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Conserved domains on  [gi|6324075|ref|NP_014145|]
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Rtc4p [Saccharomyces cerevisiae S288C]

Protein Classification

restriction of telomere capping 4 family protein( domain architecture ID 10628055)

restriction of telomere capping 4 (RTC4) family protein similar to yeast RTC4 which is a suppressor of a temperature-sensitive CDC13 allele, cdc13-1; Cdc13p plays an essential role in telomere length homeostasis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTC4 pfam14474
RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In ...
 218-364 9.31e-33

RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres. This domain is also found in proteins that contain a DNA-binding myb domain.


:

Pssm-ID: 464184  Cd Length: 121  Bit Score: 119.24  E-value: 9.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324075    218 EGKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTH--NQPATLKWWGITDF 295
Cdd:pfam14474   1 KGKTSSYYYDLAEKVVKKSGKRTLTATEFRDLDLEKFTPGYYGPRGQRIISEHILSRFSDLLRRlaVKDPLVSAWGVSDF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324075    296 CNYVLAPETLTSFCIYQLNLSNKScssktpnkhpkqqlnekeyyydpelrmlAYDLLEDTVEYGIIVAD 364
Cdd:pfam14474  81 VQYVLVPELAVRLIMEDMKVDDEE----------------------------ARDILEESSEYGLLVND 121
 
Name Accession Description Interval E-value
RTC4 pfam14474
RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In ...
 218-364 9.31e-33

RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres. This domain is also found in proteins that contain a DNA-binding myb domain.


Pssm-ID: 464184  Cd Length: 121  Bit Score: 119.24  E-value: 9.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324075    218 EGKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTH--NQPATLKWWGITDF 295
Cdd:pfam14474   1 KGKTSSYYYDLAEKVVKKSGKRTLTATEFRDLDLEKFTPGYYGPRGQRIISEHILSRFSDLLRRlaVKDPLVSAWGVSDF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324075    296 CNYVLAPETLTSFCIYQLNLSNKScssktpnkhpkqqlnekeyyydpelrmlAYDLLEDTVEYGIIVAD 364
Cdd:pfam14474  81 VQYVLVPELAVRLIMEDMKVDDEE----------------------------ARDILEESSEYGLLVND 121
 
Name Accession Description Interval E-value
RTC4 pfam14474
RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In ...
 218-364 9.31e-33

RTC4-like domain; This presumed domain is found in the RTC4 protein from yeasts. In Saccharomyces cerevisiae, Cdc13 binds telomeric DNA to recruit telomerase and to "cap" chromosome ends. RTC4 was identified in a screen to identify novel proteins and pathways that cap telomeres, or that respond to uncapped telomeres. This domain is also found in proteins that contain a DNA-binding myb domain.


Pssm-ID: 464184  Cd Length: 121  Bit Score: 119.24  E-value: 9.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324075    218 EGKISSVYYFEAKNAFKNSQKAYLSVDEFRKLNLNKFTAGFYGLKRQLRVGEEIAKRYKRALTH--NQPATLKWWGITDF 295
Cdd:pfam14474   1 KGKTSSYYYDLAEKVVKKSGKRTLTATEFRDLDLEKFTPGYYGPRGQRIISEHILSRFSDLLRRlaVKDPLVSAWGVSDF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324075    296 CNYVLAPETLTSFCIYQLNLSNKScssktpnkhpkqqlnekeyyydpelrmlAYDLLEDTVEYGIIVAD 364
Cdd:pfam14474  81 VQYVLVPELAVRLIMEDMKVDDEE----------------------------ARDILEESSEYGLLVND 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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