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Conserved domains on  [gi|6323270|ref|NP_013342|]
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Csc1p [Saccharomyces cerevisiae S288C]

Protein Classification

CSC1 family protein( domain architecture ID 11475661)

CSC1 family protein may act as an osmosensitive calcium-permeable cation channel; similar to Saccharomyces cerevisiae calcium permeable stress-gated cation channel 1, sporulation-specific protein 75, phosphate metabolism protein 7 and uncharacterized protein RSN1

Gene Ontology:  GO:0016020|GO:0005227
TCDB:  1.A.17

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
1-782 0e+00

Uncharacterized integral membrane protein [Function unknown];


:

Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 835.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    1 MTSYIERLKSAASyldtvpdehHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQ 80
Cdd:COG5594   1 MVDSKSDLFVNGA---------KPPLNRSTSAVITQLVFAGLIFLVFLILFLILRKRWKRLYAPRTNFDGQNECLPEPNP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270   81 SSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKiddGNDDDDSESSLIHLVK 160
Cdd:COG5594  72 SSYWGWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKA---TNGNSDSESGLDKLSI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  161 RIVEGSGDGDNHSAPertNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEA 240
Cdd:COG5594 149 SNVSPSNRLYAHVFL---SWFFFGYVLFIIFRELRFYVVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEE 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  241 LKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQpysenyHLLGNEQSGAVTHGENvpss 320
Cdd:COG5594 226 LKELFDKLKVGEIDSDVLCRDLGTLQELYKERDKILKKLEKALNELLNKLLKKS------HLKTNKKSGKLTPSRK---- 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  321 nnnDEDTILYSQISLGERPKMKIGYR--GIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPT--AFVTMDSVANAQM 396
Cdd:COG5594 296 ---KEFEILPEYVPDKKRPKHRIKKLnkGIFGKKVDAIDYYSAKLTKLDAEIENARKSLYENTPTksGFITFKSQASAQI 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  397 AAQAVLDPRVHYFI-TRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQ 475
Cdd:COG5594 373 AAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSRKERLFKRISANILFILLIILWAFPVAFVGTISNLNTLSSLWPFLKF 452
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  476 LLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAG-TASNYWAY 554
Cdd:COG5594 453 ILKDPPFLAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASsFSSIVWSL 532
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  555 LSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIG-FPLVKIKAKTPRQR-NELYNPPIFNFGLQLPQP 632
Cdd:COG5594 533 LKEPTSIMTLLANNLPKASNFFISYIILQGLSGFPGTLLQIVPLLLsLVLGKFKDSTPRQKwNRLETPPSFQFGTVLPQP 612
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  633 ILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGtLAGFEGGW 712
Cdd:COG5594 613 ILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLG-LFSLAKGW 691
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  713 VLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSS----IREYERDNSTVNSANE------EESYAYPYAVSELEGPMLD 782
Cdd:COG5594 692 GLSVLLFPLIVFTVIFHYYFKKMFDPLSKYIKLSSykllIPELEYLSTFSESTKVdeddkfEEVWSYFPDGFDLSIERSY 771
 
Name Accession Description Interval E-value
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
1-782 0e+00

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 835.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    1 MTSYIERLKSAASyldtvpdehHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQ 80
Cdd:COG5594   1 MVDSKSDLFVNGA---------KPPLNRSTSAVITQLVFAGLIFLVFLILFLILRKRWKRLYAPRTNFDGQNECLPEPNP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270   81 SSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKiddGNDDDDSESSLIHLVK 160
Cdd:COG5594  72 SSYWGWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKA---TNGNSDSESGLDKLSI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  161 RIVEGSGDGDNHSAPertNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEA 240
Cdd:COG5594 149 SNVSPSNRLYAHVFL---SWFFFGYVLFIIFRELRFYVVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEE 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  241 LKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQpysenyHLLGNEQSGAVTHGENvpss 320
Cdd:COG5594 226 LKELFDKLKVGEIDSDVLCRDLGTLQELYKERDKILKKLEKALNELLNKLLKKS------HLKTNKKSGKLTPSRK---- 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  321 nnnDEDTILYSQISLGERPKMKIGYR--GIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPT--AFVTMDSVANAQM 396
Cdd:COG5594 296 ---KEFEILPEYVPDKKRPKHRIKKLnkGIFGKKVDAIDYYSAKLTKLDAEIENARKSLYENTPTksGFITFKSQASAQI 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  397 AAQAVLDPRVHYFI-TRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQ 475
Cdd:COG5594 373 AAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSRKERLFKRISANILFILLIILWAFPVAFVGTISNLNTLSSLWPFLKF 452
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  476 LLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAG-TASNYWAY 554
Cdd:COG5594 453 ILKDPPFLAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASsFSSIVWSL 532
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  555 LSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIG-FPLVKIKAKTPRQR-NELYNPPIFNFGLQLPQP 632
Cdd:COG5594 533 LKEPTSIMTLLANNLPKASNFFISYIILQGLSGFPGTLLQIVPLLLsLVLGKFKDSTPRQKwNRLETPPSFQFGTVLPQP 612
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  633 ILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGtLAGFEGGW 712
Cdd:COG5594 613 ILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLG-LFSLAKGW 691
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  713 VLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSS----IREYERDNSTVNSANE------EESYAYPYAVSELEGPMLD 782
Cdd:COG5594 692 GLSVLLFPLIVFTVIFHYYFKKMFDPLSKYIKLSSykllIPELEYLSTFSESTKVdeddkfEEVWSYFPDGFDLSIERSY 771
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
435-704 3.66e-86

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 274.01  E-value: 3.66e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    435 KVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQ 514
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWILELPPKLLGLVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    515 GLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSD-TTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLL 593
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSLIEQIIDnPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    594 LVGSLIGFPLV-KIKAKTPRQRNELYN-PPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFA 671
Cdd:pfam02714 161 QLGPLILFYIKrKFLDKTPRDKYERYTtPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYV 240
                         250       260       270
                  ....*....|....*....|....*....|...
gi 6323270    672 TDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGT 704
Cdd:pfam02714 241 YVTKYESGGRFWPRALNRLLVGLYLFQLCLIGL 273
 
Name Accession Description Interval E-value
COG5594 COG5594
Uncharacterized integral membrane protein [Function unknown];
1-782 0e+00

Uncharacterized integral membrane protein [Function unknown];


Pssm-ID: 227881 [Multi-domain]  Cd Length: 827  Bit Score: 835.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    1 MTSYIERLKSAASyldtvpdehHDFRKPTAKVVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQ 80
Cdd:COG5594   1 MVDSKSDLFVNGA---------KPPLNRSTSAVITQLVFAGLIFLVFLILFLILRKRWKRLYAPRTNFDGQNECLPEPNP 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270   81 SSLFGWLTVLYKIRDEQILEYAGLDAYVFLSFFKMCIKLLSIFCFFSVCVISPVRYHFTGKiddGNDDDDSESSLIHLVK 160
Cdd:COG5594  72 SSYWGWLEPLVKIPDEFLLQYAGLDGYFFLRFLKMLIKLLFILSLILIPILLPVNYHFQKA---TNGNSDSESGLDKLSI 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  161 RIVEGSGDGDNHSAPertNVYLWMYVLFTYFFTFIAIKMAVAETKHVVSTRQAYLGKQNTITDRTIRLSGIPIELRDSEA 240
Cdd:COG5594 149 SNVSPSNRLYAHVFL---SWFFFGYVLFIIFRELRFYVVLRQAYLRSPLYQQSLLTLQNNLSSRTVLISGLPSELRSDEE 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  241 LKTRIEQLKIGTVSSITICREWGPLNKLFHCRKKILKNLELKYSECPRELRTRQpysenyHLLGNEQSGAVTHGENvpss 320
Cdd:COG5594 226 LKELFDKLKVGEIDSDVLCRDLGTLQELYKERDKILKKLEKALNELLNKLLKKS------HLKTNKKSGKLTPSRK---- 295
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  321 nnnDEDTILYSQISLGERPKMKIGYR--GIFGKEVDAIEYLEQQLKFIDAEIIEARKQHYSATPT--AFVTMDSVANAQM 396
Cdd:COG5594 296 ---KEFEILPEYVPDKKRPKHRIKKLnkGIFGKKVDAIDYYSAKLTKLDAEIENARKSLYENTPTksGFITFKSQASAQI 372
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  397 AAQAVLDPRVHYFI-TRLAPAPHDIKWDHVCLSRKDRLTKVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQ 475
Cdd:COG5594 373 AAQSQIYSRVLGKLkVEIAPAPNDIIWDNLRLSRKERLFKRISANILFILLIILWAFPVAFVGTISNLNTLSSLWPFLKF 452
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  476 LLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQGLVSYSEEEISLVSKNFFYIFVNLFLVFTLAG-TASNYWAY 554
Cdd:COG5594 453 ILKDPPFLAGILTGLLPTVALSLLMSIVPYFIRWLSYMQGLVSYSEEEIYVQNKYFAFLFVNLFLVVTLASsFSSIVWSL 532
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  555 LSDTTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLLLVGSLIG-FPLVKIKAKTPRQR-NELYNPPIFNFGLQLPQP 632
Cdd:COG5594 533 LKEPTSIMTLLANNLPKASNFFISYIILQGLSGFPGTLLQIVPLLLsLVLGKFKDSTPRQKwNRLETPPSFQFGTVLPQP 612
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  633 ILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFATDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGtLAGFEGGW 712
Cdd:COG5594 613 ILLFTITICYSIISPLILLFGAVYFILNYLAYKYNLIYVSNHSPESGGGYWPRALFQIIVGLYLFQVCLLG-LFSLAKGW 691
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270  713 VLSSCLFPLPVVTLCFLYDFEKNYLPLSKYIALSS----IREYERDNSTVNSANE------EESYAYPYAVSELEGPMLD 782
Cdd:COG5594 692 GLSVLLFPLIVFTVIFHYYFKKMFDPLSKYIKLSSykllIPELEYLSTFSESTKVdeddkfEEVWSYFPDGFDLSIERSY 771
RSN1_7TM pfam02714
Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane ...
435-704 3.66e-86

Calcium-dependent channel, 7TM region, putative phosphate; RSN1_7TM is the seven transmembrane domain region of putative phosphate transporter. The family is the 7TM region of osmosensitive calcium-permeable cation channels.


Pssm-ID: 460661  Cd Length: 273  Bit Score: 274.01  E-value: 3.66e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    435 KVYSTTVFIGLSSLFLVIPVSYLATLLNLKTLSKFWPSVGQLLKDHQWAANIVTGLLPTYLFTLLNFGIPYFYEYLTSYQ 514
Cdd:pfam02714   1 RRLIVNLAIFLLIIFWAIPVAFVGLLSNLETLTKVWPFLKWILELPPKLLGLVTGLLPPLLLSLLMALLPIILRFLSKLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    515 GLVSYSEEEISLVSKNFFYIFVNLFLVFTLAGTASNYWAYLSD-TTKIAYQLATSVKEFSLFYVDLIILQGIGMFPFKLL 593
Cdd:pfam02714  81 GAPSRSDIELSVQSKYFAFLVVNVFLVFTLASSASSLIEQIIDnPTSIPTLLATNLPKASNFFITYILLQGLSGAAGELL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    594 LVGSLIGFPLV-KIKAKTPRQRNELYN-PPIFNFGLQLPQPILILIITLIYSVMSTKILTSGLAYFIIGFYVYKYQLIFA 671
Cdd:pfam02714 161 QLGPLILFYIKrKFLDKTPRDKYERYTtPPSFDYGTVYPVFLLIFTIGLIYSVIAPLILPFGLVYFGLGYFVYKYQLLYV 240
                         250       260       270
                  ....*....|....*....|....*....|...
gi 6323270    672 TDHLPHSTGKVWPLIFRRIIVGLLLFQLTMTGT 704
Cdd:pfam02714 241 YVTKYESGGRFWPRALNRLLVGLYLFQLCLIGL 273
RSN1_TM pfam13967
Late exocytosis, associated with Golgi transport; This family represents the first three ...
32-199 1.67e-39

Late exocytosis, associated with Golgi transport; This family represents the first three transmembrane regions of 11-TM proteins involved in vesicle transport. In S. cerevisiae these proteins are members of the yeast facilitator superfamily and are integral membrane proteins localized to the cell periphery, in particular to the bud-neck region. The distribution is consistent with a role in late exocytosis which is in agreement with the proteins' ability to substitute for the function of Sro7p, required for the sorting of the protein Enap1 into Golgi-derived vesicles destined for the cell surface.


Pssm-ID: 433613  Cd Length: 158  Bit Score: 143.10  E-value: 1.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270     32 VVTTQLTIATSLGIFALLSFSILLKKWPRLYASRRYKDDGNLRLPSWNQSSLFGWLTVLYKIRDEQILEYAGLDAYVFLS 111
Cdd:pfam13967   1 AFLTSLVINLVIALVFLLLFSILRPKNKRVYAPRTYLAPEEERTPPLPGTGLFGWIPPLLKIPDEEILQHAGLDAYVFLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    112 FFKMCIKLLSIFCFFSVCVISPVRYhfTGKIDDGNDDDDSESSLIHL-VKRIVEGSGdgdnhsapertnvYLWMYVLFTY 190
Cdd:pfam13967  81 FLKMLIKIFLVGCLIGWPILLPVNA--TGGNGEDDGDSLTRTGLDKLsSSNNVEGSN-------------RLWAHVVVAY 145

                  ....*....
gi 6323270    191 FFTFIAIKM 199
Cdd:pfam13967 146 IFTGFVLYL 154
PHM7_cyt pfam14703
Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic ...
223-424 8.52e-34

Cytosolic domain of 10TM putative phosphate transporter; PHM7_cyt is the predicted cytosolic domain of integral membrane proteins, such as yeast PHM7 and TM63A_HUMAN TRANSMEMBRANE PROTEIN 63A, SwissProt:O94886. This domain usually precedes the 7TM region, pfam02714, and follows a RSN1_TM, pfam13967. Fold recognition programs consistently and with high significance predict this domain to be distantly homologous to RNA binding proteins from the RRM clan.


Pssm-ID: 464272  Cd Length: 164  Bit Score: 127.05  E-value: 8.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    223 DRTIRLSGIPIELRDSEALKTRIEQLKIGT-VSSITICREWGPLNKLFHCRKKILKNLElkysecprelrtrqpYSENYH 301
Cdd:pfam14703   1 SRTVLVTGIPKDLRSEEKLRSFFEELYPGTvVERVQIVRDVKKLPKLVEEREKAVRKLE---------------AALAKY 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323270    302 LLGNEqsgavthgenvpssnnndedtilysqiSLGERPKMKIGYRGIFGKEVDAIEYLEQQLKFIDAEIIEARKQH-YSA 380
Cdd:pfam14703  66 LKNGK---------------------------KPKKRPTHKLGFLGLFGKKVDAIDYYTEKLEELEEEIEEEREKVdKKP 118
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 6323270    381 TPTAFVTMDSVANAQMAAQAV--LDPRVHYFITRLAPAPHDIKWDH 424
Cdd:pfam14703 119 LGAAFVTFKSERSAAAAAAQInpQLMHPKGWTVELAPEPRDVIWEN 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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