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Conserved domains on  [gi|6323557|ref|NP_013628|]
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putative cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 394-645 6.85e-18

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PRK06176:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 380  Bit Score: 86.10  E-value: 6.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   394 AVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNPQsrv 472
Cdd:PRK06176 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLgADIVVHSGTKYLGGHSDVVAGLVTTNNE--- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   473 yEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARtIRINYSTEYLLDKILKPHvgenKLFKKIYYPNLTSKEtltNYD 552
Cdd:PRK06176 214 -ALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLR-MEAHQKNALCVAEFLEKH----PKVEKVYYPGLPTHP---NHE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   553 MVRcKKEGGYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNFTLAFPYTLMTYYH-ELDMAEKFGVERNLLRISVGLE 630
Cdd:PRK06176 285 LAK-KQMRGFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFMTHACiPKEQREAAGIRDGLVRLSVGIE 363

                        250
                 ....*....|....*
gi 6323557   631 SQSILGKIFQEAIDK 645
Cdd:PRK06176 364 HEQDLLEDLEQAFAK 378
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 310-464 1.26e-05

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PRK07810:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 403  Bit Score: 48.19  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   310 SGMASIFTAHRLLLQ-WDSLRLNRSRNGSDVtssppnkktVIFGfpyadtlHVLQEFN-ETYFLgEGDESSMKEltKILH 387
Cdd:PRK07810  93 SGMSAVFTALGALLGaGDRLVAARSLFGSCF---------VVCN-------EILPRWGvETVFV-DGEDLSQWE--EALS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   388 SGEQilAVFIETPSNPllkMGNLLELKRLSEL---FGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:PRK07810 154 VPTQ--AVFFETPSNP---MQSLVDIAAVSELahaAGAKVVLDNVFATPLLQRGLPLgADVVVYSGTKHIDGQGRVLGGA 228


                 .
gi 6323557   464 M 464
Cdd:PRK07810 229 I 229
 
Name Accession Description Interval E-value
PRK06176 PRK06176
cystathionine gamma-synthase;
394-645 6.85e-18

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 86.10  E-value: 6.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   394 AVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNPQsrv 472
Cdd:PRK06176 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLgADIVVHSGTKYLGGHSDVVAGLVTTNNE--- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   473 yEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARtIRINYSTEYLLDKILKPHvgenKLFKKIYYPNLTSKEtltNYD 552
Cdd:PRK06176 214 -ALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLR-MEAHQKNALCVAEFLEKH----PKVEKVYYPGLPTHP---NHE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   553 MVRcKKEGGYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNFTLAFPYTLMTYYH-ELDMAEKFGVERNLLRISVGLE 630
Cdd:PRK06176 285 LAK-KQMRGFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFMTHACiPKEQREAAGIRDGLVRLSVGIE 363

                        250
                 ....*....|....*
gi 6323557   631 SQSILGKIFQEAIDK 645
Cdd:PRK06176 364 HEQDLLEDLEQAFAK 378
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 306-631 1.00e-17

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 85.33  E-value: 1.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSPPnkktvIFGFPYADTLHVLQEFN-ETYFLGEGD----ESSMK 380
Cdd:cd00614  59 LAFSSGMAAISTVLLALL----------KAGDHVVASDD-----LYGGTYRLFERLLPKLGiEVTFVDPDDpealEAAIK 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  381 ELTKilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNV 459
Cdd:cd00614 124 PETK---------LVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRPLELgADIVVHSATKYIGGHSDV 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  460 IGGSMVLNpQSRVYEFAsRFMQLE--------DEYEDL-----LwcedAIYLERNSRDfiARTIrinysTEYLLDkilKP 526
Cdd:cd00614 195 IAGVVVGS-GEALIQRL-RFLRLAlgtilspfDAWLLLrglktL----PLRMERHSEN--ALKV-----AEFLEK---HP 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  527 HVgenklfKKIYYPNLTSKetlTNYDMVRcKKEGGYGGLFSLTF-HDEDHAAAFYDNLKLnkgPSLGTNF----TLAFPY 601
Cdd:cd00614 259 KV------ERVYYPGLPSH---PQHELAK-KQMSGYGGVFSFELkGGLEAAKKFLNALKL---FSLAVSLggveSLVEHP 325

                       330       340       350
                ....*....|....*....|....*....|.
gi 6323557  602 TLMTYYHELDMA-EKFGVERNLLRISVGLES 631
Cdd:cd00614 326 ASMTHSQLPPEErAAAGITPGLVRLSVGIED 356
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 306-630 1.22e-16

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 82.28  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSPPnkktvIFGFPYADTLHVLQEFN-ETYFLGEGD----ESSMK 380
Cdd:pfam01053  66 LAFSSGMAAITAAILALL----------KAGDHIVATDD-----LYGGTYRLFNKVLPRFGiEVTFVDTSDpedlEAAIK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    381 ELTKilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNV 459
Cdd:pfam01053 131 PNTK---------AVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLgADIVVHSATKYIGGHSDV 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    460 IGGSMVLNPQsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINySTEYLLDKILK--PHVgenklfKKI 537
Cdd:pfam01053 202 VGGVIVVNGE----ELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQ-ENAQKVAEFLEshPKV------EKV 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    538 YYPNLTSKEtltNYDMVRcKKEGGYGGLFSLTFH-DEDHAAAFYDNLKL-NKGPSLG-TNFTLAFPYTlMTYYHELDMA- 613
Cdd:pfam01053 271 YYPGLPSHP---GHELAK-RQMKGFGGMLSFELKgGLEAAKKFLDNLKLfSLAVSLGgVESLISHPAT-MTHASIPPEEr 345

                         330
                  ....*....|....*..
gi 6323557    614 EKFGVERNLLRISVGLE 630
Cdd:pfam01053 346 EAAGITDDLIRLSVGIE 362
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 306-630 1.51e-13

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 72.77  E-value: 1.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSppnkKTVifgfpYADTLHVLQEFNE------TYF-LGEGD--E 376
Cdd:COG0626  77 LAFASGMAAISAVLLALL----------KAGDHVVAS----DDL-----YGGTRRLLDKVLArfgievTFVdPTDLAavE 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  377 SSMKELTKilhsgeqilAVFIETPSNPLLKMgnlLELKRLSEL---FGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKT 452
Cdd:COG0626 138 AAIRPNTK---------LVFLETPSNPTLEV---VDIAAIAAIahaAGALLVVDNTFATPLLQRPLELgADIVVHSATKY 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  453 FSGDSNVIGGSMVLNpqsrvyefasrfmqledeyEDLLWceDAIYLERNSRDFIA------------RT--IRINYST-- 516
Cdd:COG0626 206 LGGHSDVLGGAVVGR-------------------DEELA--ERLRFLQNALGAVLspfdawlllrglKTlaLRMERHCen 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  517 -----EYLLDKilkPHVgenklfKKIYYPNLTS-------KEtltnyDMvrckkeGGYGGLFSLTFH-DEDHAAAFYDNL 583
Cdd:COG0626 265 alavaEWLEAH---PAV------ARVYYPGLPShpghelaKR-----QM------SGFGGMLSFELKgGREAARRFLDAL 324

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 6323557  584 KLNK-GPSLGTNFTLAFPYTLMTYYH-ELDMAEKFGVERNLLRISVGLE 630
Cdd:COG0626 325 KLFTlAVSLGGVESLITHPATMTHRSlPPEERAALGITDGLVRLSVGLE 373
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 310-631 9.06e-12

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 67.18  E-value: 9.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    310 SGMASIFTAHRLLLQ-WDSLRLNRSRNGSdvTSSPPNKKTVIFGFpyadtlhvlqefnETYFLGEGD----ESSMKELTK 384
Cdd:TIGR01325  77 SGMAAIFAALMALLGaGDHVVASRSLFGS--CFVVCSEILPRFGV-------------QTVFVDGTDlsawEAALKPNTK 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    385 ilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:TIGR01325 142 ---------AVFVETPSNPLQELVDIAAVAELAHAAGAKVVVDNVFATPLLQQPLKLgADVVVYSATKHIDGQGRVLGGA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    464 MvlnpqsrvyefASRFMQLEDEYEDLLWCEDAIYLERNSRDFIA--RTIRINYSTEYLLDKILKPHVGENKLFKKIYYPN 541
Cdd:TIGR01325 213 I-----------LGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKglETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPG 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    542 LTSKetlTNYDMVRCKKEGGyGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLG-TNFTLAFPYTlmTYYHELDMAEK--FG 617
Cdd:TIGR01325 282 LPSH---PQHELAKRQMSGG-GTVVTFDLDCRQAAFKVLDAMRLvDISNNLGdAKSTITHPAT--TTHRRMGPEERaaAG 355

                         330
                  ....*....|....
gi 6323557    618 VERNLLRISVGLES 631
Cdd:TIGR01325 356 IGDGLVRLSVGLED 369
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 310-464 1.26e-05

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 48.19  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   310 SGMASIFTAHRLLLQ-WDSLRLNRSRNGSDVtssppnkktVIFGfpyadtlHVLQEFN-ETYFLgEGDESSMKEltKILH 387
Cdd:PRK07810  93 SGMSAVFTALGALLGaGDRLVAARSLFGSCF---------VVCN-------EILPRWGvETVFV-DGEDLSQWE--EALS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   388 SGEQilAVFIETPSNPllkMGNLLELKRLSEL---FGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:PRK07810 154 VPTQ--AVFFETPSNP---MQSLVDIAAVSELahaAGAKVVLDNVFATPLLQRGLPLgADVVVYSGTKHIDGQGRVLGGA 228


                 .
gi 6323557   464 M 464
Cdd:PRK07810 229 I 229
 
Name Accession Description Interval E-value
PRK06176 PRK06176
cystathionine gamma-synthase;
394-645 6.85e-18

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 86.10  E-value: 6.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   394 AVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNPQsrv 472
Cdd:PRK06176 137 ALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLgADIVVHSGTKYLGGHSDVVAGLVTTNNE--- 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   473 yEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARtIRINYSTEYLLDKILKPHvgenKLFKKIYYPNLTSKEtltNYD 552
Cdd:PRK06176 214 -ALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLR-MEAHQKNALCVAEFLEKH----PKVEKVYYPGLPTHP---NHE 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   553 MVRcKKEGGYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNFTLAFPYTLMTYYH-ELDMAEKFGVERNLLRISVGLE 630
Cdd:PRK06176 285 LAK-KQMRGFSGMLSFTLKNDSEAVAFVESLKLfILGESLGGVESLVGIPAFMTHACiPKEQREAAGIRDGLVRLSVGIE 363

                        250
                 ....*....|....*
gi 6323557   631 SQSILGKIFQEAIDK 645
Cdd:PRK06176 364 HEQDLLEDLEQAFAK 378
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 306-631 1.00e-17

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 85.33  E-value: 1.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSPPnkktvIFGFPYADTLHVLQEFN-ETYFLGEGD----ESSMK 380
Cdd:cd00614  59 LAFSSGMAAISTVLLALL----------KAGDHVVASDD-----LYGGTYRLFERLLPKLGiEVTFVDPDDpealEAAIK 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  381 ELTKilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNV 459
Cdd:cd00614 124 PETK---------LVYVESPTNPTLKVVDIEAIAELAHEHGALLVVDNTFATPYLQRPLELgADIVVHSATKYIGGHSDV 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  460 IGGSMVLNpQSRVYEFAsRFMQLE--------DEYEDL-----LwcedAIYLERNSRDfiARTIrinysTEYLLDkilKP 526
Cdd:cd00614 195 IAGVVVGS-GEALIQRL-RFLRLAlgtilspfDAWLLLrglktL----PLRMERHSEN--ALKV-----AEFLEK---HP 258

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  527 HVgenklfKKIYYPNLTSKetlTNYDMVRcKKEGGYGGLFSLTF-HDEDHAAAFYDNLKLnkgPSLGTNF----TLAFPY 601
Cdd:cd00614 259 KV------ERVYYPGLPSH---PQHELAK-KQMSGYGGVFSFELkGGLEAAKKFLNALKL---FSLAVSLggveSLVEHP 325

                       330       340       350
                ....*....|....*....|....*....|.
gi 6323557  602 TLMTYYHELDMA-EKFGVERNLLRISVGLES 631
Cdd:cd00614 326 ASMTHSQLPPEErAAAGITPGLVRLSVGIED 356
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
306-630 8.40e-17

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 82.46  E-value: 8.40e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   306 FLFPSGMASIFTAHRLLLQWDSLRLnrsrnGSDVtssppnkktviFGFPYADTLHVLQEFN-ETYFLgegDESSMKELTK 384
Cdd:PRK07671  69 FAFGSGMAAITAVMMLFSSGDHVIL-----TDDV-----------YGGTYRVMTKVLNRFGiEHTFV---DTSNLEEVEE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   385 ILHSGEQilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVggivnidGLPF--------ADIVCSSLTKTFSGD 456
Cdd:PRK07671 130 AIRPNTK--AIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTF-------MTPYwqspislgADIVLHSATKYLGGH 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   457 SNVIGGSMVLNPQsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEylldKILKpHVGENKLFKK 536
Cdd:PRK07671 201 SDVVAGLVVVNSP----ELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSR----AIAE-FLNNHPAVNK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   537 IYYPNLtskETLTNYDMVRcKKEGGYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNFTLAFPYTLMTYYH-ELDMAE 614
Cdd:PRK07671 272 VYYPGL---PSHPNHELAK-EQANGFGGMISFDVGSEETANKVLERLQYfTLAESLGAVESLISIPSQMTHASiPADRRK 347

                        330
                 ....*....|....*.
gi 6323557   615 KFGVERNLLRISVGLE 630
Cdd:PRK07671 348 ELGITDGLIRISVGIE 363
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 306-630 1.22e-16

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 82.28  E-value: 1.22e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSPPnkktvIFGFPYADTLHVLQEFN-ETYFLGEGD----ESSMK 380
Cdd:pfam01053  66 LAFSSGMAAITAAILALL----------KAGDHIVATDD-----LYGGTYRLFNKVLPRFGiEVTFVDTSDpedlEAAIK 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    381 ELTKilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNV 459
Cdd:pfam01053 131 PNTK---------AVYLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLgADIVVHSATKYIGGHSDV 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    460 IGGSMVLNPQsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINySTEYLLDKILK--PHVgenklfKKI 537
Cdd:pfam01053 202 VGGVIVVNGE----ELGKELYFLQNATGAVLSPFDAWLLLRGLKTLGLRMEQHQ-ENAQKVAEFLEshPKV------EKV 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    538 YYPNLTSKEtltNYDMVRcKKEGGYGGLFSLTFH-DEDHAAAFYDNLKL-NKGPSLG-TNFTLAFPYTlMTYYHELDMA- 613
Cdd:pfam01053 271 YYPGLPSHP---GHELAK-RQMKGFGGMLSFELKgGLEAAKKFLDNLKLfSLAVSLGgVESLISHPAT-MTHASIPPEEr 345

                         330
                  ....*....|....*..
gi 6323557    614 EKFGVERNLLRISVGLE 630
Cdd:pfam01053 346 EAAGITDDLIRLSVGIE 362
PRK08064 PRK08064
cystathionine beta-lyase MetC;
306-648 9.88e-15

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 76.35  E-value: 9.88e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   306 FLFPSGMASIFTAHRLLLQWDSLRLNRsrngsDVtssppnkktviFGFPYADTLHVLQEFNETY-FLgegDESSMKELTK 384
Cdd:PRK08064  73 FAFASGMAAISTAFLLLSKGDHVLISE-----DV-----------YGGTYRMITEVLSRFGIEHtFV---DMTNLEEVAQ 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   385 ILHSGEQIlaVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:PRK08064 134 NIKPNTKL--FYVETPSNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLgADVVLHSATKFLAGHSDVLAGL 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   464 MVLNPQsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFiarTIRINYSTE--YLLDKILKPHvgenKLFKKIYYPN 541
Cdd:PRK08064 212 AVVKDE----ELAQKLYFLQNSFGAVLGVQDCWLVLRGLKTL---HVRLEHSSEtaNKIALYLQEH----PKVQNVYYPG 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   542 LTSKetlTNYDMVRCKKEGGyGGLFSLTFHDEDHAAAFYDNLKLnkgP----SLG-TNFTLAFPYTLMTYYHELDMAEKF 616
Cdd:PRK08064 281 LQTH---LGFDIQQSQATSA-GAVLSFTLQSEEAVRQFVSHVKL---PvfavSLGaVESILSYPAKMSHAAMPKEERDER 353

                        330       340       350
                 ....*....|....*....|....*....|..
gi 6323557   617 GVERNLLRISVGLESQSILGKIFQEAIDKTVE 648
Cdd:PRK08064 354 GITDGLLRLSVGLENVDDLIADFEQALSYVEE 385
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 306-630 1.51e-13

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 72.77  E-value: 1.51e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  306 FLFPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSppnkKTVifgfpYADTLHVLQEFNE------TYF-LGEGD--E 376
Cdd:COG0626  77 LAFASGMAAISAVLLALL----------KAGDHVVAS----DDL-----YGGTRRLLDKVLArfgievTFVdPTDLAavE 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  377 SSMKELTKilhsgeqilAVFIETPSNPLLKMgnlLELKRLSEL---FGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKT 452
Cdd:COG0626 138 AAIRPNTK---------LVFLETPSNPTLEV---VDIAAIAAIahaAGALLVVDNTFATPLLQRPLELgADIVVHSATKY 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  453 FSGDSNVIGGSMVLNpqsrvyefasrfmqledeyEDLLWceDAIYLERNSRDFIA------------RT--IRINYST-- 516
Cdd:COG0626 206 LGGHSDVLGGAVVGR-------------------DEELA--ERLRFLQNALGAVLspfdawlllrglKTlaLRMERHCen 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  517 -----EYLLDKilkPHVgenklfKKIYYPNLTS-------KEtltnyDMvrckkeGGYGGLFSLTFH-DEDHAAAFYDNL 583
Cdd:COG0626 265 alavaEWLEAH---PAV------ARVYYPGLPShpghelaKR-----QM------SGFGGMLSFELKgGREAARRFLDAL 324

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*....
gi 6323557  584 KLNK-GPSLGTNFTLAFPYTLMTYYH-ELDMAEKFGVERNLLRISVGLE 630
Cdd:COG0626 325 KLFTlAVSLGGVESLITHPATMTHRSlPPEERAALGITDGLVRLSVGLE 373
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
304-630 2.32e-13

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 72.02  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   304 DVFLFPSGMASIFTAHRLLLQWDSlRLNRSRNGsdvtssppnkktvifgfpYADTLHVLQEFNE-------TYflgegde 376
Cdd:PRK08574  70 DALAFNSGMAAISTLFFSLLKAGD-RVVLPMEA------------------YGTTLRLLKSLEKfgvkvvlAY------- 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   377 SSMKELTKILHSGEQILaVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSG 455
Cdd:PRK08574 124 PSTEDIIEAIKEGRTKL-VFIETMTNPTLKVIDVPEVAKAAKELGAILVVDNTFATPLLYRPLRHgADFVVHSLTKYIAG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   456 DSNVIGGSMVL---NPQSRVYEFASRF---MQLEDEYEDLLWCED-AIYLERNSRDfiARTIrinysTEYLLDKilkPHV 528
Cdd:PRK08574 203 HNDVVGGVAVAwsgEFLEELWEWRRRLgtiMQPFEAYLVLRGLKTlEVRFERQCRN--AMAI-----AEFLSEH---PKV 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   529 genklfKKIYYPNLTSKEtltnYDMV--RCKKEGGYGGLFSLTFH-DEDHAAAFYDNLKLNK-GPSLGTNFTLA-FPYTL 603
Cdd:PRK08574 273 ------AEVYYPGLPSDP----YHGVakRLFGKDLYGGVVSFRVKgGRDAVLKFLRSLKLIKpSPSLGGVESLAtYPVKS 342

                        330       340
                 ....*....|....*....|....*..
gi 6323557   604 MTYYHELDMAEKFGVERNLLRISVGLE 630
Cdd:PRK08574 343 AASPIPEEDRKALGITEDLVRLSVGLE 369
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
395-635 5.72e-13

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 71.17  E-value: 5.72e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   395 VFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVlnpqsrvy 473
Cdd:PRK08776 149 VLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFgADLVLHSTTKYINGHSDVVGGAVV-------- 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   474 efaSRFMQLedeYEDLLWCEDAIYLE----------RNSRDFIARtIRINYSTEYLLDKILKPHvgenKLFKKIYYPNLT 543
Cdd:PRK08776 221 ---ARDAEL---HQQLVWWANALGLTgspfdafltlRGLRTLDAR-LRVHQENADAIAALLDGH----AAVNQVYYPGLA 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   544 SKETltnyDMVRCKKEGGYGGLFSLTFHDEDHAA-AFYDNLK-LNKGPSLGTNFTL-AFPYTLMTYYHELDMAEKFGVER 620
Cdd:PRK08776 290 SHPG----HALAARQQKGFGAMLSFELEGGEAAVrAFVDGLRyFTLAESLGGVESLiAHPASMTHAAMTAEARAAAGISD 365

                        250
                 ....*....|....*
gi 6323557   621 NLLRISVGLESQSIL 635
Cdd:PRK08776 366 GLLRLSVGIESAEDL 380
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
375-648 8.46e-13

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 70.31  E-value: 8.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   375 DESSMKELTKILHSGEQIlaVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTF 453
Cdd:PRK08861 124 DQSDAAALDAALAKKPKL--ILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTPVLQKPLELgADFVIHSTTKYI 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   454 SGDSNVIGGSMVlnpqsrvyefasrfMQLEDEYEDLLWCEDAI---------YLE-RNSRDFIARtIRINystEYLLDKI 523
Cdd:PRK08861 202 NGHSDVIGGVLI--------------TKTKEHAEELAWWGNCIgatgtpfdsYMTlRGIRTLGAR-MRVH---EESAQQI 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   524 LKpHVGENKLFKKIYYPNLTSKetlTNYDMVRcKKEGGYGGLFSLTFHDE-DHAAAFYDNLKL-NKGPSL-GTNFTLAFP 600
Cdd:PRK08861 264 LA-YLQTQSLVGTIYHPSLPEH---PGHEIAK-KQQSGFGSMLSFEFAGSfEQLKVFVKALALfSLAESLgGVESLICHP 338

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 6323557   601 YTlMTYYHELDMA-EKFGVERNLLRISVGLESQSILGKIFQEAIDKTVE 648
Cdd:PRK08861 339 AS-MTHRAMGEEAlAEAGVSQQLLRLSVGLEDAQDLIADLDQAFAKAAE 386
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 367-643 1.58e-12

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 69.54  E-value: 1.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   367 ETYFLGEGDESSMKELTkilhsGEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIV 445
Cdd:PRK08045 118 RVLFVDQGDEQALRAAL-----AEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPALQNPLALgADLV 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   446 CSSLTKTFSGDSNVIGGSMVLNPQSRVYEFAsrfmqledeyedlLWCE---------DAIYLERNSRDFIARTIRINYST 516
Cdd:PRK08045 193 LHSCTKYLNGHSDVVAGVVIAKDPDVVTELA-------------WWANnigvtggafDSYLLLRGLRTLVPRMELAQRNA 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   517 EYLLDkilkpHVGENKLFKKIYYPNLTSKETltnyDMVRCKKEGGYGGLFSLTFH-DEDHAAAFYDNLKL-NKGPSLGTN 594
Cdd:PRK08045 260 QAIVK-----YLQTQPLVKKLYHPSLPENQG----HEIAARQQKGFGAMLSFELDgDEQTLRRFLGGLSLfTLAESLGGV 330

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323557   595 FTLAFPYTLMTYyheLDMAEK----FGVERNLLRISVGLE-SQSI---LGKIFQEAI 643
Cdd:PRK08045 331 ESLISHAATMTH---AGMAPEaraaAGISETLLRISTGIEdGEDLiadLENGFRAAN 384
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 310-631 9.06e-12

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 67.18  E-value: 9.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    310 SGMASIFTAHRLLLQ-WDSLRLNRSRNGSdvTSSPPNKKTVIFGFpyadtlhvlqefnETYFLGEGD----ESSMKELTK 384
Cdd:TIGR01325  77 SGMAAIFAALMALLGaGDHVVASRSLFGS--CFVVCSEILPRFGV-------------QTVFVDGTDlsawEAALKPNTK 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    385 ilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:TIGR01325 142 ---------AVFVETPSNPLQELVDIAAVAELAHAAGAKVVVDNVFATPLLQQPLKLgADVVVYSATKHIDGQGRVLGGA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    464 MvlnpqsrvyefASRFMQLEDEYEDLLWCEDAIYLERNSRDFIA--RTIRINYSTEYLLDKILKPHVGENKLFKKIYYPN 541
Cdd:TIGR01325 213 I-----------LGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKglETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPG 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    542 LTSKetlTNYDMVRCKKEGGyGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLG-TNFTLAFPYTlmTYYHELDMAEK--FG 617
Cdd:TIGR01325 282 LPSH---PQHELAKRQMSGG-GTVVTFDLDCRQAAFKVLDAMRLvDISNNLGdAKSTITHPAT--TTHRRMGPEERaaAG 355

                         330
                  ....*....|....
gi 6323557    618 VERNLLRISVGLES 631
Cdd:TIGR01325 356 IGDGLVRLSVGLED 369
PRK06460 PRK06460
hypothetical protein; Provisional
 395-630 1.01e-11

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 67.16  E-value: 1.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   395 VFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNpqsrvY 473
Cdd:PRK06460 134 VFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPINQKPLELgADIVVHSASKFLAGHNDVIAGLAAGY-----G 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   474 EFASRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYSTEylldKILKPHVGENKLfKKIYYPNLTSKEtltNYDM 553
Cdd:PRK06460 209 KLLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAE----QIAEFLEGHPKV-VKVYYPGLKSHV---DYEI 280

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   554 VRcKKEGGYGGLFSLTFHdedhaAAFYDNLKLNKGPSL--------GTNFTLAFPYTLMTYYHELDMAEKFGVERNLLRI 625
Cdd:PRK06460 281 AR-RVLKGFGGVLSFEVN-----GGQESALKVMKSLKLiipaqtlgGVNSVISHPATMSHRTLSLEERKIVGITDSLLRL 354


                 ....*
gi 6323557   626 SVGLE 630
Cdd:PRK06460 355 SVGIE 359
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 379-645 2.71e-10

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 62.55  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   379 MKELTKILHS------GEQILA--------VFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGivnidglPF--- 441
Cdd:PRK06767 120 LEEKFMITHSfcdmetEADIENkirpntklIFVETPINPTMKLIDLKQVIRVAKRNGLLVIVDNTFCS-------PYlqr 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   442 -----ADIVCSSLTKTFSGDSNVIGGSMVLNpqSRVYEFASRFMQleDEYEDLLWCEDAIYLERNSRDFIARTIRINYST 516
Cdd:PRK06767 193 plelgCDAVVHSATKYIGGHGDVVAGVTICK--TRALAEKIRPMR--KDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNA 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   517 EYLLDKiLKPHvgenKLFKKIYYPNLTsketLTNYDMVRCkkeggyGGLFSLTFH-DEDHAAAFYDNLKLNK-GPSLGTN 594
Cdd:PRK06767 269 EKIVSF-LKNH----DAVEGVWYPEGE----LASRQMKRG------GGVISFSIKgGKEETQAFINDLHFITiAVSLGDT 333

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6323557   595 FTL-AFPYTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKIFQEAIDK 645
Cdd:PRK06767 334 ETLiQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALKK 385
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 394-631 8.76e-10

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 61.20  E-value: 8.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   394 AVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGivnidglPF--------ADIVCSSLTKTFSGDSNVIGGSMV 465
Cdd:PRK07811 149 LIWVETPTNPLLSITDIAALAELAHDAGAKVVVDNTFAS-------PYlqqplalgADVVVHSTTKYIGGHSDVVGGALV 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   466 LNPQSRVYEFAsrFMQLE--------DEYEDL-----LwcedAIYLERNSRDfiARTIrinysTEYLLDkilKPHVgenk 532
Cdd:PRK07811 222 TNDEELDEAFA--FLQNGagavpgpfDAYLTLrglktL----AVRMDRHSEN--AEAV-----AEFLAG---HPEV---- 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   533 lfKKIYYPNLTSKetlTNYDmVRCKKEGGYGGLFSLTFHDEDHAA-AFYDNLKLnkgpslgtnFTLAFPY----TLMTYY 607
Cdd:PRK07811 282 --STVLYPGLPSH---PGHE-VAARQMRGFGGMVSVRLAGGEEAArDFCARTKV---------FTLAESLggveSLIEHP 346

                        250       260
                 ....*....|....*....|....*...
gi 6323557   608 HELDMAEKFG----VERNLLRISVGLES 631
Cdd:PRK07811 347 SAMTHASTAGsqleVPDDLVRLSVGIED 374
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
308-644 2.41e-09

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 59.70  E-value: 2.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   308 FPSGMASIFTAHRLLLqwdslrlnrsRNGSDVTSSppnkkTVIFGfpyaDT---LHVLQEFnetyflgeGDESSMKELTK 384
Cdd:PRK05939  68 FATGMAAIAAVFLTLL----------RAGDHLVSS-----QFLFG----NTnslFGTLRGL--------GVEVTMVDATD 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   385 ILHSGEQILA----VFIETPSNPLLKMGNLLELKRLSELFGFFIIIDET-----------VGgivnidglpfADIVCSSL 449
Cdd:PRK05939 121 VQNVAAAIRPntrmVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTmtspwlfrpkdVG----------ASLVINSL 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   450 TKTFSGDSNVIGGSMVlnpQSRVYEFaSRFMQLEDEYED---LLWCEDAIYlERNSRDF-------IARTIRINYSTEYL 519
Cdd:PRK05939 191 SKYIAGHGNALGGAVT---DTGLFDW-SAYPNIFPAYRKgdpQQWGLTQIR-KKGLRDMgatlsseAAHRIAIGAETLAL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   520 -----------LDKILK--PHVGenklfkKIYYPNLTSKetlTNYDMVRcKKEGGYGGLFSLTFHDEDHAAAFYDNLKLN 586
Cdd:PRK05939 266 rvdrscsnalaLAQFLEahPKVA------RVYYPGLASH---PQHARAT-ELFRHYGGLLSFELADGIDCFDFLNRLKLV 335

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323557   587 -KGPSLGTNFTLAFPYTlMTYYHELDMAEK--FGVERNLLRISVGLESQSILGKIFQEAID 644
Cdd:PRK05939 336 iKATHLGDTRTLVIPVA-PTIYYEMGAERRasMGIADSLIRVSVGIEDEADLIADFEQALD 395
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 376-648 5.54e-08

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 55.60  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   376 ESSMKELTKIlhsgeqilaVFIETPSNPLLKmgnLLELKRLSELF-----GFFIIIDETVGgivnidgLPF--------A 442
Cdd:PRK06234 143 RNALKANTKV---------VYLETPANPTLK---VTDIKAISNIAhennkECLVFVDNTFC-------TPYiqrplqlgA 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   443 DIVCSSLTKTFSGDSNVIGGSMVLNPqsrvyEFAS--RFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRiNYSTEYLL 520
Cdd:PRK06234 204 DVVVHSATKYLNGHGDVIAGFVVGKE-----EFINqvKLFGIKDMTGSVIGPFEAFLIIRGMKTLQIRMEK-HCKNAMKV 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   521 DKILKPHvgenKLFKKIYYPNLTSKEtltNYDMVRcKKEGGYGGLFSLTFHDEDHAA-AFYDNLKL-NKGPSLGTNFTLA 598
Cdd:PRK06234 278 AKFLESH----PAVEKVYYPGLESFE---YYELAK-KQMSLPGAMISFELKGGVEEGkVVMNNVKLaTLAVSLGDAETLI 349

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6323557   599 FPYTLMTY--YHELDMAEKfGVERNLLRISVGLESQSILGKIFQEAIDKTVE 648
Cdd:PRK06234 350 QHPASMTHspYTAEERKEA-GISDGLVRLSVGLEDVDDIIADLKQALDLIVK 400
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
263-630 1.13e-07

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 54.32  E-value: 1.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   263 EPHNGLVSTippePIEMSTIEEEQSVEEDAGRCALRV-CPERDV--------------FLFPSGMASIFTAHRLLLQWDS 327
Cdd:PRK08247  17 DERTGTVNP----PVYFSTAYRHEGIGESTGFDYSRTgNPTRGVleqaiadleggdqgFACSSGMAAIQLVMSLFRSGDE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   328 LRLNrsrngSDVtssppnkktvifgfpYADTLHVLQEFNETYFLG--EGDESSMKELTKILHsgEQILAVFIETPSNPLL 405
Cdd:PRK08247  93 LIVS-----SDL---------------YGGTYRLFEEHWKKWNVRfvYVNTASLKAIEQAIT--PNTKAIFIETPTNPLM 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   406 KMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNPQsrvyEFASRFMQLED 484
Cdd:PRK08247 151 QETDIAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEgADIVIHSATKYLGGHNDVLAGLVVAKGQ----ELCERLAYYQN 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   485 EYEDLLWCEDAIYLERNSRDFIARTIR----INYSTEYLLDkilKPHVgenklfKKIYYPnltsketltnydmvrckkeg 560
Cdd:PRK08247 227 AAGAVLSPFDSWLLIRGMKTLALRMRQheenAKAIAAFLNE---QPGV------TDVLYP-------------------- 277

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323557   561 GYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNftlafpYTLMTY----YHeLDMAEKF----GVERNLLRISVGLE 630
Cdd:PRK08247 278 GRGGMLSFRLQDEEWVNPFLKSLKLiTFAESLGGV------ESFITYpatqTH-ADIPEEIrianGVCNRLLRFSVGIE 349
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 389-630 2.94e-06

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 49.83  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    389 GEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLN 467
Cdd:TIGR01329 129 GPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVVDNTMMSPLLCNPLELgADIVYHSATKFLAGHSDVMAGVLAVK 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    468 PQsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNsrdfiARTIRINYSTEYLLDKILKPHVGENKLFKKIYYPNLTSKEt 547
Cdd:TIGR01329 209 GE----EIAKKVYFLQNSTGSGLAPFDCWLLLRG-----IKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHP- 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557    548 ltNYDMVRCKKEGGyGGLFSLTFHDEDHAAAFYDNLKLNK-GPSLGT-NFTLAFPYTLMTYYHELDMAEKFGVERNLLRI 625
Cdd:TIGR01329 279 --GFHLHFSQAKGA-GSVLSFETGSVALSKRLVEATKLFSiTVSFGSvNSLISMPCFMSHASIPAEVREERGLPEDLVRL 355


                  ....*
gi 6323557    626 SVGLE 630
Cdd:TIGR01329 356 SVGIE 360
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 390-630 4.30e-06

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 49.43  E-value: 4.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   390 EQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLNP 468
Cdd:PRK07269 135 EDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELgADIVLHSATKYLSGHNDVLAGVVVTND 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   469 QsrvyEFASRFMQLEDEYEDLLWCEDAIYLERNSRDFiarTIRINYSTEYLLDKI--LK--PHVgenklfKKIYYPnlts 544
Cdd:PRK07269 215 L----ELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTL---SLRMERSTANAQEVVafLKksPAV------KEVLYT---- 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   545 ketltnydmvrckkegGYGGLFSLTFHDEDHAAAFYDNLKL-NKGPSLGTNFTL-AFPYTLMTYYHELDMAEKFGVERNL 622
Cdd:PRK07269 278 ----------------GKGGMISFKVADETRIPHILNSLKVfTFAESLGGVESLiTYPTTQTHADIPAEVRHSYGLTDDL 341


                 ....*...
gi 6323557   623 LRISVGLE 630
Cdd:PRK07269 342 LRLSIGIE 349
PLN02242 PLN02242
methionine gamma-lyase
 310-628 1.16e-05

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 48.22  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   310 SGMASIFTAhrlLLQWDSlrlnrsrNGSDVTSSppnkkTVIFGFPYADTLHVL-QEFN-ETYFLGEGDESSMKEltKILH 387
Cdd:PLN02242  99 SGMSAISSV---LLQLCS-------SGGHVVAS-----NTLYGGTHALLAHFLpRKCNiTTTFVDITDLEAVKK--AVVP 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   388 SGEQILavFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPFADIVCSSLTKTFSGDSNVIGGS---- 463
Cdd:PLN02242 162 GKTKVL--YFESISNPTLTVADIPELARIAHEKGVTVVVDNTFAPMVLSPARLGADVVVHSISKFISGGADIIAGAvcgp 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   464 ---------------MVLNP--QSRV-YEFASRFMQLedeyedllwcedAIYLERNSRDFIARTIRInysteylldkilk 525
Cdd:PLN02242 240 aelvnsmmdlhhgalMLLGPtmNPKVaFELSERLPHL------------SLRMKEHCRRAMEYAKRM------------- 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   526 phvgeNKLFKKIYYPNLTS--KETLtnydMVRCKKEG-GYGGLFSLTFHDEDHAAAFYDNLKlNkgpslGTNF-----TL 597
Cdd:PLN02242 295 -----KELGLKVIYPGLEDhpQHAL----LKSMANKGyGFGGLLCLDMDTEERANRLMRYLQ-N-----STQFgfmavSL 359

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 6323557   598 AFPYTLMTYY-----HELDMAEK--FGVERNLLRISVG 628
Cdd:PLN02242 360 GYYETLMSCSgsstsSELDPEEKaaAGISPGLVRMSVG 397
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 310-464 1.26e-05

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 48.19  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   310 SGMASIFTAHRLLLQ-WDSLRLNRSRNGSDVtssppnkktVIFGfpyadtlHVLQEFN-ETYFLgEGDESSMKEltKILH 387
Cdd:PRK07810  93 SGMSAVFTALGALLGaGDRLVAARSLFGSCF---------VVCN-------EILPRWGvETVFV-DGEDLSQWE--EALS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   388 SGEQilAVFIETPSNPllkMGNLLELKRLSEL---FGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGS 463
Cdd:PRK07810 154 VPTQ--AVFFETPSNP---MQSLVDIAAVSELahaAGAKVVLDNVFATPLLQRGLPLgADVVVYSGTKHIDGQGRVLGGA 228


                 .
gi 6323557   464 M 464
Cdd:PRK07810 229 I 229
PRK05968 PRK05968
hypothetical protein; Provisional
 561-645 1.63e-05

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 47.77  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   561 GYGGLFSLTFHDEDHAAAFYDNLKLNK-GPSLGTNFTLAFP-YTLMTYYHELDMAEKFGVERNLLRISVGLESQSILGKI 638
Cdd:PRK05968 300 GTSGLFSFIFREGIDVRAFADALKLFRlGVSWGGHESLVVPaEVVLQQKAQPNSAARFGVSPRSVRLHVGLEGTEALWAD 379


                 ....*..
gi 6323557   639 FQEAIDK 645
Cdd:PRK05968 380 LEQALAA 386
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
350-465 5.79e-05

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 46.05  E-value: 5.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   350 IFGFPYADTLHVLQEFN-ETYFLGEGDESSMKELTKilhsgEQILAVFIETPSNPllkMGNLLELKRLSEL---FGFFII 425
Cdd:PRK06084 106 LYGGTYNLLAHTLPRIGiETRFAAHDDIAALEALID-----ERTKAVFCESIGNP---AGNIIDIQALADAahrHGVPLI 177

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 6323557   426 IDETVGGIVNIDglPF---ADIVCSSLTKTFSGDSNVIGGSMV 465
Cdd:PRK06084 178 VDNTVATPVLCR--PFehgADIVVHSLTKYIGGHGTSIGGIVV 218
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 389-645 8.53e-05

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 45.18  E-value: 8.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   389 GEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLN 467
Cdd:PRK07503 148 SDKTRMVYFETPANPNMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELgADLVVHSATKYLGGHGDITAGLVVGG 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   468 PQ--SRVyefasRFMQLEDEYEDLLWCEDAIYLERNSRDFIARTIRINYS----TEYLLDkilKPHVgenklfKKIYYPN 541
Cdd:PRK07503 228 KAlaDRI-----RLEGLKDMTGAVMSPFDAFLLMRGLKTLALRMDRHCASaqavAEWLAR---HPAV------ELVHYPG 293

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   542 LTS--KETLTNYDMvrcKKEGGY------GGLfsltfhdeDHAAAFYDNLKL-NKGPSLGTNFTLAFPYTLMTY--YHEL 610
Cdd:PRK07503 294 LPSfaQHALAQRQM---ALPGGMiafelkGGI--------AAGRRFMNALQLfARAVSLGDAESLAQHPASMTHstYTPE 362

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 6323557   611 DMAEKfGVERNLLRISVGLES-QSILGKIfQEAIDK 645
Cdd:PRK07503 363 ERAEH-GISEGLVRLSVGLEDvADILADL-AQALDA 396
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 394-631 1.60e-04

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 44.64  E-value: 1.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  394 AVFIETPSNPLLkmgNLLELKRLSEL---FGFFIIIDETVGG--IVNidglPF---ADIVCSSLTKTFSGDSNVIGGSMV 465
Cdd:COG2873 151 AIFGETIGNPAL---DVLDIEAIAEIaheHGVPLIVDNTFATpyLCR----PIehgADIVVHSATKYIGGHGTSIGGVIV 223

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  466 ----LNpqsrvYEFASRFMQL--EDE-YEDLLWCED----AiylernsrdFIARtIRinysTEYLLD--KILKP------ 526
Cdd:COG2873 224 dggnFD-----WAANGKFPELtePDPsYHGLVYTEAfgnaA---------FITK-AR----VQLLRDlgAALSPfnafll 284

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  527 -------------HVgENKL----F-------KKIYYPNLTSKETltnYDmvRCKK--EGGYGGLFSLTFH-DEDHAAAF 579
Cdd:COG2873 285 lqgletlslrmerHV-ENALkvaeFleahpkvAWVNYPGLPSHPY---HE--LAQKylPKGAGGVLTFGLKgGREAGKKF 358

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557  580 YDNLKLNkgpSLGTNF----TLAF-PYTlMTyyH-ELDMAE--KFGVERNLLRISVGLES 631
Cdd:COG2873 359 IDSLKLF---SHLANIgdakSLVIhPAS-TT--HsQLSEEEqaAAGVTPDLIRLSVGIED 412
PLN02509 PLN02509
cystathionine beta-lyase
 389-470 1.72e-03

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 41.17  E-value: 1.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   389 GEQILAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNVIGGSMVLN 467
Cdd:PLN02509 215 GPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELgADIVMHSATKFIAGHSDVMAGVLAVK 294


                 ...
gi 6323557   468 PQS 470
Cdd:PLN02509 295 GEK 297
PRK05613 PRK05613
O-acetylhomoserine/O-acetylserine sulfhydrylase;
307-465 2.78e-03

O-acetylhomoserine/O-acetylserine sulfhydrylase;


Pssm-ID: 168128 [Multi-domain]  Cd Length: 437  Bit Score: 40.63  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   307 LFPSGMASIFTAHrlllqwdslrLNRSRNGSDVTSSPPnkktvIFGFPYADTLHVLQEFN-ETYFLGEGD-----ESSMK 380
Cdd:PRK05613  89 AFASGQAAETAAI----------LNLAGAGDHIVTSPR-----LYGGTETLFLVTLNRLGiEVTFVENPDdpeswQAAVQ 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323557   381 ELTKilhsgeqilAVFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVGGIVNIDGLPF-ADIVCSSLTKTFSGDSNV 459
Cdd:PRK05613 154 PNTK---------AFFGETFANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELgADVVVASLTKFYTGNGSG 224


                 ....*.
gi 6323557   460 IGGSMV 465
Cdd:PRK05613 225 LGGVLI 230
PRK07582 PRK07582
cystathionine gamma-lyase; Validated
 395-462 6.34e-03

cystathionine gamma-lyase; Validated


Pssm-ID: 236061  Cd Length: 366  Bit Score: 39.21  E-value: 6.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323557   395 VFIETPSNPLLKMGNLLELKRLSELFGFFIIIDETVggivnidGLPF--------ADIVCSSLTKTFSGDSNVIGG 462
Cdd:PRK07582 136 VLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTT-------ATPLgqrplelgADLVVASDTKALTGHSDLLLG 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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