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Conserved domains on  [gi|6322287|ref|NP_012361|]
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Kre9p [Saccharomyces cerevisiae S288C]

Protein Classification

GPI-anchored and KRE9 domain-containing protein( domain architecture ID 10563532)

GPI-anchored and KRE9 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Kre9_KNH1_C pfam05390
Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in ...
 173-273 4.43e-56

Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, required for beta -1,6-glucan synthesis in yeast. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, aberrant multi-budded morphology, and mating defects. Over-expression of Knh1 suppresses growth defects of a kre9 null mutant. Knh1 is required for propionic acid resistance.


:

Pssm-ID: 398842  Cd Length: 101  Bit Score: 175.59  E-value: 4.43e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287    173 SRSFTVPYTKQTGTSRFAPMQMQPNTKVTATTWTRKFATSAVTYYSTFGSLPEQATTITPGWSYTISSGVNYATPASMPS 252
Cdd:pfam05390   1 SASFTVPYTLQTGKTRFAPMQTQPGTTVTATTWSRRFPTSAVTYYSTLRPSPVQLTTITPGWSYTITSDVNYATPAPFPS 80

                          90       100
                  ....*....|....*....|.
gi 6322287    253 DNGGWYKPSKRLSLSARKINM 273
Cdd:pfam05390  81 DNGGWYNPSKRLSLSTRKLNA 101
Kre9_KNH pfam10342
Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain ...
 27-133 1.42e-07

Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain found in a family of serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. This family includes Kre9. In A. fumigatus these proteins play a role in fungal cell wall organization. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organizms as it interacts with MAPK. The family is also found in archaea and bacteria.


:

Pssm-ID: 463051  Cd Length: 94  Bit Score: 48.50  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287     27 SPSSKATFSPSGgtvSVPVEWMDNGAYPSlskisTFTFSLCTGPNNNIDCVAVLASKITPSEltqddkvYSYTAEFASTL 106
Cdd:pfam10342   1 SPSSGDVVDAGS---PFTITWSDVPTDPG-----TVTLYLCNGPSNNPPPVATLASGIDNSG-------GSYTWTPPTDL 65

                          90       100
                  ....*....|....*....|....*..
gi 6322287    107 TGNGQYYIQVFAQVDGQGYTIHYTPRF 133
Cdd:pfam10342  66 PAGSGYQIQIVSETNANTGIYNYSPRF 92
 
Name Accession Description Interval E-value
Kre9_KNH1_C pfam05390
Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in ...
 173-273 4.43e-56

Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, required for beta -1,6-glucan synthesis in yeast. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, aberrant multi-budded morphology, and mating defects. Over-expression of Knh1 suppresses growth defects of a kre9 null mutant. Knh1 is required for propionic acid resistance.


Pssm-ID: 398842  Cd Length: 101  Bit Score: 175.59  E-value: 4.43e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287    173 SRSFTVPYTKQTGTSRFAPMQMQPNTKVTATTWTRKFATSAVTYYSTFGSLPEQATTITPGWSYTISSGVNYATPASMPS 252
Cdd:pfam05390   1 SASFTVPYTLQTGKTRFAPMQTQPGTTVTATTWSRRFPTSAVTYYSTLRPSPVQLTTITPGWSYTITSDVNYATPAPFPS 80

                          90       100
                  ....*....|....*....|.
gi 6322287    253 DNGGWYKPSKRLSLSARKINM 273
Cdd:pfam05390  81 DNGGWYNPSKRLSLSTRKLNA 101
Kre9_KNH pfam10342
Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain ...
 27-133 1.42e-07

Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain found in a family of serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. This family includes Kre9. In A. fumigatus these proteins play a role in fungal cell wall organization. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organizms as it interacts with MAPK. The family is also found in archaea and bacteria.


Pssm-ID: 463051  Cd Length: 94  Bit Score: 48.50  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287     27 SPSSKATFSPSGgtvSVPVEWMDNGAYPSlskisTFTFSLCTGPNNNIDCVAVLASKITPSEltqddkvYSYTAEFASTL 106
Cdd:pfam10342   1 SPSSGDVVDAGS---PFTITWSDVPTDPG-----TVTLYLCNGPSNNPPPVATLASGIDNSG-------GSYTWTPPTDL 65

                          90       100
                  ....*....|....*....|....*..
gi 6322287    107 TGNGQYYIQVFAQVDGQGYTIHYTPRF 133
Cdd:pfam10342  66 PAGSGYQIQIVSETNANTGIYNYSPRF 92
 
Name Accession Description Interval E-value
Kre9_KNH1_C pfam05390
Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in ...
 173-273 4.43e-56

Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; This is the C-terminal domain found in KRE9 and KNH1 proteins which are involved in encoding cell surface O glycoproteins, required for beta -1,6-glucan synthesis in yeast. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, aberrant multi-budded morphology, and mating defects. Over-expression of Knh1 suppresses growth defects of a kre9 null mutant. Knh1 is required for propionic acid resistance.


Pssm-ID: 398842  Cd Length: 101  Bit Score: 175.59  E-value: 4.43e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287    173 SRSFTVPYTKQTGTSRFAPMQMQPNTKVTATTWTRKFATSAVTYYSTFGSLPEQATTITPGWSYTISSGVNYATPASMPS 252
Cdd:pfam05390   1 SASFTVPYTLQTGKTRFAPMQTQPGTTVTATTWSRRFPTSAVTYYSTLRPSPVQLTTITPGWSYTITSDVNYATPAPFPS 80

                          90       100
                  ....*....|....*....|.
gi 6322287    253 DNGGWYKPSKRLSLSARKINM 273
Cdd:pfam05390  81 DNGGWYNPSKRLSLSTRKLNA 101
Kre9_KNH pfam10342
Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain ...
 27-133 1.42e-07

Kre9/KNH-like N-terminal Ig-like domain; This entry represents the N-terminal Ig-like domain found in a family of serine- threonine-rich membrane-anchored proteins, anchored by glycosyl-phosphatidylinositol. This family includes Kre9. In A. fumigatus these proteins play a role in fungal cell wall organization. In Lentinula edodes this family is involved in fruiting body formation, and may have a more general role in signalling in other organizms as it interacts with MAPK. The family is also found in archaea and bacteria.


Pssm-ID: 463051  Cd Length: 94  Bit Score: 48.50  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322287     27 SPSSKATFSPSGgtvSVPVEWMDNGAYPSlskisTFTFSLCTGPNNNIDCVAVLASKITPSEltqddkvYSYTAEFASTL 106
Cdd:pfam10342   1 SPSSGDVVDAGS---PFTITWSDVPTDPG-----TVTLYLCNGPSNNPPPVATLASGIDNSG-------GSYTWTPPTDL 65

                          90       100
                  ....*....|....*....|....*..
gi 6322287    107 TGNGQYYIQVFAQVDGQGYTIHYTPRF 133
Cdd:pfam10342  66 PAGSGYQIQIVSETNANTGIYNYSPRF 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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