NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6321838|ref|NP_011914|]
View 

Yhk8p [Saccharomyces cerevisiae S288C]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 77-505 1.96e-140

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 409.27  E-value: 1.96e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17323   2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLI 235
Cdd:cd17323  82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITqSLGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  236 TSGCCLVMIIFTIPetykpmllirkakrlrkekndqryyavlevtreqtsllsaiflstkrpfglllrdrMMGVLCFYTG 315
Cdd:cd17323 162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  316 LELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLF-QKTFEWRVKRNNGVKTPEMRFEPLFYGAFL 394
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  395 TPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSM 474
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 6321838  475 GVNWAGFLLAMVTVAMIPVPFLFTKYGARLR 505
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 77-505 1.96e-140

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 409.27  E-value: 1.96e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17323   2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLI 235
Cdd:cd17323  82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITqSLGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  236 TSGCCLVMIIFTIPetykpmllirkakrlrkekndqryyavlevtreqtsllsaiflstkrpfglllrdrMMGVLCFYTG 315
Cdd:cd17323 162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  316 LELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLF-QKTFEWRVKRNNGVKTPEMRFEPLFYGAFL 394
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  395 TPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSM 474
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 6321838  475 GVNWAGFLLAMVTVAMIPVPFLFTKYGARLR 505
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
MFS_1 pfam07690
Major Facilitator Superfamily;
82-464 3.08e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.13  E-value: 3.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     82 TSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKT 161
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    162 ITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-SYKWTFITLLITSGCC 240
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    241 LVMIIFTIPETykpmllirkakrlrkekndqryyavlevTREQTSLLSAIFLSTKRPFGLLLRDRMMgvLCFYTGLELAI 320
Cdd:pfam07690 165 AVLLLLPRPPP----------------------------ESKRPKPAEEARLSLIVAWKALLRDPVL--WLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    321 IYLYFVAFPYVFKKLYNFGPMEIAcsyIGIMVGMILSAPTCLLFQKTFEWRVKRNNGVktpemrfePLFYGAFLTPVGLF 400
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAG---LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAALGLL 283

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321838    401 IFAFTCYKHVHWIAPIigsaIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVRCIMAGVFP 464
Cdd:pfam07690 284 LLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
68-456 1.53e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.45  E-value: 1.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   68 STARRYYISSLITFTSMVITMISSSWTLPS-THIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYAL 146
Cdd:COG2814   3 ATPRRRWLALLALALGAFLSGLGIGIVLPAlPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  147 TLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-S 225
Cdd:COG2814  83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  226 YKWTFITLLITSGCCLVMIIFTIPETykpmlliRKAKRLRKekndqryyavlevtreqtsllsaiflstKRPFGLLLRDR 305
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPES-------RPAARARL----------------------------RGSLRELLRRP 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  306 MMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTC-LLFQKTFEWRVkrnngvktpemr 384
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAgRLADRFGRRRL------------ 275

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321838  385 fepLFYGAFLTPVGLFIFAFTcykhVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVR 456
Cdd:COG2814 276 ---LLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAF 341
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-251 1.37e-22

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 93.48  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    116 TLYVFGLGIGPLFLSPLSEL----YGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIF 191
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321838    192 DKDQIGIPMAIYTTSAFLGPSLGPIIGGALYH-QSYKWTFITLLITSGCCLVMIIFTIPET 251
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQfLGWRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
95-254 1.58e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 69.17  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    95 LPS-THIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSG 173
Cdd:PRK11102  11 LPAlPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   174 FFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-SYKWTFITLLITSGCCLVMIIFTIPETY 252
Cdd:PRK11102  91 LAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWfSWHAIFWVLALAAILAAALVFFFIPETL 170


                 ..
gi 6321838   253 KP 254
Cdd:PRK11102 171 PK 172
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 77-505 1.96e-140

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 409.27  E-value: 1.96e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17323   2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLI 235
Cdd:cd17323  82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITqSLGWRWIFWFLAI 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  236 TSGCCLVMIIFTIPetykpmllirkakrlrkekndqryyavlevtreqtsllsaiflstkrpfglllrdrMMGVLCFYTG 315
Cdd:cd17323 162 ISGFCLILIFLFLP--------------------------------------------------------IVLLLGLYVG 185

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  316 LELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLF-QKTFEWRVKRNNGVKTPEMRFEPLFYGAFL 394
Cdd:cd17323 186 LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFL 265

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  395 TPVGLFIFAFTCYKHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSM 474
Cdd:cd17323 266 FPIGLFIFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 6321838  475 GVNWAGFLLAMVTVAMIPVPFLFTKYGARLR 505
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
MFS_1 pfam07690
Major Facilitator Superfamily;
82-464 3.08e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 112.13  E-value: 3.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     82 TSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKT 161
Cdd:pfam07690   5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    162 ITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-SYKWTFITLLITSGCC 240
Cdd:pfam07690  85 LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfGWRAAFLILAILSLLA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    241 LVMIIFTIPETykpmllirkakrlrkekndqryyavlevTREQTSLLSAIFLSTKRPFGLLLRDRMMgvLCFYTGLELAI 320
Cdd:pfam07690 165 AVLLLLPRPPP----------------------------ESKRPKPAEEARLSLIVAWKALLRDPVL--WLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    321 IYLYFVAFPYVFKKLYNFGPMEIAcsyIGIMVGMILSAPTCLLFQKTFEWRVKRNNGVktpemrfePLFYGAFLTPVGLF 400
Cdd:pfam07690 215 AFFGLLTYLPLYQEVLGLSALLAG---LLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL--------LALLLLILAALGLL 283

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321838    401 IFAFTCYKHVHWIAPIigsaIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVRCIMAGVFP 464
Cdd:pfam07690 284 LLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
68-456 1.53e-26

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.45  E-value: 1.53e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   68 STARRYYISSLITFTSMVITMISSSWTLPS-THIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYAL 146
Cdd:COG2814   3 ATPRRRWLALLALALGAFLSGLGIGIVLPAlPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  147 TLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-S 225
Cdd:COG2814  83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  226 YKWTFITLLITSGCCLVMIIFTIPETykpmlliRKAKRLRKekndqryyavlevtreqtsllsaiflstKRPFGLLLRDR 305
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPES-------RPAARARL----------------------------RGSLRELLRRP 207

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  306 MMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTC-LLFQKTFEWRVkrnngvktpemr 384
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAgRLADRFGRRRL------------ 275

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321838  385 fepLFYGAFLTPVGLFIFAFTcykhVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVR 456
Cdd:COG2814 276 ---LLIGLLLLALGLLLLALA----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAF 341
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 74-491 1.50e-25

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 108.05  E-value: 1.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   74 YISSLITFTSMVITMISSSwtLPSthIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQ 153
Cdd:cd17320   3 LLALLVALGPLAIDMYLPA--LPA--IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  154 CLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGAL-YHQSYKWTFIT 232
Cdd:cd17320  79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLlLFFGWRAIFVF 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  233 LLITSGCCLVMIIFTIPETYKPmllirkakrlrkekndqryyavlevtREQTSLLSAIFLStkrpFGLLLRDRMMGVLCF 312
Cdd:cd17320 159 LALLGLLLLLLVLLFLPETLPE--------------------------EKRKPLLSSLLRA----YKRVLKNRRFLGYAL 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  313 YTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCllfqktfEWRVKRNNGVKTpeMRFEPLFYGA 392
Cdd:cd17320 209 ALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLN-------GRLVRRFGPRRL--LRLGLLLLLA 279

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  393 FLtpVGLFIFAFTCYKHVHWIapIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYK 472
Cdd:cd17320 280 AA--LVLLLAALLGGLSLWPL--VAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355

                       410
                ....*....|....*....
gi 6321838  473 SMGVNWAGFLLAMVTVAMI 491
Cdd:cd17320 356 GTALPMGLLILVLGLLALL 374
2_A_01_02 TIGR00880
Multidrug resistance protein;
116-251 1.37e-22

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 93.48  E-value: 1.37e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    116 TLYVFGLGIGPLFLSPLSEL----YGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIF 191
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLltdrFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321838    192 DKDQIGIPMAIYTTSAFLGPSLGPIIGGALYH-QSYKWTFITLLITSGCCLVMIIFTIPET 251
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQfLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 98-491 3.20e-21

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 95.31  E-value: 3.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   98 THIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGS 177
Cdd:cd17324  23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  178 AFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGAL-YHQSYKWTFITLLITSGCCLVMIIFTIPEtykpml 256
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPS------ 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  257 lirkakrlRKEKNDQRYYAVlevtreqtsllsaiflstkRPFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLY 336
Cdd:cd17324 177 --------LPPKKPGSLGLL-------------------SSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  337 NFGPMEIACSYIGIMVGMILSAPtclLFQKTFEWRVKRnngvktpemrfePLFYGAFLTPVGLFIFAFTcykHVHWIAPI 416
Cdd:cd17324 230 GFSSSAIIGLLLLFGVAGVVGSP---LAGRLADRGGRR------------ALLIALLLLAAALLLLTLL---GPSPLLLL 291

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321838  417 IGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSMGVNWAGFLLAMVTVAMI 491
Cdd:cd17324 292 VGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-497 9.29e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 93.79  E-value: 9.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSwTLPSthIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17325   2 SLALFLDMLGYGIIIP-ILPL--YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLI 235
Cdd:cd17325  79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAA 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  236 TSGCCLVMIIFTIPETYKPmllirKAKRLRKEKndqryyavlevtreqtsllsaiflSTKRPFGLLLRDRMMGVLCFYTG 315
Cdd:cd17325 159 LALLALVLALLLLPEPRPP-----PNKRAVSAA------------------------RLRSGLRLLLRDRRLLALFLAIF 209

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  316 LELAIIYLYFVAFPYVFKKLYNFGPMEIacsyigimvGMILSAP--TCLLFQKTFEWRVKRNNgvktpemRFEPLFYGAF 393
Cdd:cd17325 210 VLAFAFGALEPFLPLYAAELGGLSPAQI---------GLLFGAQglASALSQPPAGKLSDRIG-------RKPLILIGLL 273

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  394 LTPVGLFIFAFTcykhVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAYRRYA-ASGMACNTFVRCIMAGVFPLFGLQMYK 472
Cdd:cd17325 274 LSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYD 349

                       410       420
                ....*....|....*....|....*
gi 6321838  473 SMGVNWAGFLLAMVTVAMIPVPFLF 497
Cdd:cd17325 350 AFGFATPFLAAAALLLLAAVLFLLL 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 79-497 6.63e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.56  E-value: 6.63e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   79 ITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIW 158
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  159 SKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ---SYKWTFITLLI 235
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgfGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  236 TSGCCLVMIIFTIPETYKPMLLIRKAKRlrkekndqryyavlevtreqtsllsaiFLSTKRPFGLLLRDRMMGVLCFYTG 315
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAS---------------------------SKSVLKLLKRVLKNPGLWLLLLAIF 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  316 LELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLFqktfewrVKRNNGVKtpemrfePLFYGAFLT 395
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLL-------SDRLIGRK-------PLLLIGLLL 279

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  396 PVGLFIFAFTcykHVHWIAPIIGSAIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVRCIMAGVFPLFGLQMYkSM 474
Cdd:cd06174 280 MALGLALLLL---APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL-AA 355

                       410       420
                ....*....|....*....|...
gi 6321838  475 GVNWAGFLLAMVTVAMIPVPFLF 497
Cdd:cd06174 356 TFGLTGAFLVLAVLLLLAAILLL 378
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 73-491 7.15e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 82.23  E-value: 7.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   73 YYISSLITF-TSMVITMISSSwtLPSthIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSII 151
Cdd:cd17474   1 LYAVFFATLlAVLGVSIVDPI--LPA--IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  152 WQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFI 231
Cdd:cd17474  77 GGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFF 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  232 TLLITSGCCLVMIIFTIPETYKPmllirkakrlrkekndqryyavlEVTREQTSLLSAIFLSTKRPFGLLLRDRMMGVLC 311
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEK-----------------------AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFL 213

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  312 FYTglelaiiylYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPtcllfqKTFEWRVKRNNGVKTpemrfepLFYG 391
Cdd:cd17474 214 YFA---------FLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL------FVGRLLKKRFGARRI-------LVIG 271

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  392 AFLTPVGLFIFAFTcyKHVHWIAPIIGSAIFGSGVYF-VFTGVFAYTVDAYRRYAASGMacNTFVRCIMAGVFPLFGLQM 470
Cdd:cd17474 272 LLLYALSLLLLGFV--PSLALLLIAIVLFGLGLGLNLpLLTTLVTELAPEEERGTASSL--YNFVRFLGQAVGPLLFGLL 347

                       410       420
                ....*....|....*....|.
gi 6321838  471 YKSMGVNWAGFLLAMVTVAMI 491
Cdd:cd17474 348 LEIFGLSAPFLVGAAIALAAA 368
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 104-358 9.89e-16

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 78.96  E-value: 9.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    104 FHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVA 183
Cdd:TIGR00710  35 LSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVIS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    184 GGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGG-ALYHQSYKWTFITLLITSGCCLVMIIFTIPETYKPMLLIRKAK 262
Cdd:TIGR00710 115 QALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGyILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQIST 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    263 rlrkekndqryyavlevtreqtsllsaiflsTKRPFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPME 342
Cdd:TIGR00710 195 -------------------------------YFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSV 243

                         250
                  ....*....|....*.
gi 6321838    343 IACSYIGIMVGMILSA 358
Cdd:TIGR00710 244 FGLLFALNIIAMIFGG 259
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
66-496 1.73e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 74.91  E-value: 1.73e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   66 HMSTARRYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYA 145
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  146 LTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ- 224
Cdd:COG2271  82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAf 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  225 SYKWTFItllITSGCCLVMIIFTIpetykpmllirkakrlrkekndqryyavlevtreqtsllsaiflstkrpfglllrd 304
Cdd:COG2271 162 GWRAAFL---ILGLPGLLLALLRF-------------------------------------------------------- 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  305 rmmGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTC-LLFQKTFEWRVKrnngvktpem 383
Cdd:COG2271 183 ---WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGgWLSDRLGRRRKL---------- 249

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  384 rfePLFYGAFLTPVGLFIFAFTcykHVHWIApIIGSAIFGSGVYFVFTGVFAYTVDAY-RRYAASGMACNTFVRCIMAGV 462
Cdd:COG2271 250 ---VLAIGLLLAALALLLLALL---PSPALA-IALLFLAGFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGAL 322

                       410       420       430
                ....*....|....*....|....*....|....*
gi 6321838  463 FPLFGLQMYKSMGVNWA-GFLLAMVTVAMIPVPFL 496
Cdd:COG2271 323 GPLLVGYLLDATGYQAAfLLLAALALLAALLALLL 357
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 100-355 2.56e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 70.61  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  100 IIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAF 179
Cdd:COG0477  40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  180 LSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGAL-YHQSYKWTFITLLITSGCCLVMIIFtIPETYKPMLLI 258
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLvAALGWRWIFLINAPLGLLALVLRLR-LPESRGLLLAL 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  259 RKAKRLRKEKNDQRYYAVLEVTREQTSLLSAIFLSTKRPFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNF 338
Cdd:COG0477 199 LALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLAL 278

                       250
                ....*....|....*..
gi 6321838  339 GPMEIACSYIGIMVGMI 355
Cdd:COG0477 279 LLLLLLLLLLLLLALLL 295
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
95-254 1.58e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 69.17  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    95 LPS-THIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSG 173
Cdd:PRK11102  11 LPAlPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   174 FFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQ-SYKWTFITLLITSGCCLVMIIFTIPETY 252
Cdd:PRK11102  91 LAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWfSWHAIFWVLALAAILAAALVFFFIPETL 170


                 ..
gi 6321838   253 KP 254
Cdd:PRK11102 171 PK 172
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 83-244 2.51e-12

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 68.35  E-value: 2.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   83 SMVITMISSSWTLPSTHIIEH-FHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKT 161
Cdd:cd17321   4 AVFLAALDVTIVNVALPTIARdLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  162 ITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLITSGCC 240
Cdd:cd17321  84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLeLFGWRWIFLINVPIGLVA 163


                ....
gi 6321838  241 LVMI 244
Cdd:cd17321 164 LLLA 167
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 78-234 4.26e-11

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 64.52  E-value: 4.26e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   78 LITFTSMVITMISSSwTLPstHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTI 157
Cdd:cd17503   3 LGAFMAILDTTIVNV-ALP--TIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321838  158 WSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLL 234
Cdd:cd17503  80 LAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTdNLSWRWIFYINL 157
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
77-253 4.68e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 64.51  E-value: 4.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSWTlpSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRR--ITFLYALTLSIIWQC 154
Cdd:COG2271 186 ALAYFLVYFALYGFLTWL--PTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALL 263

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  155 LTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITL 233
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLdATGYQAAFLLL 343

                       170       180
                ....*....|....*....|
gi 6321838  234 LITSGCCLVMIIFTIPETYK 253
Cdd:COG2271 344 AALALLAALLALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
70-246 1.59e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.89  E-value: 1.59e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   70 ARRYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLS 149
Cdd:COG2223   1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  150 IIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHqSYKWT 229
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-AFGWR 159

                       170
                ....*....|....*..
gi 6321838  230 fITLLITSGCCLVMIIF 246
Cdd:COG2223 160 -NAFLILGILLLVVAVL 175
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
99-251 9.90e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 57.26  E-value: 9.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    99 HIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFfGSA 178
Cdd:PRK15402  38 AVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGI-GLC 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321838   179 FLSVAG-GAIADIFDK-DQIGIpMAIYTTSAFLGPSLGPIIGGALYH-QSYKWTFITLLITSGCCLVMIIFTIPET 251
Cdd:PRK15402 117 FIGAVGyAAIQESFEEaDAIKI-TALMANVALLAPLLGPLVGAALIHvLPWRGMFVLFAALAALSFFGLWRAMPET 191
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 101-254 2.85e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 2.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  101 IEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFL 180
Cdd:cd17489  23 AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFT 102

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321838  181 SVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLITSGCCLVMiIFTIPETYKP 254
Cdd:cd17489 103 TAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAVLALLALLL-VFLVKDPPPV 176
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
71-210 5.71e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.59  E-value: 5.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   71 RRYYISSLITFTSMVITMisSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSI 150
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFF--ALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  151 IWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLG 210
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 81-249 1.20e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 53.74  E-value: 1.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   81 FTSMVITMISSSWTLP--STHIIEHFHISHEVSTLGITLYVFGLG--IGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17330   2 FLVVFLDALGFGIVFPvlPFYVREFNKLGASGYYVGLLQSSYSLGqfLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAfLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYH-QSYKWTFITLLI 235
Cdd:cd17330  82 GLSRNLWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTpYGYALPFLVAAA 160

                       170
                ....*....|....
gi 6321838  236 TSGCCLVMIIFTIP 249
Cdd:cd17330 161 LALLNLVLVLFFLP 174
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 72-256 1.50e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.34  E-value: 1.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   72 RYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALtlsII 151
Cdd:cd17319   1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSM---LL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  152 WQCLTI---WSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYK 227
Cdd:cd17319  78 WSLFTAltgFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLlLFGWR 157

                       170       180
                ....*....|....*....|....*....
gi 6321838  228 WTFITLLITSGCCLVMIIFTIPETYKPML 256
Cdd:cd17319 158 WAFIIEGLLGLLLAVLWWFYLRQVWGLAL 186
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 97-248 2.97e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.57  E-value: 2.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   97 STHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSEL-YGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFF 175
Cdd:cd17474 222 PFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG 301

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321838  176 GSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLlitSGCCLVMIIFTI 248
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLeIFGLSAPFLVG---AAIALAAAVLLA 372
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 111-246 5.52e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 52.24  E-value: 5.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  111 STLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGfFGSAFLSVAGGAIADI 190
Cdd:cd06179  34 STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIG-IGAGTQGLGAAVASEL 112

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6321838  191 FDKDQIGIPMAIYTTSAFLGPSLGPIIGGAL---YHQSYKWTFITLLITSGCCLVMIIF 246
Cdd:cd06179 113 VPNKYRGLVQGVVNLVASPGSALGPLIAGALveaNAAGWRWIFYINAIFNALALILLFF 171
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 75-254 5.70e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 51.81  E-value: 5.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   75 ISSLITFTSMVITMISSSwtLPstHIIEHFH-ISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQ 153
Cdd:cd17473   4 LLLASTLTVMAGAAIAPA--LP--AIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  154 CLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFITL 233
Cdd:cd17473  80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVY 159

                       170       180
                ....*....|....*....|.
gi 6321838  234 LItSGCCLVMIIFTIPETYKP 254
Cdd:cd17473 160 LL-ALPVLILVLLFLPEPARK 179
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 76-495 5.78e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 51.81  E-value: 5.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   76 SSLITFTSMVITMISSSwtLPSthIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCL 155
Cdd:cd17504   2 ALAALAVMLVETMLSPA--LPT--IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  156 TIWSKTITGVMFGRFLSGfFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITll 234
Cdd:cd17504  78 AAFAPNLPVLIAGRALQG-IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVqHLGWRWIFWT-- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  235 iTSGCCLVMIIFTipetykPMLLIRkakrlrkekndqryyavlevtreqtsllsaiflstkrpfglLLRDRMMGVLCFYT 314
Cdd:cd17504 155 -AAPVAVLLAALV------PLIDLR-----------------------------------------LLRRRNVLLANITA 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  315 GLELAIIYLYFVAFPYVFK----KLYNFGPMEIACSYIGIMVGMILSAPtcllfqktFEWRVKRNNGVKTpemrfePLFY 390
Cdd:cd17504 187 LLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGP--------LAGRLIARVGPRR------VLLI 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  391 GAFLTPVGLFIFAFtcyKHVHWIAPIIGSAIFGSGVYFVFTGVF---AYTVDAYRRYAASGMacNTFVRCIMAGVFPLFg 467
Cdd:cd17504 253 GLVISAVGLLLLAL---LHSSLWALVVALLLIGIGLGLAFASLPnivVESVPPDRTGIATGM--NTVLRTIGSAIGPAI- 326

                       410       420
                ....*....|....*....|....*...
gi 6321838  468 lqmyksmgvnwAGFLLAMVTVAMIPVPF 495
Cdd:cd17504 327 -----------AGAILTTYTVSITSGGV 343
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
67-508 1.06e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 51.01  E-value: 1.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   67 MSTARRYYISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYAL 146
Cdd:COG0738   1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  147 TLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQ---IGIPMAIYTTSAFLGPSLGPIIGGALYH 223
Cdd:COG0738  81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAasrLNLLHAFFSLGALLGPLLGGLLILLGLS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  224 QSYKWTFITLLITSGCCLVMIIFT-IPETykpmllirkakrlrkekndqryyavlEVTREQTSLLSAIFLSTKRPFGLLL 302
Cdd:COG0738 161 LSWHLPYLILAVLLLLLALLFLRSkLPEI--------------------------EEEEEEAAGSAASLKSLLKNPRLLL 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  303 rdrMMGVLCFYTGLELAIiylyFVAFPYVFKKLYNFGPME----IACSYIGIMVGMILSAPTcllfqktfewrVKRNNGV 378
Cdd:COG0738 215 ---GGLAIFLYVGAEGAI----GDWLPLYLKDVLGLSEATaalgLSLFWGGMTIGRFLGGFL-----------LKRFGPV 276

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  379 KTpemrfepLFYGAFLTPVGLFIFAFTcykHVHWIApIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGMA-CNTFVRC 457
Cdd:COG0738 277 RL-------LRLSALLAAVGLLLALLA---PGPWLA-LIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSaVLIMGIV 345

                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|.
gi 6321838  458 IMAGVFPLFGLqMYKSMGVNWAgFLLAMVTVAMIpvpFLFTKYGARLRAKS 508
Cdd:COG0738 346 GGAIGPPLIGF-LADAFGLRAA-FLVPLVCYLLI---LLLALALKRKRRKK 391
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 99-250 1.15e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 50.84  E-value: 1.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     99 HIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSA 178
Cdd:TIGR00711  27 TIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGP 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321838    179 FLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLITSGCCLVMIIFTIPE 250
Cdd:TIGR00711 107 LIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIeNYHWRWIFLINVPIGIIVVVVAFFILPR 179
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 99-244 1.77e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.87  E-value: 1.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   99 HIIEHFHISHEVSTLGiTLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSA 178
Cdd:cd17502  21 TIVAEFGGLSLVSWVG-TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGG 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321838  179 FLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLITSGCCLVMI 244
Cdd:cd17502 100 LMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTdHLSWRWCFYINLPIGGLALALL 166
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 71-490 4.08e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.15  E-value: 4.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   71 RRYYISSLITFTSMVITMISSSWtlpstHIIEHFHISHEVSTLGITLYVFGLGIGPlFLSPLSELYGRRIT-----FLYA 145
Cdd:cd06173   2 RLLWLAQLLSALGDWIFTVALPW-----LVLQLTGSALLVGLVLAAFFLPFLLFSP-FAGVLADRFDRRRLliladLLRA 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  146 LTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYhqS 225
Cdd:cd06173  76 LLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLV--A 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  226 YKWTFITLLITSGCCLVMIIFtipetykpMLLIRKAKRLRKEKNDQRYYAVLEVTreqtsllsaiflstkrpFGLLLRDR 305
Cdd:cd06173 154 LLGPGGAFAINALSFLLSALL--------LLFIRRPPPAAPGESSSLLLRDLREG-----------------LRYLRRSP 208

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  306 MMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEI----ACSYIGIMVGMILSAptcllfqktfeWRVKRNNGVKTp 381
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYglllAAFGVGALLGALLLG-----------RLSKRRRRGRL- 276

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  382 emrfepLFYGAFLTPVGLFIFAFTcykHVHWIApIIGSAIFGsgvyfVFTGVFAYTVDAYR------RYAASGMAC-NTF 454
Cdd:cd06173 277 ------LLIGALLLGLALLVLGLS---PSLWLL-LAALFLLG-----LAGGLFNVPLNTLLqlrvpdELRGRVFSVyNAL 341

                       410       420       430
                ....*....|....*....|....*....|....*.
gi 6321838  455 VRCIMAGVFPLFGLqMYKSMGVNWAGFLLAMVTVAM 490
Cdd:cd06173 342 NSGAMPLGALLAGL-LADALGLSAVFLLAGALLLLA 376
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
71-248 5.25e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 48.72  E-value: 5.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   71 RRYYISSLITFTSMVITMISSSWTlpSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSI 150
Cdd:COG2223 205 PRFWLLSLLYFGTFGSFIGFSSWL--PPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMA 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  151 IWQCLTIW-SKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY--HQSYK 227
Cdd:COG2223 283 LGLLLLALaLGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdaTGSYT 362

                       170       180
                ....*....|....*....|.
gi 6321838  228 WTFITLLITSGCCLVMIIFTI 248
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLY 383
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 88-449 5.35e-06

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 48.47  E-value: 5.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   88 MISSSWTLPSTHIIEHFHISheVSTLGITLYVFGLG--IGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGV 165
Cdd:cd17333  10 LTDALLGILGPSLEEAFNLN--VADVSVIFSSQNAGylIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLF 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  166 MFGRFLSGFFGSAFLSVAGGAIADIFDKDQiGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFITLLITSGCCLVMII 245
Cdd:cd17333  88 VVLMFLAGLGAGILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAIL 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  246 FTipetykpmllirkakRLRKEKNDQRYYAVLEVTREQTSLLSAIFLSTKRPFGLLlrdrmmgvLCFYTGLELAIIYLYF 325
Cdd:cd17333 167 IL---------------LTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALA--------LFLYVGAETAFSSWVP 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  326 VAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPtcllfqktfewrVKRNNGVKTpemrfePLFYGAFLTPVGLFIFAFT 405
Cdd:cd17333 224 SYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP------------ISRRIKPHT------LLVLSGSGALLGLLILLLA 285

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....
gi 6321838  406 CYKHVHwiapIIGSAIFGSGVYFVFTGVFAYTVDAYRRYAASGM 449
Cdd:cd17333 286 PTLVVG----LVATALLGLFMAALFPTILSLGISNLPYAKGKGT 325
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 65-246 5.90e-06

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 48.38  E-value: 5.90e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   65 RHMSTARRYYISSLITFT-SMVITMISSSWtlpSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFL 143
Cdd:cd17353 207 REMLRTPTFWLLWLMFFLnATAGLMLIGQA---KPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLS 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  144 YALTLSIIWQ-CLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY 222
Cdd:cd17353 284 IAFLIQGVAMfLLPFIGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL 363

                       170       180
                ....*....|....*....|....*
gi 6321838  223 H-QSYKWTFITLLITSGCCLVMIIF 246
Cdd:cd17353 364 YtGGYNAAFIIAAALSLVALALALL 388
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 112-246 7.15e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.96  E-value: 7.15e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  112 TLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIF 191
Cdd:cd17317  28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6321838  192 DKDQIGIpMAIYTTSAFlgpSLGPIIGGALYHQSYKWTFITLLITSGCCLVMIIF 246
Cdd:cd17317 108 GPKYRSF-VGILFGLFW---ALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLL 158
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 120-273 9.63e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.96  E-value: 9.63e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  120 FGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIP 199
Cdd:cd17358  52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL 131

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321838  200 MAIYTTSAFLGPSLGPIIGgalYHQSYKWTFITLLITSGcCLVMIIFTIPETykPMLLIRKAKRLRKEKNDQRY 273
Cdd:cd17358 132 GSLNQLLVNIGILLGYVLG---SFLPWRTLALIGAIPPV-VFLILLFFIPES--PRWLAKKGREEEAEKSLQFL 199
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
100-249 1.30e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  100 IIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFfGSAF 179
Cdd:COG2807  44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA-GIAV 122

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321838  180 LSVAG-GAIADIFDkDQIGIPMAIYTTSAFLGPSLGPIIGGALYHqSYKWTFiTLLITSGCCLVMIIFTIP 249
Cdd:COG2807 123 GNVLLpGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAA-ALGWRG-ALAVWALLALLALLLWLP 190
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 81-277 1.34e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 47.22  E-value: 1.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   81 FTSMVITMISSSWTLPST--HIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIW 158
Cdd:cd17329   5 LIGSFLNRLGFFMVWPFMaiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  159 SKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFITLLITSG 238
Cdd:cd17329  85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFL 164

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6321838  239 CCLVMIIFTIPETYKPMLLIRKAKRLRKEKNDQRYYAVL 277
Cdd:cd17329 165 LAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFL 203
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
99-253 1.38e-05

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 47.51  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    99 HIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSA 178
Cdd:PRK15403  41 NVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICF 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321838   179 FLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYH-QSYKWTFITLLITSGCCLVMIIFTIPETYK 253
Cdd:PRK15403 121 IATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHfVHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
78-221 6.09e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.28  E-value: 6.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   78 LITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTI 157
Cdd:COG2211 233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321838  158 WSK--TITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQI-------GIPMAIYTTSAFLGPSLGPIIGGAL 221
Cdd:COG2211 313 FLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLL 385
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 75-495 1.35e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.13  E-value: 1.35e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   75 ISSLITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQC 154
Cdd:cd17316   2 LLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  155 LTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGalyhqsykwtfitll 234
Cdd:cd17316  82 LIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAS--------------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  235 itsgccLVMIIFTIPETYKPMLLIrkakrlrkekndqryyavlevtreqtSLLSAIFlstkrpfGLLLRDRMMGVLCFYT 314
Cdd:cd17316 147 ------LLIPLLSGDWGWRILFLI--------------------------GALPALL-------ALLLRRRTLLLILLWF 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  315 GLeLAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVGMILSAPTCLLFQKTFEwrvkrnngvktpemRFEPLFYGAFL 394
Cdd:cd17316 188 FI-SFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG--------------RKKTLVIGLIL 252

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  395 TPVGLFIFAFTCYKHVHWIapIIGSAIFGSGVYFVFTGVFAYTVDAY---RRYAASGMACNtFVRCIMAGVFPLFGLQMY 471
Cdd:cd17316 253 SGILALPLFYLLSGSPTLL--LLLLFILSFFVGGVWGALYAYLAELFpteVRATGVGLSYN-LGRLGGGGAPPLIALLLA 329

                       410       420
                ....*....|....*....|....
gi 6321838  472 KSMGVNWAGFLLAMVTVAMIPVPF 495
Cdd:cd17316 330 STGGTGVPALILALLAIVALIVAL 353
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 100-273 1.45e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  100 IIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFfGSAF 179
Cdd:cd17478  22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI-GSAA 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  180 LSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALY-HQSYKWTFITLLITSgccLVMIIFTIPetYKPMLLI 258
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVaLFGGLGLLILLIIPG---LAVALLLLR--LRPLKKP 175

                       170
                ....*....|....*
gi 6321838  259 RKAKRLRKEKNDQRY 273
Cdd:cd17478 176 EAKKAAAKSSARSTL 190
MFS_1 pfam07690
Major Facilitator Superfamily;
78-215 1.61e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     78 LITFTSMVITMISSSWTLPSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTI 157
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321838    158 W---SKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGP 215
Cdd:pfam07690 284 LlslTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 92-248 3.83e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.75  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     92 SWTLPSTHIIEHFHISHevSTLGITLYVFGL--GIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGR 169
Cdd:TIGR00881  13 NFALAMPYLVEEIGLSK--TDLGLLLSSFSIayGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALW 90

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321838    170 FLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFItlLITSGCClvMIIFTI 248
Cdd:TIGR00881  91 ALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--FIVPGII--AIIVSL 165
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 96-175 4.28e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.56  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   96 PSTHIIEHFHISHEVSTLGITLYVFGLG--IGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSG 173
Cdd:cd17315  19 ALLYIAKDLGFGLSTSLQGLVVSSLLLGaaIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLG 98


                ..
gi 6321838  174 FF 175
Cdd:cd17315  99 LG 100
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 15-250 5.35e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 42.70  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     15 LTSTEEEHCsiNSDKAAKL----DLELTSERKNDGKQSHEVTFN-EDIADPEDIARHMSTARRYYISSLITFTSMvitMI 89
Cdd:TIGR00898  31 LGATPEHHC--RLPDAANLssrcELNLTLPRLPDGRPESCLRFMvDQWANPSLLGCEPLKLSDLGLAATEPCLDG---WE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838     90 SSSWTLPSTHIIEhFHISHEVS---TLGITLYVFGLGIGPLFLSPLSELYGRRItflyALTLSIIWQC----LTIWSKTI 162
Cdd:TIGR00898 106 YSYDTFSSTIVTE-WDLVCEDAwkvDLTQSCFFVGVLLGSFVFGYLSDRFGRKK----VLLLSTLVTAvsgvLTAFSPNY 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    163 TGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQigipMAIYTTSAFLGPSLGPII--GGALYHQSYKWTFITLLITSGCC 240
Cdd:TIGR00898 181 TVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQ----RAIVGTLIQVFFSLGLVLlpLVAYFIPDWRWLQLAVSLPTFLF 256

                         250
                  ....*....|
gi 6321838    241 LVMIIFtIPE 250
Cdd:TIGR00898 257 FLLSWF-VPE 265
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 106-274 6.10e-04

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 42.25  E-value: 6.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  106 ISHEVSTL--GITLYVFGLG--IGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGV---MFGRFLSGFFGSA 178
Cdd:cd17357  42 LSDSELDLlwSLIVSIFFIGgaIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPellIFGRFLVGIACGL 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  179 FLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIG-----GALYHQSYKWTFITLLITSGCClvmIIFTIPETYK 253
Cdd:cd17357 122 STGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGlpsvlGTETLWPYLLFFPGIPALLQLA---ALPFFPESPK 198

                       170       180
                ....*....|....*....|.
gi 6321838  254 pMLLIRKAKRLRKEKNDQRYY 274
Cdd:cd17357 199 -FLLISKGDEEEAEKSLKFLR 218
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
197-497 1.04e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  197 GIPMAIYTTSAFLGPSLGPII---GGALYHQSYKWTFITLLITSGCCLVMIIFTIPETYKPmllirkakrlrkekndqry 273
Cdd:COG2211 150 SWRFAFAGLGGLLASVLPPPLvaaFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVP------------------- 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  274 yavlevTREQTSLLSAiflstkrpFGLLLRDRMMGVLCFYTGLELAIIYLYFVAFPYVFKKLYNFGPMEIACSYIGIMVG 353
Cdd:COG2211 211 ------EEEKVSLKES--------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLA 276

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  354 MILSAPTCLLFQKTFEwrvKRNngvktpemrfePLFYGAFLTPVGLFIFAFTCYKHVHW-IAPIIGSAIFGSGVYFVFTG 432
Cdd:COG2211 277 ALLGAPLWPRLAKRFG---KKK-----------AFIIGLLLAALGLLLLFFLGPGNLWLlLVLAALAGIGLGAILVLPWA 342

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321838  433 VFAYTVDA-----YRRYAASGMACNTFVRCIMAGVFPLFGLQMYKSMG----VNWAGFLLAMVTVAMIPVPFLF 497
Cdd:COG2211 343 MLADVVDYdewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagAAQSPSALTGIRLLFFLLPAVL 416
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 99-221 1.38e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.03  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   99 HIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFGSA 178
Cdd:cd17365  24 ALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGA 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6321838  179 FLSVAGGAIADIFDKDQIGIPMAIYttsaFLGPSLGPIIGGAL 221
Cdd:cd17365 104 AMPNAITLVSEYAPARRRSLAVTLM----FCGYPLGAALGGFL 142
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 83-258 1.96e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 40.32  E-value: 1.96e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   83 SMVITMISSSWTLPSTHII-EHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKT 161
Cdd:cd17476   6 AQLLNQAGLGSVIVILPIIgDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  162 ITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQI-GIPMAIYTTSAFLGPSLGPIIGGAL-YHQSYKWTFITLLITSGC 239
Cdd:cd17476  86 FIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRkNIVFSLFGATAPLGFALGGVFGGLFaQLAWWPWIFWFLAILAAI 165

                       170
                ....*....|....*....
gi 6321838  240 CLVMIIFTIPETYKPMLLI 258
Cdd:cd17476 166 VAVAAIFWTSPSFIAVLLA 184
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 106-259 2.10e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.29  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  106 ISHEVSTLGITLYVFGL-----GIGPLFLSP----LSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGFFG 176
Cdd:cd17390  19 LSTHIRSLGASPTVIGLigsvyGALQLFSSPlvgsWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  177 SAfLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALyHQSYKWTFITLLITSGCCLVM--IIFTIPETYKP 254
Cdd:cd17390  99 HT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHL-AETDGGFYYVALLCSAIFILNagLVWFLLSKLWD 176


                ....*
gi 6321838  255 MLLIR 259
Cdd:cd17390 177 LLLVR 181
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 103-221 2.65e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 40.23  E-value: 2.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  103 HFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITfLYALTLSIIWQCLTIWSKTITGV--MFGRFLSGFFGSAFL 180
Cdd:cd17477 217 RLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRV-LLGCALLGALAALLLPLVPGLPLalLVLLFLWGGAAGPLY 295

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6321838  181 SVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGAL 221
Cdd:cd17477 296 TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 77-248 3.99e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   77 SLITFTSMVITMISSSWTlpSTHIIEHFHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLT 156
Cdd:cd17333 205 ALALFLYVGAETAFSSWV--PSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLIL 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  157 IWSKTITGVMFGRFLSGFFGSAfLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGALYHQSYKWTFitLLIT 236
Cdd:cd17333 283 LLAPTLVVGLVATALLGLFMAA-LFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA--MLLI 359

                       170
                ....*....|..
gi 6321838  237 SGCCLVMIIFTI 248
Cdd:cd17333 360 TILYAIIFVLAL 371
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 117-174 5.33e-03

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 38.99  E-value: 5.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321838  117 LYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSGF 174
Cdd:cd17445  44 CFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGA 101
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 142-247 5.91e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 5.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  142 FLYALTLSIIWQCLTIWSKTITGVMFGrflsgfFGSAFLSVAGGAIA-DIFDKDQIGIPMAIYTTSAFLGPSLGPIIGGA 220
Cdd:cd17489 265 LLLALGLLLLSFAGSPWMLLLAAVLYG------LGFGLLFPALQALAvDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL 338

                        90       100
                ....*....|....*....|....*...
gi 6321838  221 LY-HQSYKWTFITLLITSGCCLVMIIFT 247
Cdd:cd17489 339 VAeLFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 138-272 6.25e-03

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 39.15  E-value: 6.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  138 RRITFLYALTLSIIwQCLTIWSKTITGVMFGRFLSGFFGSAFLSVAGGAIADIFDKDQIGIPMAIYTTSAFLGPSLGPII 217
Cdd:cd17327  71 SKWLSVFIVLWGLL-TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLL 149

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321838  218 GGALYH-------QSYKWTF-ITLLITSGCCLVMIIFTIPETYKPMLLIRKAKRLRKEKNDQR 272
Cdd:cd17327 150 AYGVFKilgvgglAGWRWLFiIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN 212
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 127-248 6.63e-03

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 38.80  E-value: 6.63e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838  127 LFLSPLSELYGRRITFLYALT---LSIIWQCLTIWSKTITGVMF---GRFLSGFFG--SAFLSVAGGAIADIFDKDQIGI 198
Cdd:cd17386  48 LFLGSWSDRYGRKPPLLMSLVgllLSSLILVLIVYFTTVPSVWWfylSAIPLALFGgfTAFLSASFAYISDISSEKKRTY 127

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6321838  199 PMAIYTTSAFLGPSLGPIIGGALYHQ-SYKWTFitlLITSGCCLVMIIFTI 248
Cdd:cd17386 128 RMAILEVALGLGGFLGSLLSGHLFKAlGYAWSF---SISAALLLIALLYIL 175
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
95-277 8.05e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 38.72  E-value: 8.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838    95 LPSTHIIEH-FHISHEVSTLGITLYVFGLGIGPLFLSPLSELYGRRITFLYALTLSIIWQCLTIWSKTITGVMFGRFLSG 173
Cdd:PRK11043  26 LPAFKAIQAdLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321838   174 fFGSAFLSVAGGAI-ADIFDKDQI-GIPMAIYTTSAfLGPSLGPIIGGALY-HQSYKWTFITLLITSgccLVMIIFTipe 250
Cdd:PRK11043 106 -VGVCSAAVIWQALvIDRYPAQKAnRVFATIMPLVA-LSPALAPLLGAWLLnHFGWQAIFATLFAIT---LLLILPT--- 177

                        170       180
                 ....*....|....*....|....*..
gi 6321838   251 tykpMLLIRKAKRLRKEKNDQRYYAVL 277
Cdd:PRK11043 178 ----LRLKPSKKARKQSQDALTFKQLL 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH