFVVLDEADT 291
Cdd:cd17955 81 YQIAEQFRALGAPLGLRC---CVIVGGMDMVKQALelsKRPHIVVATPGRLADHLRSSDDTT--KVLSRVKFLVLDEADR 155
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6321374 292 LLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKtMQRLFP 334
Cdd:cd17955 156 LLTGSFEDDLATILSALPPKRQTLLFSATLTDALKA-LKELFG 197
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
366-530 |
2.62e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 69.16 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 366 SKIKALAQTLYAISNDdtepgfekRCIIFVNEKKNVPEivNLLNKKFGHNAIGLTGEDTFEERSEkimpflspprplsev 445
Cdd:pfam00271 1 EKLEALLELLKKERGG--------KVLIFSQTKKTLEA--ELLLEKEGIKVARLHGDLSQEEREE--------------- 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 446 vaqstspptSLKKFeipdsnivigklkntnsngtapSNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGR 525
Cdd:pfam00271 56 ---------ILEDF----------------------RKGKIDVLVATDVAERGLDLPDVDLVINYDLPWNPASYIQRIGR 104
|
....*
gi 6321374 526 TARMK 530
Cdd:pfam00271 105 AGRAG 109
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
137-331 |
1.01e-13 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 70.04 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKrisknlmdPKLQIHAIA--AETGSGKTMAYLIPLIDYLkrqeLETPELWETLrknvlirsiILVPTHELV 214
Cdd:cd17954 23 PTKIQEEAIP--------VALQGRDIIglAETGSGKTAAFALPILQAL----LENPQRFFAL---------VLAPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYETVSKTKTLLGLNSF----KWDKATSYRDLLEniknRIDILVTTPGKLL------NLFSIRmitrpdkvlsKVGFV 284
Cdd:cd17954 82 QQISEQFEALGSSIGLKSAvlvgGMDMMAQAIALAK----KPHVIVATPGRLVdhlentKGFSLK----------SLKFL 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6321374 285 VLDEADTLLDRSWLEETHSAIKRIP-NINHLIFcSATIPQEFNKtMQR 331
Cdd:cd17954 148 VMDEADRLLNMDFEPEIDKILKVIPrERTTYLF-SATMTTKVAK-LQR 193
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
164-332 |
1.05e-13 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 70.14 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQeletPELwetLRKNVLIrSIILVPTHELVDQVYETVSKTKTLLGLNSF-------KWD 236
Cdd:cd17952 34 AKTGSGKTAAFIWPMLVHIMDQ----REL---EKGEGPI-AVIVAPTRELAQQIYLEAKKFGKAYNLRVVavygggsKWE 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 237 KAtsyrdllENIKNRIDILVTTPGKLlnlfsIRMITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRI-PNINHLI 315
Cdd:cd17952 106 QA-------KALQEGAEIVVATPGRL-----IDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGHVrPDRQTLL 173
|
170
....*....|....*..
gi 6321374 316 FcSATipqeFNKTMQRL 332
Cdd:cd17952 174 F-SAT----FKKKIEQL 185
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
137-320 |
1.35e-13 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 69.59 E-value: 1.35e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLkrqeLETPelwetlRKNVLIRSIILVPTHELV 214
Cdd:cd17947 13 PTPIQAAAIPLAllGKDIC--------ASAVTGSGKTAAFLLPILERL----LYRP------KKKAATRVLVLVPTRELA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 215 DQVYE--------TVSKTKTLLGLNSFKWDKATsyrdllenIKNRIDILVTTPGKLLNLfsirMITRPDKVLSKVGFVVL 286
Cdd:cd17947 75 MQCFSvlqqlaqfTDITFALAVGGLSLKAQEAA--------LRARPDIVIATPGRLIDH----LRNSPSFDLDSIEILVL 142
|
170 180 190
....*....|....*....|....*....|....
gi 6321374 287 DEADTLLDRSWLEETHSAIKRIPNINHLIFCSAT 320
Cdd:cd17947 143 DEADRMLEEGFADELKEILRLCPRTRQTMLFSAT 176
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
163-320 |
3.13e-13 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 68.54 E-value: 3.13e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 163 AAETGSGKTMAYLIPLIDYLKRQELETpelwetlRKNVLIrsIILVPTHELVDQVYETVsktKTLLGLNSFKWDK---AT 239
Cdd:cd17942 33 AAKTGSGKTLAFLIPAIELLYKLKFKP-------RNGTGV--IIISPTRELALQIYGVA---KELLKYHSQTFGIvigGA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 240 SYRDLLENIKNRIDILVTTPGKLLNlfsiRMITRPDKVLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSA 319
Cdd:cd17942 101 NRKAEAEKLGKGVNILVATPGRLLD----HLQNTKGFLYKNLQCLIIDEADRILEIGFEEEMRQIIKLLPKRRQTMLFSA 176
|
.
gi 6321374 320 T 320
Cdd:cd17942 177 T 177
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
137-327 |
4.29e-13 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 68.52 E-value: 4.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIsknLMDPKLqihaIA-AETGSGKTMAYLIPLIDYLKRQELETPelwetLRKNVLIRSIILVPTHELVD 215
Cdd:cd17951 13 PTPIQMQGLPTI---LSGRDM----IGiAFTGSGKTLVFTLPLIMFALEQEKKLP-----FIKGEGPYGLIVCPSRELAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLL------GLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEA 289
Cdd:cd17951 81 QTHEVIEYYCKALqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKIN-----LDICRYLCLDEA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 6321374 290 DTLLDRSWLEETHSAIKRIPNINHLIFCSATIP---QEFNK 327
Cdd:cd17951 156 DRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPkkiQNFAK 196
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
130-339 |
4.50e-13 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 67.96 E-value: 4.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 130 KTSENIIPSPIQtvaIKRISKNLMDPKLqihAIAAETGSGKTMAYLIPLIDYLKrQELETPElwetlrknvlirSIILVP 209
Cdd:cd17962 6 KKAGYEVPTPIQ---MQMIPVGLLGRDI---LASADTGSGKTAAFLLPVIIRCL-TEHRNPS------------ALILTP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 210 THELVDQVYEtvsKTKTLL-GLNSFKWDKATSYRDL---LENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVV 285
Cdd:cd17962 67 TRELAVQIED---QAKELMkGLPPMKTALLVGGLPLppqLYRLQQGVKVIIATPGRLLDILKQSSVE-----LDNIKIVV 138
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 6321374 286 LDEADTLLDRSWLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPI 339
Cdd:cd17962 139 VDEADTMLKMGFQQQVLDILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
483-530 |
4.90e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.54 E-value: 4.90e-13
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 6321374 483 NKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMK 530
Cdd:smart00490 35 NGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
135-322 |
6.86e-13 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 67.49 E-value: 6.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 135 IIPSPIQTVAIKRIsknlmdpkLQIHAI--AAETGSGKTMAYLIPLIDYLKRQeletPELWET-LRKNVLirsiILVPTH 211
Cdd:cd17958 11 EKPSPIQSQAWPII--------LQGIDLigVAQTGTGKTLAYLLPGFIHLDLQ----PIPREQrNGPGVL----VLTPTR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 212 ELVDQVYETVSKTKtLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADT 291
Cdd:cd17958 75 ELALQIEAECSKYS-YKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVIN-----LKSITYLVLDEADR 148
|
170 180 190
....*....|....*....|....*....|.
gi 6321374 292 LLDRSWLEETHSAIKRIPNINHLIFCSATIP 322
Cdd:cd17958 149 MLDMGFEPQIRKILLDIRPDRQTIMTSATWP 179
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
137-324 |
1.48e-12 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 67.76 E-value: 1.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRI--SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQ---ELETPELWETLRKNVLIRSIILVPTH 211
Cdd:cd18051 44 PTPVQKHAIPIIksKRDLM--------ACAQTGSGKTAAFLLPILSQIYEQgpgESLPSESGYYGRRKQYPLALVLAPTR 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 212 ELVDQVYETVSKtktllglnsFKW-------------DKATSYRDLLENIKnridILVTTPGKLLNlfsirMITRPDKVL 278
Cdd:cd18051 116 ELASQIYDEARK---------FAYrsrvrpcvvyggaDIGQQMRDLERGCH----LLVATPGRLVD-----MLERGKIGL 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 6321374 279 SKVGFVVLDEADTLLDRSWleETHsaIKRI--------PNINHLIFCSATIPQE 324
Cdd:cd18051 178 DYCKYLVLDEADRMLDMGF--EPQ--IRRIveqdtmppTGERQTLMFSATFPKE 227
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
141-329 |
1.79e-12 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 66.07 E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 141 QTVAIKRIS--KNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQeletpelwetlrKNVliRSIILVPTHELV-DQV 217
Cdd:cd17923 5 QAEAIEAARagRSVV--------VTTGTASGKSLCYQLPILEALLRD------------PGS--RALYLYPTKALAqDQL 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 218 yETVSKT--KTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPgKLLNLFSIRMITRPDKVLSKVGFVVLDEADT---- 291
Cdd:cd17923 63 -RSLRELleQLGLGIRVATYDGDTPREERRAIIRNPPRILLTNP-DMLHYALLPHHDRWARFLRNLRYVVLDEAHTyrgv 140
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6321374 292 -------LLDRswLEETHSAIKRIPNInhlIFCSATI--PQEFNKTM 329
Cdd:cd17923 141 fgshvalLLRR--LRRLCRRYGADPQF---ILTSATIgnPAEHARTL 182
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
139-323 |
1.89e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 63.05 E-value: 1.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 139 PIQTVAIKRI---SKNLMdpklqihaIAAETGSGKTMAYLIPLIDYLKRQEletpelwetlrknvlIRSIILVPTHELVD 215
Cdd:cd17921 4 PIQREALRALylsGDSVL--------VSAPTSSGKTLIAELAILRALATSG---------------GKAVYIAPTRALVN 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSKTKTLLGLN------SFKWDKATSYrdlleniknRIDILVTTPGKLLNLfsirMITRPDKVLSKVGFVVLDEA 289
Cdd:cd17921 61 QKEADLRERFGPLGKNvglltgDPSVNKLLLA---------EADILVATPEKLDLL----LRNGGERLIQDVRLVVVDEA 127
|
170 180 190
....*....|....*....|....*....|....*...
gi 6321374 290 DTLLD--RSW-LEETHSAIKRI-PNINhLIFCSATIPQ 323
Cdd:cd17921 128 HLIGDgeRGVvLELLLSRLLRInKNAR-FVGLSATLPN 164
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
164-324 |
2.80e-10 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 60.79 E-value: 2.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQELetpelwetLRKNVLIRSIILVPTHELVDQVYETVSKTKTLLGLNSF----KWDKAT 239
Cdd:cd18049 68 AQTGSGKTLSYLLPAIVHINHQPF--------LERGDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTciygGAPKGP 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 240 SYRDLleniKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFCSA 319
Cdd:cd18049 140 QIRDL----ERGVEICIATPGRLIDFLEAGKTN-----LRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSA 210
|
....*
gi 6321374 320 TIPQE 324
Cdd:cd18049 211 TWPKE 215
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
137-340 |
4.71e-10 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 59.40 E-value: 4.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNlMDPKLQihaiaAETGSGKTMAYLIPLIdylkrQELETpelweTLRKnvlIRSIILVPTHELVDQ 216
Cdd:cd18045 22 PSAIQQRAIKPIIKG-RDVIAQ-----SQSGTGKTATFSISVL-----QCLDI-----QVRE---TQALILSPTRELAVQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 VYETVSKTKTLLGLNSFKWDKATSYRDLLENIKNRIDILVTTPGKLLNlfsirMITRPDKVLSKVGFVVLDEADTLLDRS 296
Cdd:cd18045 83 IQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFD-----MIRRRSLRTRHIKMLVLDEADEMLNKG 157
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 6321374 297 WLEETHSAIKRIPNINHLIFCSATIPQEFNKTMQRLFPTVVPIM 340
Cdd:cd18045 158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
164-324 |
6.17e-10 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 60.41 E-value: 6.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 164 AETGSGKTMAYLIPLIDYLKRQELetpelwetLRKNVLIRSIILVPTHELVDQV------YETVSKTKTLLGLNSFKwdK 237
Cdd:cd18050 106 AQTGSGKTLAYLLPAIVHINHQPY--------LERGDGPICLVLAPTRELAQQVqqvaddYGKSSRLKSTCIYGGAP--K 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 238 ATSYRDLleniKNRIDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEADTLLDRSWLEETHSAIKRIPNINHLIFC 317
Cdd:cd18050 176 GPQIRDL----ERGVEICIATPGRLIDFLEAGKTN-----LRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMW 246
|
....*..
gi 6321374 318 SATIPQE 324
Cdd:cd18050 247 SATWPKE 253
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
484-539 |
4.90e-08 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 50.40 E-value: 4.90e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 6321374 484 KSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTAR-MKQGGRVFMLT 539
Cdd:cd18785 21 SSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRgGKDEGEVILFV 77
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
137-338 |
6.25e-08 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 52.96 E-value: 6.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIsknLMDPKLqiHAIA-AETGSGKTMAYLIPLIDYLKRQELETpelwetlrknvliRSIILVPTHELVD 215
Cdd:cd17963 17 PSKIQETALPLI---LSDPPE--NLIAqSQSGTGKTAAFVLAMLSRVDPTLKSP-------------QALCLAPTRELAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 216 QVYETVSK------TKTLLGLNSfKWDKATsyrdllENIKNRIdiLVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEA 289
Cdd:cd17963 79 QIGEVVEKmgkftgVKVALAVPG-NDVPRG------KKITAQI--VIGTPGTVLDWLKKRQLD-----LKKIKILVLDEA 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 6321374 290 DTLLDRSWLEETHSAIKRI--PNINHLIFcSATipqeFNKTMQRLFPTVVP 338
Cdd:cd17963 145 DVMLDTQGHGDQSIRIKRMlpRNCQILLF-SAT----FPDSVRKFAEKIAP 190
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
161-322 |
1.73e-07 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 53.75 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 161 AIAAETGSGKTM-AYLIpLIDYLKRQEletpelwetlrknvliRSIILVPTHELVDQVYETVSKTKTLLGLnsfKWDKAT 239
Cdd:COG1204 42 VVSAPTASGKTLiAELA-ILKALLNGG----------------KALYIVPLRALASEKYREFKRDFEELGI---KVGVST 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 240 SYRDLLENIKNRIDILVTTPGKLLNLFSirmiTRPDkVLSKVGFVVLDEADTLLDRS---WLEETHSAIKRI-PNINhLI 315
Cdd:COG1204 102 GDYDSDDEWLGRYDILVATPEKLDSLLR----NGPS-WLRDVDLVVVDEAHLIDDESrgpTLEVLLARLRRLnPEAQ-IV 175
|
....*..
gi 6321374 316 FCSATIP 322
Cdd:COG1204 176 ALSATIG 182
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
100-540 |
2.64e-07 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 53.49 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 100 FDQLLILPPVRDAVKEIISKESLKLQDSRKKTSenIIPSPIQTVAIKRIsKNLMDPKLQIHAIAAETGSGKT--MAYLIp 177
Cdd:COG1061 46 TREDGRRLPEEDTERELAEAEALEAGDEASGTS--FELRPYQQEALEAL-LAALERGGGRGLVVAPTGTGKTvlALALA- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 178 lidylkrQELETPelwetlrKNVLIrsiiLVPTHELVDQVYETVSK--TKTLLGLNSFKWDKatsyrdlleniknriDIL 255
Cdd:COG1061 122 -------AELLRG-------KRVLV----LVPRRELLEQWAEELRRflGDPLAGGGKKDSDA---------------PIT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 256 VTTPGKLLNLFSIrmitrpDKVLSKVGFVVLDEADTLLDRSWLEethsAIKRIPNiNHLIFCSATiPQEFNKTMQRLFPT 335
Cdd:COG1061 169 VATYQSLARRAHL------DELGDRFGLVIIDEAHHAGAPSYRR----ILEAFPA-AYRLGLTAT-PFRSDGREILLFLF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 336 VVPIMTPRLHKL-------PFalDFKVINSALSPfKGSKIKALAQTL-YAISNDDT-----------EPGFEKRCIIFVN 396
Cdd:COG1061 237 DGIVYEYSLKEAiedgylaPP--EYYGIRVDLTD-ERAEYDALSERLrEALAADAErkdkilrellrEHPDDRKTLVFCS 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 397 EKKNVPEIVNLLNKKfGHNAIGLTGEDTFEERSEKImpflspprplsevvaqstspptslKKFEipdsnivigklkntns 476
Cdd:COG1061 314 SVDHAEALAELLNEA-GIRAAVVTGDTPKKEREEIL------------------------EAFR---------------- 352
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321374 477 ngtapsNKSLHVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARMKQGGRVFMLTD 540
Cdd:COG1061 353 ------DGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGKEDALVYD 410
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
162-333 |
3.58e-07 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 53.30 E-value: 3.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 162 IAAETGSGKTMAYLIPLIdylkrqeletpelwETLRKNVLIRSIILVPTHELV-DQvYETVSK--TKTLLGLNSFKWDKA 238
Cdd:COG1205 76 IATPTASGKSLAYLLPVL--------------EALLEDPGATALYLYPTKALArDQ-LRRLRElaEALGLGVRVATYDGD 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 239 TSyRDLLENIKNRIDILVTTP-----GKLLNLFSIRmitrpdKVLSKVGFVVLDEADT-----------LLDRswleeth 302
Cdd:COG1205 141 TP-PEERRWIREHPDIVLTNPdmlhyGLLPHHTRWA------RFFRNLRYVVIDEAHTyrgvfgshvanVLRR------- 206
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 6321374 303 saIKRI-------PninHLIFCSATI--PQEFnktMQRLF 333
Cdd:COG1205 207 --LRRIcrhygsdP---QFILASATIgnPAEH---AERLT 238
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
382-538 |
1.31e-06 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 48.12 E-value: 1.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 382 DTEPGFEKRCIIFVNEKKNVPEIVNLLNKkfghnaigltgedtfeersekIMPFLSPprplSEVVAQSTSppTSLKKFEI 461
Cdd:cd18801 24 KKQEGSDTRVIIFSEFRDSAEEIVNFLSK---------------------IRPGIRA----TRFIGQASG--KSSKGMSQ 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321374 462 PDSNIVIGKLKNTNSNgtapsnkslhVLVTTDLMARGLNFKGVRNVVLYDVPKTSIDLIHRVGRTARmKQGGRVFML 538
Cdd:cd18801 77 KEQKEVIEQFRKGGYN----------VLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR-KRQGRVVVL 142
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
166-289 |
8.50e-06 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 46.88 E-value: 8.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 166 TGSGKTM-AYLipLIDYLKRQELETPELwetlRKnvliRSIILVPTHELVDQVYETVsKTKTLL-------GLNSFKWDK 237
Cdd:cd18034 25 TGSGKTLiAVM--LIKEMGELNRKEKNP----KK----RAVFLVPTVPLVAQQAEAI-RSHTDLkvgeysgEMGVDKWTK 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 6321374 238 ATSYRDLLENiknriDILVTTPGKLLNLFSIRMITrpdkvLSKVGFVVLDEA 289
Cdd:cd18034 94 ERWKEELEKY-----DVLVMTAQILLDALRHGFLS-----LSDINLLIFDEC 135
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
137-334 |
1.89e-05 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 46.17 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRIsknLMDPKLQIHAiAAETGSGKTMAYLIPLIDYLKRQELetpelwetlrknvLIRSIILVPTHELVDQ 216
Cdd:cd18048 41 PSKIQENALPMM---LADPPQNLIA-QSQSGTGKTAAFVLAMLSRVDALKL-------------YPQCLCLSPTFELALQ 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 ---VYETVSK----TKTLLGLNSFKWDKATSYRDlleniknriDILVTTPGKLLN-LFSIRMITrpdkvLSKVGFVVLDE 288
Cdd:cd18048 104 tgkVVEEMGKfcvgIQVIYAIRGNRPGKGTDIEA---------QIVIGTPGTVLDwCFKLRLID-----VTNISVFVLDE 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6321374 289 ADTLLDRSWLEETHSAIKR-IPNINHLIFCSATIPQEFNKTMQRLFP 334
Cdd:cd18048 170 ADVMINVQGHSDHSVRVKRsMPKECQMLLFSATFEDSVWAFAERIVP 216
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
128-321 |
4.13e-05 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 44.63 E-value: 4.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 128 RKKTSENiiPSPIQTVAIKRISKNlmdpklQIHAIAAETGSGKT---MAYLIPLidYLKRQeletpelwetlrknvliRS 204
Cdd:cd17924 11 KKKTGFP--PWGAQRTWAKRLLRG------KSFAIIAPTGVGKTtfgLATSLYL--ASKGK-----------------RS 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 205 IILVPTHELVDQVYETVSKTKTLLGLN-----SFKWDKATSYRDLLENIKNR-IDILVTTpgkllNLFSIRmitRPDKVL 278
Cdd:cd17924 64 YLIFPTKSLVKQAYERLSKYAEKAGVEvkilvYHSRLKKKEKEELLEKIEKGdFDILVTT-----NQFLSK---NFDLLS 135
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6321374 279 SKV-GFVVLDEADTLLDRSwleethSAIKRIPN---INHLIFCSATI 321
Cdd:cd17924 136 NKKfDFVFVDDVDAVLKSS------KNIDRLLKllgFGQLVVSSATG 176
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
129-432 |
5.22e-05 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 45.84 E-value: 5.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 129 KKTSENIIPSPIQTVAIKRISKNLMDPKlQIHAIAAETGSGKTMAYLIPLIDYLKRQELEtpelwetlrknvliRSIILV 208
Cdd:COG1203 120 KKSKPRTPINPLQNEALELALEAAEEEP-GLFILTAPTGGGKTEAALLFALRLAAKHGGR--------------RIIYAL 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 209 PTHELVDQVYETVSKT----------KTLLGLNSFKWDKATSYRDLLENIKN-RIDILVTTPGKLLN-LFS------IRM 270
Cdd:COG1203 185 PFTSIINQTYDRLRDLfgedvllhhsLADLDLLEEEEEYESEARWLKLLKELwDAPVVVTTIDQLFEsLFSnrkgqeRRL 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 271 ITRPDKVlskvgfVVLDEADTlLDRSWLEETHSAIKRIPNIN-HLIFCSATIPQEFNKTMQRLFPtVVPIMTPRLHKLPF 349
Cdd:COG1203 265 HNLANSV------IILDEVQA-YPPYMLALLLRLLEWLKNLGgSVILMTATLPPLLREELLEAYE-LIPDEPEELPEYFR 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 350 ALDFK---VINSALSpfkgskIKALAQTLYAISNDDtepgfeKRCIIFVNEKKNVPEIVNLLNKKFGH-NAIGLTGEDTF 425
Cdd:COG1203 337 AFVRKrveLKEGPLS------DEELAELILEALHKG------KSVLVIVNTVKDAQELYEALKEKLPDeEVYLLHSRFCP 404
|
....*..
gi 6321374 426 EERSEKI 432
Cdd:COG1203 405 ADRSEIE 411
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
137-288 |
9.90e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 43.17 E-value: 9.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNLMDPKLQIHAIAAETGSGKTMAYLIPLIDYLKRQeletpelwetlrKNVlirsIILVPTHELVDQ 216
Cdd:cd17918 16 LTKDQAQAIKDIEKDLHSPEPMDRLLSGDVGSGKTLVALGAALLAYKNG------------KQV----AILVPTEILAHQ 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321374 217 VYEtvsKTKTLLGlnSFKWDKATSYRDllENIKNRIDILVTTpGKLLNLfsirmitrpDKVLSKVGFVVLDE 288
Cdd:cd17918 80 HYE---EARKFLP--FINVELVTGGTK--AQILSGISLLVGT-HALLHL---------DVKFKNLDLVIVDE 134
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
137-324 |
1.50e-04 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 43.10 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 137 PSPIQTVAIKRISKNlMDPKLQihaiaAETGSGKTMAYLIPLIdylkrQELETPElwetlrKNVLIrsIILVPTHELVDQ 216
Cdd:cd17950 25 PSEVQHECIPQAILG-MDVLCQ-----AKSGMGKTAVFVLSTL-----QQLEPVD------GQVSV--LVICHTRELAFQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 217 V---YETVSK------TKTLLGLNSFKWDkatsyRDLLENikNRIDILVTTPGKLLNLfsirmITRPDKVLSKVGFVVLD 287
Cdd:cd17950 86 IsneYERFSKympnvkTAVFFGGVPIKKD-----IEVLKN--KCPHIVVGTPGRILAL-----VREKKLKLSHVKHFVLD 153
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 6321374 288 EADTLLD----RSWLEEthsAIKRIPNINHLIFCSATIPQE 324
Cdd:cd17950 154 ECDKMLEqldmRRDVQE---IFRATPHDKQVMMFSATLSKE 191
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
134-289 |
3.21e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 41.50 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 134 NIIPSPIQTVAIKRISKNLmdPKLQIHA-IAAETGSGKTMAYLIpLIDYLKRQELEtpelwetlrKNVLirsiILVPTHE 212
Cdd:pfam04851 1 KLELRPYQIEAIENLLESI--KNGQKRGlIVMATGSGKTLTAAK-LIARLFKKGPI---------KKVL----FLVPRKD 64
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321374 213 LVDQVYETVSKtktllgLNSFKWDKATSYR-DLLENIKNRIDILVTTPGKllnLFSIRMITRPDKVLSKVGFVVLDEA 289
Cdd:pfam04851 65 LLEQALEEFKK------FLPNYVEIGEIISgDKKDESVDDNKIVVTTIQS---LYKALELASLELLPDFFDVIIIDEA 133
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
166-320 |
3.89e-04 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 41.14 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321374 166 TGSGKT--MAYLIplidylkrqeletpelWETLRKNVLIrsiiLVPTHELVDQvyeTVSKTKTLLGlnsfkwdKATSYRD 243
Cdd:cd17926 27 TGSGKTltALALI----------------AYLKELRTLI----VVPTDALLDQ---WKERFEDFLG-------DSSIGLI 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321374 244 LLENIK--NRIDILVTTPGKLLNLFSirmitRPDKVLSKVGFVVLDEADTLLDRSWleethSAIKRIPNINHLIFCSAT 320
Cdd:cd17926 77 GGGKKKdfDDANVVVATYQSLSNLAE-----EEKDLFDQFGLLIVDEAHHLPAKTF-----SEILKELNAKYRLGLTAT 145
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
141-186 |
2.73e-03 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 40.68 E-value: 2.73e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 6321374 141 QTVAIKRISKNLMDPKlqIHAIAAETGSGKTMAYLIPLIDYLKRQE 186
Cdd:COG1199 19 QREMAEAVARALAEGR--HLLIEAGTGTGKTLAYLVPALLAARETG 62
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
488-538 |
4.53e-03 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 39.71 E-value: 4.53e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 6321374 488 VLVTTDLMARGLNFKGVRNVVLYD-VPkTSIDLIHRVGRTARmKQGGRVFML 538
Cdd:COG1111 414 VLVATSVAEEGLDIPEVDLVIFYEpVP-SEIRSIQRKGRTGR-KREGRVVVL 463
|
|
| dinG |
PRK11747 |
ATP-dependent DNA helicase DinG; Provisional |
111-179 |
7.61e-03 |
|
ATP-dependent DNA helicase DinG; Provisional
Pssm-ID: 236966 [Multi-domain] Cd Length: 697 Bit Score: 39.04 E-value: 7.61e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321374 111 DAVKEIISKESLKLQDSRKktseNIIPSPIQTVAIKRISKNLMDPKLQIHAIA---AETGSGKTMAYLIPLI 179
Cdd:PRK11747 4 DALKAQIRQAYKALQEQLP----GFIPRAGQRQMIAEVAKTLAGEYLKDGRILvieAGTGVGKTLSYLLAGI 71
|
|
| |
