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Conserved domains on  [gi|398365305|ref|NP_012991|]
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Pam17p [Saccharomyces cerevisiae S288C]

Protein Classification

presequence translocated-associated motor subunit PAM17( domain architecture ID 10554119)

presequence translocated-associated motor subunit PAM17 that as a component of the presequence translocase-associated motor (PAM) is involved in the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; similar to Saccharomyces cerevisiae Pam17p

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pam17 pfam08566
Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives ...
 38-195 2.80e-93

Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins.


:

Pssm-ID: 400743  Cd Length: 165  Bit Score: 269.03  E-value: 2.80e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365305   38 SQPASLQDSSILTWSDFFKLRKQQRRINVGSSLFTALLGCNVSWAYLSTMEIDPTQMLFGFDPLTVISAGIIASGALGYL 117
Cdd:pfam08566   8 ASAAAAPAQPKLTWNEFFKLRKSRRRIQLVSSIPTALGGTGGGAAYLSTGEIDPTQQIFGLDPFVVLGLATLACGALGWL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365305  118 LGPIVGSQVFKLSHNQQLAQFNNKNKEFLKHIINNRVDASSQSFSNPVPDYYGEKIGSLKEYKQWLRDCHAYAKKAKE 195
Cdd:pfam08566  88 LGPSLGNAVFKLLHRKKLKQMEAKEKEFLARIKKNRVDPSSQSFSNPVPDYYGEKIGSLADYRQWLRDQRAFNRKAKE 165
 
Name Accession Description Interval E-value
Pam17 pfam08566
Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives ...
 38-195 2.80e-93

Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins.


Pssm-ID: 400743  Cd Length: 165  Bit Score: 269.03  E-value: 2.80e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365305   38 SQPASLQDSSILTWSDFFKLRKQQRRINVGSSLFTALLGCNVSWAYLSTMEIDPTQMLFGFDPLTVISAGIIASGALGYL 117
Cdd:pfam08566   8 ASAAAAPAQPKLTWNEFFKLRKSRRRIQLVSSIPTALGGTGGGAAYLSTGEIDPTQQIFGLDPFVVLGLATLACGALGWL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365305  118 LGPIVGSQVFKLSHNQQLAQFNNKNKEFLKHIINNRVDASSQSFSNPVPDYYGEKIGSLKEYKQWLRDCHAYAKKAKE 195
Cdd:pfam08566  88 LGPSLGNAVFKLLHRKKLKQMEAKEKEFLARIKKNRVDPSSQSFSNPVPDYYGEKIGSLADYRQWLRDQRAFNRKAKE 165
 
Name Accession Description Interval E-value
Pam17 pfam08566
Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives ...
 38-195 2.80e-93

Mitochondrial import protein Pam17; The presequence translocase-associated motor (PAM) drives the completion of preprotein translocation into the mitochondrial matrix. The Pam17 subunit is required for formation of a stable complex between cochaperones Pam16 and Pam18 and promotes the association of Pam16-Pam18 with the presequence translocase. Mitochondria lacking Pam17 are selectively impaired in the import of matrix proteins.


Pssm-ID: 400743  Cd Length: 165  Bit Score: 269.03  E-value: 2.80e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365305   38 SQPASLQDSSILTWSDFFKLRKQQRRINVGSSLFTALLGCNVSWAYLSTMEIDPTQMLFGFDPLTVISAGIIASGALGYL 117
Cdd:pfam08566   8 ASAAAAPAQPKLTWNEFFKLRKSRRRIQLVSSIPTALGGTGGGAAYLSTGEIDPTQQIFGLDPFVVLGLATLACGALGWL 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365305  118 LGPIVGSQVFKLSHNQQLAQFNNKNKEFLKHIINNRVDASSQSFSNPVPDYYGEKIGSLKEYKQWLRDCHAYAKKAKE 195
Cdd:pfam08566  88 LGPSLGNAVFKLLHRKKLKQMEAKEKEFLARIKKNRVDPSSQSFSNPVPDYYGEKIGSLADYRQWLRDQRAFNRKAKE 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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