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Conserved domains on  [gi|6322778|ref|NP_012851|]
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Stb6p [Saccharomyces cerevisiae S288C]

Protein Classification

suppressor of defective silencing 3( domain architecture ID 230097)

suppressor of defective silencing 3 (SUDS3, formerly SDS3) is an integral component of Sin3/HDAC complex and is required for HDAC activity.

Gene Ontology:  GO:0000122|GO:0006338|GO:0070822|GO:0042826

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sds3 super family cl21737
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 601-687 4.26e-03

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


The actual alignment was detected with superfamily member pfam08598:

Pssm-ID: 430099  Cd Length: 218  Bit Score: 39.26  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322778    601 DLMFRQSLNKLQEMCERCKRGSNEfhwEYgnmQNKQQILESEK-KDMKSLSSKLKYNVRILDRRVR-DVEASVDHFDRKL 678
Cdd:pfam08598  17 DKLYRNKLTALQTELQLLHQGSHP---EL---LQYYRDLEEERdAELKRLRLREEYQLKRIDIETKaDRTAAHQEFKKLV 90


                  ....*....
gi 6322778    679 EDVRKKLLE 687
Cdd:pfam08598  91 KLLKEKLYD 99
 
Name Accession Description Interval E-value
Sds3 pfam08598
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 601-687 4.26e-03

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


Pssm-ID: 430099  Cd Length: 218  Bit Score: 39.26  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322778    601 DLMFRQSLNKLQEMCERCKRGSNEfhwEYgnmQNKQQILESEK-KDMKSLSSKLKYNVRILDRRVR-DVEASVDHFDRKL 678
Cdd:pfam08598  17 DKLYRNKLTALQTELQLLHQGSHP---EL---LQYYRDLEEERdAELKRLRLREEYQLKRIDIETKaDRTAAHQEFKKLV 90


                  ....*....
gi 6322778    679 EDVRKKLLE 687
Cdd:pfam08598  91 KLLKEKLYD 99
 
Name Accession Description Interval E-value
Sds3 pfam08598
Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing ...
 601-687 4.26e-03

Sds3-like; Repression of gene transcription is mediated by histone deacetylases containing repressor-co-repressor complexes, which are recruited to promoters of target genes via interactions with sequence-specific transcription factors. The co-repressor complex contains a core of at least seven proteins. This family represents the conserved region found in Sds3, Dep1 and BRMS1-homolog p40 proteins.


Pssm-ID: 430099  Cd Length: 218  Bit Score: 39.26  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322778    601 DLMFRQSLNKLQEMCERCKRGSNEfhwEYgnmQNKQQILESEK-KDMKSLSSKLKYNVRILDRRVR-DVEASVDHFDRKL 678
Cdd:pfam08598  17 DKLYRNKLTALQTELQLLHQGSHP---EL---LQYYRDLEEERdAELKRLRLREEYQLKRIDIETKaDRTAAHQEFKKLV 90


                  ....*....
gi 6322778    679 EDVRKKLLE 687
Cdd:pfam08598  91 KLLKEKLYD 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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