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Conserved domains on  [gi|6322975|ref|NP_013047|]
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uncharacterized protein YLL053C [Saccharomyces cerevisiae S288C]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 20-128 9.40e-28

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member TIGR00861:

Pssm-ID: 444743 [Multi-domain]  Cd Length: 216  Bit Score: 102.38  E-value: 9.40e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     20 TPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAV--EKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSL 97
Cdd:TIGR00861 105 FPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDdrNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSL 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322975     98 GAAVAAR--YFPHyHWIYWISPLLGAFLAWSVW 128
Cdd:TIGR00861 185 GPALFAGlaGWGN-HWVYWVGPIIGAILGALVY 216
 
Name Accession Description Interval E-value
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 20-128 9.40e-28

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 102.38  E-value: 9.40e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     20 TPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAV--EKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSL 97
Cdd:TIGR00861 105 FPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDdrNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSL 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322975     98 GAAVAAR--YFPHyHWIYWISPLLGAFLAWSVW 128
Cdd:TIGR00861 185 GPALFAGlaGWGN-HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 25-124 7.76e-22

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 86.99  E-value: 7.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     25 LFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETN--FMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVA 102
Cdd:pfam00230 119 LFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSlgTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVV 198

                          90       100
                  ....*....|....*....|..
gi 6322975    103 ARYFpHYHWIYWISPLLGAFLA 124
Cdd:pfam00230 199 LWKW-DDHWVYWVGPFIGAALG 219
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 26-131 8.45e-22

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 87.10  E-value: 8.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975   26 FTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARY 105
Cdd:COG0580 120 FATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL 199

                        90       100       110
                ....*....|....*....|....*....|.
gi 6322975  106 FPH-----YHWIYWISPLLGAFLAWSVWQLL 131
Cdd:COG0580 200 GKGgsdwgYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 26-131 3.05e-21

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 85.77  E-value: 3.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975   26 FTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNF--MAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAA 103
Cdd:cd00333 119 FGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPggLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFT 198

                        90       100       110
                ....*....|....*....|....*....|
gi 6322975  104 RYFPH--YHWIYWISPLLGAFLAWSVWQLL 131
Cdd:cd00333 199 GLARHwhYFWVYWVGPLIGAIAGALVYDYV 228
PLN00166 PLN00166
aquaporin TIP2; Provisional
 2-146 1.44e-10

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 57.25  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     2 WFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAH- 80
Cdd:PLN00166 105 WIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIAPIAIGFIVGAn 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322975    81 -MALTGYTGTGVNPARSLGAAVAARYFPHyHWIYWISPLLGAFLAWSVWQLLQILDYTTYVNAEKAA 146
Cdd:PLN00166 185 iLAAGPFSGGSMNPARSFGPAVVSGDFSQ-IWIYWVGPLVGGALAGLIYGDVFIGSYAAAPTSEDYA 250
 
Name Accession Description Interval E-value
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 20-128 9.40e-28

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 102.38  E-value: 9.40e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     20 TPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAV--EKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSL 97
Cdd:TIGR00861 105 FPGNLAVNGSASAGVSSGQAFFVEFIGTAILVLVIFATTDdrNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSL 184

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322975     98 GAAVAAR--YFPHyHWIYWISPLLGAFLAWSVW 128
Cdd:TIGR00861 185 GPALFAGlaGWGN-HWVYWVGPIIGAILGALVY 216
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 25-124 7.76e-22

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 86.99  E-value: 7.76e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     25 LFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETN--FMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVA 102
Cdd:pfam00230 119 LFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSlgTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVV 198

                          90       100
                  ....*....|....*....|..
gi 6322975    103 ARYFpHYHWIYWISPLLGAFLA 124
Cdd:pfam00230 199 LWKW-DDHWVYWVGPFIGAALG 219
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 26-131 8.45e-22

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 87.10  E-value: 8.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975   26 FTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARY 105
Cdd:COG0580 120 FATSPAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL 199

                        90       100       110
                ....*....|....*....|....*....|.
gi 6322975  106 FPH-----YHWIYWISPLLGAFLAWSVWQLL 131
Cdd:COG0580 200 GKGgsdwgYLWVPIVAPILGAALAALLYRAL 230
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 26-131 3.05e-21

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 85.77  E-value: 3.05e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975   26 FTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNF--MAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAA 103
Cdd:cd00333 119 FGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTDDPNGPPPggLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFT 198

                        90       100       110
                ....*....|....*....|....*....|
gi 6322975  104 RYFPH--YHWIYWISPLLGAFLAWSVWQLL 131
Cdd:cd00333 199 GLARHwhYFWVYWVGPLIGAIAGALVYDYV 228
PLN00166 PLN00166
aquaporin TIP2; Provisional
 2-146 1.44e-10

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 57.25  E-value: 1.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     2 WFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAH- 80
Cdd:PLN00166 105 WIAQCLGSIVACLLLVFVTNGESVPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLGTIAPIAIGFIVGAn 184

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322975    81 -MALTGYTGTGVNPARSLGAAVAARYFPHyHWIYWISPLLGAFLAWSVWQLLQILDYTTYVNAEKAA 146
Cdd:PLN00166 185 iLAAGPFSGGSMNPARSFGPAVVSGDFSQ-IWIYWVGPLVGGALAGLIYGDVFIGSYAAAPTSEDYA 250
PLN00027 PLN00027
aquaporin TIP; Provisional
 2-137 5.22e-09

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 52.87  E-value: 5.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     2 WFPQIIAGMAAGGAASAMTPGKVLFTNALGLGCSRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHM 81
Cdd:PLN00027 107 WIAQLLGSVVACLLLKFSTGGLETSAFSLSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGIIAPIAIGFIVGAN 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6322975    82 ALTG--YTGTGVNPARSLGAAVAArYFPHYHWIYWISPLLGAFLAWSVWQLLQILDYT 137
Cdd:PLN00027 187 ILAGgaFDGASMNPAVSFGPAVVS-WTWTNHWVYWAGPLIGGGIAGLVYELIFIGSTT 243
PRK05420 PRK05420
aquaporin Z; Provisional
 52-131 6.58e-08

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 49.97  E-value: 6.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975    52 LTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAV-AARYFPHYHWIYWISPLLGAFLAWSVWQL 130
Cdd:PRK05420 146 LLVILGATDKRAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALfVGGWALEQLWLFWVAPIVGAIIGGLIYRL 225


                 .
gi 6322975   131 L 131
Cdd:PRK05420 226 L 226
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 35-135 5.05e-07

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 47.60  E-value: 5.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975    35 SRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYhWIYW 114
Cdd:PLN00182 157 SSGQALVAEIIISFLLMFVISGVATDSRAVGELAGIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGI-WVYI 235

                         90       100
                 ....*....|....*....|.
gi 6322975   115 ISPLLGAFLAWSVWQLLQILD 135
Cdd:PLN00182 236 VGPFVGIIAGGFVYNLIRFTD 256
PLN00026 PLN00026
aquaporin NIP; Provisional
 35-135 2.01e-06

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 46.01  E-value: 2.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975    35 SRSRGLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYhWIYW 114
Cdd:PLN00026 185 STGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYRAI-WIYL 263

                         90       100
                 ....*....|....*....|.
gi 6322975   115 ISPLLGAFLAWSVWQLLQILD 135
Cdd:PLN00026 264 VAPTLGALAGAGTYTAVKLRE 284
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 25-133 8.84e-06

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 44.08  E-value: 8.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975    25 LFTNALGLGCSRSrgLFLEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAAR 104
Cdd:PLN00183 151 LMTTKPAQGCSSA--FWVEFIATFIVMFLAASLTSQPQSLGHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSW 228

                         90       100
                 ....*....|....*....|....*....
gi 6322975   105 YFPHYhWIYWISPLLGAFLAWSVWQLLQI 133
Cdd:PLN00183 229 DFKDI-WIYITAPTIGAVAGALMFHLLRL 256
PLN00184 PLN00184
aquaporin NIP1; Provisional
 42-135 1.52e-04

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 40.39  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975    42 LEMFGTAVLCLTVLMTAVEKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARYFPHYhWIYWISPLLGA 121
Cdd:PLN00184 183 MEFIVTFYLMFIISGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGI-WIYIVAPTLGA 261

                         90
                 ....*....|....
gi 6322975   122 FLAWSVWQLLQILD 135
Cdd:PLN00184 262 IAGAWVYNTVRYTD 275
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 38-124 1.67e-03

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 37.23  E-value: 1.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975   38 RGLFLEMFGTAVLCLTVLMTAV------EKRETNFMAALPIGISLFMAHMALTGYTGTGVNPARSLGAAVAARyFPHYHW 111
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLavklagGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGR-FPLIRV 79

                        90
                ....*....|....
gi 6322975  112 I-YWISPLLGAFLA 124
Cdd:cd00333  80 IpYIIAQLLGAILG 93
PLN00167 PLN00167
aquaporin TIP5; Provisional
 2-124 3.25e-03

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 36.42  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322975     2 WFPQIIAGMAAGGAASAMTPGKVLFTNAL-----GLGCSrsrglFLEMFGTAVLCLTVLmTAVEKRETNFMAALPIGISL 76
Cdd:PLN00167 109 WISQMLASVMACLFLKVTTVGQHVPTYKIaeemtGFGAS-----VLEGVLTFGLVYTVY-AAGDPRRGLLGAIGPLAIGL 182

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 6322975    77 FMAHMALTG--YTGTGVNPARSLGAAVAARYFPHyHWIYWISPLLGAFLA 124
Cdd:PLN00167 183 VAGANVLAAgpFSGGSMNPACAFGSAVVAGSFKN-QAVYWVGPLLGGAVA 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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