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Conserved domains on  [gi|6323095|ref|NP_013167|]
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signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]

Protein Classification

signal peptidase complex subunit 3 family protein( domain architecture ID 10518971)

signal peptidase complex subunit 3 (SPCS3) family protein similar to SPCS3, a component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-177 7.13e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


:

Pssm-ID: 461357  Cd Length: 172  Bit Score: 232.45  E-value: 7.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095      1 MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLinnnafsvPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNT 80
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD--------TSSISNIVPSVKVKNSRYYGSVRGKPKDNAKITFDLDA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095     81 DLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGkFEGKDLVFKLHWNVQP 160
Cdd:pfam04573  73 DLSPLFNWNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNS-LRGRNVTLTLHWNVMP 151

                         170
                  ....*....|....*..
gi 6323095    161 WVGLLTYGETVGNYTLT 177
Cdd:pfam04573 152 WVGLLPYGETAGSSSFT 168
 
Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-177 7.13e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


Pssm-ID: 461357  Cd Length: 172  Bit Score: 232.45  E-value: 7.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095      1 MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLinnnafsvPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNT 80
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD--------TSSISNIVPSVKVKNSRYYGSVRGKPKDNAKITFDLDA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095     81 DLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGkFEGKDLVFKLHWNVQP 160
Cdd:pfam04573  73 DLSPLFNWNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNS-LRGRNVTLTLHWNVMP 151

                         170
                  ....*....|....*..
gi 6323095    161 WVGLLTYGETVGNYTLT 177
Cdd:pfam04573 152 WVGLLPYGETAGSSSFT 168
PTZ00116 PTZ00116
signal peptidase; Provisional
 49-164 6.77e-11

signal peptidase; Provisional


Pssm-ID: 173408  Cd Length: 185  Bit Score: 58.52  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095    49 VKTLINVRTSRYFGSQRGKAKENMKIKFDLNTDLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDV 128
Cdd:PTZ00116  39 MSTNIKVKSVKRLVYNRHIKGDEAVLSLDLSYDMSKAFNWNLKQLFLYVLVTYETPEKVKNEVIIQDYIITNKKQAKKTY 118

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 6323095   129 NDLRSKYSIWDIEDGkFEGKDLVFKLHWNVQPWVGL 164
Cdd:PTZ00116 119 KNFITKYSLKDYNNG-LRNNNINLQVCYKYMPIVGL 153
 
Name Accession Description Interval E-value
SPC22 pfam04573
Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum ...
 1-177 7.13e-79

Signal peptidase subunit; Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.


Pssm-ID: 461357  Cd Length: 172  Bit Score: 232.45  E-value: 7.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095      1 MFSFVQRFQNVSNQAFSMGIVMVVFIMASSYYQLinnnafsvPSNIDNVKTLINVRTSRYFGSQRGKAKENMKIKFDLNT 80
Cdd:pfam04573   1 MHSLLQRLNAVSAFALTVLAVLCALIALSSLFQD--------TSSISNIVPSVKVKNSRYYGSVRGKPKDNAKITFDLDA 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095     81 DLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDVNDLRSKYSIWDIEDGkFEGKDLVFKLHWNVQP 160
Cdd:pfam04573  73 DLSPLFNWNTKQLFVYLTAEYETKKNSVNQVVIWDKIIRSKEDAKLNLKNAKSKYSFWDDGNS-LRGRNVTLTLHWNVMP 151

                         170
                  ....*....|....*..
gi 6323095    161 WVGLLTYGETVGNYTLT 177
Cdd:pfam04573 152 WVGLLPYGETAGSSSFT 168
PTZ00116 PTZ00116
signal peptidase; Provisional
 49-164 6.77e-11

signal peptidase; Provisional


Pssm-ID: 173408  Cd Length: 185  Bit Score: 58.52  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323095    49 VKTLINVRTSRYFGSQRGKAKENMKIKFDLNTDLTPLFNWNTKQVFVYLTAEYNSTEKITSEVTFWDKIIKSKDDAVIDV 128
Cdd:PTZ00116  39 MSTNIKVKSVKRLVYNRHIKGDEAVLSLDLSYDMSKAFNWNLKQLFLYVLVTYETPEKVKNEVIIQDYIITNKKQAKKTY 118

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 6323095   129 NDLRSKYSIWDIEDGkFEGKDLVFKLHWNVQPWVGL 164
Cdd:PTZ00116 119 KNFITKYSLKDYNNG-LRNNNINLQVCYKYMPIVGL 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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