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Conserved domains on  [gi|6323005|ref|NP_013077|]
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nucleoporin POM33 [Saccharomyces cerevisiae S288C]

Protein Classification

TMEM33/Pom33 family protein( domain architecture ID 6872)

TMEM33/Pom33 family protein similar to Saccharomyces cerevisiae pore membrane protein of 33 kDa (Pom33) and pore and endoplasmic reticulum protein of 33 kDa (Per33)

Gene Ontology:  GO:0061024|GO:0071786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM33_Pom33 super family cl04200
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 19-264 1.56e-15

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


The actual alignment was detected with superfamily member pfam03661:

Pssm-ID: 461009  Cd Length: 237  Bit Score: 73.85  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     19 KSLVQRFMAvaKSLQFAWFTGHSVVLISSILYLLKM------SEFYYRsAYLGVIESFGIIIYQQF----FTRnEPLQTq 88
Cdd:pfam03661   4 ESLLQHVIA--NKIELALWATRLLTIIFTILYIIPIfgsshpYSAYYK-ALLANAATSALRLHQRLpqfqLSR-EFLQR- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     89 daaatkasiksrvagLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLpkvfHLSSKDSSKILSFID 168
Cdd:pfam03661  79 ---------------LLLEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLD----VLGSNSWWGARLLIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005    169 KFVVQYNDLcMHWVGTAELLIFILVLFRAILcFQRSWIILVVYAIFIKLRYEN--SKYMKAAFAQWRVRMDGIISHPSIP 246
Cdd:pfam03661 140 LVEFQSQNI-LRLIAFTEIFIMPLTIVLLFS-GRASLLTPFIYYQFLSLRYSSrrNPYTRNAFSELRILLEHLANHPRCP 217

                         250
                  ....*....|....*...
gi 6323005    247 PFVKRAYNAIKMSLIRLS 264
Cdd:pfam03661 218 AFIRSLILKLISFVSRLA 235
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 19-264 1.56e-15

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 73.85  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     19 KSLVQRFMAvaKSLQFAWFTGHSVVLISSILYLLKM------SEFYYRsAYLGVIESFGIIIYQQF----FTRnEPLQTq 88
Cdd:pfam03661   4 ESLLQHVIA--NKIELALWATRLLTIIFTILYIIPIfgsshpYSAYYK-ALLANAATSALRLHQRLpqfqLSR-EFLQR- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     89 daaatkasiksrvagLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLpkvfHLSSKDSSKILSFID 168
Cdd:pfam03661  79 ---------------LLLEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLD----VLGSNSWWGARLLIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005    169 KFVVQYNDLcMHWVGTAELLIFILVLFRAILcFQRSWIILVVYAIFIKLRYEN--SKYMKAAFAQWRVRMDGIISHPSIP 246
Cdd:pfam03661 140 LVEFQSQNI-LRLIAFTEIFIMPLTIVLLFS-GRASLLTPFIYYQFLSLRYSSrrNPYTRNAFSELRILLEHLANHPRCP 217

                         250
                  ....*....|....*...
gi 6323005    247 PFVKRAYNAIKMSLIRLS 264
Cdd:pfam03661 218 AFIRSLILKLISFVSRLA 235
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 19-264 1.56e-15

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 73.85  E-value: 1.56e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     19 KSLVQRFMAvaKSLQFAWFTGHSVVLISSILYLLKM------SEFYYRsAYLGVIESFGIIIYQQF----FTRnEPLQTq 88
Cdd:pfam03661   4 ESLLQHVIA--NKIELALWATRLLTIIFTILYIIPIfgsshpYSAYYK-ALLANAATSALRLHQRLpqfqLSR-EFLQR- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005     89 daaatkasiksrvagLLKSEDVLYLVLANFWLFTPRFSFSLIPFFAFAVFHVLIYVEKVLLpkvfHLSSKDSSKILSFID 168
Cdd:pfam03661  79 ---------------LLLEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLD----VLGSNSWWGARLLIS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323005    169 KFVVQYNDLcMHWVGTAELLIFILVLFRAILcFQRSWIILVVYAIFIKLRYEN--SKYMKAAFAQWRVRMDGIISHPSIP 246
Cdd:pfam03661 140 LVEFQSQNI-LRLIAFTEIFIMPLTIVLLFS-GRASLLTPFIYYQFLSLRYSSrrNPYTRNAFSELRILLEHLANHPRCP 217

                         250
                  ....*....|....*...
gi 6323005    247 PFVKRAYNAIKMSLIRLS 264
Cdd:pfam03661 218 AFIRSLILKLISFVSRLA 235
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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