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Conserved domains on  [gi|6322571|ref|NP_012645|]
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Pxp2p [Saccharomyces cerevisiae S288C]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10495839)

carboxymuconolactone decarboxylase (CMD) family protein; similar to Anaeromyxobacter sp. alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity, and to Saccharomyces cerevisiae peroxisomal protein 2 (Pxp2) which is probably involved in peroxisome formation or maintenance as well as in amino acid metabolism

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 214-282 5.34e-06

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


:

Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 43.84  E-value: 5.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322571    214 AFDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAILISQWCGVSWKSGVVK 282
Cdd:pfam02627  15 LWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAAAE 83
 
Name Accession Description Interval E-value
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 214-282 5.34e-06

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 43.84  E-value: 5.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322571    214 AFDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAILISQWCGVSWKSGVVK 282
Cdd:pfam02627  15 LWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAAAE 83
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 187-271 1.19e-05

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 43.40  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322571  187 TRVVNNLNSSYPDLWYYTLvHVYGPLFAfDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAI 266
Cdd:COG0599  12 PRALEALAEFAPEFAEAFE-ALFGDVWA-RGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAA 89


                ....*
gi 6322571  267 LISQW 271
Cdd:COG0599  90 VYAGF 94
 
Name Accession Description Interval E-value
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 214-282 5.34e-06

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 43.84  E-value: 5.34e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322571    214 AFDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAILISQWCGVSWKSGVVK 282
Cdd:pfam02627  15 LWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALAAAE 83
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 187-271 1.19e-05

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 43.40  E-value: 1.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322571  187 TRVVNNLNSSYPDLWYYTLvHVYGPLFAfDEILSAQETSLVIIASLVPQDVNPQLRGHLKGALNIGCDKETVEAVRGLAI 266
Cdd:COG0599  12 PRALEALAEFAPEFAEAFE-ALFGDVWA-RGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAA 89


                ....*
gi 6322571  267 LISQW 271
Cdd:COG0599  90 VYAGF 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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