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Conserved domains on  [gi|398366169|ref|NP_013518|]
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Pun1p [Saccharomyces cerevisiae S288C]

Protein Classification

SUR7/PalI family protein( domain architecture ID 10535294)

SUR7/PalI family protein such as fungal protein SUR7, that is involved in sporulation and affects the sphingolipid composition of the plasma membrane, and pH-response regulator protein palI/RIM9, that is required for the proteolytic cleavage of the transcriptional repressor RIM101 in response to alkaline ambient pH

Gene Ontology:  GO:0005886
PubMed:  11784867

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 6-240 2.29e-34

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


:

Pssm-ID: 399580  Cd Length: 201  Bit Score: 122.83  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169    6 TLFFAAIFSLGALILAIVACAGSTKNYSPINKIYCAELDLSQMKVStvlpslssatlsslglPSYINIGLWSYCTVDSsH 85
Cdd:pfam06687   1 LTLLSLLLLLAALLLLIFVILGGISNSSPLNNIYLLEADTSGISGA----------------PDFYRWGVWGYCGNSD-N 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169   86 NIQSCSSPHGIQNFNLSslvyDNINNNEALELmdsvasvvlPEKLKSKMTYYNNLVKCMFITILIGIVLTFVNLVFNVLR 165
Cdd:pfam06687  64 NNTNCSKPSAGYPFDPL----DNFGTNSNGKL---------PSSFRDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLA 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366169  166 WIIHIRPLTWFGAFFSFFAFAALLVSIGSCLGTYsyikYILKHNYSDYGISMSIGRNYQGLMWGAVVGALLNFIL 240
Cdd:pfam06687 131 IFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALF----VKARNAFKDYGISASLGVKWFAFLWLAVAAALLSLIS 201
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 6-240 2.29e-34

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 122.83  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169    6 TLFFAAIFSLGALILAIVACAGSTKNYSPINKIYCAELDLSQMKVStvlpslssatlsslglPSYINIGLWSYCTVDSsH 85
Cdd:pfam06687   1 LTLLSLLLLLAALLLLIFVILGGISNSSPLNNIYLLEADTSGISGA----------------PDFYRWGVWGYCGNSD-N 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169   86 NIQSCSSPHGIQNFNLSslvyDNINNNEALELmdsvasvvlPEKLKSKMTYYNNLVKCMFITILIGIVLTFVNLVFNVLR 165
Cdd:pfam06687  64 NNTNCSKPSAGYPFDPL----DNFGTNSNGKL---------PSSFRDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLA 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366169  166 WIIHIRPLTWFGAFFSFFAFAALLVSIGSCLGTYsyikYILKHNYSDYGISMSIGRNYQGLMWGAVVGALLNFIL 240
Cdd:pfam06687 131 IFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALF----VKARNAFKDYGISASLGVKWFAFLWLAVAAALLSLIS 201
 
Name Accession Description Interval E-value
SUR7 pfam06687
SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity ...
 6-240 2.29e-34

SUR7/PalI family; This family consists of several fungal-specific SUR7 proteins. Its activity regulates expression of RVS161, a homolog of human endophilin, suggesting a function for both in endocytosis. The protein carries four transmembrane domains and is thus likely to act as an anchoring protein for the eisosome to the plasma membrane. Eisosomes are the immobile protein complexes, that include the proteins Pil1 and Lsp1, which co-localize with sites of protein and lipid endocytosis at the plasma membrane. SUR7 protein may play a role in sporulation. This family also includes PalI which is part of a pH signal transduction cascade. Based on the similarity of PalI to the yeast Rim9 meiotic signal transduction component it has been suggested that PalI might be a membrane sensor for ambient pH.


Pssm-ID: 399580  Cd Length: 201  Bit Score: 122.83  E-value: 2.29e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169    6 TLFFAAIFSLGALILAIVACAGSTKNYSPINKIYCAELDLSQMKVStvlpslssatlsslglPSYINIGLWSYCTVDSsH 85
Cdd:pfam06687   1 LTLLSLLLLLAALLLLIFVILGGISNSSPLNNIYLLEADTSGISGA----------------PDFYRWGVWGYCGNSD-N 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366169   86 NIQSCSSPHGIQNFNLSslvyDNINNNEALELmdsvasvvlPEKLKSKMTYYNNLVKCMFITILIGIVLTFVNLVFNVLR 165
Cdd:pfam06687  64 NNTNCSKPSAGYPFDPL----DNFGTNSNGKL---------PSSFRDTLSTYYYLSRFMFIVHIIALFFTVIALILGLLA 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366169  166 WIIHIRPLTWFGAFFSFFAFAALLVSIGSCLGTYsyikYILKHNYSDYGISMSIGRNYQGLMWGAVVGALLNFIL 240
Cdd:pfam06687 131 IFSHSRRGLLVNLLLSFLAFLFTLLAALLDTALF----VKARNAFKDYGISASLGVKWFAFLWLAVAAALLSLIS 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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