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Conserved domains on  [gi|6322645|ref|NP_012718|]
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Eap1p [Saccharomyces cerevisiae S288C]

Protein Classification

polyadenylate binding domain-containing protein( domain architecture ID 1000730)

polyadenylate binding domain-containing protein may contain RNA recognition motifs and may recognize the poly-A of mRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eap1 pfam20566
eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from ...
 103-252 2.07e-37

eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from yeast, which plays a role in cell growth and is implicated in the TOR signaling cascade. Eap1 binds to eIF4E and regulates translation. It competes with eIF4G (the large subunit of the cap-binding complex, eukaryotic initiation factor 4F (eIF4F)) for binding to eIF4E and accelerates mRNA degradation by promoting decapping. It associates with Puf5p and Dhh1p, being essential for Puf5p mediated repression. This family also includes the uncharacterized protein from S. pombe SPCC14G10.04, which has been shown to interact with eIF4E, 4F complex subunits.


:

Pssm-ID: 466715  Cd Length: 152  Bit Score: 136.05  E-value: 2.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    103 QYKTYAYSMNELYHLKPSLASAsyeedpLISELVRSLPKRKFWRLRMGPPD----QKHANNHHFNGNNGGGSWKAGYKNG 178
Cdd:pfam20566   1 SSKAHVYSINELLSLSKSVPKE------LIEEKVANLPKKKFWRLHQRFPDhirqNKNANNHNNNGNNGGSSSKDRGGDN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    179 KNDERRMSRTKNMQGGKRRSQ-----------QDDEEKKIDQEMLEMDKNLQlggDVGHSIADFEDWKAKMKELELKKls 247
Cdd:pfam20566  75 GQFERRNSKNKNSRNNNGRKGskfskndrsfvEEKDIEVNNDELLALEEEFQ---PTGNSMADFEAWKAKMKELERKK-- 149


                  ....*
gi 6322645    248 ksKGI 252
Cdd:pfam20566 150 --KGL 152
PABP-1234 super family cl31127
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 555-622 3.77e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


The actual alignment was detected with superfamily member TIGR01628:

Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 3.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322645    555 MPPLPQGFPIPPN---GMLPVTGQQPQPPYPnMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLP 622
Cdd:TIGR01628 409 FNGQPLGWPRMSMmptPMGPGGPLRPNGLAP-MNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLP 478
 
Name Accession Description Interval E-value
Eap1 pfam20566
eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from ...
 103-252 2.07e-37

eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from yeast, which plays a role in cell growth and is implicated in the TOR signaling cascade. Eap1 binds to eIF4E and regulates translation. It competes with eIF4G (the large subunit of the cap-binding complex, eukaryotic initiation factor 4F (eIF4F)) for binding to eIF4E and accelerates mRNA degradation by promoting decapping. It associates with Puf5p and Dhh1p, being essential for Puf5p mediated repression. This family also includes the uncharacterized protein from S. pombe SPCC14G10.04, which has been shown to interact with eIF4E, 4F complex subunits.


Pssm-ID: 466715  Cd Length: 152  Bit Score: 136.05  E-value: 2.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    103 QYKTYAYSMNELYHLKPSLASAsyeedpLISELVRSLPKRKFWRLRMGPPD----QKHANNHHFNGNNGGGSWKAGYKNG 178
Cdd:pfam20566   1 SSKAHVYSINELLSLSKSVPKE------LIEEKVANLPKKKFWRLHQRFPDhirqNKNANNHNNNGNNGGSSSKDRGGDN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    179 KNDERRMSRTKNMQGGKRRSQ-----------QDDEEKKIDQEMLEMDKNLQlggDVGHSIADFEDWKAKMKELELKKls 247
Cdd:pfam20566  75 GQFERRNSKNKNSRNNNGRKGskfskndrsfvEEKDIEVNNDELLALEEEFQ---PTGNSMADFEAWKAKMKELERKK-- 149


                  ....*
gi 6322645    248 ksKGI 252
Cdd:pfam20566 150 --KGL 152
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 555-622 3.77e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 3.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322645    555 MPPLPQGFPIPPN---GMLPVTGQQPQPPYPnMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLP 622
Cdd:TIGR01628 409 FNGQPLGWPRMSMmptPMGPGGPLRPNGLAP-MNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLP 478
 
Name Accession Description Interval E-value
Eap1 pfam20566
eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from ...
 103-252 2.07e-37

eIF4E-associated protein; This fungal family includes eIF4E-associated protein (Eap1) from yeast, which plays a role in cell growth and is implicated in the TOR signaling cascade. Eap1 binds to eIF4E and regulates translation. It competes with eIF4G (the large subunit of the cap-binding complex, eukaryotic initiation factor 4F (eIF4F)) for binding to eIF4E and accelerates mRNA degradation by promoting decapping. It associates with Puf5p and Dhh1p, being essential for Puf5p mediated repression. This family also includes the uncharacterized protein from S. pombe SPCC14G10.04, which has been shown to interact with eIF4E, 4F complex subunits.


Pssm-ID: 466715  Cd Length: 152  Bit Score: 136.05  E-value: 2.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    103 QYKTYAYSMNELYHLKPSLASAsyeedpLISELVRSLPKRKFWRLRMGPPD----QKHANNHHFNGNNGGGSWKAGYKNG 178
Cdd:pfam20566   1 SSKAHVYSINELLSLSKSVPKE------LIEEKVANLPKKKFWRLHQRFPDhirqNKNANNHNNNGNNGGSSSKDRGGDN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322645    179 KNDERRMSRTKNMQGGKRRSQ-----------QDDEEKKIDQEMLEMDKNLQlggDVGHSIADFEDWKAKMKELELKKls 247
Cdd:pfam20566  75 GQFERRNSKNKNSRNNNGRKGskfskndrsfvEEKDIEVNNDELLALEEEFQ---PTGNSMADFEAWKAKMKELERKK-- 149


                  ....*
gi 6322645    248 ksKGI 252
Cdd:pfam20566 150 --KGL 152
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 555-622 3.77e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.18  E-value: 3.77e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322645    555 MPPLPQGFPIPPN---GMLPVTGQQPQPPYPnMMLQGNFPPNFQQGFGSNSPMPIPSIINANGKNVTNQLP 622
Cdd:TIGR01628 409 FNGQPLGWPRMSMmptPMGPGGPLRPNGLAP-MNAVRAPSRNAQNAAQKPPMQPVMYPPNYQSLPLSQDLP 478
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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