nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 398364983  28 GLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGN-YVVFGEAKVDNF 74
Cdd:cd22054    1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDtYIVFGEAKIEDL 48

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 398364983  28 GLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGN-YVVFGEAKVDNF 74
Cdd:cd22054    1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDtYIVFGEAKIEDL 48

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins; The family contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins found in archaea and bacteria. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. The family also includes huntingtin-interacting protein K (HYPK), also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K. It is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It may be involved in regulating cell growth, cell cycle, unfolded protein response and cell death. All members in this family contain an ubiquitin-associated (UBA) domain.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 398364983 137 KDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLS 173
Cdd:cd14278    1 EEDIELVMSQTGVSREEAIKALRENKGDVVDAILELT 37

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364983  135 LNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLS 173
Cdd:pfam19026   3 VKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 398364983  134 DLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK 174
Cdd:TIGR00264  76 EITEDDIELVMKQCNVSKEEARRALEECGGDLAEAIMKLEE 116

nascent polypeptide-associated complex (NAC), alpha subunit; The nascent polypeptide-associated complex (NAC) is a complex, conserved from archaea to human, that plays an important role in co translational targeting of nascent polypeptides to the endoplasmic reticulum (ER). In eukaryotes, under physiological conditions, the complex is a stable heterodimer of the NAC alpha subunit and the NAC beta subunit, also known as basal transcription factor 3b (BTF3b). An imbalance of the relative concentrations has been observed in diseases, like Alzheimer's, AIDS, and ulcerative colitis. NAC alpha consists of a NAC domain, also present in BTF3, and a unique C-terminal ubiquitin-associated (UBA) domain.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 398364983  28 GLKQIPGIIRVTFRKKDNQIYAIEKPEVFRSAGGN-YVVFGEAKVDNF 74
Cdd:cd22054    1 GLKPVPGVTRVTIKKSKNILFVINKPDVYKSPGSDtYIVFGEAKIEDL 48

UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins; The family contains nascent polypeptide-associated complex subunit alpha (NACA), putative NACA-like protein (NACP1), nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD), and similar proteins found in archaea and bacteria. NACA, also called NAC-alpha or Alpha-NAC, together with BTF3, also called Beta-NAC, form the nascent polypeptide-associated complex (NAC) which is a cytosolic protein chaperone that contacts the nascent polypeptide chains as they emerge from the ribosome. Besides, NACA has a high affinity for nucleic acids and exists as part of several protein complexes playing a role in proliferation, apoptosis, or degradation. It is a cytokine-modulated specific transcript in the human TF-1 erythroleukemic cell line. It also acts as a transcriptional co-activator in osteoblasts by binding to phosphorylated c-Jun, a member of the activator-protein-1 (AP-1) family. Moreover, NACA binds to and regulates the adaptor protein Fas-associated death domain (FADD). In addition, NACA functions as a novel factor participating in the positive regulation of human erythroid-cell differentiation. The biological function of NACP1 (also called Alpha-NAC pseudogene 1 or NAC-alpha pseudogene 1) and NACAD remain unclear. The family also includes huntingtin-interacting protein K (HYPK), also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K. It is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It may be involved in regulating cell growth, cell cycle, unfolded protein response and cell death. All members in this family contain an ubiquitin-associated (UBA) domain.

                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 398364983 137 KDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLS 173
Cdd:cd14278    1 EEDIELVMSQTGVSREEAIKALRENKGDVVDAILELT 37

Transcription factor homologous to NACalpha-BTF3 [Transcription];

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 398364983 138 DDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLS 173
Cdd:COG1308   79 EDVELVAEQTGVSEEEAREALEEANGDLAEAILKLE 114

HYPK UBA domain; This entry represents the UBA domain found at the C-terminus of the HYPK protein and its homologs. This domain in HYPK mediates a protein interaction with the Naa15 C-terminus.

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 398364983  135 LNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLS 173
Cdd:pfam19026   3 VKKEDVELIMTELEVSKAKAERALREHGGDVVAALRALL 41

UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins; HYPK, also called Huntingtin yeast partner K or Huntingtin yeast two-hybrid protein K, is an intrinsically unstructured Huntingtin (HTT)-interacting protein with chaperone-like activity. It is involved in regulating cell growth, cell cycle, unfolded protein response, and cell death. All members in this subfamily contain an N-terminal ubiquitin-associated (UBA) that shows high sequence similarity with that of eukaryotic nascent polypeptide-associated complex proteins (NAC) which is one of the cytosolic chaperones that contact the nascent polypeptide chains as they emerge from the ribosome and assist in post-translational processes.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 398364983 135 LNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSL 172
Cdd:cd14361    3 VKKEDVELIVNELEVSKAQAERALREHNGDVVKALRAL 40

alpha-NAC-related protein; This hypothetical protein is found so far only in the Archaea. Its C-terminal domain of about 40 amino acids is homologous to the C-termini of the nascent polypeptide-associated complex alpha chain (alpha-NAC) and its yeast ortholog Egd2p and to the huntingtin-interacting protein HYPK. It shows weaker similarity, possibly through shared structural constraints rather than through homology, with the amino-terminal domain of elongation factor Ts. Alpha-NAC plays a role in preventing nascent polypeptides from binding inappropriately to membrane-targeting apparatus during translation, but is also active as a transcription regulator. [Unknown function, General]

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 398364983  134 DLNKDDIELVVQQTNVSKNQAIKALKAHNGDLVNAIMSLSK 174
Cdd:TIGR00264  76 EITEDDIELVMKQCNVSKEEARRALEECGGDLAEAIMKLEE 116

NAC domain; This family contains the NAC domain, named after the nascent polypeptide-associated complex (NAC) whose subunits contain NAC domains. In eukaryotes, the NAC complex, which plays an important role in co-translational targeting of nascent polypeptides to endoplasmic reticulum (ER), consists of 2 subunits: NAC alpha and a shortened splice variant of the basal transcription factor 3 (BTF3; also called BTF3b or NAC beta). The full length BTF3a protein excites transcription.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 398364983  32 IPGIIRVTFRKKDNQIYAIEKPEVFRSAGGN-YVVFGEAKVDN 73
Cdd:cd21114    1 IPGIEEVTMVMEDGSVIVFTMPKVQASLASNvFVVTGEATREQ 43