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Concise Results
Standard Results
Full Results
putative ubiquitin-protein ligase UFD4 [Saccharomyces cerevisiae S288C]
Protein Classification
HECT-type E3 ubiquitin transferase ( domain architecture ID 11472073 )
HECT-type E3 ubiquitin transferase accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester, and then directly transfers the ubiquitin to targeted substrates
List of domain hits
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
581-1482
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 851.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 581 T L L VGGL S L L DL I C KK FSELF FPSIKREGI FDL V KD L S VDF N NI D LKED GN E N I SLSDE E G DLH SSI EEC D EGDEEYDYE 660
Cdd:COG5021 1 D L R VGGL L L E DL S C RL FSELF RSNSSVRAE FDL S KD E S GVR N SL D YGAA GN K N M SLSDE K G LVR SSI AAL D GLQNRDCLR 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 661 FT D MEIPD SV KPKKI S IHI FR TLS L AYIK N KGVNLVNRV LS QMNVE Q EAITEELHQ IE G V V S I LEN PSTP D KTE edwkgi 740
Cdd:COG5021 81 SL D PLSVL SV DGLQT S ETS FR SSA L NPYV N EFLCENDVR LS SSITI Q VSDESKQNV IE D V F S G LEN LGSV D VLS ------ 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 741 WSVL K KCI F H E DFDVSG F E F T S TG L A S SIT K R I TS S T V SHFI LA K S FL E VF E DCIDR F LEILQ SALT RLE NF SIV D C G LH 820
Cdd:COG5021 155 TEAT K GID F L E ILITRD F L F S S CS L N S DFL K I I SG S S V KSRK LA V S NV E KS E PDNVL F GLPYR SALT MRT NF LKL D T G NL 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 821 D G GGVSS LA KE I K IKLV YD gd ASKDNI G T D L SS T I VSVHCIA S F T S LN EF L RHRMVRMR F LN SL IPNLTSS ST E AD REEE 900
Cdd:COG5021 235 S G EVQAL LA RY I S IKLV IK -- KLYLGP G P D A SS R I STLIIRL S N T N LN RR L SYILSHSS F ED SL LRLNSLF ST R AD SFGR 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 901 ENC LDH M R KKNFDFFYDN E KVDM EST V F G V IF N tfvrrnrdlktlw DD THT IK FCKSLE G N N RES EA AE E AN E GK K LRDF 980
Cdd:COG5021 313 TYY LDH D R ILTQYSRPLL E ETLG EST S F L V VN N ------------- DD SSS IK DLPHQV G S N PFL EA HP E FS E LL K NQSR 379
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 981 YKK R E F AQVD TG S S AD I LT L LD FL H S CGVK S D S FINSKLSAK L A R QL DE PLV VAS GALPDWS lfl T R RF P F L FPFD TR ML 1060
Cdd:COG5021 380 GTT R D F RNKP TG W S SS I ED L GQ FL F S DFLT S S S TYEDLRREQ L G R ES DE SFY VAS NVQQQRA --- S R EG P L L SGWK TR LN 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1061 F L QCTS F GYG R LIQ L W KN K S K - GS KDLR N DEALQQLGRIT RRKL RI S R K T --- IF ATG L K I LSKYGSSPDVLEI E YQE E A 1136
Cdd:COG5021 457 N L YRFY F VEH R KKT L T KN D S R l GS FISL N KLDIRRIKEDK RRKL FY S L K Q kak IF DPY L H I KVRRDRVFEDSYR E IMD E S 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1137 G TG L GP TLE FYS V VSKYFARKS L NMWRCNSY S YRSEMDVDTTDD YIT TL L FPE P L NP F S N - N EKVIEL F GY LG TFVARSL 1215
Cdd:COG5021 537 G DD L KK TLE IEF V GEEGIDAGG L TREWLFLL S KEMFNPDYGLFE YIT ED L YTL P I NP L S S i N PEHLSY F KF LG RVIGKAI 616
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1216 L D N RILD FR FSK V F FEL L HRMSTPN V TTVPS D V E TCLLMIE L VDPLLAKS lkyiva NK D DNM T L E SL S LTFTVP gndd I E 1295
Cdd:COG5021 617 Y D S RILD VQ FSK A F YKK L LGKPVSL V DLESL D P E LYRSLVW L LNNDIDET ------ IL D LTF T V E DD S FGESRT ---- V E 686
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1296 LIP G G C N K S LNSS N VE EY IHG V I D QI L G K GI EKQ LK AF IE GFS KVFSYERML I LFPD EL VDIF G RVE ED w SMATLYTNLN 1375
Cdd:COG5021 687 LIP N G R N I S VTNE N KK EY VKK V V D YK L N K RV EKQ FS AF KS GFS EIIPPDLLQ I FDES EL ELLI G GIP ED - IDIDDWKSNT 765
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1376 A E HGYT M DS S II HD F IS IIS A F GKH ER RLF LQF L TG SPKL PI G GFK S L NPKFT V VLKHA E D G L T A D EY LPS VM TC A N Y LK 1455
Cdd:COG5021 766 A Y HGYT E DS P II VW F WE IIS E F DFE ER AKL LQF V TG TSRI PI N GFK D L QGSDG V RKFTI E K G G T D D DR LPS AH TC F N R LK 845
890 900
....*....|....*....|....*..
gi 398364789 1456 LP K Y T SK DIM RS R L CQ AI E EGAG AF LL 1482
Cdd:COG5021 846 LP E Y S SK EKL RS K L LT AI N EGAG FG LL 872
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
581-1482
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 851.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 581 T L L VGGL S L L DL I C KK FSELF FPSIKREGI FDL V KD L S VDF N NI D LKED GN E N I SLSDE E G DLH SSI EEC D EGDEEYDYE 660
Cdd:COG5021 1 D L R VGGL L L E DL S C RL FSELF RSNSSVRAE FDL S KD E S GVR N SL D YGAA GN K N M SLSDE K G LVR SSI AAL D GLQNRDCLR 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 661 FT D MEIPD SV KPKKI S IHI FR TLS L AYIK N KGVNLVNRV LS QMNVE Q EAITEELHQ IE G V V S I LEN PSTP D KTE edwkgi 740
Cdd:COG5021 81 SL D PLSVL SV DGLQT S ETS FR SSA L NPYV N EFLCENDVR LS SSITI Q VSDESKQNV IE D V F S G LEN LGSV D VLS ------ 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 741 WSVL K KCI F H E DFDVSG F E F T S TG L A S SIT K R I TS S T V SHFI LA K S FL E VF E DCIDR F LEILQ SALT RLE NF SIV D C G LH 820
Cdd:COG5021 155 TEAT K GID F L E ILITRD F L F S S CS L N S DFL K I I SG S S V KSRK LA V S NV E KS E PDNVL F GLPYR SALT MRT NF LKL D T G NL 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 821 D G GGVSS LA KE I K IKLV YD gd ASKDNI G T D L SS T I VSVHCIA S F T S LN EF L RHRMVRMR F LN SL IPNLTSS ST E AD REEE 900
Cdd:COG5021 235 S G EVQAL LA RY I S IKLV IK -- KLYLGP G P D A SS R I STLIIRL S N T N LN RR L SYILSHSS F ED SL LRLNSLF ST R AD SFGR 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 901 ENC LDH M R KKNFDFFYDN E KVDM EST V F G V IF N tfvrrnrdlktlw DD THT IK FCKSLE G N N RES EA AE E AN E GK K LRDF 980
Cdd:COG5021 313 TYY LDH D R ILTQYSRPLL E ETLG EST S F L V VN N ------------- DD SSS IK DLPHQV G S N PFL EA HP E FS E LL K NQSR 379
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 981 YKK R E F AQVD TG S S AD I LT L LD FL H S CGVK S D S FINSKLSAK L A R QL DE PLV VAS GALPDWS lfl T R RF P F L FPFD TR ML 1060
Cdd:COG5021 380 GTT R D F RNKP TG W S SS I ED L GQ FL F S DFLT S S S TYEDLRREQ L G R ES DE SFY VAS NVQQQRA --- S R EG P L L SGWK TR LN 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1061 F L QCTS F GYG R LIQ L W KN K S K - GS KDLR N DEALQQLGRIT RRKL RI S R K T --- IF ATG L K I LSKYGSSPDVLEI E YQE E A 1136
Cdd:COG5021 457 N L YRFY F VEH R KKT L T KN D S R l GS FISL N KLDIRRIKEDK RRKL FY S L K Q kak IF DPY L H I KVRRDRVFEDSYR E IMD E S 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1137 G TG L GP TLE FYS V VSKYFARKS L NMWRCNSY S YRSEMDVDTTDD YIT TL L FPE P L NP F S N - N EKVIEL F GY LG TFVARSL 1215
Cdd:COG5021 537 G DD L KK TLE IEF V GEEGIDAGG L TREWLFLL S KEMFNPDYGLFE YIT ED L YTL P I NP L S S i N PEHLSY F KF LG RVIGKAI 616
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1216 L D N RILD FR FSK V F FEL L HRMSTPN V TTVPS D V E TCLLMIE L VDPLLAKS lkyiva NK D DNM T L E SL S LTFTVP gndd I E 1295
Cdd:COG5021 617 Y D S RILD VQ FSK A F YKK L LGKPVSL V DLESL D P E LYRSLVW L LNNDIDET ------ IL D LTF T V E DD S FGESRT ---- V E 686
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1296 LIP G G C N K S LNSS N VE EY IHG V I D QI L G K GI EKQ LK AF IE GFS KVFSYERML I LFPD EL VDIF G RVE ED w SMATLYTNLN 1375
Cdd:COG5021 687 LIP N G R N I S VTNE N KK EY VKK V V D YK L N K RV EKQ FS AF KS GFS EIIPPDLLQ I FDES EL ELLI G GIP ED - IDIDDWKSNT 765
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1376 A E HGYT M DS S II HD F IS IIS A F GKH ER RLF LQF L TG SPKL PI G GFK S L NPKFT V VLKHA E D G L T A D EY LPS VM TC A N Y LK 1455
Cdd:COG5021 766 A Y HGYT E DS P II VW F WE IIS E F DFE ER AKL LQF V TG TSRI PI N GFK D L QGSDG V RKFTI E K G G T D D DR LPS AH TC F N R LK 845
890 900
....*....|....*....|....*..
gi 398364789 1456 LP K Y T SK DIM RS R L CQ AI E EGAG AF LL 1482
Cdd:COG5021 846 LP E Y S SK EKL RS K L LT AI N EGAG FG LL 872
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
1127-1478
1.01e-117
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 372.34
E-value: 1.01e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1127 VLEIE YQ - EE AGT G L G P T L EF YSVV SK YFARKSLNMW R CNSYS Y rsemdvdttddyitt LL F P E P LNP F S N N E K v IEL F G 1205
Cdd:smart00119 6 VLEIE FE g EE GLD G G G V T R EF FFLL SK ELFNPDYGLF R YSPND Y --------------- LL Y P N P RSG F A N E E H - LSY F R 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1206 YL G TFVARS L L DNR I LD FR F SKV F FEL L HRMST pnvttvpsdvet C L LMI E LV DP L L A KSLK YIVA N K D DNMT L E --- S L 1282
Cdd:smart00119 70 FI G RVLGKA L Y DNR L LD LF F ARP F YKK L LGKPV ------------ T L HDL E SL DP E L Y KSLK WLLL N N D TSEE L D ltf S I 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1283 S LT FTVPGNDDI EL I PGG C N KSLNSS N VE EY I H G VI DQI L G KGIEKQL K AF I EGFS K V FS y E RM L I LF PD E LVDIFGRVE 1362
Cdd:smart00119 138 V LT SEFGQVKVV EL K PGG S N IPVTEE N KK EY V H L VI EYR L N KGIEKQL E AF R EGFS E V IP - E NL L K LF DP E ELELLICGS 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1363 EDWSMAT L YT N LNAEH GY TMD S SI I HD F ISIISA F GKH ERR LF LQF L TGS PK LP I GGF KS L N PKFT VVLKHAE dglta DE 1442
Cdd:smart00119 217 PEIDVDD L KS N TEYKG GY SAN S QT I KW F WEVVES F TNE ERR KL LQF V TGS SR LP V GGF AA L S PKFT IRKAGSD ----- DE 291
330 340 350
....*....|....*....|....*....|....*.
gi 398364789 1443 Y LP SVM TC A N Y LKLP K Y T SK D I M R SR L CQ AI E EG A G 1478
Cdd:smart00119 292 R LP TAH TC F N R LKLP P Y S SK E I L R EK L LL AI N EG K G 327
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
1102-1478
9.30e-111
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 354.18
E-value: 9.30e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1102 K LRIS R KT I FATG L KI LSK YG SS -- PD VLE I E YQE E A G TG - L G P T L EF YSV VSK YFARK S LNMW R CNSYSYR semdvdtt 1178
Cdd:cd00078 2 K ITVR R DR I LEDA L RQ LSK VS SS dl KK VLE V E FVG E E G ID a G G V T R EF FTL VSK ELFNP S YGLF R YTPDDSG -------- 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1179 ddyitt LL F P E P LNPF sn N E KVIE LF GY LG TFVARS L LDN R I LD FR FS KV F FEL L HRMST pnvttvpsdvet C L LMI E LV 1258
Cdd:cd00078 74 ------ LL Y P N P SSFA -- D E DHLK LF RF LG RLLGKA L YEG R L LD LP FS RA F YKK L LGKPL ------------ S L EDL E EL 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1259 DP L L A KSLK YIVA N KD D NMT LE --- SLS L TFTVP G NDDI EL I PGG CNKSLNSS N V EEY IHGVI D QI L G KGIE K Q LK AF IE 1335
Cdd:cd00078 134 DP E L Y KSLK ELLD N DG D EDD LE ltf TIE L DSSFG G AVTV EL K PGG RDIPVTNE N K EEY VDLYV D YR L N KGIE E Q VE AF RD 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1336 GFS K V FSY E RMLILF P D EL VDIFGRV e ED WSMAT L YT N LNAEH GY TM DS SI I HD F ISIISA F GKH ER RL FLQF L TGS PK L 1415
Cdd:cd00078 214 GFS E V IPE E LLSLFT P E EL ELLICGS - ED IDLED L KK N TEYKG GY SS DS PT I QW F WEVLES F TNE ER KK FLQF V TGS SR L 292
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398364789 1416 P I GGF KS LNPKFT VVLKH aedgl TA D EY LP SVM TC A N Y LKLP K Y T SK D I M R SR L CQ AI E EGAG 1478
Cdd:cd00078 293 P V GGF AD LNPKFT IRRVG ----- SP D DR LP TAH TC F N L LKLP P Y S SK E I L R EK L LY AI N EGAG 350
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
1148-1483
2.92e-74
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 249.83
E-value: 2.92e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1148 SVV SK YFARKSLNMWRCN sysyrsemdvd T T DD Y itt LLFPE P LNPF S NNEKVIEL F GY LG TFVARSLLDNRI LD FR F SK 1227
Cdd:pfam00632 1 TLL SK ELFDPNYGLFEYE ----------- T E DD R --- TYWFN P SSSE S PDLELLDY F KF LG KLLGKAIYNGIL LD LP F PP 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1228 V F FE - LL HRMS T PN vttvps D vetcllm I E LV DP L L A KSLK YIVANKD D nm TL E S L S LTFT V P GNDD --- IELIP G G C N K 1303
Cdd:pfam00632 67 F F YK k LL GEPL T LE ------ D ------- L E SI DP E L Y KSLK SLLNMDN D -- DD E D L G LTFT I P VFGE skt IELIP N G R N I 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1304 SLNSS N V EEYI HGVI D QI L G K G IE K QL K AF IE GF SK V FSY E RMLILF P D EL VD - I F G RV E E D WSM at L YT N LNAEH GYT M 1382
Cdd:pfam00632 132 PVTNE N K EEYI RLYV D YR L N K S IE P QL E AF RK GF YS V IPK E ALSLFT P E EL EL l I C G SP E I D VED -- L KK N TEYDG GYT K 209
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1383 D S SI I HD F IS I ISA F GKHE RRLFL Q F L TGS PK LP I GGFKSL n PKFT V V L K HAE D glta D EY LP SVM TC A N Y LKLP K Y T SK 1462
Cdd:pfam00632 210 N S PT I QW F WE I LEE F SPEQ RRLFL K F V TGS SR LP V GGFKSL - PKFT I V R K GGD D ---- D DR LP TAH TC F N R LKLP D Y S SK 284
330 340
....*....|....*....|.
gi 398364789 1463 D I MRSR L CQ AIEEG A G a F L LS 1483
Cdd:pfam00632 285 E I LKEK L LI AIEEG E G - F G LS 304
Name
Accession
Description
Interval
E-value
HUL4
COG5021 Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
581-1482
0e+00
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 227354 [Multi-domain]
Cd Length: 872
Bit Score: 851.37
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 581 T L L VGGL S L L DL I C KK FSELF FPSIKREGI FDL V KD L S VDF N NI D LKED GN E N I SLSDE E G DLH SSI EEC D EGDEEYDYE 660
Cdd:COG5021 1 D L R VGGL L L E DL S C RL FSELF RSNSSVRAE FDL S KD E S GVR N SL D YGAA GN K N M SLSDE K G LVR SSI AAL D GLQNRDCLR 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 661 FT D MEIPD SV KPKKI S IHI FR TLS L AYIK N KGVNLVNRV LS QMNVE Q EAITEELHQ IE G V V S I LEN PSTP D KTE edwkgi 740
Cdd:COG5021 81 SL D PLSVL SV DGLQT S ETS FR SSA L NPYV N EFLCENDVR LS SSITI Q VSDESKQNV IE D V F S G LEN LGSV D VLS ------ 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 741 WSVL K KCI F H E DFDVSG F E F T S TG L A S SIT K R I TS S T V SHFI LA K S FL E VF E DCIDR F LEILQ SALT RLE NF SIV D C G LH 820
Cdd:COG5021 155 TEAT K GID F L E ILITRD F L F S S CS L N S DFL K I I SG S S V KSRK LA V S NV E KS E PDNVL F GLPYR SALT MRT NF LKL D T G NL 234
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 821 D G GGVSS LA KE I K IKLV YD gd ASKDNI G T D L SS T I VSVHCIA S F T S LN EF L RHRMVRMR F LN SL IPNLTSS ST E AD REEE 900
Cdd:COG5021 235 S G EVQAL LA RY I S IKLV IK -- KLYLGP G P D A SS R I STLIIRL S N T N LN RR L SYILSHSS F ED SL LRLNSLF ST R AD SFGR 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 901 ENC LDH M R KKNFDFFYDN E KVDM EST V F G V IF N tfvrrnrdlktlw DD THT IK FCKSLE G N N RES EA AE E AN E GK K LRDF 980
Cdd:COG5021 313 TYY LDH D R ILTQYSRPLL E ETLG EST S F L V VN N ------------- DD SSS IK DLPHQV G S N PFL EA HP E FS E LL K NQSR 379
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 981 YKK R E F AQVD TG S S AD I LT L LD FL H S CGVK S D S FINSKLSAK L A R QL DE PLV VAS GALPDWS lfl T R RF P F L FPFD TR ML 1060
Cdd:COG5021 380 GTT R D F RNKP TG W S SS I ED L GQ FL F S DFLT S S S TYEDLRREQ L G R ES DE SFY VAS NVQQQRA --- S R EG P L L SGWK TR LN 456
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1061 F L QCTS F GYG R LIQ L W KN K S K - GS KDLR N DEALQQLGRIT RRKL RI S R K T --- IF ATG L K I LSKYGSSPDVLEI E YQE E A 1136
Cdd:COG5021 457 N L YRFY F VEH R KKT L T KN D S R l GS FISL N KLDIRRIKEDK RRKL FY S L K Q kak IF DPY L H I KVRRDRVFEDSYR E IMD E S 536
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1137 G TG L GP TLE FYS V VSKYFARKS L NMWRCNSY S YRSEMDVDTTDD YIT TL L FPE P L NP F S N - N EKVIEL F GY LG TFVARSL 1215
Cdd:COG5021 537 G DD L KK TLE IEF V GEEGIDAGG L TREWLFLL S KEMFNPDYGLFE YIT ED L YTL P I NP L S S i N PEHLSY F KF LG RVIGKAI 616
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1216 L D N RILD FR FSK V F FEL L HRMSTPN V TTVPS D V E TCLLMIE L VDPLLAKS lkyiva NK D DNM T L E SL S LTFTVP gndd I E 1295
Cdd:COG5021 617 Y D S RILD VQ FSK A F YKK L LGKPVSL V DLESL D P E LYRSLVW L LNNDIDET ------ IL D LTF T V E DD S FGESRT ---- V E 686
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1296 LIP G G C N K S LNSS N VE EY IHG V I D QI L G K GI EKQ LK AF IE GFS KVFSYERML I LFPD EL VDIF G RVE ED w SMATLYTNLN 1375
Cdd:COG5021 687 LIP N G R N I S VTNE N KK EY VKK V V D YK L N K RV EKQ FS AF KS GFS EIIPPDLLQ I FDES EL ELLI G GIP ED - IDIDDWKSNT 765
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1376 A E HGYT M DS S II HD F IS IIS A F GKH ER RLF LQF L TG SPKL PI G GFK S L NPKFT V VLKHA E D G L T A D EY LPS VM TC A N Y LK 1455
Cdd:COG5021 766 A Y HGYT E DS P II VW F WE IIS E F DFE ER AKL LQF V TG TSRI PI N GFK D L QGSDG V RKFTI E K G G T D D DR LPS AH TC F N R LK 845
890 900
....*....|....*....|....*..
gi 398364789 1456 LP K Y T SK DIM RS R L CQ AI E EGAG AF LL 1482
Cdd:COG5021 846 LP E Y S SK EKL RS K L LT AI N EGAG FG LL 872
HECTc
smart00119 Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to ...
1127-1478
1.01e-117
Domain Homologous to E6-AP Carboxyl Terminus with; E3 ubiquitin-protein ligases. Can bind to E2 enzymes.
Pssm-ID: 214523
Cd Length: 328
Bit Score: 372.34
E-value: 1.01e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1127 VLEIE YQ - EE AGT G L G P T L EF YSVV SK YFARKSLNMW R CNSYS Y rsemdvdttddyitt LL F P E P LNP F S N N E K v IEL F G 1205
Cdd:smart00119 6 VLEIE FE g EE GLD G G G V T R EF FFLL SK ELFNPDYGLF R YSPND Y --------------- LL Y P N P RSG F A N E E H - LSY F R 69
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1206 YL G TFVARS L L DNR I LD FR F SKV F FEL L HRMST pnvttvpsdvet C L LMI E LV DP L L A KSLK YIVA N K D DNMT L E --- S L 1282
Cdd:smart00119 70 FI G RVLGKA L Y DNR L LD LF F ARP F YKK L LGKPV ------------ T L HDL E SL DP E L Y KSLK WLLL N N D TSEE L D ltf S I 137
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1283 S LT FTVPGNDDI EL I PGG C N KSLNSS N VE EY I H G VI DQI L G KGIEKQL K AF I EGFS K V FS y E RM L I LF PD E LVDIFGRVE 1362
Cdd:smart00119 138 V LT SEFGQVKVV EL K PGG S N IPVTEE N KK EY V H L VI EYR L N KGIEKQL E AF R EGFS E V IP - E NL L K LF DP E ELELLICGS 216
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1363 EDWSMAT L YT N LNAEH GY TMD S SI I HD F ISIISA F GKH ERR LF LQF L TGS PK LP I GGF KS L N PKFT VVLKHAE dglta DE 1442
Cdd:smart00119 217 PEIDVDD L KS N TEYKG GY SAN S QT I KW F WEVVES F TNE ERR KL LQF V TGS SR LP V GGF AA L S PKFT IRKAGSD ----- DE 291
330 340 350
....*....|....*....|....*....|....*.
gi 398364789 1443 Y LP SVM TC A N Y LKLP K Y T SK D I M R SR L CQ AI E EG A G 1478
Cdd:smart00119 292 R LP TAH TC F N R LKLP P Y S SK E I L R EK L LL AI N EG K G 327
HECTc
cd00078 HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It ...
1102-1478
9.30e-111
HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains.
Pssm-ID: 238033 [Multi-domain]
Cd Length: 352
Bit Score: 354.18
E-value: 9.30e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1102 K LRIS R KT I FATG L KI LSK YG SS -- PD VLE I E YQE E A G TG - L G P T L EF YSV VSK YFARK S LNMW R CNSYSYR semdvdtt 1178
Cdd:cd00078 2 K ITVR R DR I LEDA L RQ LSK VS SS dl KK VLE V E FVG E E G ID a G G V T R EF FTL VSK ELFNP S YGLF R YTPDDSG -------- 73
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1179 ddyitt LL F P E P LNPF sn N E KVIE LF GY LG TFVARS L LDN R I LD FR FS KV F FEL L HRMST pnvttvpsdvet C L LMI E LV 1258
Cdd:cd00078 74 ------ LL Y P N P SSFA -- D E DHLK LF RF LG RLLGKA L YEG R L LD LP FS RA F YKK L LGKPL ------------ S L EDL E EL 133
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1259 DP L L A KSLK YIVA N KD D NMT LE --- SLS L TFTVP G NDDI EL I PGG CNKSLNSS N V EEY IHGVI D QI L G KGIE K Q LK AF IE 1335
Cdd:cd00078 134 DP E L Y KSLK ELLD N DG D EDD LE ltf TIE L DSSFG G AVTV EL K PGG RDIPVTNE N K EEY VDLYV D YR L N KGIE E Q VE AF RD 213
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1336 GFS K V FSY E RMLILF P D EL VDIFGRV e ED WSMAT L YT N LNAEH GY TM DS SI I HD F ISIISA F GKH ER RL FLQF L TGS PK L 1415
Cdd:cd00078 214 GFS E V IPE E LLSLFT P E EL ELLICGS - ED IDLED L KK N TEYKG GY SS DS PT I QW F WEVLES F TNE ER KK FLQF V TGS SR L 292
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398364789 1416 P I GGF KS LNPKFT VVLKH aedgl TA D EY LP SVM TC A N Y LKLP K Y T SK D I M R SR L CQ AI E EGAG 1478
Cdd:cd00078 293 P V GGF AD LNPKFT IRRVG ----- SP D DR LP TAH TC F N L LKLP P Y S SK E I L R EK L LY AI N EGAG 350
HECT
pfam00632 HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl ...
1148-1483
2.92e-74
HECT-domain (ubiquitin-transferase); The name HECT comes from Homologous to the E6-AP Carboxyl Terminus.
Pssm-ID: 459880
Cd Length: 304
Bit Score: 249.83
E-value: 2.92e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1148 SVV SK YFARKSLNMWRCN sysyrsemdvd T T DD Y itt LLFPE P LNPF S NNEKVIEL F GY LG TFVARSLLDNRI LD FR F SK 1227
Cdd:pfam00632 1 TLL SK ELFDPNYGLFEYE ----------- T E DD R --- TYWFN P SSSE S PDLELLDY F KF LG KLLGKAIYNGIL LD LP F PP 66
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1228 V F FE - LL HRMS T PN vttvps D vetcllm I E LV DP L L A KSLK YIVANKD D nm TL E S L S LTFT V P GNDD --- IELIP G G C N K 1303
Cdd:pfam00632 67 F F YK k LL GEPL T LE ------ D ------- L E SI DP E L Y KSLK SLLNMDN D -- DD E D L G LTFT I P VFGE skt IELIP N G R N I 131
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1304 SLNSS N V EEYI HGVI D QI L G K G IE K QL K AF IE GF SK V FSY E RMLILF P D EL VD - I F G RV E E D WSM at L YT N LNAEH GYT M 1382
Cdd:pfam00632 132 PVTNE N K EEYI RLYV D YR L N K S IE P QL E AF RK GF YS V IPK E ALSLFT P E EL EL l I C G SP E I D VED -- L KK N TEYDG GYT K 209
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364789 1383 D S SI I HD F IS I ISA F GKHE RRLFL Q F L TGS PK LP I GGFKSL n PKFT V V L K HAE D glta D EY LP SVM TC A N Y LKLP K Y T SK 1462
Cdd:pfam00632 210 N S PT I QW F WE I LEE F SPEQ RRLFL K F V TGS SR LP V GGFKSL - PKFT I V R K GGD D ---- D DR LP TAH TC F N R LKLP D Y S SK 284
330 340
....*....|....*....|.
gi 398364789 1463 D I MRSR L CQ AIEEG A G a F L LS 1483
Cdd:pfam00632 285 E I LKEK L LI AIEEG E G - F G LS 304
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
