forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; This subfamily includes VPS64 (also called factor arrest protein 9 or FAR9) and factor arrest protein 10 (FAR10), which participate in the control of the re-entry into the cell cycle following pheromone treatment. VPS64 is also involved in vacuolar protein sorting. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267   73 TYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLrggkrVDSHTFSQVRSDNGNFDSRVLSRNHALLSCD 152
Cdd:cd22695   1 THILVLKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNSGS-----KRDLFSQQVRPDNGNFDSRVLSRNHACLSCD 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323267  153 PLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEE 210
Cdd:cd22695  76 PTTGKVYIRDLKSSNGTFVNGQKIRQNDVELKVGDEVDLGTDIDSKIEHRKISAYVEE 133

forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; This subfamily includes VPS64 (also called factor arrest protein 9 or FAR9) and factor arrest protein 10 (FAR10), which participate in the control of the re-entry into the cell cycle following pheromone treatment. VPS64 is also involved in vacuolar protein sorting. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267   73 TYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLrggkrVDSHTFSQVRSDNGNFDSRVLSRNHALLSCD 152
Cdd:cd22695   1 THILVLKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNSGS-----KRDLFSQQVRPDNGNFDSRVLSRNHACLSCD 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323267  153 PLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEE 210
Cdd:cd22695  76 PTTGKVYIRDLKSSNGTFVNGQKIRQNDVELKVGDEVDLGTDIDSKIEHRKISAYVEE 133

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323267  137 FDSRVLSRNHALLSCDPltGKVYIRDLKSSNGTFINGQRIgSNDVEIKVGDVIDLGT 193
Cdd:COG1716  35 LDDPTVSRRHARIRRDG--GGWVLEDLGSTNGTFVNGQRV-TEPAPLRDGDVIRLGK 88

Protein MAK16 homolog; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267   316 HLEYTNKLLVEKNDQQLVKL-QNGLR-RKLSGK-YEKIIEQNRNQVKQLERDhmffkksfEVKKRRNNEKQKSMEREied 392
Cdd:PLN00040  96 HLAYWPKFLVHKNKQRLTKMtQYLIRmRKLALKtREKIVTTPRKLLKRERRR--------ESKAQKAAQLEKSIEKE--- 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6323267   393 LKTRLE-----------VERYKNSQMMKKNKQKEQELSTASKKKTTEHDTR 432
Cdd:PLN00040 165 LLERLKsgtygdiynfpSKSYNKVLEMEEVEEAEEELPKSDKNPNSKKKSR 215

forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; This subfamily includes VPS64 (also called factor arrest protein 9 or FAR9) and factor arrest protein 10 (FAR10), which participate in the control of the re-entry into the cell cycle following pheromone treatment. VPS64 is also involved in vacuolar protein sorting. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267   73 TYILVLTSLNGTFESKHVVIPFKPDGLKLGRPVANSNSSSSSSLrggkrVDSHTFSQVRSDNGNFDSRVLSRNHALLSCD 152
Cdd:cd22695   1 THILVLKSLNATFETKFLVVPFKPDGLKLGRPVTNSVNKNNSGS-----KRDLFSQQVRPDNGNFDSRVLSRNHACLSCD 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323267  153 PLTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIEHRKISATVEE 210
Cdd:cd22695  76 PTTGKVYIRDLKSSNGTFVNGQKIRQNDVELKVGDEVDLGTDIDSKIEHRKISAYVEE 133

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6323267    137 FDSRVLSRNHALLSCDPlTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDL 191
Cdd:pfam00498  13 LDDPSVSRRHAEIRYDG-GGRFYLEDLGSTNGTFVNGQRLGPEPVRLKDGDVIRL 66

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6323267  138 DSRVLSRNHALLSCDPltGKVYIRDLKSSNGTFINGQRIgSNDVEIKVGDVIDLG 192
Cdd:cd00060  34 DDPSVSRRHARIEVDG--GGVYLEDLGSTNGTFVNGKRI-TPPVPLQDGDVIRLG 85

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323267  121 RVDSHTFSQVRSDNGN--FDSRVLSRNHALLScdPLTGKVYIRDLKSSNGTFINGQRIGSndVEIKVGDVIDLGTDI 195
Cdd:cd22698  17 ELDQDEFTIGRSSNNDirLNDHSVSRHHARIV--RQGDKCNLTDLGSTNGTFLNGIRVGT--HELKHGDRIQLGETI 89

first forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the first FHA domain. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6323267  137 FDSRVLSRNHALLSCDPlTGKVYiRDLKSSNGTFINGQRIGSndVEIKVGDVIDLG 192
Cdd:cd22694  30 LDDPRVSRRHALLEFDG-DGWVY-TDLGSRNGTYLNGRRVQQ--VKLSDGTRVRLG 81

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267  131 RSDNGNF--DSRVLSRNHALLSC-------DPLtgkVYIRDLkSSNGTFINGQRIGS-NDVEIKVGDVIDLGTDIDTKIE 200
Cdd:cd22670  28 RSPSCDIviNDPFVSRTHCRIYSvqfdessAPL---VYVEDL-SSNGTYLNGKLIGRnNTVLLSDGDVIEIAHSATFVYV 103

                .
gi 6323267  201 H 201
Cdd:cd22670 104 H 104

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6323267  138 DSRVLSRNHALLSCDPltGKVYIRDLKSSNGTFINGQRIG-------SNDVEIKVGDVI 189
Cdd:cd22682  35 DDDSVSRYHAKLAVNP--SAVSIIDLGSTNGTIVNGKKIPklascdlQNGDQIKIGNTI 91

forkhead associated (FHA) domain found in centrosomal protein of 170 kDa protein B (Cep170B) and similar proteins; Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323267  139 SRVLSRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSND-VEIKVGDVIDLGTDIDT----KIEHR 202
Cdd:cd22725  36 SRSVDKQHAVINYDQDTDEHWVKDLGSLNGTFVNDVRIPDQKyITLKLNDVIRFGYDSNMyvleRSQHK 104

forkhead associated (FHA) domain found in Mycobacterium tuberculosis FHA domain-containing protein FhaA and similar proteins; FhaA regulates cell growth and peptidoglycan synthesis by binding to MviN. It may inhibit the late stages of peptidoglycan synthesis. It contains an FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323267  128 SQVRSDNGnfdsrVLSRNHALLSCDplTGKVYIRDLKSSNGTFINGQRIgSNDVEIKVGDVIDLGT 193
Cdd:cd22668  28 ADFRLPDT-----GVSRRHAEIRWD--GQVAHLTDLGSTNGTTVNNAPV-TPEWRLADGDVITLGH 85

forkhead associated (FHA) domain found in protein phosphatase 1 regulatory inhibitor subunit 8 (PPP1R8) and similar proteins; PPP1R8, also called nuclear inhibitor of protein phosphatase 1 (NIPP-1), is an inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. It may also be involved in pre-mRNA splicing and binds DNA and might act as a transcriptional repressor. PPP1R8 seems to be required for cell proliferation. PPP1R8 contains an FHA domain that mediates interactions with threonine-phosphorylated maternal embryonic leucine zipper kinase (MELK). The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6323267  143 SRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSND-VEIKVGDVIDLG 192
Cdd:cd22674  48 SRVHAALVYHKHLNRVFLIDLGSTHGTFVGGIRLEPHKpQQLPIDSTLRFG 98

forkhead associated (FHA) domain found in Chlamydia trachomatis Ct664 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Chlamydia trachomatis Ct664 protein. Ct664 situates within the type III secretion system cluster that also encodes an STPK (CT673 in C. trachomatis), suggesting a role of CT664 in the chlamydial type III secretion system by mediating phosphorylation-dependent protein-protein interactions. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 6323267  142 LSRNHALLSCDPlTGKVYIRDLKSSNGTFINGQRIGSNDvEIKVGDVIDLGT 193
Cdd:cd22696  41 ISRQHARLSIDQ-DNRVFIEDLSSKNGVLVNGKPIEGKE-EISGSDVISLGT 90

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1), FHA domain-containing protein DDL, and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This family also includes Arabidopsis thaliana FHA domain-containing protein DDL and similar proteins. DDL, also called protein DAWDLE, is involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. It may facilitate DCL1 to access or recognize primary miRNAs. DDL binds RNA non-specifically. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6323267  156 GKVYIRDLKSSNGTFINGQRIGSND-VEIKVGDVIDLG 192
Cdd:cd22676  65 IRPYIIDLGSTNGTFLNGEKIEPRRyYELREKDVLKFG 102

forkhead associated (FHA) domain found in Arabidopsis thaliana Protein PARALLEL SPINDLE 1 (PS1) and similar proteins; PS1 is an FHA domain-containing protein required for normal spindle orientation at male meiosis II and normal formation of tetrad of microspores. It is not involved in female meiosis. Mutations in PS1 lead to the production of diploid pollen grains. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6323267  143 SRNHALLSCDPLTGKVYIRDLKSSNGTFINGQRIGSND-VEIKVGDVIDLG 192
Cdd:cd22691  49 SRFHLEIRIIPSRRKITLTDLSSVHGTWVNGQRIEPGVpVELEEGDTVRLG 99

forkhead associated (FHA) domain found in nibrin and similar proteins; Nibrin (NBN), also called cell cycle regulatory protein p95, or Nijmegen breakage syndrome protein 1 (NBS1), is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. Nibrin modulates the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. Nibrin also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. Nibrin is a major player in the control of intra-S-phase checkpoint. This subfamily also includes Schizosaccharomyces pombe DNA repair and telomere maintenance protein Nbs1 and Arabidopsis thaliana AtNbs1. SpNbs1 is an FHA domain-containing protein required for DNA damage repair and S-phase DNA damage checkpoint. It is involved in telomere length maintenance and maintenance of chromatin structure. AtNbs1 is a component of MRN complex. It also functions in the very early stages of meiosis. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323267  143 SRNHALLSCDPLTG---------KVYIRDLkSSNGTFINGQRIGSND-VEIKVGDVIDLGT 193
Cdd:cd22667  40 SRKHATLTVLHPEAnlsdpdtrpELTLKDL-SKYGTFVNGEKLKGGSeVTLKDGDVITFGV 99

forkhead associated (FHA) domain found in checkpoint kinase 2 (Chk2) and similar proteins; Chk2, also called Hucds1, Cds1 homolog, or serine/threonine-protein kinase Chk2, plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267  123 DSHTFSQVRSDNGNFDSRVLSRNHALLS------------CDPLTGKVYIRDLkSSNGTFINGQRIGSNDV-EIKVGDVI 189
Cdd:cd22666  19 DEYTFGRDKSCDYCFDSPALKKTSYYRTyskkhfrifrekGSKNTYPVFLEDH-SSNGTFVNGEKIGKGKKrPLNNNDEI 97

                ...
gi 6323267  190 DLG 192
Cdd:cd22666  98 ALS 100

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323267  143 SRNHALLSCDplTGKVYIRDLKSSNGTFINGQRIGSNDVEIKVGDVIDLGTDIDTKIE 200
Cdd:cd22680  41 SRNHARITVD--SNEIYIEDLGSTNGTFVNDFKRIKGPAKLHPNDIIKLGRTTVLKVT 96

forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; PML1 is an FHA domain-containing protein required for efficient splicing and pre-mRNA nuclear retention. It is a component of the pre-mRNA retention and splicing (RES) complex composed of at least BUD13, IST3, and PML1. It contains an FHA domain, which is a small phosphopeptide recognition module.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6323267  157 KVYIRDLKSSNGTFINGQRI-GSNDVEIKVGDVIDLGTDIDTKI 199
Cdd:cd22681  83 KPYIMDLDSSNGTCLNDNVIpSSRYVELRSGDVITFSKSNDYEL 126

forkhead associated (FHA) domain found in Smad nuclear-interacting protein 1 (SNIP1) and similar proteins; SNIP1 is an FHA domain-containing protein required for pre-mRNA splicing as a component of the spliceosome. It inhibits NF-kappaB signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. It is involved in microRNA (miRNA) biogenesis. SNIP1 is a regulator of the cell cycle and cyclin D1 expression and may be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex, which associates with both the 3'end of the CCND1 gene and its mRNA. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30
                ....*....|....*....|....*....|....*..
gi 6323267  157 KVYIRDLKSSNGTFINGQRIGSND-VEIKVGDVIDLG 192
Cdd:cd22718 102 RPYIIDLESANGTFLNNKKIEPQRyYELKEKDVLKFG 138

Protein MAK16 homolog; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267   316 HLEYTNKLLVEKNDQQLVKL-QNGLR-RKLSGK-YEKIIEQNRNQVKQLERDhmffkksfEVKKRRNNEKQKSMEREied 392
Cdd:PLN00040  96 HLAYWPKFLVHKNKQRLTKMtQYLIRmRKLALKtREKIVTTPRKLLKRERRR--------ESKAQKAAQLEKSIEKE--- 164

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6323267   393 LKTRLE-----------VERYKNSQMMKKNKQKEQELSTASKKKTTEHDTR 432
Cdd:PLN00040 165 LLERLKsgtygdiynfpSKSYNKVLEMEEVEEAEEELPKSDKNPNSKKKSR 215

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.

                        10        20        30
                ....*....|....*....|....*....|....*
gi 6323267  158 VYIRDLkSSNGTFINGQRIGSND-VEIKVGDVIDL 191
Cdd:cd22690  57 VYVTDT-STNGTFINNNRLGKGSqSLLQDGDEIVL 90

Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267  198 KIEHRKISATVEELFVQPLLESPIfenedSDDCHTITEKEEAAAITSHIygDSNNLELEEVI------LGSDTEILSGIF 271
Cdd:COG5244  99 KQENHEDRIHFEESKIRRLEETIE-----ALKSTEKEEIVELRRENEEL--DKINLSLRERIsseepeLNKDGSKLSYDE 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267  272 INNCIGTSPTLSNIIKTLAMEIPFSkcdnfkLQSMENFLINYTTHLEYTNKLLVEKNDQQLVKlqnglrrklsgkyeKII 351
Cdd:COG5244 172 LKEFVEESRVQVYDMVELVSDISET------LNRNGSIQRSSVRECERSNIHDVLFLVNGILD--------------GVI 231

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323267  352 EQNRNQVKQLERDHMFFKKSFEVKKRRNN------EKQKSMEREIEDLKTRLeverYKNsQMMKKNKQKEQELSTASKKK 425
Cdd:COG5244 232 DELNGELERLRRQLVSLMSSHGIEVEENSrlkatlEKFQSLELKVNTLQEEL----YQN-KLLKKFYQIYEPFAQAALSS 306

                       250
                ....*....|...
gi 6323267  426 TTEHDTRGVPGMN 438
Cdd:COG5244 307 QLQYLAEVIESEN 319