NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398364427|ref|NP_012219|]
View 

putative protein phosphatase regulator PIG2 [Saccharomyces cerevisiae S288C]

Protein Classification

CBM21 domain-containing protein( domain architecture ID 10505868)

CBM21 domain-containing protein carries a family 21 carbohydrate-binding module (CBM21), such as found in many eukaryotic proteins involved in glycogen metabolism, which might mediate interactions with glycogen; similar to regulatory subunits 3A, 3B, 3C, 3E, 3F, and 3G of protein phosphatase 1

Gene Ontology:  GO:0005515
PubMed:  16262690
SCOP:  4007352

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CBM_21 pfam03370
Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic ...
 388-507 2.14e-32

Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.


:

Pssm-ID: 427265  Cd Length: 112  Bit Score: 120.03  E-value: 2.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364427  388 RGRPVFLQEITLLTGfhNMVIIGKVFVKNIYFDKKIIVRYTWDAWRTFHESECVYFSNANGILPGSNMDIFKFSIDDIHN 467
Cdd:pfam03370   3 QGQPVCLERLFLSDD--KKSLVGTVRVKNLAFEKRVAVRYTFDNWKTISDVPAEYVPDARSSLDGDNYDRFKFKIPLPPL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 398364427  468 PNDKDSNIsqlEFCIQYLTWGvdrsrKEYWDNNDSANYKI 507
Cdd:pfam03370  81 LNLEGKTL---EFCIRYEVNG-----QEYWDNNNGKNYQV 112
 
Name Accession Description Interval E-value
CBM_21 pfam03370
Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic ...
 388-507 2.14e-32

Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.


Pssm-ID: 427265  Cd Length: 112  Bit Score: 120.03  E-value: 2.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364427  388 RGRPVFLQEITLLTGfhNMVIIGKVFVKNIYFDKKIIVRYTWDAWRTFHESECVYFSNANGILPGSNMDIFKFSIDDIHN 467
Cdd:pfam03370   3 QGQPVCLERLFLSDD--KKSLVGTVRVKNLAFEKRVAVRYTFDNWKTISDVPAEYVPDARSSLDGDNYDRFKFKIPLPPL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 398364427  468 PNDKDSNIsqlEFCIQYLTWGvdrsrKEYWDNNDSANYKI 507
Cdd:pfam03370  81 LNLEGKTL---EFCIRYEVNG-----QEYWDNNNGKNYQV 112
 
Name Accession Description Interval E-value
CBM_21 pfam03370
Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic ...
 388-507 2.14e-32

Carbohydrate/starch-binding module (family 21); This family consists of several eukaryotic proteins that are thought to be involved in the regulation of glycogen metabolism. For instance, the mouse PTG protein has been shown to interact with glycogen synthase, phosphorylase kinase, phosphorylase a: these three enzymes have key roles in the regulation of glycogen metabolism. PTG also binds the catalytic subunit of protein phosphatase 1 (PP1C) and localizes it to glycogen. Subsets of similar interactions have been observed with several other members of this family, such as the yeast PIG1, PIG2, GAC1 and GIP2 proteins. While the precise function of these proteins is not known, they may serve a scaffold function, bringing together the key enzymes in glycogen metabolism. This family is a carbohydrate binding domain.


Pssm-ID: 427265  Cd Length: 112  Bit Score: 120.03  E-value: 2.14e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364427  388 RGRPVFLQEITLLTGfhNMVIIGKVFVKNIYFDKKIIVRYTWDAWRTFHESECVYFSNANGILPGSNMDIFKFSIDDIHN 467
Cdd:pfam03370   3 QGQPVCLERLFLSDD--KKSLVGTVRVKNLAFEKRVAVRYTFDNWKTISDVPAEYVPDARSSLDGDNYDRFKFKIPLPPL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 398364427  468 PNDKDSNIsqlEFCIQYLTWGvdrsrKEYWDNNDSANYKI 507
Cdd:pfam03370  81 LNLEGKTL---EFCIRYEVNG-----QEYWDNNNGKNYQV 112
CBM53 pfam16760
Starch/carbohydrate-binding module (family 53);
416-508 1.51e-07

Starch/carbohydrate-binding module (family 53);


Pssm-ID: 465261 [Multi-domain]  Cd Length: 76  Bit Score: 48.83  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364427  416 NIYFDKK----IIVRYTWDAWRTFHESECVYFSnangilPGSNMDIFKFSIDdIHnpndkdSNISQLEFCIqyltwgvdR 491
Cdd:pfam16760   1 NIYYNGSlakeVYIHGGFNGWKNVQDVPMEKLP------PTGGGDWFSATVP-VP------EDAYVLDFVF--------K 59

                          90
                  ....*....|....*..
gi 398364427  492 SRKEYWDNNDSANYKID 508
Cdd:pfam16760  60 DGAGNWDNNNGQNYHIP 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH